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Genetics of Human Longevity From Incomplete Data: New Findings From the Long Life Family Study.

Publication ,  Journal Article
Yashin, AI; Arbeev, KG; Wu, D; Arbeeva, LS; Bagley, O; Stallard, E; Kulminski, AM; Akushevich, I; Fang, F; Wojczynski, MK; Christensen, K ...
Published in: The journals of gerontology. Series A, Biological sciences and medical sciences
October 2018

The special design of the Long Life Family Study provides a unique opportunity to investigate the genetics of human longevity by analyzing data on exceptional lifespans in families. In this article, we performed two series of genome wide association studies of human longevity which differed with respect to whether missing lifespan data were predicted or not predicted. We showed that the use of predicted lifespan is most beneficial when the follow-up period is relatively short. In addition to detection of strong associations of SNPs in APOE, TOMM40, NECTIN2, and APOC1 genes with longevity, we also detected a strong new association with longevity of rs1927465, located between the CYP26A1 and MYOF genes on chromosome 10. The association was confirmed using data from the Health and Retirement Study. We discuss the biological relevance of the detected SNPs to human longevity.

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Published In

The journals of gerontology. Series A, Biological sciences and medical sciences

DOI

EISSN

1758-535X

ISSN

1079-5006

Publication Date

October 2018

Volume

73

Issue

11

Start / End Page

1472 / 1481

Related Subject Headings

  • United States
  • Retinoic Acid 4-Hydroxylase
  • Polymorphism, Single Nucleotide
  • Pedigree
  • Nectins
  • Muscle Proteins
  • Mitochondrial Precursor Protein Import Complex Proteins
  • Membrane Transport Proteins
  • Membrane Proteins
  • Male
 

Citation

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Yashin, A. I., Arbeev, K. G., Wu, D., Arbeeva, L. S., Bagley, O., Stallard, E., … Ukraintseva, S. V. (2018). Genetics of Human Longevity From Incomplete Data: New Findings From the Long Life Family Study. The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, 73(11), 1472–1481. https://doi.org/10.1093/gerona/gly057
Yashin, Anatoliy I., Konstantin G. Arbeev, Deqing Wu, Liubov S. Arbeeva, Olivia Bagley, Eric Stallard, Alexander M. Kulminski, et al. “Genetics of Human Longevity From Incomplete Data: New Findings From the Long Life Family Study.The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences 73, no. 11 (October 2018): 1472–81. https://doi.org/10.1093/gerona/gly057.
Yashin AI, Arbeev KG, Wu D, Arbeeva LS, Bagley O, Stallard E, et al. Genetics of Human Longevity From Incomplete Data: New Findings From the Long Life Family Study. The journals of gerontology Series A, Biological sciences and medical sciences. 2018 Oct;73(11):1472–81.
Yashin, Anatoliy I., et al. “Genetics of Human Longevity From Incomplete Data: New Findings From the Long Life Family Study.The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, vol. 73, no. 11, Oct. 2018, pp. 1472–81. Epmc, doi:10.1093/gerona/gly057.
Yashin AI, Arbeev KG, Wu D, Arbeeva LS, Bagley O, Stallard E, Kulminski AM, Akushevich I, Fang F, Wojczynski MK, Christensen K, Newman AB, Boudreau RM, Province MA, Thielke S, Perls TT, An P, Elo I, Ukraintseva SV. Genetics of Human Longevity From Incomplete Data: New Findings From the Long Life Family Study. The journals of gerontology Series A, Biological sciences and medical sciences. 2018 Oct;73(11):1472–1481.
Journal cover image

Published In

The journals of gerontology. Series A, Biological sciences and medical sciences

DOI

EISSN

1758-535X

ISSN

1079-5006

Publication Date

October 2018

Volume

73

Issue

11

Start / End Page

1472 / 1481

Related Subject Headings

  • United States
  • Retinoic Acid 4-Hydroxylase
  • Polymorphism, Single Nucleotide
  • Pedigree
  • Nectins
  • Muscle Proteins
  • Mitochondrial Precursor Protein Import Complex Proteins
  • Membrane Transport Proteins
  • Membrane Proteins
  • Male