Skip to main content
Journal cover image

Development of a Computerized 4-D MRI Phantom for Liver Motion Study.

Publication ,  Journal Article
Wang, C; Yin, F-F; Segars, WP; Chang, Z; Ren, L
Published in: Technol Cancer Res Treat
December 2017

PURPOSE: To develop a 4-dimensional computerized magnetic resonance imaging phantom with image textures extracted from real patient scans for liver motion studies. METHODS: The proposed phantom was developed based on the current version of 4-dimensional extended cardiac-torso computerized phantom and a clinical magnetic resonance scan. Initially, the extended cardiac-torso phantom was voxelized in abdominal-chest region at the end of exhalation phase. Structures/tissues were classified into 4 categories: (1) Seven key textured organs, including liver, gallbladder, spleen, stomach, heart, kidneys, and pancreas, were mapped from a clinical T1-weighted liver magnetic resonance scan using deformable registration. (2) Large textured soft tissue volumes were simulated via an iterative pattern generation method using the same magnetic resonance scan. (3) Lung and intestine structures were generated by assigning uniform intensity with proper noise modeling. (4) Bony structures were generated by assigning the magnetic resonance values. A spherical hypointensity tumor was inserted into the liver. Other respiratory phases of the 4-dimensional phantom were generated using the backward deformation vector fields exported by the extended cardiac-torso program, except that bony structures were generated separately for each phase. A weighted image filtering process was utilized to improve the overall tissue smoothness at each phase. RESULTS: Three 4-dimensional series with different motion amplitudes were generated. The developed motion phantom produced good illustrations of abdominal-chest region with anatomical structures in key organs and texture patterns in large soft tissue volumes. In a standard series, the tumor volume was measured as 13.90 ± 0.11 cm3 in a respiratory cycle and the tumor's maximum center-of-mass shift was 2.95 cm/1.84 cm on superior-inferior/anterior-posterior directions. The organ motion during the respiratory cycle was well rendered. The developed motion phantom has the flexibility of motion pattern variation, organ geometry variation, and tumor modeling variation. CONCLUSIONS: A 4-D computerized phantom was developed and could be used to produce image series with synthetic magnetic resonance textures for magnetic resonance imaging research of liver motion.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Technol Cancer Res Treat

DOI

EISSN

1533-0338

Publication Date

December 2017

Volume

16

Issue

6

Start / End Page

1051 / 1059

Location

United States

Related Subject Headings

  • Oncology & Carcinogenesis
  • 3211 Oncology and carcinogenesis
  • 1112 Oncology and Carcinogenesis
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Wang, C., Yin, F.-F., Segars, W. P., Chang, Z., & Ren, L. (2017). Development of a Computerized 4-D MRI Phantom for Liver Motion Study. Technol Cancer Res Treat, 16(6), 1051–1059. https://doi.org/10.1177/1533034617723753
Wang, Chunhao, Fang-Fang Yin, W. P. Segars, Zheng Chang, and Lei Ren. “Development of a Computerized 4-D MRI Phantom for Liver Motion Study.Technol Cancer Res Treat 16, no. 6 (December 2017): 1051–59. https://doi.org/10.1177/1533034617723753.
Wang C, Yin F-F, Segars WP, Chang Z, Ren L. Development of a Computerized 4-D MRI Phantom for Liver Motion Study. Technol Cancer Res Treat. 2017 Dec;16(6):1051–9.
Wang, Chunhao, et al. “Development of a Computerized 4-D MRI Phantom for Liver Motion Study.Technol Cancer Res Treat, vol. 16, no. 6, Dec. 2017, pp. 1051–59. Pubmed, doi:10.1177/1533034617723753.
Wang C, Yin F-F, Segars WP, Chang Z, Ren L. Development of a Computerized 4-D MRI Phantom for Liver Motion Study. Technol Cancer Res Treat. 2017 Dec;16(6):1051–1059.
Journal cover image

Published In

Technol Cancer Res Treat

DOI

EISSN

1533-0338

Publication Date

December 2017

Volume

16

Issue

6

Start / End Page

1051 / 1059

Location

United States

Related Subject Headings

  • Oncology & Carcinogenesis
  • 3211 Oncology and carcinogenesis
  • 1112 Oncology and Carcinogenesis