Scholars@Duke
Carolyn Glass

Carolyn Glass

Associate Professor of Pathology
Pathology
carolyn.glass@duke.edu
214D Davison Building, 40 Duke Medicine Circle, Box #3712 DUHS, Durham, NC 27710
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Selected Publications

Ultrastructural cardiac pathology: the wide (yet so very small) world of cardiac electron microscopy.

Journal Article Cardiovasc Pathol · June 14, 2024 Electron microscopy (EM) was a popular diagnostic tool in the 1970s and early 80s. With the adoption of newer, less expensive techniques, such as immunohistochemistry, the role of EM in diagnostic surgical pathology has dwindled substantially. Nowadays, ev ... Full text Link to item Cite

The 2022 Banff Meeting Lung Report.

Journal Article Am J Transplant · April 2024 The Lung Session of the 2022 16th Banff Foundation for Allograft Pathology Conference-held in Banff, Alberta-focused on non-rejection lung allograft pathology and novel technologies for the detection of allograft injury. A multidisciplinary panel reviewed ... Full text Link to item Cite

Tensorial tomographic Fourier ptychography with applications to muscle tissue imaging

Journal Article Advanced Photonics · March 1, 2024 We report tensorial tomographic Fourier ptychography (T2oFu), a nonscanning label-free tomographic microscopy method for simultaneous imaging of quantitative phase and anisotropic specimen information in 3D. Built upon Fourier ptychography, a quantitative ... Full text Cite

The over diagnosis of diffuse mesothelioma: An analysis of 311 cases with recommendations for the avoidance of pitfalls.

Journal Article Ann Diagn Pathol · February 2024 BACKGROUND: The diagnosis of mesothelioma may be challenging. We investigated a large database of cases in order to determine the frequency with which a diagnosis of mesothelioma was made incorrectly and the most frequent causes of error. DESIGN: A databas ... Full text Link to item Cite

A machine learning algorithm improves the diagnostic accuracy of the histologic component of antibody mediated rejection (AMR-H) in cardiac transplant endomyocardial biopsies.

Journal Article Cardiovasc Pathol · 2024 BACKGROUND: Pathologic antibody mediated rejection (pAMR) remains a major driver of graft failure in cardiac transplant patients. The endomyocardial biopsy remains the primary diagnostic tool but presents with challenges, particularly in distinguishing the ... Full text Link to item Cite

Cardiac magnetic resonance imaging characterization of acute rejection in a porcine heterotopic heart transplantation model.

Journal Article PLoS One · 2024 Preclinical disease models are important for the advancement of therapeutics towards human clinical trials. One of the difficult tasks of developing a well-characterized model is having a reliable modality with which to trend the progression of disease. Ac ... Full text Link to item Cite

Diagnostic Approach to Pulmonary B-Cell Lymphomas in Small Biopsies, with Practical Recommendations to Avoid Misinterpretation.

Journal Article Diagnostics (Basel) · October 26, 2023 Pulmonary lymphomas are rare. With the current less invasive approaches used to obtain material for diagnosis, the diagnosis of pulmonary lymphoma is now frequently established in a small biopsy rather than in a resection. Therefore, the diagnosis has beco ... Full text Link to item Cite

International Association for the Study of Lung Cancer Study of Reproducibility in Assessment of Pathologic Response in Resected Lung Cancers After Neoadjuvant Therapy.

Journal Article J Thorac Oncol · October 2023 INTRODUCTION: Pathologic response has been proposed as an early clinical trial end point of survival after neoadjuvant treatment in clinical trials of NSCLC. The International Association for the Study of Lung Cancer (IASLC) published recommendations for p ... Full text Link to item Cite

Chronological trends in the causation of malignant mesothelioma: Fiber burden analysis of 619 cases over four decades.

Journal Article Environ Res · August 1, 2023 Malignant mesothelioma is a relatively rare malignancy with a strong association with prior asbestos exposure. A percentage of cases is not related to asbestos, and fiber analysis of lung tissue is a useful methodology for identifying idiopathic or spontan ... Full text Link to item Cite

Transvenous Endomyocardial Biopsy Technique for Intra-abdominal Heterotopic Cardiac Grafts.

Journal Article J Cardiovasc Transl Res · June 2023 The porcine intra-abdominal heterotopic heart transplantation model allows for the assessment of immunologic effects on cardiac transplantation without relying on the allograft to maintain hemodynamic support for the animal. Historically, allograft functio ... Full text Link to item Cite

The Banff 2022 Lung Summary Report

Journal Article · May 15, 2023 Cite

Ex Vivo Gene Delivery to Porcine Cardiac Allografts Using a Myocardial-Enhanced Adeno-Associated Viral Vector.

