Daptomycin use in infants: report of two cases with peak and trough drug concentrations.
Publication
, Journal Article
Cohen-Wolkowiez, M; Smith, PB; Benjamin, DK; Fowler, VG; Wade, KC
Published in: J Perinatol
March 2008
We report two infants treated with daptomycin for methicillin-resistant Staphylococcus aureus infection and describe peak and trough blood concentrations measured during therapy. The peak concentrations were 41.7 and 36.7 mcg ml(-1), and the 12-hour trough concentrations were 12.7 and 16.3 mcg ml(-1), respectively. Even though the infants received higher doses than adults, their drug concentrations were comparable to those observed in adults treated with regular dosing of daptomycin.
Duke Scholars
Published In
J Perinatol
DOI
ISSN
0743-8346
Publication Date
March 2008
Volume
28
Issue
3
Start / End Page
233 / 234
Location
United States
Related Subject Headings
- Staphylococcus aureus
- Staphylococcal Infections
- Pediatrics
- Methicillin Resistance
- Infant, Premature
- Infant, Newborn
- Infant
- Humans
- Drug Monitoring
- Daptomycin
Citation
APA
Chicago
ICMJE
MLA
NLM
Cohen-Wolkowiez, M., Smith, P. B., Benjamin, D. K., Fowler, V. G., & Wade, K. C. (2008). Daptomycin use in infants: report of two cases with peak and trough drug concentrations. J Perinatol, 28(3), 233–234. https://doi.org/10.1038/sj.jp.7211898
Cohen-Wolkowiez, M., P. B. Smith, D. K. Benjamin, V. G. Fowler, and K. C. Wade. “Daptomycin use in infants: report of two cases with peak and trough drug concentrations.” J Perinatol 28, no. 3 (March 2008): 233–34. https://doi.org/10.1038/sj.jp.7211898.
Cohen-Wolkowiez M, Smith PB, Benjamin DK, Fowler VG, Wade KC. Daptomycin use in infants: report of two cases with peak and trough drug concentrations. J Perinatol. 2008 Mar;28(3):233–4.
Cohen-Wolkowiez, M., et al. “Daptomycin use in infants: report of two cases with peak and trough drug concentrations.” J Perinatol, vol. 28, no. 3, Mar. 2008, pp. 233–34. Pubmed, doi:10.1038/sj.jp.7211898.
Cohen-Wolkowiez M, Smith PB, Benjamin DK, Fowler VG, Wade KC. Daptomycin use in infants: report of two cases with peak and trough drug concentrations. J Perinatol. 2008 Mar;28(3):233–234.
Published In
J Perinatol
DOI
ISSN
0743-8346
Publication Date
March 2008
Volume
28
Issue
3
Start / End Page
233 / 234
Location
United States
Related Subject Headings
- Staphylococcus aureus
- Staphylococcal Infections
- Pediatrics
- Methicillin Resistance
- Infant, Premature
- Infant, Newborn
- Infant
- Humans
- Drug Monitoring
- Daptomycin