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Immune recovery in adult patients after myeloablative dual umbilical cord blood, matched sibling, and matched unrelated donor hematopoietic cell transplantation.

Publication ,  Journal Article
Kanda, J; Chiou, L-W; Szabolcs, P; Sempowski, GD; Rizzieri, DA; Long, GD; Sullivan, KM; Gasparetto, C; Chute, JP; Morris, A; McPherson, J ...
Published in: Biol Blood Marrow Transplant
November 2012

Immunologic reconstitution after allogeneic hematopoietic cell transplantation is a critical component of successful outcome. Umbilical cord blood (UCB) transplantation in adult recipients is associated with slow and often inadequate immune recovery. We characterized the kinetics and extent of immune recovery in 95 adult recipients after a dual UCB (n = 29) and matched sibling donor (n = 33) or matched unrelated donor (n = 33) transplantation. All patients were treated with myeloablative conditioning. There were no differences in the immune recovery profile of matched sibling donor and matched unrelated donor recipients. Significantly lower levels of CD3+, CD4+, and CD8+ T cells were observed in UCB recipients until 6 months after transplantation. Lower levels of regulatory T cells persisted until 1 year after transplantation. Thymopoiesis as measured by TCR rearrangement excision circle was comparable among all recipients by 6 months after transplantation. In a subset of patients 1 year after transplantation with similar levels of circulating T cells and TCR rearrangement excision circle, there was no difference in TCR diversity. Compared to HLA-identical matched sibling donor and matched unrelated donor adult hematopoietic cell transplantation recipients, quantitative lymphoid recovery in UCB transplantation recipients is slower in the first 3 months, but these differences disappeared by 6 to 12 months after transplantation.

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Published In

Biol Blood Marrow Transplant

DOI

EISSN

1523-6536

Publication Date

November 2012

Volume

18

Issue

11

Start / End Page

1664 / 1676.e1

Location

United States

Related Subject Headings

  • Unrelated Donors
  • Transplantation, Homologous
  • Transplantation Conditioning
  • T-Lymphocytes
  • Siblings
  • Recovery of Function
  • Prospective Studies
  • Myeloablative Agonists
  • Middle Aged
  • Male
 

Citation

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Kanda, J., Chiou, L.-W., Szabolcs, P., Sempowski, G. D., Rizzieri, D. A., Long, G. D., … Horwitz, M. E. (2012). Immune recovery in adult patients after myeloablative dual umbilical cord blood, matched sibling, and matched unrelated donor hematopoietic cell transplantation. Biol Blood Marrow Transplant, 18(11), 1664-1676.e1. https://doi.org/10.1016/j.bbmt.2012.06.005
Kanda, Junya, Lun-Wei Chiou, Paul Szabolcs, Gregory D. Sempowski, David A. Rizzieri, Gwynn D. Long, Keith M. Sullivan, et al. “Immune recovery in adult patients after myeloablative dual umbilical cord blood, matched sibling, and matched unrelated donor hematopoietic cell transplantation.Biol Blood Marrow Transplant 18, no. 11 (November 2012): 1664-1676.e1. https://doi.org/10.1016/j.bbmt.2012.06.005.
Kanda J, Chiou L-W, Szabolcs P, Sempowski GD, Rizzieri DA, Long GD, et al. Immune recovery in adult patients after myeloablative dual umbilical cord blood, matched sibling, and matched unrelated donor hematopoietic cell transplantation. Biol Blood Marrow Transplant. 2012 Nov;18(11):1664-1676.e1.
Kanda, Junya, et al. “Immune recovery in adult patients after myeloablative dual umbilical cord blood, matched sibling, and matched unrelated donor hematopoietic cell transplantation.Biol Blood Marrow Transplant, vol. 18, no. 11, Nov. 2012, pp. 1664-1676.e1. Pubmed, doi:10.1016/j.bbmt.2012.06.005.
Kanda J, Chiou L-W, Szabolcs P, Sempowski GD, Rizzieri DA, Long GD, Sullivan KM, Gasparetto C, Chute JP, Morris A, McPherson J, Hale J, Livingston JA, Broadwater G, Niedzwiecki D, Chao NJ, Horwitz ME. Immune recovery in adult patients after myeloablative dual umbilical cord blood, matched sibling, and matched unrelated donor hematopoietic cell transplantation. Biol Blood Marrow Transplant. 2012 Nov;18(11):1664-1676.e1.
Journal cover image

Published In

Biol Blood Marrow Transplant

DOI

EISSN

1523-6536

Publication Date

November 2012

Volume

18

Issue

11

Start / End Page

1664 / 1676.e1

Location

United States

Related Subject Headings

  • Unrelated Donors
  • Transplantation, Homologous
  • Transplantation Conditioning
  • T-Lymphocytes
  • Siblings
  • Recovery of Function
  • Prospective Studies
  • Myeloablative Agonists
  • Middle Aged
  • Male