Contribution of Baroreceptor Function to Pain Perception and Perioperative Outcomes.

Journal Article (Journal Article;Review)

Baroreceptors are mechanosensitive elements of the peripheral nervous system that maintain homeostasis by coordinating physiologic responses to external and internal stimuli. While it is recognized that carotid and cardiopulmonary baroreceptor reflexes modulate autonomic output to mitigate excessive fluctuations in arterial blood pressure and to maintain intravascular volume, increasing evidence suggests that baroreflex pathways also project to key regions of the central nervous system that regulate somatosensory, somatomotor, and central nervous system arousal. In addition to maintaining autonomic homeostasis, baroreceptor activity modulates the perception of pain, as well as neuroimmune, neuroendocrine, and cognitive responses to physical and psychologic stressors. This review summarizes the role that baroreceptor pathways play in modulating acute and chronic pain perception. The contribution of baroreceptor function to postoperative outcomes is also presented. Finally, methods that enhance baroreceptor function, which hold promise in improving postoperative and pain management outcomes, are presented.

Full Text

Duke Authors

Cited Authors

  • Suarez-Roca, H; Klinger, RY; Podgoreanu, MV; Ji, R-R; Sigurdsson, MI; Waldron, N; Mathew, JP; Maixner, W

Published Date

  • April 2019

Published In

Volume / Issue

  • 130 / 4

Start / End Page

  • 634 - 650

PubMed ID

  • 30418212

Pubmed Central ID

  • PMC6417948

Electronic International Standard Serial Number (EISSN)

  • 1528-1175

Digital Object Identifier (DOI)

  • 10.1097/ALN.0000000000002510


  • eng

Conference Location

  • United States