Journal Article Hum Gene Ther · April 2023 Transplantation, the gold standard intervention for organ failure, is a clinical field that is ripe for applications of gene therapy. One of the major challenges in applying gene therapy to this field is the need for a method that achieves consistent and r ... Full text Link to item Cite

A Porcine Model of Acute Rejection for Cardiac Transplantation

Conference JOURNAL OF HEART AND LUNG TRANSPLANTATION · 2023 Cite

Diagnostic approach to prevascular (anterior) mediastinal lymphomas: when thoracic pathology meets hematopathology.

Journal Article Mediastinum · 2023 Lymphomas are among the most common malignant tumors occurring in the anterior/prevascular mediastinum. Their diagnoses can be challenging in small biopsies, the current most common method of sampling of an anterior mediastinal mass. Because the initial cl ... Full text Link to item Cite

NIH SenNet Consortium to map senescent cells throughout the human lifespan to understand physiological health.

Journal Article Nat Aging · December 2022 Cells respond to many stressors by senescing, acquiring stable growth arrest, morphologic and metabolic changes, and a proinflammatory senescence-associated secretory phenotype. The heterogeneity of senescent cells (SnCs) and senescence-associated secretor ... Full text Link to item Cite

Ultrastructural cardiac pathology: the wide (yet so very small) world of cardiac electron microscopy.

Journal Article Cardiovasc Pathol · June 14, 2024 Electron microscopy (EM) was a popular diagnostic tool in the 1970s and early 80s. With the adoption of newer, less expensive techniques, such as immunohistochemistry, the role of EM in diagnostic surgical pathology has dwindled substantially. Nowadays, ev ... Full text Link to item Cite

The 2022 Banff Meeting Lung Report.

Journal Article Am J Transplant · April 2024 The Lung Session of the 2022 16th Banff Foundation for Allograft Pathology Conference-held in Banff, Alberta-focused on non-rejection lung allograft pathology and novel technologies for the detection of allograft injury. A multidisciplinary panel reviewed ... Full text Link to item Cite

Tensorial tomographic Fourier ptychography with applications to muscle tissue imaging

Journal Article Advanced Photonics · March 1, 2024 We report tensorial tomographic Fourier ptychography (T2oFu), a nonscanning label-free tomographic microscopy method for simultaneous imaging of quantitative phase and anisotropic specimen information in 3D. Built upon Fourier ptychography, a quantitative ... Full text Cite

The over diagnosis of diffuse mesothelioma: An analysis of 311 cases with recommendations for the avoidance of pitfalls.

Journal Article Ann Diagn Pathol · February 2024 BACKGROUND: The diagnosis of mesothelioma may be challenging. We investigated a large database of cases in order to determine the frequency with which a diagnosis of mesothelioma was made incorrectly and the most frequent causes of error. DESIGN: A databas ... Full text Link to item Cite

A machine learning algorithm improves the diagnostic accuracy of the histologic component of antibody mediated rejection (AMR-H) in cardiac transplant endomyocardial biopsies.

Journal Article Cardiovasc Pathol · 2024 BACKGROUND: Pathologic antibody mediated rejection (pAMR) remains a major driver of graft failure in cardiac transplant patients. The endomyocardial biopsy remains the primary diagnostic tool but presents with challenges, particularly in distinguishing the ... Full text Link to item Cite

Cardiac magnetic resonance imaging characterization of acute rejection in a porcine heterotopic heart transplantation model.

Journal Article PLoS One · 2024 Preclinical disease models are important for the advancement of therapeutics towards human clinical trials. One of the difficult tasks of developing a well-characterized model is having a reliable modality with which to trend the progression of disease. Ac ... Full text Link to item Cite

Diagnostic Approach to Pulmonary B-Cell Lymphomas in Small Biopsies, with Practical Recommendations to Avoid Misinterpretation.

Journal Article Diagnostics (Basel) · October 26, 2023 Pulmonary lymphomas are rare. With the current less invasive approaches used to obtain material for diagnosis, the diagnosis of pulmonary lymphoma is now frequently established in a small biopsy rather than in a resection. Therefore, the diagnosis has beco ... Full text Link to item Cite

International Association for the Study of Lung Cancer Study of Reproducibility in Assessment of Pathologic Response in Resected Lung Cancers After Neoadjuvant Therapy.

Journal Article J Thorac Oncol · October 2023 INTRODUCTION: Pathologic response has been proposed as an early clinical trial end point of survival after neoadjuvant treatment in clinical trials of NSCLC. The International Association for the Study of Lung Cancer (IASLC) published recommendations for p ... Full text Link to item Cite

Chronological trends in the causation of malignant mesothelioma: Fiber burden analysis of 619 cases over four decades.

