Disrupted Maturation of the Microbiota and Metabolome among Extremely Preterm Infants with Postnatal Growth Failure.

Published online

Journal Article

Growth failure during infancy is a major global problem that has adverse effects on long-term health and neurodevelopment. Preterm infants are disproportionately affected by growth failure and its effects. Herein we found that extremely preterm infants with postnatal growth failure have disrupted maturation of the intestinal microbiota, characterized by persistently low diversity, dominance of pathogenic bacteria within the Enterobacteriaceae family, and a paucity of strictly anaerobic taxa including Veillonella relative to infants with appropriate postnatal growth. Metabolomic profiling of infants with growth failure demonstrated elevated serum acylcarnitines, fatty acids, and other byproducts of lipolysis and fatty acid oxidation. Machine learning algorithms for normal maturation of the microbiota and metabolome among infants with appropriate growth revealed a pattern of delayed maturation of the microbiota and metabolome among infants with growth failure. Collectively, we identified novel microbial and metabolic features of growth failure in preterm infants and potentially modifiable targets for intervention.

Full Text

Duke Authors

Cited Authors

  • Younge, NE; Newgard, CB; Cotten, CM; Goldberg, RN; Muehlbauer, MJ; Bain, JR; Stevens, RD; O'Connell, TM; Rawls, JF; Seed, PC; Ashley, PL

Published Date

  • June 3, 2019

Published In

Volume / Issue

  • 9 / 1

Start / End Page

  • 8167 -

PubMed ID

  • 31160673

Pubmed Central ID

  • 31160673

Electronic International Standard Serial Number (EISSN)

  • 2045-2322

Digital Object Identifier (DOI)

  • 10.1038/s41598-019-44547-y

Language

  • eng

Conference Location

  • England