Skip to main content

Yolk-sac-derived macrophages progressively expand in the mouse kidney with age.

Publication ,  Journal Article
Ide, S; Yahara, Y; Kobayashi, Y; Strausser, SA; Ide, K; Watwe, A; Xu-Vanpala, S; Privratsky, JR; Crowley, SD; Shinohara, ML; Alman, BA; Souma, T
Published in: Elife
April 17, 2020

Renal macrophages represent a highly heterogeneous and specialized population of myeloid cells with mixed developmental origins from the yolk-sac and hematopoietic stem cells (HSC). They promote both injury and repair by regulating inflammation, angiogenesis, and tissue remodeling. Recent reports highlight differential roles for ontogenically distinct renal macrophage populations in disease. However, little is known about how these populations change over time in normal, uninjured kidneys. Prior reports demonstrated a high proportion of HSC-derived macrophages in the young adult kidney. Unexpectedly, using genetic fate-mapping and parabiosis studies, we found that yolk-sac-derived macrophages progressively expand in number with age and become a major contributor to the renal macrophage population in older mice. This chronological shift in macrophage composition involves local cellular proliferation and recruitment from circulating progenitors and may contribute to the distinct immune responses, limited reparative capacity, and increased disease susceptibility of kidneys in the elderly population.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Elife

DOI

EISSN

2050-084X

Publication Date

April 17, 2020

Volume

9

Location

England

Related Subject Headings

  • Yolk Sac
  • Receptors, Granulocyte-Macrophage Colony-Stimulating Factor
  • Mice
  • Macrophages
  • Kidney
  • CX3C Chemokine Receptor 1
  • Animals
  • Aging
  • 42 Health sciences
  • 32 Biomedical and clinical sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Ide, S., Yahara, Y., Kobayashi, Y., Strausser, S. A., Ide, K., Watwe, A., … Souma, T. (2020). Yolk-sac-derived macrophages progressively expand in the mouse kidney with age. Elife, 9. https://doi.org/10.7554/eLife.51756
Ide, Shintaro, Yasuhito Yahara, Yoshihiko Kobayashi, Sarah A. Strausser, Kana Ide, Anisha Watwe, Shengjie Xu-Vanpala, et al. “Yolk-sac-derived macrophages progressively expand in the mouse kidney with age.Elife 9 (April 17, 2020). https://doi.org/10.7554/eLife.51756.
Ide S, Yahara Y, Kobayashi Y, Strausser SA, Ide K, Watwe A, et al. Yolk-sac-derived macrophages progressively expand in the mouse kidney with age. Elife. 2020 Apr 17;9.
Ide, Shintaro, et al. “Yolk-sac-derived macrophages progressively expand in the mouse kidney with age.Elife, vol. 9, Apr. 2020. Pubmed, doi:10.7554/eLife.51756.
Ide S, Yahara Y, Kobayashi Y, Strausser SA, Ide K, Watwe A, Xu-Vanpala S, Privratsky JR, Crowley SD, Shinohara ML, Alman BA, Souma T. Yolk-sac-derived macrophages progressively expand in the mouse kidney with age. Elife. 2020 Apr 17;9.

Published In

Elife

DOI

EISSN

2050-084X

Publication Date

April 17, 2020

Volume

9

Location

England

Related Subject Headings

  • Yolk Sac
  • Receptors, Granulocyte-Macrophage Colony-Stimulating Factor
  • Mice
  • Macrophages
  • Kidney
  • CX3C Chemokine Receptor 1
  • Animals
  • Aging
  • 42 Health sciences
  • 32 Biomedical and clinical sciences