Journal Article Environ Res · August 1, 2023 Malignant mesothelioma is a relatively rare malignancy with a strong association with prior asbestos exposure. A percentage of cases is not related to asbestos, and fiber analysis of lung tissue is a useful methodology for identifying idiopathic or spontan ... Full text Link to item Cite

Transvenous Endomyocardial Biopsy Technique for Intra-abdominal Heterotopic Cardiac Grafts.

Journal Article J Cardiovasc Transl Res · June 2023 The porcine intra-abdominal heterotopic heart transplantation model allows for the assessment of immunologic effects on cardiac transplantation without relying on the allograft to maintain hemodynamic support for the animal. Historically, allograft functio ... Full text Link to item Cite

The Banff 2022 Lung Summary Report

Journal Article · May 15, 2023 Cite

Ex Vivo Gene Delivery to Porcine Cardiac Allografts Using a Myocardial-Enhanced Adeno-Associated Viral Vector.

Journal Article Hum Gene Ther · April 2023 Transplantation, the gold standard intervention for organ failure, is a clinical field that is ripe for applications of gene therapy. One of the major challenges in applying gene therapy to this field is the need for a method that achieves consistent and r ... Full text Link to item Cite

A Porcine Model of Acute Rejection for Cardiac Transplantation

Conference JOURNAL OF HEART AND LUNG TRANSPLANTATION · 2023 Cite

Diagnostic approach to prevascular (anterior) mediastinal lymphomas: when thoracic pathology meets hematopathology.

Journal Article Mediastinum · 2023 Lymphomas are among the most common malignant tumors occurring in the anterior/prevascular mediastinum. Their diagnoses can be challenging in small biopsies, the current most common method of sampling of an anterior mediastinal mass. Because the initial cl ... Full text Link to item Cite

NIH SenNet Consortium to map senescent cells throughout the human lifespan to understand physiological health.

Journal Article Nat Aging · December 2022 Cells respond to many stressors by senescing, acquiring stable growth arrest, morphologic and metabolic changes, and a proinflammatory senescence-associated secretory phenotype. The heterogeneity of senescent cells (SnCs) and senescence-associated secretor ... Full text Link to item Cite

Transplanting thoracic COVID-19 positive donors: An institutional protocol and report of the first 14 cases.

Journal Article J Heart Lung Transplant · October 2022 We present our institution's protocol for evaluating and transplanting thoracic organs from COVID-19 positive donors and report the outcomes to date. Hearts from donors testing positive for COVID-19 on any test were eligible for transplantation at our inst ... Full text Link to item Cite

Lung allograft standardized histological analysis (LASHA) template: A research consensus proposal.

Journal Article J Heart Lung Transplant · October 2022 BACKGROUND: Routine monitoring of lung-transplanted patients is crucial for the identification of immunological and non-immunological complications. Determining the etiology of acute allograft dysfunction, particularly in alloimmune-mediated disorders, rel ... Full text Link to item Cite

Transcriptional and Immune Landscape of Cardiac Sarcoidosis.

Journal Article Circ Res · September 30, 2022 BACKGROUND: Cardiac involvement is an important determinant of mortality among sarcoidosis patients. Although granulomatous inflammation is a hallmark finding in cardiac sarcoidosis, the precise immune cell populations that comprise the granuloma remain un ... Full text Link to item Cite

Rapid tissue prototyping with micro-organospheres.

Journal Article Stem Cell Reports · September 13, 2022 In vitro tissue models hold great promise for modeling diseases and drug responses. Here, we used emulsion microfluidics to form micro-organospheres (MOSs), which are droplet-encapsulated miniature three-dimensional (3D) tissue models that can be establish ... Full text Open Access Link to item Cite

A multiple instance learning approach for detecting COVID-19 in peripheral blood smears.

Journal Article PLOS Digit Health · August 2022 A wide variety of diseases are commonly diagnosed via the visual examination of cell morphology within a peripheral blood smear. For certain diseases, such as COVID-19, morphological impact across the multitude of blood cell types is still poorly understoo ... Full text Open Access Link to item Cite

Genetic variants in DDO and PEX5L in peroxisome-related pathways predict non-small cell lung cancer survival.

Journal Article Mol Carcinog · July 2022 Peroxisomes play a role in lipid metabolism and regulation of reactive oxygen species, but its role in development and progression of non-small cell lung cancer (NSCLC) is not well understood. Here, we investigated the associations between 9708 single-nucl ... Full text Open Access Link to item Cite

BRG1 is a biomarker of hypertrophic cardiomyopathy in human heart specimens.

