A precision medicine approach to stress testing using metabolomics and microribonucleic acids.

Journal Article (Journal Article)

Both transcriptomics and metabolomics hold promise for identifying acute coronary syndrome (ACS) but they have not been used in combination, nor have dynamic changes in levels been assessed as a diagnostic tool. We assessed integrated analysis of peripheral blood miRNA and metabolite analytes to distinguish patients with myocardial ischemia on cardiac stress testing. We isolated and quantified miRNA and metabolites before and after stress testing from seven patients with myocardial ischemia and 1:1 matched controls. The combined miRNA and metabolomic data were analyzed jointly in a supervised, dimension-reducing discriminant analysis. We implemented a baseline model (T0) and a stress-delta model. This novel integrative analysis of the baseline levels of metabolites and miRNA expression showed modest performance for distinguishing cases from controls. The stress-delta model showed worse performance. This pilot study shows potential for an integrated precision medicine approach to cardiac stress testing.

Full Text

Duke Authors

Cited Authors

  • Limkakeng, AT; Rowlette, L-L; Hatch, A; Nixon, AB; Ilkayeva, O; Corcoran, D; Modliszewski, J; Griffin, SM; Ginsburg, GS; Voora, D

Published Date

  • July 2022

Published In

Volume / Issue

  • 19 / 4

Start / End Page

  • 287 - 297

PubMed ID

  • 35466688

Electronic International Standard Serial Number (EISSN)

  • 1744-828X

Digital Object Identifier (DOI)

  • 10.2217/pme-2021-0021

Language

  • eng

Conference Location

  • England