Skip to main content

Meteorin-like facilitates skeletal muscle repair through a Stat3/IGF-1 mechanism.

Publication ,  Journal Article
Baht, GS; Bareja, A; Lee, DE; Rao, RR; Huang, R; Huebner, JL; Bartlett, DB; Hart, CR; Gibson, JR; Lanza, IR; Kraus, VB; Gregory, SG ...
Published in: Nat Metab
March 2020

The immune system plays a multifunctional role throughout the regenerative process, regulating both pro-/anti-inflammatory phases and progenitor cell function. In the present study, we identify the myokine/cytokine Meteorin-like (Metrnl) as a critical regulator of muscle regeneration. Mice genetically lacking Metrnl have impaired muscle regeneration associated with a reduction in immune cell infiltration and an inability to transition towards an anti-inflammatory phenotype. Isochronic parabiosis, joining wild-type and whole-body Metrnl knock-out (KO) mice, returns Metrnl expression in the injured muscle and improves muscle repair, providing supportive evidence for Metrnl secretion from infiltrating immune cells. Macrophage-specific Metrnl KO mice are also deficient in muscle repair. During muscle regeneration, Metrnl works, in part, through Stat3 activation in macrophages, resulting in differentiation to an anti-inflammatory phenotype. With regard to myogenesis, Metrnl induces macrophage-dependent insulin-like growth factor 1 production, which has a direct effect on primary muscle satellite cell proliferation. Perturbations in this pathway inhibit efficacy of Metrnl in the regenerative process. Together, these studies identify Metrnl as an important regulator of muscle regeneration and a potential therapeutic target to enhance tissue repair.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Nat Metab

DOI

EISSN

2522-5812

Publication Date

March 2020

Volume

2

Issue

3

Start / End Page

278 / 289

Location

Germany

Related Subject Headings

  • STAT3 Transcription Factor
  • Nerve Tissue Proteins
  • Muscle, Skeletal
  • Mice, Knockout
  • Mice
  • Insulin-Like Growth Factor I
  • Animals
  • 3210 Nutrition and dietetics
  • 3208 Medical physiology
  • 3205 Medical biochemistry and metabolomics
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Baht, G. S., Bareja, A., Lee, D. E., Rao, R. R., Huang, R., Huebner, J. L., … White, J. P. (2020). Meteorin-like facilitates skeletal muscle repair through a Stat3/IGF-1 mechanism. Nat Metab, 2(3), 278–289. https://doi.org/10.1038/s42255-020-0184-y
Baht, Gurpreet S., Akshay Bareja, David E. Lee, Rajesh R. Rao, Rong Huang, Janet L. Huebner, David B. Bartlett, et al. “Meteorin-like facilitates skeletal muscle repair through a Stat3/IGF-1 mechanism.Nat Metab 2, no. 3 (March 2020): 278–89. https://doi.org/10.1038/s42255-020-0184-y.
Baht GS, Bareja A, Lee DE, Rao RR, Huang R, Huebner JL, et al. Meteorin-like facilitates skeletal muscle repair through a Stat3/IGF-1 mechanism. Nat Metab. 2020 Mar;2(3):278–89.
Baht, Gurpreet S., et al. “Meteorin-like facilitates skeletal muscle repair through a Stat3/IGF-1 mechanism.Nat Metab, vol. 2, no. 3, Mar. 2020, pp. 278–89. Pubmed, doi:10.1038/s42255-020-0184-y.
Baht GS, Bareja A, Lee DE, Rao RR, Huang R, Huebner JL, Bartlett DB, Hart CR, Gibson JR, Lanza IR, Kraus VB, Gregory SG, Spiegelman BM, White JP. Meteorin-like facilitates skeletal muscle repair through a Stat3/IGF-1 mechanism. Nat Metab. 2020 Mar;2(3):278–289.

Published In

Nat Metab

DOI

EISSN

2522-5812

Publication Date

March 2020

Volume

2

Issue

3

Start / End Page

278 / 289

Location

Germany

Related Subject Headings

  • STAT3 Transcription Factor
  • Nerve Tissue Proteins
  • Muscle, Skeletal
  • Mice, Knockout
  • Mice
  • Insulin-Like Growth Factor I
  • Animals
  • 3210 Nutrition and dietetics
  • 3208 Medical physiology
  • 3205 Medical biochemistry and metabolomics