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Choroid development and feasibility of choroidal imaging in the preterm and term infants utilizing SD-OCT.

Publication ,  Journal Article
Moreno, TA; O'Connell, RV; Chiu, SJ; Farsiu, S; Cabrera, MT; Maldonado, RS; Tran-Viet, D; Freedman, SF; Wallace, DK; Toth, CA
Published in: Invest Ophthalmol Vis Sci
June 14, 2013

PURPOSE: To determine whether choroidal imaging is feasible in preterm and term infants using an 840-nm portable spectral domain optical coherence tomography (SD-OCT) system without the use of enhanced-depth imaging techniques and to assess choroidal development by comparing choroidal thickness of preterm infants, term infants, and adults. METHODS: SD-OCT images were obtained from 86 preterm infants, 59 term infants, and nine adults using a portable SD-OCT system plus nine adults using a tabletop system. An unprocessed image across the macula from one randomly selected eye of each participant was selected for determination of whether the choroidal-scleral junction (CSJ) could be visualized and for measurement of choroidal thickness. RESULTS: Subfoveal CSJ was visualized in 96% of young-preterm infants (imaged from 30-36 weeks postmenstrual age [PMA]); 78% of term-aged preterm infants (imaged from 37-42 weeks PMA); 49% of term infants; and 39% of adult subjects. Racial pigmentation did not affect CSJ visibility in young-preterm infants (P = 0.57). Subfoveal choroidal thickness (SFCT) in young-preterm infants, term-aged preterm infants, term infants, and adults was 176 ± 53 μm, 289 ± 92 μm, 329 ± 66 μm, and 258 ± 66 μm, respectively, and these were all statistically significantly different from one another except term-aged preterms to adults. CONCLUSIONS: Infant choroid can be imaged with a portable SD-OCT system without enhanced depth imaging. Melanin in the RPE and choroid does not hinder outer choroidal imaging in young-preterm infants without advanced retinopathy of prematurity (ROP). In preterm infants, choroidal thickness increased with age but was thinner when compared to term infants suggesting delayed development due to ROP.

Duke Scholars

Published In

Invest Ophthalmol Vis Sci

DOI

EISSN

1552-5783

Publication Date

June 14, 2013

Volume

54

Issue

6

Start / End Page

4140 / 4147

Location

United States

Related Subject Headings

  • Tomography, Optical Coherence
  • Prospective Studies
  • Ophthalmology & Optometry
  • Male
  • Infant, Premature
  • Infant, Newborn
  • Humans
  • Female
  • Feasibility Studies
  • Choroid Diseases
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Moreno, T. A., O’Connell, R. V., Chiu, S. J., Farsiu, S., Cabrera, M. T., Maldonado, R. S., … Toth, C. A. (2013). Choroid development and feasibility of choroidal imaging in the preterm and term infants utilizing SD-OCT. Invest Ophthalmol Vis Sci, 54(6), 4140–4147. https://doi.org/10.1167/iovs.12-11471
Moreno, Tomas A., Rachelle V. O’Connell, Stephanie J. Chiu, Sina Farsiu, Michelle T. Cabrera, Ramiro S. Maldonado, Du Tran-Viet, Sharon F. Freedman, David K. Wallace, and Cynthia A. Toth. “Choroid development and feasibility of choroidal imaging in the preterm and term infants utilizing SD-OCT.Invest Ophthalmol Vis Sci 54, no. 6 (June 14, 2013): 4140–47. https://doi.org/10.1167/iovs.12-11471.
Moreno TA, O’Connell RV, Chiu SJ, Farsiu S, Cabrera MT, Maldonado RS, et al. Choroid development and feasibility of choroidal imaging in the preterm and term infants utilizing SD-OCT. Invest Ophthalmol Vis Sci. 2013 Jun 14;54(6):4140–7.
Moreno, Tomas A., et al. “Choroid development and feasibility of choroidal imaging in the preterm and term infants utilizing SD-OCT.Invest Ophthalmol Vis Sci, vol. 54, no. 6, June 2013, pp. 4140–47. Pubmed, doi:10.1167/iovs.12-11471.
Moreno TA, O’Connell RV, Chiu SJ, Farsiu S, Cabrera MT, Maldonado RS, Tran-Viet D, Freedman SF, Wallace DK, Toth CA. Choroid development and feasibility of choroidal imaging in the preterm and term infants utilizing SD-OCT. Invest Ophthalmol Vis Sci. 2013 Jun 14;54(6):4140–4147.

Published In

Invest Ophthalmol Vis Sci

DOI

EISSN

1552-5783

Publication Date

June 14, 2013

Volume

54

Issue

6

Start / End Page

4140 / 4147

Location

United States

Related Subject Headings

  • Tomography, Optical Coherence
  • Prospective Studies
  • Ophthalmology & Optometry
  • Male
  • Infant, Premature
  • Infant, Newborn
  • Humans
  • Female
  • Feasibility Studies
  • Choroid Diseases