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Brain anatomic effects of electroconvulsive therapy. A prospective magnetic resonance imaging study.

Publication ,  Journal Article
Coffey, CE; Weiner, RD; Djang, WT; Figiel, GS; Soady, SA; Patterson, LJ; Holt, PD; Spritzer, CE; Wilkinson, WE
Published in: Arch Gen Psychiatry
November 1991

To determine prospectively whether electroconvulsive therapy (ECT) produces structural brain changes, 35 inpatients with depression underwent magnetic resonance imaging before and twice after (at 2 to 3 days and at 6 months) completion of a course of brief-pulse, bilateral ECT. The magnetic resonance images were analyzed blindly for evidence of changes in brain structure using two approaches: measurement of regional brain volumes and a pairwise global comparison. Structural brain abnormalities were present in many patients before ECT. The course of ECT produced no acute or delayed (6-month) change in brain structure as measured by alterations of the total volumes of the lateral ventricles, the third ventricle, the frontal lobes, the temporal lobes, or the amygdala-hippocampal complex. In five subjects, the pairwise global comparisons revealed an apparent increase in subcortical hyperintensity, most likely secondary to progression of ongoing cerebrovascular disease during follow-up. Our results confirm and extend previous imaging studies that also found no relationship between ECT and brain damage.

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Published In

Arch Gen Psychiatry

DOI

ISSN

0003-990X

Publication Date

November 1991

Volume

48

Issue

11

Start / End Page

1013 / 1021

Location

United States

Related Subject Headings

  • Psychiatry
  • Prospective Studies
  • Middle Aged
  • Male
  • Magnetic Resonance Imaging
  • Humans
  • Hippocampus
  • Female
  • Electroconvulsive Therapy
  • Depressive Disorder
 

Citation

APA
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ICMJE
MLA
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Coffey, C. E., Weiner, R. D., Djang, W. T., Figiel, G. S., Soady, S. A., Patterson, L. J., … Wilkinson, W. E. (1991). Brain anatomic effects of electroconvulsive therapy. A prospective magnetic resonance imaging study. Arch Gen Psychiatry, 48(11), 1013–1021. https://doi.org/10.1001/archpsyc.1991.01810350053008
Coffey, C. E., R. D. Weiner, W. T. Djang, G. S. Figiel, S. A. Soady, L. J. Patterson, P. D. Holt, C. E. Spritzer, and W. E. Wilkinson. “Brain anatomic effects of electroconvulsive therapy. A prospective magnetic resonance imaging study.Arch Gen Psychiatry 48, no. 11 (November 1991): 1013–21. https://doi.org/10.1001/archpsyc.1991.01810350053008.
Coffey CE, Weiner RD, Djang WT, Figiel GS, Soady SA, Patterson LJ, et al. Brain anatomic effects of electroconvulsive therapy. A prospective magnetic resonance imaging study. Arch Gen Psychiatry. 1991 Nov;48(11):1013–21.
Coffey, C. E., et al. “Brain anatomic effects of electroconvulsive therapy. A prospective magnetic resonance imaging study.Arch Gen Psychiatry, vol. 48, no. 11, Nov. 1991, pp. 1013–21. Pubmed, doi:10.1001/archpsyc.1991.01810350053008.
Coffey CE, Weiner RD, Djang WT, Figiel GS, Soady SA, Patterson LJ, Holt PD, Spritzer CE, Wilkinson WE. Brain anatomic effects of electroconvulsive therapy. A prospective magnetic resonance imaging study. Arch Gen Psychiatry. 1991 Nov;48(11):1013–1021.

Published In

Arch Gen Psychiatry

DOI

ISSN

0003-990X

Publication Date

November 1991

Volume

48

Issue

11

Start / End Page

1013 / 1021

Location

United States

Related Subject Headings

  • Psychiatry
  • Prospective Studies
  • Middle Aged
  • Male
  • Magnetic Resonance Imaging
  • Humans
  • Hippocampus
  • Female
  • Electroconvulsive Therapy
  • Depressive Disorder