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Perspective on Oncogenic Processes at the End of the Beginning of Cancer Genomics.

Publication ,  Journal Article
Ding, L; Bailey, MH; Porta-Pardo, E; Thorsson, V; Colaprico, A; Bertrand, D; Gibbs, DL; Weerasinghe, A; Huang, K-L; Tokheim, C; Jayasinghe, R ...
Published in: Cell
April 5, 2018

The Cancer Genome Atlas (TCGA) has catalyzed systematic characterization of diverse genomic alterations underlying human cancers. At this historic junction marking the completion of genomic characterization of over 11,000 tumors from 33 cancer types, we present our current understanding of the molecular processes governing oncogenesis. We illustrate our insights into cancer through synthesis of the findings of the TCGA PanCancer Atlas project on three facets of oncogenesis: (1) somatic driver mutations, germline pathogenic variants, and their interactions in the tumor; (2) the influence of the tumor genome and epigenome on transcriptome and proteome; and (3) the relationship between tumor and the microenvironment, including implications for drugs targeting driver events and immunotherapies. These results will anchor future characterization of rare and common tumor types, primary and relapsed tumors, and cancers across ancestry groups and will guide the deployment of clinical genomic sequencing.

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Published In

Cell

DOI

EISSN

1097-4172

Publication Date

April 5, 2018

Volume

173

Issue

2

Start / End Page

305 / 320.e10

Location

United States

Related Subject Headings

  • Tumor Microenvironment
  • Transcriptome
  • Neoplasms
  • Mutation
  • Microsatellite Instability
  • Metabolic Networks and Pathways
  • Humans
  • Genomics
  • Genes, Neoplasm
  • Developmental Biology
 

Citation

APA
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ICMJE
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Ding, L., Bailey, M. H., Porta-Pardo, E., Thorsson, V., Colaprico, A., Bertrand, D., … Cancer Genome Atlas Research Network. (2018). Perspective on Oncogenic Processes at the End of the Beginning of Cancer Genomics. Cell, 173(2), 305-320.e10. https://doi.org/10.1016/j.cell.2018.03.033
Ding, Li, Matthew H. Bailey, Eduard Porta-Pardo, Vesteinn Thorsson, Antonio Colaprico, Denis Bertrand, David L. Gibbs, et al. “Perspective on Oncogenic Processes at the End of the Beginning of Cancer Genomics.Cell 173, no. 2 (April 5, 2018): 305-320.e10. https://doi.org/10.1016/j.cell.2018.03.033.
Ding L, Bailey MH, Porta-Pardo E, Thorsson V, Colaprico A, Bertrand D, et al. Perspective on Oncogenic Processes at the End of the Beginning of Cancer Genomics. Cell. 2018 Apr 5;173(2):305-320.e10.
Ding, Li, et al. “Perspective on Oncogenic Processes at the End of the Beginning of Cancer Genomics.Cell, vol. 173, no. 2, Apr. 2018, pp. 305-320.e10. Pubmed, doi:10.1016/j.cell.2018.03.033.
Ding L, Bailey MH, Porta-Pardo E, Thorsson V, Colaprico A, Bertrand D, Gibbs DL, Weerasinghe A, Huang K-L, Tokheim C, Cortés-Ciriano I, Jayasinghe R, Chen F, Yu L, Sun S, Olsen C, Kim J, Taylor AM, Cherniack AD, Akbani R, Suphavilai C, Nagarajan N, Stuart JM, Mills GB, Wyczalkowski MA, Vincent BG, Hutter CM, Zenklusen JC, Hoadley KA, Wendl MC, Shmulevich L, Lazar AJ, Wheeler DA, Getz G, Cancer Genome Atlas Research Network. Perspective on Oncogenic Processes at the End of the Beginning of Cancer Genomics. Cell. 2018 Apr 5;173(2):305-320.e10.
Journal cover image

Published In

Cell

DOI

EISSN

1097-4172

Publication Date

April 5, 2018

Volume

173

Issue

2

Start / End Page

305 / 320.e10

Location

United States

Related Subject Headings

  • Tumor Microenvironment
  • Transcriptome
  • Neoplasms
  • Mutation
  • Microsatellite Instability
  • Metabolic Networks and Pathways
  • Humans
  • Genomics
  • Genes, Neoplasm
  • Developmental Biology