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Effects of unexpected changes in visual scenes on the human acoustic startle response and prepulse inhibition.

Publication ,  Journal Article
Larrauri, JA; Rosenthal, MZ; Levin, ED; McClernon, FJ; Schmajuk, NA
Published in: Behav Processes
January 2012

Prepulse inhibition (PPI) refers to the process wherein startle responses to salient stimuli (e.g., startling sound pulses) are attenuated by the presentation of another stimulus (e.g., a brief pre-pulse) immediately before the startling stimulus. Accordingly, deficits in PPI reflect atypical sensorimotor gating that is linked to neurobehavioral systems underlying responsivity to emotionally evocative cues. Little is known about the effects of changes in visual contextual information in PPI among humans. In this study, the effects of introducing unexpected changes in the visual scenes presented on a computer monitor on the human auditory startle response and PPI were assessed in young adults. Based on our animal data showing that unexpected transitions from a dark to a light environment reduce the startle response and PPI in rats after the illumination transition, it was hypothesized that novel changes in visual scenes would produce similar effects in humans. Results show that PPI decreased when elements were added to or removed from visual scenes, and that this effect declined after repeated presentations of the modified scene, supporting the interpretation that the PPI reduction was due to novel information being processed. These findings are the first to demonstrate that novel visual stimuli can impair sensorimotor gating of auditory stimuli in humans.

Duke Scholars

Published In

Behav Processes

DOI

EISSN

1872-8308

Publication Date

January 2012

Volume

89

Issue

1

Start / End Page

1 / 7

Location

Netherlands

Related Subject Headings

  • Young Adult
  • Visual Perception
  • Sensory Gating
  • Reflex, Startle
  • Photic Stimulation
  • Pharmacology & Pharmacy
  • Male
  • Humans
  • Heart Rate
  • Galvanic Skin Response
 

Citation

APA
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ICMJE
MLA
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Larrauri, J. A., Rosenthal, M. Z., Levin, E. D., McClernon, F. J., & Schmajuk, N. A. (2012). Effects of unexpected changes in visual scenes on the human acoustic startle response and prepulse inhibition. Behav Processes, 89(1), 1–7. https://doi.org/10.1016/j.beproc.2011.09.011
Larrauri, J. A., M. Z. Rosenthal, E. D. Levin, F. J. McClernon, and N. A. Schmajuk. “Effects of unexpected changes in visual scenes on the human acoustic startle response and prepulse inhibition.Behav Processes 89, no. 1 (January 2012): 1–7. https://doi.org/10.1016/j.beproc.2011.09.011.
Larrauri JA, Rosenthal MZ, Levin ED, McClernon FJ, Schmajuk NA. Effects of unexpected changes in visual scenes on the human acoustic startle response and prepulse inhibition. Behav Processes. 2012 Jan;89(1):1–7.
Larrauri, J. A., et al. “Effects of unexpected changes in visual scenes on the human acoustic startle response and prepulse inhibition.Behav Processes, vol. 89, no. 1, Jan. 2012, pp. 1–7. Pubmed, doi:10.1016/j.beproc.2011.09.011.
Larrauri JA, Rosenthal MZ, Levin ED, McClernon FJ, Schmajuk NA. Effects of unexpected changes in visual scenes on the human acoustic startle response and prepulse inhibition. Behav Processes. 2012 Jan;89(1):1–7.
Journal cover image

Published In

Behav Processes

DOI

EISSN

1872-8308

Publication Date

January 2012

Volume

89

Issue

1

Start / End Page

1 / 7

Location

Netherlands

Related Subject Headings

  • Young Adult
  • Visual Perception
  • Sensory Gating
  • Reflex, Startle
  • Photic Stimulation
  • Pharmacology & Pharmacy
  • Male
  • Humans
  • Heart Rate
  • Galvanic Skin Response