Scholars@Duke
Kunal Patel

Kunal Patel

Assistant Professor of Surgery
Surgery, Cardiovascular and Thoracic Surgery

Selected Publications

Identification and validation of a threshold for early posttransplant bronchoalveolar fluid hyaluronan that distinguishes lung recipients at risk for chronic lung allograft dysfunction.

Journal Article J Heart Lung Transplant · October 22, 2024 BACKGROUND: Few tools exist for the early identification of patients at risk for chronic lung allograft dysfunction (CLAD). We previously showed hyaluronan (HA), a matrix molecule that regulates lung inflammation and fibrosis, accumulates in bronchoalveola ... Full text Link to item Cite

Opioid Use, Disposition, and Parent Satisfaction Following Common Pediatric Surgical Procedures.

Journal Article Am Surg · January 2024 INTRODUCTION: There is wide variability in prescribing practices among providers, even for patients undergoing the same operations. Our study aims to analyze the variation in opioid prescription practices using a patient-centered approach to establish more ... Full text Link to item Cite

A novel injury site-natural antibody targeted complement inhibitor protects against lung transplant injury.

Journal Article Am J Transplant · June 2021 Complement is known to play a role in ischemia and reperfusion injury (IRI). A general paradigm is that complement is activated by self-reactive natural IgM antibodies (nAbs), after they engage postischemic neoepitopes. However, a role for nAbs in lung tra ... Full text Open Access Link to item Cite

Emphysema-associated Autoreactive Antibodies Exacerbate Post-Lung Transplant Ischemia-Reperfusion Injury.

Journal Article Am J Respir Cell Mol Biol · June 2019 Chronic obstructive pulmonary disease-associated chronic inflammation has been shown to lead to an autoimmune phenotype characterized in part by the presence of lung autoreactive antibodies. We hypothesized that ischemia-reperfusion injury (IRI) liberates ... Full text Open Access Link to item Cite

Donor pretreatment with nebulized complement C3a receptor antagonist mitigates brain-death induced immunological injury post-lung transplant.

Journal Article Am J Transplant · October 2018 Donor brain death (BD) is an inherent part of lung transplantation (LTx) and a key contributor to ischemia-reperfusion injury (IRI). Complement activation occurs as a consequence of BD in other solid organ Tx and exacerbates IRI, but the role of complement ... Full text Open Access Link to item Cite

C3a receptor antagonism as a novel therapeutic target for chronic rhinosinusitis.

Journal Article Mucosal Immunol · September 2018 Chronic rhinosinusitis with nasal polyps (CRSwNP) is an inflammatory disease with an unknown etiology. Recent studies have implicated the complement system as a potential modulator of disease immunopathology. We performed proteomic pathway enrichment analy ... Full text Open Access Link to item Cite

Organ preservation with targeted rapamycin nanoparticles: a pre-treatment strategy preventing chronic rejection in vivo.

Journal Article RSC Adv · July 23, 2018 Hypothermic preservation is the standard of care for storing organs prior to transplantation. Endothelial and epithelial injury associated with hypothermic storage causes downstream graft injury and, as such, the choice of an ideal donor organ preservation ... Full text Link to item Cite

Organ preservation, ischemia reperfusion injury, and nanotherapeutics in transplantation

Chapter · May 23, 2018 Over the past 30 years, solid organ transplantation has advanced tremendously in many facets, with great strides made in organ selection and allocation to the monitoring and treatment of rejection. Despite these breakthroughs, organ preservation and chroni ... Full text Cite

Nanotechnological Approaches to Immunosuppression and Tolerance Induction.

Journal Article Curr Transplant Rep · June 2017 PURPOSE OF REVIEW: Several preclinical studies have engineered nanoparticles for immune regulation, and have shown promising results in the fields of autoimmunity and cancer. In solid organ transplantation, the use of nanoparticle-based immune regulation h ... Full text Link to item Cite

Dietary vitamin D3 deficiency exacerbates sinonasal inflammation and alters local 25(OH)D3 metabolism.

Journal Article PLoS One · 2017 RATIONALE: Patients with chronic rhinosinusitis with nasal polyps (CRSwNP) have been shown to be vitamin D3 (VD3) deficient, which is associated with more severe disease and increased polyp size. To gain mechanistic insights into these observational studie ... Full text Open Access Link to item Cite

Utilization of Machine Perfusion and Nanotechnology for Liver Transplantation

Journal Article Current Transplantation Reports · December 1, 2015 Over the past four decades, advances in the technology supporting solid organ transplantation have been remarkable. Transplantation is now entering a new era where multidisciplinary approaches, including the use of bioengineering, are being utilized in the ... Full text Cite

Laparoscopic repair of gastro-duodenal fistula secondary to band erosion.

Journal Article J Minim Access Surg · October 2014 Laparoscopic gastric banding is one of the most common surgical treatments for morbid obesity performed worldwide. The procedure, however, has many well-documented risks and complications, including band erosion. We present here a gastric banding patient w ... Full text Link to item Cite

Why are medical students 'checking out' of active learning in a new curriculum?

Journal Article Med Educ · March 2014 OBJECTIVES: The University of Virginia School of Medicine recently transformed its pre-clerkship medical education programme to emphasise student engagement and active learning in the classroom. As in other medical schools, many students are opting out of ... Full text Open Access Link to item Cite

Burn management in sub-Saharan Africa: opportunities for implementation of dedicated training and development of specialty centers.

Journal Article Burns · February 2014 BACKGROUND: In low- and middle-income countries burn injuries remain responsible for a large burden of death and disability. Given an annual worldwide incidence of almost 11 million new individuals affected per year, major burn injuries have a higher annua ... Full text Link to item Cite