Journal Article Sci Rep · May 17, 2022 Hypertrophic cardiomyopathy (HCM) is a genetic disease of the sarcomere that causes otherwise unexplained cardiac hypertrophy and is associated with sudden death. While previous studies showed the role of the epigenetic modifier Brg1 in mouse models of HCM ... Full text Link to item Cite

Single nucleotide polymorphisms in FOXP1 and RORA of the lymphocyte activation-related pathway affect survival of lung cancer patients.

Journal Article Transl Lung Cancer Res · May 2022 BACKGROUND: Lymphocyte activation is part of a complex microenvironment that affects the development and progression of solid tumors. The present study analyzed the associations between genetic variants in lymphocyte activation-related genes and survival o ... Full text Open Access Link to item Cite

Late onset cardiovascular dysfunction in adult mice resulting from galactic cosmic ray exposure.

Journal Article iScience · April 15, 2022 The complex and inaccessible space radiation environment poses an unresolved risk to astronaut cardiovascular health during long-term space exploration missions. To model this risk, healthy male c57BL/6 mice aged six months (corresponding to an astronaut o ... Full text Link to item Cite

Quantitative Jones matrix imaging using vectorial Fourier ptychography.

Journal Article Biomed Opt Express · March 1, 2022 This paper presents a microscopic imaging technique that uses variable-angle illumination to recover the complex polarimetric properties of a specimen at high resolution and over a large field-of-view. The approach extends Fourier ptychography, which is a ... Full text Link to item Cite

The Role of Machine Learning in Cardiovascular Pathology.

Journal Article Can J Cardiol · February 2022 Machine learning has seen slow but steady uptake in diagnostic pathology over the past decade to assess digital whole-slide images. Machine learning tools have incredible potential to standardise, and likely even improve, histopathologic diagnoses, but the ... Full text Link to item Cite

Transplanting Thoracic COVID-19 Positive Donors: Overcoming the Pandemic

Conference JOURNAL OF HEART AND LUNG TRANSPLANTATION · 2022 Cite

Tensorial tomographic differential phase-contrast microscopy

Conference IEEE International Conference on Computational Photography, ICCP 2022 · January 1, 2022 We report Tensorial Tomographic Differential Phase-Contrast microscopy (T2DPC), a quantitative label-free tomographic imaging method for simultaneous measurement of phase and anisotropy. T2DPC extends differential phase-contrast microscopy, a quantitative ... Full text Cite

Potentially functional variants of ERAP1, PSMF1 and NCF2 in the MHC-I-related pathway predict non-small cell lung cancer survival.

Journal Article Cancer Immunol Immunother · October 2021 BACKGROUND: Cellular immunity against tumor cells is highly dependent on antigen presentation by major histocompatibility complex class I (MHC-I) molecules. However, few published studies have investigated associations between functional variants of MHC-I- ... Full text Open Access Link to item Cite

Quantitative Jones matrix imaging using vectorial Fourier ptychography

Journal Article · September 30, 2021 This paper presents a microscopic imaging technique that uses variable-angle illumination to recover the complex polarimetric properties of a specimen at high resolution and over a large field-of-view. The approach extends Fourier ptychography, which is a ... Open Access Link to item Cite

Genetic variants of CHEK1, PRIM2 and CDK6 in the mitotic phase-related pathway are associated with nonsmall cell lung cancer survival.

Journal Article Int J Cancer · September 15, 2021 The mitotic phase is a vital step in cell division and may be involved in cancer progression, but it remains unclear whether genetic variants in mitotic phase-related pathways genes impact the survival of these patients. Here, we investigated associations ... Full text Open Access Link to item Cite

Potentially functional variants of HBEGF and ITPR3 in GnRH signaling pathway genes predict survival of non-small cell lung cancer patients.

Journal Article Transl Res · July 2021 The gonadotropin-releasing hormone (GnRH) signaling pathway controls reproductive functions and cancer growth and progression. However, few studies investigated roles of genetic variants of GnRH pathway genes in survival of patients with non-small cell lun ... Full text Open Access Link to item Cite

SMARCA4 and Other SWItch/Sucrose NonFermentable Family Genomic Alterations in NSCLC: Clinicopathologic Characteristics and Outcomes to Immune Checkpoint Inhibition.

Journal Article J Thorac Oncol · July 2021 INTRODUCTION: The SWItch/Sucrose Nonfermentable (SWI/SNF) chromatin remodeling complex acts as a regulatory component of transcription, and inactivating mutations (muts) within the complex are implicated in genomic instability, higher tumor mutational burd ... Full text Link to item Cite

Malignant Peritoneal Mesothelioma Arising in Young Adults With Long-standing Indwelling Intra-abdominal Shunt Catheters.

