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Cardiovascular clinical research in South America.

Publication ,  Journal Article
Nicolau, JC; Corbalan, R; Diaz, R; Bahit, C; Armstrong, PW; Granger, CB; Lopes, RD
Published in: Am Heart J
June 2013

In recent years, international clinical trials have increasingly included large numbers of patients and research sites from developing countries. In South America particularly, enrollment in randomized clinical trials has increased substantially. Despite this significant growth of late, there has been little systematic assessment of the role of this region in cardiovascular clinical trials. South America has several strengths with respect to conducting and participating in clinical trials. These include a large population, a high prevalence of cardiovascular diseases, reliable quality of data, a track record of important contributions to previous clinical trials, and good patient adherence and retention in trials. Labor costs also tend to be lower than those in high-income countries. On the other hand, clinical research in this region of the world faces limitations posed by a relatively small clinical trials network with limited operations expertise, as well as prolonged regulatory approval timelines, diversity in health care systems, limited training opportunities in clinical research, and a low patient level of education. Thus, there are many opportunities to improve the conduct of clinical research in South America, but strategies and systems must be developed to overcome barriers in this economically growing region and to establish a robust infrastructure for clinical trials, including high-quality investigator networks.

Duke Scholars

Published In

Am Heart J

DOI

EISSN

1097-6744

Publication Date

June 2013

Volume

165

Issue

6

Start / End Page

848 / 853

Location

United States

Related Subject Headings

  • South America
  • Humans
  • Delivery of Health Care
  • Cardiovascular System & Hematology
  • Cardiovascular Diseases
  • Biomedical Research
  • 3201 Cardiovascular medicine and haematology
  • 1117 Public Health and Health Services
  • 1102 Cardiorespiratory Medicine and Haematology
 

Citation

APA
Chicago
ICMJE
MLA
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Nicolau, J. C., Corbalan, R., Diaz, R., Bahit, C., Armstrong, P. W., Granger, C. B., & Lopes, R. D. (2013). Cardiovascular clinical research in South America. Am Heart J, 165(6), 848–853. https://doi.org/10.1016/j.ahj.2013.02.004
Nicolau, José C., Ramon Corbalan, Rafael Diaz, Cecilia Bahit, Paul W. Armstrong, Christopher B. Granger, and Renato D. Lopes. “Cardiovascular clinical research in South America.Am Heart J 165, no. 6 (June 2013): 848–53. https://doi.org/10.1016/j.ahj.2013.02.004.
Nicolau JC, Corbalan R, Diaz R, Bahit C, Armstrong PW, Granger CB, et al. Cardiovascular clinical research in South America. Am Heart J. 2013 Jun;165(6):848–53.
Nicolau, José C., et al. “Cardiovascular clinical research in South America.Am Heart J, vol. 165, no. 6, June 2013, pp. 848–53. Pubmed, doi:10.1016/j.ahj.2013.02.004.
Nicolau JC, Corbalan R, Diaz R, Bahit C, Armstrong PW, Granger CB, Lopes RD. Cardiovascular clinical research in South America. Am Heart J. 2013 Jun;165(6):848–853.
Journal cover image

Published In

Am Heart J

DOI

EISSN

1097-6744

Publication Date

June 2013

Volume

165

Issue

6

Start / End Page

848 / 853

Location

United States

Related Subject Headings

  • South America
  • Humans
  • Delivery of Health Care
  • Cardiovascular System & Hematology
  • Cardiovascular Diseases
  • Biomedical Research
  • 3201 Cardiovascular medicine and haematology
  • 1117 Public Health and Health Services
  • 1102 Cardiorespiratory Medicine and Haematology