Caspofungin for the treatment of azole resistant candidemia in a premature infant.

Journal Article (Journal Article)

Candidemia is common in extremely low birth weight infants and is associated with substantial mortality and morbidity. Treatment options have traditionally been limited to amphotericin B deoxycholate or fluconazole. We present a case of a premature infant with persistent candidemia despite antifungal treatment that responded to therapy with caspofungin, an echinocandin antifungal. The infant's Candida isolate developed resistance to azoles during fluconazole administration and also suffered from severe hypercalcemia during the initiation of caspofungin therapy.

Full Text

Duke Authors

Cited Authors

  • Smith, PB; Steinbach, WJ; Cotten, CM; Schell, WA; Perfect, JR; Walsh, TJ; Benjamin, DK

Published Date

  • February 2007

Published In

Volume / Issue

  • 27 / 2

Start / End Page

  • 127 - 129

PubMed ID

  • 17262048

International Standard Serial Number (ISSN)

  • 0743-8346

Digital Object Identifier (DOI)

  • 10.1038/


  • eng

Conference Location

  • United States