Perspective on Oncogenic Processes at the End of the Beginning of Cancer Genomics.

Journal Article (Journal Article)

The Cancer Genome Atlas (TCGA) has catalyzed systematic characterization of diverse genomic alterations underlying human cancers. At this historic junction marking the completion of genomic characterization of over 11,000 tumors from 33 cancer types, we present our current understanding of the molecular processes governing oncogenesis. We illustrate our insights into cancer through synthesis of the findings of the TCGA PanCancer Atlas project on three facets of oncogenesis: (1) somatic driver mutations, germline pathogenic variants, and their interactions in the tumor; (2) the influence of the tumor genome and epigenome on transcriptome and proteome; and (3) the relationship between tumor and the microenvironment, including implications for drugs targeting driver events and immunotherapies. These results will anchor future characterization of rare and common tumor types, primary and relapsed tumors, and cancers across ancestry groups and will guide the deployment of clinical genomic sequencing.

Full Text

Duke Authors

Cited Authors

  • Ding, L; Bailey, MH; Porta-Pardo, E; Thorsson, V; Colaprico, A; Bertrand, D; Gibbs, DL; Weerasinghe, A; Huang, K-L; Tokheim, C; Cortés-Ciriano, I; Jayasinghe, R; Chen, F; Yu, L; Sun, S; Olsen, C; Kim, J; Taylor, AM; Cherniack, AD; Akbani, R; Suphavilai, C; Nagarajan, N; Stuart, JM; Mills, GB; Wyczalkowski, MA; Vincent, BG; Hutter, CM; Zenklusen, JC; Hoadley, KA; Wendl, MC; Shmulevich, L; Lazar, AJ; Wheeler, DA; Getz, G; Cancer Genome Atlas Research Network,

Published Date

  • April 5, 2018

Published In

Volume / Issue

  • 173 / 2

Start / End Page

  • 305 - 320.e10

PubMed ID

  • 29625049

Pubmed Central ID

  • PMC5916814

Electronic International Standard Serial Number (EISSN)

  • 1097-4172

Digital Object Identifier (DOI)

  • 10.1016/j.cell.2018.03.033


  • eng

Conference Location

  • United States