Caspofungin for the treatment of azole resistant candidemia in a premature infant.
Journal Article (Journal Article)
Candidemia is common in extremely low birth weight infants and is associated with substantial mortality and morbidity. Treatment options have traditionally been limited to amphotericin B deoxycholate or fluconazole. We present a case of a premature infant with persistent candidemia despite antifungal treatment that responded to therapy with caspofungin, an echinocandin antifungal. The infant's Candida isolate developed resistance to azoles during fluconazole administration and also suffered from severe hypercalcemia during the initiation of caspofungin therapy.
Full Text
Duke Authors
- Benjamin Jr., Daniel Kelly
- Cotten, Charles Michael
- Perfect, John Robert
- Schell, Wiley Alexander
- Smith, Phillip Brian
Cited Authors
- Smith, PB; Steinbach, WJ; Cotten, CM; Schell, WA; Perfect, JR; Walsh, TJ; Benjamin, DK
Published Date
- February 2007
Published In
Volume / Issue
- 27 / 2
Start / End Page
- 127 - 129
PubMed ID
- 17262048
International Standard Serial Number (ISSN)
- 0743-8346
Digital Object Identifier (DOI)
- 10.1038/sj.jp.7211637
Language
- eng
Conference Location
- United States