Daptomycin use in infants: report of two cases with peak and trough drug concentrations.
Journal Article (Journal Article)
We report two infants treated with daptomycin for methicillin-resistant Staphylococcus aureus infection and describe peak and trough blood concentrations measured during therapy. The peak concentrations were 41.7 and 36.7 mcg ml(-1), and the 12-hour trough concentrations were 12.7 and 16.3 mcg ml(-1), respectively. Even though the infants received higher doses than adults, their drug concentrations were comparable to those observed in adults treated with regular dosing of daptomycin.
Full Text
Duke Authors
Cited Authors
- Cohen-Wolkowiez, M; Smith, PB; Benjamin, DK; Fowler, VG; Wade, KC
Published Date
- March 2008
Published In
Volume / Issue
- 28 / 3
Start / End Page
- 233 - 234
PubMed ID
- 18309318
Pubmed Central ID
- PMC2752140
International Standard Serial Number (ISSN)
- 0743-8346
Digital Object Identifier (DOI)
- 10.1038/sj.jp.7211898
Language
- eng
Conference Location
- United States