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Nicotinamide riboside supplementation confers marginal metabolic benefits in obese mice without remodeling the muscle acetyl-proteome.

Publication ,  Journal Article
Williams, AS; Koves, TR; Pettway, YD; Draper, JA; Slentz, DH; Grimsrud, PA; Ilkayeva, OR; Muoio, DM
Published in: iScience
January 21, 2022

Nicotinamide riboside supplements (NRS) have been touted as a nutraceutical that promotes cardiometabolic and musculoskeletal health by enhancing nicotinamide adenine dinucleotide (NAD+) biosynthesis, mitochondrial function, and/or the activities of NAD-dependent sirtuin deacetylase enzymes. This investigation examined the impact of NRS on whole body energy homeostasis, skeletal muscle mitochondrial function, and corresponding shifts in the acetyl-lysine proteome, in the context of diet-induced obesity using C57BL/6NJ mice. The study also included a genetically modified mouse model that imposes greater demand on sirtuin flux and associated NAD+ consumption, specifically within muscle tissues. In general, whole body glucose control was marginally improved by NRS when administered at the midpoint of a chronic high-fat diet, but not when given as a preventative therapy upon initiation of the diet. Contrary to anticipated outcomes, the study produced little evidence that NRS increases tissue NAD+ levels, augments mitochondrial function, and/or mitigates diet-induced hyperacetylation of the skeletal muscle proteome.

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Published In

iScience

DOI

EISSN

2589-0042

Publication Date

January 21, 2022

Volume

25

Issue

1

Start / End Page

103635

Location

United States
 

Citation

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Chicago
ICMJE
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Williams, A. S., Koves, T. R., Pettway, Y. D., Draper, J. A., Slentz, D. H., Grimsrud, P. A., … Muoio, D. M. (2022). Nicotinamide riboside supplementation confers marginal metabolic benefits in obese mice without remodeling the muscle acetyl-proteome. IScience, 25(1), 103635. https://doi.org/10.1016/j.isci.2021.103635
Williams, Ashley S., Timothy R. Koves, Yasminye D. Pettway, James A. Draper, Dorothy H. Slentz, Paul A. Grimsrud, Olga R. Ilkayeva, and Deborah M. Muoio. “Nicotinamide riboside supplementation confers marginal metabolic benefits in obese mice without remodeling the muscle acetyl-proteome.IScience 25, no. 1 (January 21, 2022): 103635. https://doi.org/10.1016/j.isci.2021.103635.
Williams AS, Koves TR, Pettway YD, Draper JA, Slentz DH, Grimsrud PA, et al. Nicotinamide riboside supplementation confers marginal metabolic benefits in obese mice without remodeling the muscle acetyl-proteome. iScience. 2022 Jan 21;25(1):103635.
Williams, Ashley S., et al. “Nicotinamide riboside supplementation confers marginal metabolic benefits in obese mice without remodeling the muscle acetyl-proteome.IScience, vol. 25, no. 1, Jan. 2022, p. 103635. Pubmed, doi:10.1016/j.isci.2021.103635.
Williams AS, Koves TR, Pettway YD, Draper JA, Slentz DH, Grimsrud PA, Ilkayeva OR, Muoio DM. Nicotinamide riboside supplementation confers marginal metabolic benefits in obese mice without remodeling the muscle acetyl-proteome. iScience. 2022 Jan 21;25(1):103635.
Journal cover image

Published In

iScience

DOI

EISSN

2589-0042

Publication Date

January 21, 2022

Volume

25

Issue

1

Start / End Page

103635

Location

United States