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Integration of cone-beam CT in stereotactic body radiation therapy.

Publication ,  Journal Article
Yin, F-F; Wang, Z; Yoo, S; Wu, QJ; Kirkpatrick, J; Larrier, N; Meyer, J; Willett, CG; Marks, LB
Published in: Technol Cancer Res Treat
April 2008

This report describes the technique and initial experience using cone beam CT (CBCT) for localization of treatment targets in patients undergoing stereotactic body radiation therapy (SBRT). Patients selected for SBRT underwent 3-D or 4-D CT scans in a customized immobilization cradle. GTV, CTV, ITV, and PTV were defined. Intensity-modulated radiation beams, multiple 3-D conformal beams, or dynamic conformal arcs were delivered using a Varian 21EX with 120-leaf MLC. CBCT images were obtained prior to each fraction, and registered to the planning CT by using soft tissue and bony structures to assure accurate isocenter localization. Patients were repositioned for treatment based on the CBCT images. Radiographic images (kV, MV, or CBCT) were taken before and after beam delivery to further assess set-up accuracy. Ten patients with lung, liver, and spine lesions received 29 fractions of treatment using this technique. The prescription doses ranged 1250 approximately 6000 cGy in 1 approximately 5 fractions. Compared to traditional 2-D matching using bony structures, CBCT corrects target deviation from 1 mm to 15 mm, with an average of 5 mm. Comparison of pre-treatment to post-treatment radiographic images demonstrated an average 2 mm deviation (ranging from 0-4 mm). Improved immobilization may enhance positioning accuracy. Typical total "in-room" times for the patients are approximately 1 hour. CBCT-guided SBRT is feasible and enhances setup accuracy using 3-D anatomical information.

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Published In

Technol Cancer Res Treat

DOI

ISSN

1533-0346

Publication Date

April 2008

Volume

7

Issue

2

Start / End Page

133 / 139

Location

United States

Related Subject Headings

  • Radiotherapy, Conformal
  • Radiotherapy Planning, Computer-Assisted
  • Radiosurgery
  • Oncology & Carcinogenesis
  • Neoplasms
  • Humans
  • Cone-Beam Computed Tomography
  • 3211 Oncology and carcinogenesis
  • 1112 Oncology and Carcinogenesis
 

Citation

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MLA
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Yin, F.-F., Wang, Z., Yoo, S., Wu, Q. J., Kirkpatrick, J., Larrier, N., … Marks, L. B. (2008). Integration of cone-beam CT in stereotactic body radiation therapy. Technol Cancer Res Treat, 7(2), 133–139. https://doi.org/10.1177/153303460800700206
Yin, Fang-Fang, Zhiheng Wang, Sua Yoo, Q Jackie Wu, John Kirkpatrick, Nicole Larrier, Jeffrey Meyer, Christopher G. Willett, and Lawrence B. Marks. “Integration of cone-beam CT in stereotactic body radiation therapy.Technol Cancer Res Treat 7, no. 2 (April 2008): 133–39. https://doi.org/10.1177/153303460800700206.
Yin F-F, Wang Z, Yoo S, Wu QJ, Kirkpatrick J, Larrier N, et al. Integration of cone-beam CT in stereotactic body radiation therapy. Technol Cancer Res Treat. 2008 Apr;7(2):133–9.
Yin, Fang-Fang, et al. “Integration of cone-beam CT in stereotactic body radiation therapy.Technol Cancer Res Treat, vol. 7, no. 2, Apr. 2008, pp. 133–39. Pubmed, doi:10.1177/153303460800700206.
Yin F-F, Wang Z, Yoo S, Wu QJ, Kirkpatrick J, Larrier N, Meyer J, Willett CG, Marks LB. Integration of cone-beam CT in stereotactic body radiation therapy. Technol Cancer Res Treat. 2008 Apr;7(2):133–139.
Journal cover image

Published In

Technol Cancer Res Treat

DOI

ISSN

1533-0346

Publication Date

April 2008

Volume

7

Issue

2

Start / End Page

133 / 139

Location

United States

Related Subject Headings

  • Radiotherapy, Conformal
  • Radiotherapy Planning, Computer-Assisted
  • Radiosurgery
  • Oncology & Carcinogenesis
  • Neoplasms
  • Humans
  • Cone-Beam Computed Tomography
  • 3211 Oncology and carcinogenesis
  • 1112 Oncology and Carcinogenesis