Journal Article Am J Surg Pathol · February 1, 2021 Only 50% to 70% of patients with mesothelioma report asbestos exposure. Other exposures (eg, radiation) play a role in some cases, but some patients have no obvious cause. We describe a series of patients with long-standing indwelling intra-abdominal shunt ... Full text Link to item Cite

PD-1 and PD-L1 expression in cardiac transplantation.

Journal Article Cardiovasc Pathol · 2021 Programmed death-ligand 1 (PD-L1), a transmembrane protein and member of the CD28 T cell family is associated with lymphocyte activation.1 PD-L1 expression is upregulated on activated antigen presenting cells such as monocytes, myeloid and dendritic cells. ... Full text Link to item Cite

BRG1 IS A BIOMARKER OF HYPERTROPHIC CARDIOMYOPATHY IN HUMAN HEART SPECIMENS

Conference JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY · 2021 Cite

Genetic variants of DOCK2, EPHB1 and VAV2 in the natural killer cell-related pathway are associated with non-small cell lung cancer survival.

Journal Article Am J Cancer Res · 2021 Although natural killer (NK) cells are a known major player in anti-tumor immunity, the effect of genetic variation in NK-associated genes on survival in patients with non-small cell lung cancer (NSCLC) remains unknown. Here, in 1,185 with NSCLC cases of a ... Open Access Link to item Cite

Genetic Variants of CLEC4E and BIRC3 in Damage-Associated Molecular Patterns-Related Pathway Genes Predict Non-Small Cell Lung Cancer Survival.

Journal Article Front Oncol · 2021 Accumulating evidence supports a role of various damage-associated molecular patterns (DAMPs) in progression of lung cancer, but roles of genetic variants of the DAMPs-related pathway genes in lung cancer survival remain unknown. We investigated associatio ... Full text Open Access Link to item Cite

Potentially functional genetic variants in PLIN2, SULT2A1 and UGT1A9 genes of the ketone pathway and survival of nonsmall cell lung cancer.

Journal Article Int J Cancer · September 15, 2020 The ketone metabolism pathway is a principle procedure in physiological homeostasis and induces cancer cells to switch between glycolysis and oxidative phosphorylation for energy production. We conducted a two-phase analysis for associations between geneti ... Full text Open Access Link to item Cite

Novel Variants of ELP2 and PIAS1 in the Interferon Gamma Signaling Pathway Are Associated with Non-Small Cell Lung Cancer Survival.

Journal Article Cancer Epidemiol Biomarkers Prev · August 2020 BACKGROUND: IFNγ is a pleiotropic cytokine that plays critical immunomodulatory roles in intercellular communication in innate and adaptive immune responses. Despite recognition of IFNγ signaling effects on host defense against viral infection and its util ... Full text Open Access Link to item Cite

Novel genetic variants in KIF16B and NEDD4L in the endosome-related genes are associated with nonsmall cell lung cancer survival.

Journal Article Int J Cancer · July 15, 2020 The endosome is a membrane-bound organ inside most eukaryotic cells, playing an important role in adaptive immunity by delivering endocytosed antigens to both MHC class I and II pathways. Here, by analyzing genotyping data from two published genome-wide as ... Full text Open Access Link to item Cite

APOB Genotypes and CDH13 Haplotypes in the Cholesterol-Related Pathway Genes Predict Non-Small Cell Lung Cancer Survival.

Journal Article Cancer Epidemiol Biomarkers Prev · June 2020 BACKGROUND: Several oncogenic signals are involved in the synthesis, metabolism, transportation, and modulation of cholesterol. However, the roles of genetic variants of the cholesterol pathway genes in cancer survival remain unclear. METHODS: We investiga ... Full text Open Access Link to item Cite

The Use of Artificial Intelligence (AI) Machine Learning to Determine Myocyte Damage in Cardiac Transplant Acute Cellular Rejection

Conference The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · April 1, 2020 PURPOSE: Cardiac transplant patients must be on lifelong surveillance for the occurrence of acute cellular rejection (ACR). Despite potent immunosuppressants, ACR occurs when recipient T cells recognize donor antigens to cause cardiac myocyte destruction. ... Full text Cite

Detecting Acute Cellular Rejection in Lung Transplant Biopsies by Artificial Intelligence: A Novel Deep Learning Approach

Conference The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · April 1, 2020 PURPOSE: Acute cellular rejection (ACR), and its relation to chronic lung allograft dysfunction (CLAD), is an important cause of morbidity and mortality in lung transplant patients. ACR occurs in more than one third of lung transplant recipients in the fir ... Full text Cite

Conida in Post-Transplant Lung Biopsies and Associated Infections

Conference LABORATORY INVESTIGATION · March 1, 2020 Link to item Cite

EZH2 Expression in SMARCA4-mutant Primary Lung Malignancies

Conference LABORATORY INVESTIGATION · March 1, 2020 Link to item Cite

Molecular Analysis of a Patient With Neurofibromatosis 2 (NF2) and Peritoneal Malignant Mesothelioma.

