Daptomycin use in infants: report of two cases with peak and trough drug concentrations.

Journal Article (Journal Article)

We report two infants treated with daptomycin for methicillin-resistant Staphylococcus aureus infection and describe peak and trough blood concentrations measured during therapy. The peak concentrations were 41.7 and 36.7 mcg ml(-1), and the 12-hour trough concentrations were 12.7 and 16.3 mcg ml(-1), respectively. Even though the infants received higher doses than adults, their drug concentrations were comparable to those observed in adults treated with regular dosing of daptomycin.

Full Text

Duke Authors

Cited Authors

  • Cohen-Wolkowiez, M; Smith, PB; Benjamin, DK; Fowler, VG; Wade, KC

Published Date

  • March 2008

Published In

Volume / Issue

  • 28 / 3

Start / End Page

  • 233 - 234

PubMed ID

  • 18309318

Pubmed Central ID

  • PMC2752140

International Standard Serial Number (ISSN)

  • 0743-8346

Digital Object Identifier (DOI)

  • 10.1038/sj.jp.7211898


  • eng

Conference Location

  • United States