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Reclassification of cardiovascular risk using integrated clinical and molecular biosignatures: Design of and rationale for the Measurement to Understand the Reclassification of Disease of Cabarrus and Kannapolis (MURDOCK) Horizon 1 Cardiovascular Disease Study.

Publication ,  Journal Article
Shah, SH; Granger, CB; Hauser, ER; Kraus, WE; Sun, J-L; Pieper, K; Nelson, CL; Delong, ER; Califf, RM; Newby, LK ...
Published in: Am Heart J
September 2010

BACKGROUND: Clinical predictive models leave gaps in our ability to stratify cardiovascular risk. High-throughput molecular profiling promises to improve risk classification. METHODS: Horizon 1 of the Measurement to Understand the Reclassification of Disease of Cabarrus and Kannapolis (MURDOCK) Study was conceived to apply emerging molecular techniques to existing data sets to characterize mechanistic diversity underlying complex human diseases, response to therapy, and prognosis. No previous studies have applied multiple, complementary molecular techniques in combination with well-developed clinical risk models to refine cardiovascular risk prediction. The MURDOCK Cardiovascular Disease Study will assess molecular profiles integrated with clinical data in "clinomic" profiles for cardiovascular risk classification. CONCLUSION: Herein, we describe the design of and rationale for the MURDOCK Cardiovascular Disease Study.

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Published In

Am Heart J

DOI

EISSN

1097-6744

Publication Date

September 2010

Volume

160

Issue

3

Start / End Page

371 / 379.e2

Location

United States

Related Subject Headings

  • Risk Assessment
  • Research Design
  • Proportional Hazards Models
  • Precision Medicine
  • Patient Selection
  • North Carolina
  • Myocardial Infarction
  • Models, Statistical
  • Humans
  • Genomics
 

Citation

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Shah, S. H., Granger, C. B., Hauser, E. R., Kraus, W. E., Sun, J.-L., Pieper, K., … MURDOCK Horizon 1 Cardiovascular Disease Investigators, . (2010). Reclassification of cardiovascular risk using integrated clinical and molecular biosignatures: Design of and rationale for the Measurement to Understand the Reclassification of Disease of Cabarrus and Kannapolis (MURDOCK) Horizon 1 Cardiovascular Disease Study. Am Heart J, 160(3), 371-379.e2. https://doi.org/10.1016/j.ahj.2010.06.051
Shah, Svati H., Christopher B. Granger, Elizabeth R. Hauser, William E. Kraus, Jie-Lena Sun, Karen Pieper, Charlotte L. Nelson, et al. “Reclassification of cardiovascular risk using integrated clinical and molecular biosignatures: Design of and rationale for the Measurement to Understand the Reclassification of Disease of Cabarrus and Kannapolis (MURDOCK) Horizon 1 Cardiovascular Disease Study.Am Heart J 160, no. 3 (September 2010): 371-379.e2. https://doi.org/10.1016/j.ahj.2010.06.051.
Shah SH, Granger CB, Hauser ER, Kraus WE, Sun J-L, Pieper K, Nelson CL, Delong ER, Califf RM, Newby LK, MURDOCK Horizon 1 Cardiovascular Disease Investigators. Reclassification of cardiovascular risk using integrated clinical and molecular biosignatures: Design of and rationale for the Measurement to Understand the Reclassification of Disease of Cabarrus and Kannapolis (MURDOCK) Horizon 1 Cardiovascular Disease Study. Am Heart J. 2010 Sep;160(3):371-379.e2.
Journal cover image

Published In

Am Heart J

DOI

EISSN

1097-6744

Publication Date

September 2010

Volume

160

Issue

3

Start / End Page

371 / 379.e2

Location

United States

Related Subject Headings

  • Risk Assessment
  • Research Design
  • Proportional Hazards Models
  • Precision Medicine
  • Patient Selection
  • North Carolina
  • Myocardial Infarction
  • Models, Statistical
  • Humans
  • Genomics