Journal Article Am J Surg Pathol · February 2020 Neurofibromatosis type 2 (NF2), an inherited disorder associated with multiple inherited schwannomas, meningiomas and ependymomas is caused by an autosomal dominant, likely loss of function germline mutation of the NF2 gene. Interestingly, biallelic NF2 ge ... Full text Link to item Cite

Novel genetic variants in HDAC2 and PPARGC1A of the CREB-binding protein pathway predict survival of non-small-cell lung cancer.

Journal Article Mol Carcinog · January 2020 The CREB-binding protein (CBP) pathway plays an important role in transcription and activity of acetyltransferase that acetylates lysine residues of histones and nonhistone proteins. In the present study, we hypothesized that genetic variants in the CBP pa ... Full text Open Access Link to item Cite

Novel genetic variants of KIR3DL2 and PVR involved in immunoregulatory interactions are associated with non-small cell lung cancer survival.

Journal Article Am J Cancer Res · 2020 Immunoregulatory interactions play a pivotal role in immune surveillance, recognition, and killing, particularly its internal pathway, likely playing an important role in immune escape. By using two genotyping datasets, one from the Prostate, Lung, Colorec ... Open Access Link to item Cite

Novel genetic variants of SYK and ITGA1 related lymphangiogenesis signaling pathway predict non-small cell lung cancer survival.

Journal Article Am J Cancer Res · 2020 Although lymphangiogenesis is a vital step in lung cancer metastasis, the association between lymphangiogenesis and non-small cell lung cancer (NSCLC) survival remains unclear. Since single-nucleotide polymorphisms (SNPs) have been reported to predict NSCL ... Open Access Link to item Cite

CD68/CD31 immunohistochemistry double stain demonstrates increased accuracy in diagnosing pathologic antibody-mediated rejection in cardiac transplant patients.

Journal Article Am J Transplant · November 2019 Pathologic antibody-mediated rejection (pAMR) occurs in 10% of cardiac transplant patients and is associated with increased mortality. The endomyocardial biopsy remains the primary diagnostic tool to detect and define pAMR. However, certain challenges aris ... Full text Link to item Cite

Pulmonary Granular Cell Tumors: A Study of 4 Cases Including a Malignant Phenotype.

Journal Article Am J Surg Pathol · October 2019 Granular cell tumors are lesions of Schwannian phenotype that most frequently arise in the skin, breast, and tongue. Pulmonary granular cell tumors (pGCTs) are exceedingly rare and only a handful of cases worldwide have been reported as malignant. We repor ... Full text Link to item Cite

Late Breaking Abstract - B cell adaptive immune profile in emphysema-predominant COPD

Conference Molecular pathology and funct. genomics · September 28, 2019 Full text Cite

A Series of Rare Granular Cell Tumors of Pulmonary Origin

Conference LABORATORY INVESTIGATION · March 1, 2019 Link to item Cite

Thrombus on the inflow cannula of the HeartWare HVAD: an update.

Journal Article Cardiovasc Pathol · 2019 BACKGROUND: The HeartWare HVAD (Medtronic, Minneapolis, MN) is a continuous-flow left ventricular assist device (LVAD) approved by the FDA in 2012 as a bridge to transplant in patients with end-stage left ventricular heart failure. The current inflow cannu ... Full text Link to item Cite

Unique Intradural Inflammatory Mass Containing Precipitated Morphine: Confirmatory Analysis by LESA-MS and MALDI-MS.

Journal Article Pain Pract · September 2018 Opioids are often used for analgesia via continuous intrathecal delivery by implantable devices. A higher concentration and daily dose of opioid have been postulated as risk factors for intrathecal granuloma formation. We present a 42-year-old female patie ... Full text Link to item Cite

Giant cell aortitis mimicking intramural hematoma.

Journal Article J Cardiovasc Comput Tomogr · 2017 Full text Link to item Cite

Natural history of cranial fibrous dysplasia revealed during long-term follow-up: Case report and literature review.

Journal Article Surg Neurol Int · 2017 BACKGROUND: Fibrous dysplasia (FD) is a rare developmental disease characterized by the replacement of bone marrow with proliferating fibro-osseous tissue. There exist three forms of FD-monostotic, polyostotic, and that associated with McCune-Albright synd ... Full text Link to item Cite

Winning the battle, but losing the war: mechanisms and morphology of cancer-therapy-associated cardiovascular toxicity.

