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Daptomycin use in infants: report of two cases with peak and trough drug concentrations.

Publication ,  Journal Article
Cohen-Wolkowiez, M; Smith, PB; Benjamin, DK; Fowler, VG; Wade, KC
Published in: J Perinatol
March 2008

We report two infants treated with daptomycin for methicillin-resistant Staphylococcus aureus infection and describe peak and trough blood concentrations measured during therapy. The peak concentrations were 41.7 and 36.7 mcg ml(-1), and the 12-hour trough concentrations were 12.7 and 16.3 mcg ml(-1), respectively. Even though the infants received higher doses than adults, their drug concentrations were comparable to those observed in adults treated with regular dosing of daptomycin.

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Published In

J Perinatol

DOI

ISSN

0743-8346

Publication Date

March 2008

Volume

28

Issue

3

Start / End Page

233 / 234

Location

United States

Related Subject Headings

  • Staphylococcus aureus
  • Staphylococcal Infections
  • Pediatrics
  • Methicillin Resistance
  • Infant, Premature
  • Infant, Newborn
  • Infant
  • Humans
  • Drug Monitoring
  • Daptomycin
 

Citation

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Chicago
ICMJE
MLA
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Cohen-Wolkowiez, M., Smith, P. B., Benjamin, D. K., Fowler, V. G., & Wade, K. C. (2008). Daptomycin use in infants: report of two cases with peak and trough drug concentrations. J Perinatol, 28(3), 233–234. https://doi.org/10.1038/sj.jp.7211898
Cohen-Wolkowiez, M., P. B. Smith, D. K. Benjamin, V. G. Fowler, and K. C. Wade. “Daptomycin use in infants: report of two cases with peak and trough drug concentrations.J Perinatol 28, no. 3 (March 2008): 233–34. https://doi.org/10.1038/sj.jp.7211898.
Cohen-Wolkowiez M, Smith PB, Benjamin DK, Fowler VG, Wade KC. Daptomycin use in infants: report of two cases with peak and trough drug concentrations. J Perinatol. 2008 Mar;28(3):233–4.
Cohen-Wolkowiez, M., et al. “Daptomycin use in infants: report of two cases with peak and trough drug concentrations.J Perinatol, vol. 28, no. 3, Mar. 2008, pp. 233–34. Pubmed, doi:10.1038/sj.jp.7211898.
Cohen-Wolkowiez M, Smith PB, Benjamin DK, Fowler VG, Wade KC. Daptomycin use in infants: report of two cases with peak and trough drug concentrations. J Perinatol. 2008 Mar;28(3):233–234.

Published In

J Perinatol

DOI

ISSN

0743-8346

Publication Date

March 2008

Volume

28

Issue

3

Start / End Page

233 / 234

Location

United States

Related Subject Headings

  • Staphylococcus aureus
  • Staphylococcal Infections
  • Pediatrics
  • Methicillin Resistance
  • Infant, Premature
  • Infant, Newborn
  • Infant
  • Humans
  • Drug Monitoring
  • Daptomycin