Quantitation of 211At in small volumes for evaluation of targeted radiotherapy in animal models.
Publication
, Journal Article
Johnson, EL; Turkington, TG; Jaszczak, RJ; Gilland, DR; Vaidyanathan, G; Greer, KL; Coleman, RE; Zalutsky, MR
Published in: Nucl Med Biol
January 1995
We have evaluated SPECT and two planar imaging methods, geometric mean (GM) and buildup factor (BF), for their potential to quantitate in vivo 211At distributions in rat spinal subarachnoid spaces using phantom studies. The use of medium-energy collimators and the small diameter (3 mm) of the subarachnoid space complicate quantitation. Net activities from distributions in various backgrounds were obtained using a large region of interest with background subtraction. Results showed quantitation accuracy within 10% for SPECT and BF in low backgrounds increasing to 25% at higher background levels while GM errors ranged from 20 to 45%. We have also obtained images of [211At]astatide distributions, administered intrathecally, in rats.
Duke Scholars
Published In
Nucl Med Biol
DOI
ISSN
0969-8051
Publication Date
January 1995
Volume
22
Issue
1
Start / End Page
45 / 54
Location
United States
Related Subject Headings
- Tomography, Emission-Computed, Single-Photon
- Rats
- Radiometry
- Nuclear Medicine & Medical Imaging
- Female
- Astatine
- Animals
- 3202 Clinical sciences
- 1103 Clinical Sciences
Citation
APA
Chicago
ICMJE
MLA
NLM
Johnson, E. L., Turkington, T. G., Jaszczak, R. J., Gilland, D. R., Vaidyanathan, G., Greer, K. L., … Zalutsky, M. R. (1995). Quantitation of 211At in small volumes for evaluation of targeted radiotherapy in animal models. Nucl Med Biol, 22(1), 45–54. https://doi.org/10.1016/0969-8051(94)00077-w
Johnson, E. L., T. G. Turkington, R. J. Jaszczak, D. R. Gilland, G. Vaidyanathan, K. L. Greer, R. E. Coleman, and M. R. Zalutsky. “Quantitation of 211At in small volumes for evaluation of targeted radiotherapy in animal models.” Nucl Med Biol 22, no. 1 (January 1995): 45–54. https://doi.org/10.1016/0969-8051(94)00077-w.
Johnson EL, Turkington TG, Jaszczak RJ, Gilland DR, Vaidyanathan G, Greer KL, et al. Quantitation of 211At in small volumes for evaluation of targeted radiotherapy in animal models. Nucl Med Biol. 1995 Jan;22(1):45–54.
Johnson, E. L., et al. “Quantitation of 211At in small volumes for evaluation of targeted radiotherapy in animal models.” Nucl Med Biol, vol. 22, no. 1, Jan. 1995, pp. 45–54. Pubmed, doi:10.1016/0969-8051(94)00077-w.
Johnson EL, Turkington TG, Jaszczak RJ, Gilland DR, Vaidyanathan G, Greer KL, Coleman RE, Zalutsky MR. Quantitation of 211At in small volumes for evaluation of targeted radiotherapy in animal models. Nucl Med Biol. 1995 Jan;22(1):45–54.
Published In
Nucl Med Biol
DOI
ISSN
0969-8051
Publication Date
January 1995
Volume
22
Issue
1
Start / End Page
45 / 54
Location
United States
Related Subject Headings
- Tomography, Emission-Computed, Single-Photon
- Rats
- Radiometry
- Nuclear Medicine & Medical Imaging
- Female
- Astatine
- Animals
- 3202 Clinical sciences
- 1103 Clinical Sciences