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Measuring astatine-211 distributions with SPECT.

Publication ,  Journal Article
Turkington, TG; Zalutsky, MR; Jaszczak, RJ; Garg, PK; Vaidyanathan, G; Coleman, RE
Published in: Phys Med Biol
August 1993

We have investigated standard SPECT techniques (rotating gamma cameras, multi-hole collimators, and filtered backprojection reconstruction) for imaging astatine-211 distributions. Since 211At emits alpha particles, this nuclide has potential for use in radiotherapy. The capability of imaging this nuclide would allow in vivo evaluation of the distribution and stability of potential 211At-labelled radiotherapeutic agents. 211At decay yields x-rays in the 77-92 keV range in addition to 500-900 keV gamma rays. This study evaluates the feasibility of SPECT imaging using the x-ray emissions of 211At. We have evaluated several collimators, with the determination that the medium-energy collimators we used are suitable, with 7% penetration (uncollimated counts versus collimated counts). Several phantoms were imaged and attenuation coefficients were measured (narrow-beam mu = 0.182 cm-1 for 77-80 keV x-rays in water). Reconstructed images demonstrate qualitative capabilities and a simple quantitative study demonstrates good correction for attenuation and scatter (approximately 10% error), at low count densities, at least for the phantom geometries used in this study.

Duke Scholars

Published In

Phys Med Biol

DOI

ISSN

0031-9155

Publication Date

August 1993

Volume

38

Issue

8

Start / End Page

1121 / 1130

Location

England

Related Subject Headings

  • Tomography, Emission-Computed, Single-Photon
  • Nuclear Medicine & Medical Imaging
  • Astatine
  • 5105 Medical and biological physics
  • 1103 Clinical Sciences
  • 0903 Biomedical Engineering
  • 0299 Other Physical Sciences
 

Citation

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ICMJE
MLA
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Turkington, T. G., Zalutsky, M. R., Jaszczak, R. J., Garg, P. K., Vaidyanathan, G., & Coleman, R. E. (1993). Measuring astatine-211 distributions with SPECT. Phys Med Biol, 38(8), 1121–1130. https://doi.org/10.1088/0031-9155/38/8/010
Turkington, T. G., M. R. Zalutsky, R. J. Jaszczak, P. K. Garg, G. Vaidyanathan, and R. E. Coleman. “Measuring astatine-211 distributions with SPECT.Phys Med Biol 38, no. 8 (August 1993): 1121–30. https://doi.org/10.1088/0031-9155/38/8/010.
Turkington TG, Zalutsky MR, Jaszczak RJ, Garg PK, Vaidyanathan G, Coleman RE. Measuring astatine-211 distributions with SPECT. Phys Med Biol. 1993 Aug;38(8):1121–30.
Turkington, T. G., et al. “Measuring astatine-211 distributions with SPECT.Phys Med Biol, vol. 38, no. 8, Aug. 1993, pp. 1121–30. Pubmed, doi:10.1088/0031-9155/38/8/010.
Turkington TG, Zalutsky MR, Jaszczak RJ, Garg PK, Vaidyanathan G, Coleman RE. Measuring astatine-211 distributions with SPECT. Phys Med Biol. 1993 Aug;38(8):1121–1130.

Published In

Phys Med Biol

DOI

ISSN

0031-9155

Publication Date

August 1993

Volume

38

Issue

8

Start / End Page

1121 / 1130

Location

England

Related Subject Headings

  • Tomography, Emission-Computed, Single-Photon
  • Nuclear Medicine & Medical Imaging
  • Astatine
  • 5105 Medical and biological physics
  • 1103 Clinical Sciences
  • 0903 Biomedical Engineering
  • 0299 Other Physical Sciences