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Genome-wide scan of copy number variation in late-onset Alzheimer's disease.

Publication ,  Journal Article
Heinzen, EL; Need, AC; Hayden, KM; Chiba-Falek, O; Roses, AD; Strittmatter, WJ; Burke, JR; Hulette, CM; Welsh-Bohmer, KA; Goldstein, DB
Published in: J Alzheimers Dis
2010

Alzheimer's disease is a complex and progressive neurodegenerative disease leading to loss of memory, cognitive impairment, and ultimately death. To date, six large-scale genome-wide association studies have been conducted to identify SNPs that influence disease predisposition. These studies have confirmed the well-known APOE epsilon4 risk allele, identified a novel variant that influences disease risk within the APOE epsilon4 population, found a SNP that modifies the age of disease onset, as well as reported the first sex-linked susceptibility variant. Here we report a genome-wide scan of Alzheimer's disease in a set of 331 cases and 368 controls, extending analyses for the first time to include assessments of copy number variation. In this analysis, no new SNPs show genome-wide significance. We also screened for effects of copy number variation, and while nothing was significant, a duplication in CHRNA7 appears interesting enough to warrant further investigation.

Duke Scholars

Published In

J Alzheimers Dis

DOI

EISSN

1875-8908

Publication Date

2010

Volume

19

Issue

1

Start / End Page

69 / 77

Location

Netherlands

Related Subject Headings

  • Young Adult
  • Polymorphism, Single Nucleotide
  • Neurology & Neurosurgery
  • Middle Aged
  • Male
  • Humans
  • Genome-Wide Association Study
  • Genetic Variation
  • Genetic Predisposition to Disease
  • Female
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Heinzen, E. L., Need, A. C., Hayden, K. M., Chiba-Falek, O., Roses, A. D., Strittmatter, W. J., … Goldstein, D. B. (2010). Genome-wide scan of copy number variation in late-onset Alzheimer's disease. J Alzheimers Dis, 19(1), 69–77. https://doi.org/10.3233/JAD-2010-1212
Heinzen, Erin L., Anna C. Need, Kathleen M. Hayden, Ornit Chiba-Falek, Allen D. Roses, Warren J. Strittmatter, James R. Burke, Christine M. Hulette, Kathleen A. Welsh-Bohmer, and David B. Goldstein. “Genome-wide scan of copy number variation in late-onset Alzheimer's disease.J Alzheimers Dis 19, no. 1 (2010): 69–77. https://doi.org/10.3233/JAD-2010-1212.
Heinzen EL, Need AC, Hayden KM, Chiba-Falek O, Roses AD, Strittmatter WJ, et al. Genome-wide scan of copy number variation in late-onset Alzheimer's disease. J Alzheimers Dis. 2010;19(1):69–77.
Heinzen, Erin L., et al. “Genome-wide scan of copy number variation in late-onset Alzheimer's disease.J Alzheimers Dis, vol. 19, no. 1, 2010, pp. 69–77. Pubmed, doi:10.3233/JAD-2010-1212.
Heinzen EL, Need AC, Hayden KM, Chiba-Falek O, Roses AD, Strittmatter WJ, Burke JR, Hulette CM, Welsh-Bohmer KA, Goldstein DB. Genome-wide scan of copy number variation in late-onset Alzheimer's disease. J Alzheimers Dis. 2010;19(1):69–77.

Published In

J Alzheimers Dis

DOI

EISSN

1875-8908

Publication Date

2010

Volume

19

Issue

1

Start / End Page

69 / 77

Location

Netherlands

Related Subject Headings

  • Young Adult
  • Polymorphism, Single Nucleotide
  • Neurology & Neurosurgery
  • Middle Aged
  • Male
  • Humans
  • Genome-Wide Association Study
  • Genetic Variation
  • Genetic Predisposition to Disease
  • Female