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Caspofungin for the treatment of azole resistant candidemia in a premature infant.

Publication ,  Journal Article
Smith, PB; Steinbach, WJ; Cotten, CM; Schell, WA; Perfect, JR; Walsh, TJ; Benjamin, DK
Published in: J Perinatol
February 2007

Candidemia is common in extremely low birth weight infants and is associated with substantial mortality and morbidity. Treatment options have traditionally been limited to amphotericin B deoxycholate or fluconazole. We present a case of a premature infant with persistent candidemia despite antifungal treatment that responded to therapy with caspofungin, an echinocandin antifungal. The infant's Candida isolate developed resistance to azoles during fluconazole administration and also suffered from severe hypercalcemia during the initiation of caspofungin therapy.

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Published In

J Perinatol

DOI

ISSN

0743-8346

Publication Date

February 2007

Volume

27

Issue

2

Start / End Page

127 / 129

Location

United States

Related Subject Headings

  • Voriconazole
  • Triazoles
  • Pyrimidines
  • Peptides, Cyclic
  • Pediatrics
  • Male
  • Lipopeptides
  • Infant, Premature, Diseases
  • Infant, Premature
  • Infant, Newborn
 

Citation

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Smith, P. B., Steinbach, W. J., Cotten, C. M., Schell, W. A., Perfect, J. R., Walsh, T. J., & Benjamin, D. K. (2007). Caspofungin for the treatment of azole resistant candidemia in a premature infant. J Perinatol, 27(2), 127–129. https://doi.org/10.1038/sj.jp.7211637
Smith, P. B., W. J. Steinbach, C. M. Cotten, W. A. Schell, J. R. Perfect, T. J. Walsh, and D. K. Benjamin. “Caspofungin for the treatment of azole resistant candidemia in a premature infant.J Perinatol 27, no. 2 (February 2007): 127–29. https://doi.org/10.1038/sj.jp.7211637.
Smith PB, Steinbach WJ, Cotten CM, Schell WA, Perfect JR, Walsh TJ, et al. Caspofungin for the treatment of azole resistant candidemia in a premature infant. J Perinatol. 2007 Feb;27(2):127–9.
Smith, P. B., et al. “Caspofungin for the treatment of azole resistant candidemia in a premature infant.J Perinatol, vol. 27, no. 2, Feb. 2007, pp. 127–29. Pubmed, doi:10.1038/sj.jp.7211637.
Smith PB, Steinbach WJ, Cotten CM, Schell WA, Perfect JR, Walsh TJ, Benjamin DK. Caspofungin for the treatment of azole resistant candidemia in a premature infant. J Perinatol. 2007 Feb;27(2):127–129.

Published In

J Perinatol

DOI

ISSN

0743-8346

Publication Date

February 2007

Volume

27

Issue

2

Start / End Page

127 / 129

Location

United States

Related Subject Headings

  • Voriconazole
  • Triazoles
  • Pyrimidines
  • Peptides, Cyclic
  • Pediatrics
  • Male
  • Lipopeptides
  • Infant, Premature, Diseases
  • Infant, Premature
  • Infant, Newborn