Journal Article Cardiovasc Pathol · 2017 In the United States, the lifetime risk of a cancer diagnosis is nearly 40%; in 2016, that represents almost 1.6 million new patients, and despite advances in early diagnosis and treatment, roughly 35% will ultimately die of their malignancy. Fortunately, ... Full text Link to item Cite

Misdiagnosis of cardiac amyloidosis type by standard immunohistochemistry

Journal Article Journal of the American College of Cardiology · 2017 Cite

Pathology of the SynCardia Total Artificial Heart: A Case Series

Conference LABORATORY INVESTIGATION · February 1, 2015 Link to item Cite

The role of EVI1 in myeloid malignancies.

Journal Article Blood Cells Mol Dis · 2014 The EVI1 oncogene at human chr 3q26 is rearranged and/or overexpressed in a subset of acute myeloid leukemias and myelodysplasias. The EVI1 protein is a 135 kDa transcriptional regulator with DNA-binding zinc finger domains. Here we provide a critical revi ... Full text Link to item Cite

Essential role of PR-domain protein MDS1-EVI1 in MLL-AF9 leukemia.

Journal Article Blood · October 17, 2013 A subgroup of leukemogenic mixed-lineage leukemia (MLL) fusion proteins (MFPs) including MLL-AF9 activates the Mecom locus and exhibits extremely poor clinical prognosis. Mecom encodes EVI1 and MDS1-EVI1 (ME) proteins via alternative transcription start si ... Full text Link to item Cite

Global Identification of EVI1 Target Genes in Acute Myeloid Leukemia.

Journal Article PLoS One · 2013 The ecotropic virus integration site 1 (EVI1) transcription factor is associated with human myeloid malignancy of poor prognosis and is overexpressed in 8-10% of adult AML and strikingly up to 27% of pediatric MLL-rearranged leukemias. For the first time, ... Full text Link to item Cite

Controversies in VTOS: Is there ever a role for venous stents in VTOS?

Chapter · January 1, 2013 The bony venous thoracic outlet creates significant extrinsic force upon the subclavian vein, and intravascular stents in this location thus perform very poorly. There is some literature supporting the use of stents after decompression, but no level I evid ... Full text Cite

Recruiting strategies for potential 0+5 vascular residency applicants.

Journal Article Ann Vasc Surg · January 2012 BACKGROUND: The 0+5 integrated vascular residency training pathway was established in 2006 to allow for trainee-focused training culminating in vascular surgery certification only. An early concern was whether enough medical students could be recruited dir ... Full text Link to item Cite

The perspective of the vascular surgery trainee on new ACGME regulations, fatigue, resident training, and patient safety.

Journal Article Vasc Endovascular Surg · November 2011 OBJECTIVE: To assess the opinions of vascular surgery trainees on the new Accreditation Council for Graduate Medical Education (ACGME) guidelines. METHODS: A questionnaire was developed and electronically distributed to trainee members of the Society for V ... Full text Link to item Cite

Midabdominal aortic coarctation presenting with severe pre-eclampsia.

Journal Article J Vasc Surg · August 2011 This is a case report of a 23-year-old pregnant woman with uncontrolled hypertension, resulting in delivery of her baby at 28 weeks. Postpartum, she further developed claudication and postprandial abdominal discomfort and was diagnosed with coarctation of ... Full text Link to item Cite

Costoclavicular venous decompression in patients with threatened arteriovenous hemodialysis access.

Journal Article Ann Vasc Surg · July 2011 BACKGROUND: Autologous arteriovenous fistulas are frequently threatened by central venous obstruction. Although this is frequently ascribed to indwelling catheters and neointimal venous remodeling, we believe that extrinsic compression of the subclavian ve ... Full text Link to item Cite

Long-term results of endoscopic versus open saphenous vein harvest for lower extremity bypass.

Journal Article Ann Vasc Surg · January 2011 BACKGROUND: Endoscopic saphenous vein harvest (EVH) has been shown to lower wound infection rates and cost compared with conventional harvest, although long-term patency data are lacking. A small series of studies has recently suggested that patency is inf ... Full text Link to item Cite

Importance of ultrasound evaluation in the diagnosis of venous insufficiency: guidelines and techniques.

Journal Article Semin Vasc Surg · June 2010 Recent advances in the treatment of venous insufficiency have led to an increased utilization of venous ultrasonography by practitioners. Knowing the fundamentals of anatomy and physiology are essential to be successful. This article reviews the common use ... Full text Link to item Cite

PS230. A Novel In Vitro Model of Chronic Venous Insufficiency

Conference Journal of Vascular Surgery · June 2010 Full text Cite

A large-scale study of the upper arm basilic transposition for hemodialysis.

