A randomized comparative study to determine the effect of omeprazole on the peak serum concentration of itraconazole oral solution.
Publication
, Journal Article
Johnson, MD; Hamilton, CD; Drew, RH; Sanders, LL; Pennick, GJ; Perfect, JR
Published in: J Antimicrob Chemother
February 2003
To determine the effect of omeprazole on peak serum concentrations (C(max)) of itraconazole oral solution (IOS), we carried out a randomized, open-label, prospective, crossover study. Fifteen healthy, non-pregnant adults received a single dose of IOS 400 mg on two occasions, at least 7 days apart, with omeprazole 40 mg nightly for 7 days before either IOS dose 1 or 2. C(max), time to C(max) (T(max)) and AUC(0-8) were determined for itraconazole and its active metabolite, hydroxyitraconazole, for each dose and compared. Omeprazole did not significantly affect the C(max), T(max) or AUC(0-8) of itraconazole or hydroxyitraconazole when administered as IOS.
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Published In
J Antimicrob Chemother
DOI
ISSN
0305-7453
Publication Date
February 2003
Volume
51
Issue
2
Start / End Page
453 / 457
Location
England
Related Subject Headings
- Pharmaceutical Solutions
- Omeprazole
- Middle Aged
- Microbiology
- Male
- Itraconazole
- Humans
- Female
- Drug Interactions
- Biotransformation
Citation
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ICMJE
MLA
NLM
Johnson, M. D., Hamilton, C. D., Drew, R. H., Sanders, L. L., Pennick, G. J., & Perfect, J. R. (2003). A randomized comparative study to determine the effect of omeprazole on the peak serum concentration of itraconazole oral solution. J Antimicrob Chemother, 51(2), 453–457. https://doi.org/10.1093/jac/dkg089
Johnson, Melissa D., Carol D. Hamilton, Richard H. Drew, Linda L. Sanders, Gennethel J. Pennick, and John R. Perfect. “A randomized comparative study to determine the effect of omeprazole on the peak serum concentration of itraconazole oral solution.” J Antimicrob Chemother 51, no. 2 (February 2003): 453–57. https://doi.org/10.1093/jac/dkg089.
Johnson MD, Hamilton CD, Drew RH, Sanders LL, Pennick GJ, Perfect JR. A randomized comparative study to determine the effect of omeprazole on the peak serum concentration of itraconazole oral solution. J Antimicrob Chemother. 2003 Feb;51(2):453–7.
Johnson, Melissa D., et al. “A randomized comparative study to determine the effect of omeprazole on the peak serum concentration of itraconazole oral solution.” J Antimicrob Chemother, vol. 51, no. 2, Feb. 2003, pp. 453–57. Pubmed, doi:10.1093/jac/dkg089.
Johnson MD, Hamilton CD, Drew RH, Sanders LL, Pennick GJ, Perfect JR. A randomized comparative study to determine the effect of omeprazole on the peak serum concentration of itraconazole oral solution. J Antimicrob Chemother. 2003 Feb;51(2):453–457.
Published In
J Antimicrob Chemother
DOI
ISSN
0305-7453
Publication Date
February 2003
Volume
51
Issue
2
Start / End Page
453 / 457
Location
England
Related Subject Headings
- Pharmaceutical Solutions
- Omeprazole
- Middle Aged
- Microbiology
- Male
- Itraconazole
- Humans
- Female
- Drug Interactions
- Biotransformation