Cefazolin pharmacokinetics in premature infants.
Journal Article (Journal Article)
OBJECTIVE: Pharmacokinetic (PK) data to guide cefazolin dosing in premature infants are virtually non-existent. Therefore, we aimed to characterize cefazolin PK in infants aged ≤32 weeks of gestation at birth. STUDY DESIGN: We conducted a prospective, open-label PK and safety study of cefazolin in infants ≤32 weeks gestation from a University Medical Center. We administered intravenous cefazolin and collected both timed and scavenged blood samples. We analyzed data using non-linear mixed effect modeling and simulated several dosage regimens to achieve target concentrations against methicillin-susceptible Staphylococcus aureus. RESULTS: We analyzed 40 samples from nine infants and observed that premature infants had lower clearance and greater volume of distribution for cefazolin compared to older children. The median (range) individual Bayesian estimates were 0.03 L/h/kg (0.01-0.08) for clearance and 0.39 L/kg (0.31-0.52) for volume. CONCLUSION: Simulations suggested reduced cefazolin dosing based on postmenstrual age achieve target concentrations and potentially reduce unnecessary exposure.
Full Text
Duke Authors
- Balevic, Stephen Joseph
- Benjamin Jr., Daniel Kelly
- Cohen-Wolkowiez, Michael
- Smith, Phillip Brian
- Zimmerman, Kanecia Obie
Cited Authors
- Balevic, SJ; Smith, PB; Testoni, D; Wu, H; Brouwer, KLR; Zimmerman, KO; Rivera-Chaparro, ND; Benjamin, DK; Cohen-Wolkowiez, M
Published Date
- September 2019
Published In
Volume / Issue
- 39 / 9
Start / End Page
- 1213 - 1218
PubMed ID
- 30944398
Pubmed Central ID
- PMC6713589
Electronic International Standard Serial Number (EISSN)
- 1476-5543
Digital Object Identifier (DOI)
- 10.1038/s41372-019-0368-z
Language
- eng
Conference Location
- United States