Journal Article Ann Vasc Surg · January 2010 BACKGROUND: The incidence of stage 5 chronic kidney disease requiring immediate hemodialysis treatment continues to rise with an increasing number of patients with an unsuitable cephalic vein or failed radio- and brachiocephalic fistulae. In these patients ... Full text Link to item Cite

Stent placement after DVT thrombolysis/mechanical thrombectomy

Journal Article Endovascular Today · January 7, 2009 Cite

Subclavian vein to right atrial appendage bypass without sternotomy to maintain arteriovenous access in patients with complete central vein occlusion, a new approach.

Journal Article Ann Vasc Surg · 2009 Given the increasing numbers of patients requiring long-term hemodialysis, there is an inevitably increasing population of patients with occluded central venous inflow (subclavian, innominate, and caval) despite access or access possibilities in the arm. I ... Full text Link to item Cite

A meta-analysis of preoperative duplex ultrasound vessel diameters for successful radiocephalic fistula placement

Journal Article Journal for Vascular Ultrasound · January 1, 2009 Background. - The Kidney Dialysis Outcomes Quality Initiative (K/DOQI) guidelines for vascular access recommend the use of radiocephalic wrist arteriovenous fistulas (RCAVFs) as the initial option for dialysis access. The survival rate of a successfully pl ... Full text Cite

Stenting after venous thrombolysis

Journal Article Endovascular Today · 2009 Cite

Tourette's syndrome and the law.

Journal Article J Neuropsychiatry Clin Neurosci · 2006 Diminished legal responsibility and mental capacity have been used in defense of individuals with neurological disorders charged with legal misdemeanors, including criminal behavior. The purpose of this report is to 1) critically examine the mechanisms tha ... Full text Link to item Cite

Malignant phonic tics

Chapter · 2005 Cite

Atypical parkinsonism and motor neuron syndrome in a Biosphere 2 participant: a possible complication of chronic hypoxia and carbon monoxide toxicity?

Journal Article Mov Disord · April 2004 Exogenous toxins and chronic hypoxia have been implicated in the etiopathogenesis of a variety of neurological disorders, but it is not always possible to establish a cause-effect relationships. We describe a patient who presented with an unusual gait diso ... Full text Link to item Cite

Migraine and Tourette syndrome - Reply

Journal Article Arch Neurol · 2004 Cite

Premonitory sensory phenomenon in Tourette's syndrome.

Journal Article Mov Disord · December 2003 We administered a questionnaire designed to probe for premonitory sensations associated with motor tics to 50 patients with Tourette's syndrome (TS). Premonitory sensations were reported by 46 (92%) patients, and the most common sensation was an urge to mo ... Full text Link to item Cite

Migraine headache in patients with Tourette syndrome.

Journal Article Arch Neurol · November 2003 BACKGROUND: Tourette syndrome (TS) is recognized as one of the most common childhood movement disorders, characterized by motor and phonic tics often associated with neurobehavioral comorbidities, such as obsessive-compulsive disorder. Neurotransmitter dys ... Full text Link to item Cite

Tourettism and dystonia after subcortical stroke.

Journal Article Mov Disord · July 2002 The term "tourettism" has been used to describe Tourette syndrome (TS)-like symptoms secondary to some specific cause. Tics associated with attention deficit hyperactivity disorder (ADHD), obsessive-compulsive disorder (OCD), or both, are commonly present ... Full text Link to item Cite

Daytime sleepiness and other sleep disorders in Parkinson's disease.

Journal Article Neurology · October 23, 2001 BACKGROUND: PD is associated with a variety of sleep problems. The dopamine agonists (DA) pramipexole and ropinirole were recently implicated in causing "sleep attacks" and motor vehicle accidents. METHODS: In order to determine the overall rate of subject ... Full text Link to item Cite

Botulinum toxin in the treatment of tics.

Journal Article Arch Neurol · August 2000 OBJECTIVE: To evaluate the safety and efficacy of botulinum toxin A (BTX) injections in the treatment of tics in patients with Tourette syndrome (TS). BACKGROUND: BTX is an effective treatment for an increasing number of conditions characterized by abnorma ... Full text Link to item Cite

Differential diagnosis of ascites.

Chapter · 1997 The differential diagnosis of ascites often leads to confusion and an inability to exclude its multitude of causes in many patients. In this review, we outline the clinical features and laboratory investigations that usually elucidate the cause of ascites ... Full text Link to item Cite