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Maggie L DiNome

Professor of Surgery
Surgical Oncology
4101 Macon Pond Road, Raleigh, NC 27607

Selected Publications


Axillary nodal disease burden is not associated with an elevated 21-gene recurrence score in post-menopausal women presenting with a clinically negative axilla.

Journal Article Am J Surg · July 2024 BACKGROUND: The predictive and prognostic value of the recurrence score (RS) has emphasized the importance of tumor biology and has reduced the prognostic implications of limited nodal burden in post-menopausal women with HR+/HER2-invasive breast cancer (I ... Full text Link to item Cite

Racial/Ethnic Disparities in Pathologic Complete Response and Overall Survival in Patients With Triple-Negative Breast Cancer Treated With Neoadjuvant Chemotherapy.

Journal Article J Clin Oncol · May 10, 2024 PURPOSE: Black women have higher rates of death from triple-negative breast cancer (TNBC) than White women. We hypothesized that pathologic complete response (pCR) to neoadjuvant chemotherapy (NAC) and overall survival (OS) may vary by race/ethnicity in pa ... Full text Link to item Cite

Anatomy Versus Biology: What Guides Chemotherapy Decisions in Older Patients With Breast Cancer?

Journal Article J Surg Res · April 2024 INTRODUCTION: With the increasing utilization of genomic assays, such as the Oncotype DX recurrence score (RS), the relevance of anatomic staging has been questioned for select older patients with breast cancer. We sought to evaluate differences in chemoth ... Full text Link to item Cite

Retained Biopsy Site Markers After Breast Lesion Surgical Resection: Associations With Residual Malignancy.

Journal Article AJR Am J Roentgenol · January 2024 BACKGROUND. Biopsy site markers (BSMs) placed during image-guided core needle biopsy (CNB) are typically targeted for surgical excision, along with the breast imaging abnormality. Retained BSMs raise concern of incomplete resection of the breast abnormalit ... Full text Link to item Cite

Chromatin insulation orchestrates matrix metalloproteinase gene cluster expression reprogramming in aggressive breast cancer tumors.

Journal Article Mol Cancer · November 28, 2023 BACKGROUND: Triple-negative breast cancer (TNBC) is an aggressive subtype that exhibits a high incidence of distant metastases and lacks targeted therapeutic options. Here we explored how the epigenome contributes to matrix metalloprotease (MMP) dysregulat ... Full text Link to item Cite

Epigenetic Profiles of Triple-Negative Breast Cancers of African American and White Females.

Journal Article JAMA Netw Open · October 2, 2023 IMPORTANCE: Triple-negative breast cancer (TNBC) is the most aggressive breast cancer subtype and appears to have disproportionately higher incidence and worse outcomes among younger African American females. OBJECTIVE: To investigate whether epigenetic di ... Full text Link to item Cite

Neoadjuvant Chemotherapy and Endocrine Therapy for Older Patients with Estrogen Receptor Positive Breast Cancer: Comparison of Approaches.

Journal Article Ann Surg Oncol · October 2023 BACKGROUND: Benefits of a pathologic complete response (pCR) following neoadjuvant therapy are well established, yet outcomes for older women are understudied. We sought to examine the pCR and overall survival (OS) rates of women with estrogen receptor (ER ... Full text Link to item Cite

A Pilot Study of Neoadjuvant Nivolumab, Ipilimumab, and Intralesional Oncolytic Virotherapy for HER2-negative Breast Cancer.

Journal Article Cancer Res Commun · August 2023 PURPOSE: Neoadjuvant combination immune checkpoint blockade and intralesional oncolytic virotherapy have the potential to activate antitumor responses in patients with breast cancer. EXPERIMENTAL DESIGN: Eligibility for this pilot phase I trial included pa ... Full text Link to item Cite

Construction and validation of a gene expression classifier to predict immunotherapy response in primary triple-negative breast cancer.

Journal Article Commun Med (Lond) · July 10, 2023 BACKGROUND: Immune checkpoint inhibitors (ICI) improve clinical outcomes in triple-negative breast cancer (TNBC) patients. However, a subset of patients does not respond to treatment. Biomarkers that show ICI predictive potential in other solid tumors, suc ... Full text Link to item Cite

Survival Benefit of Chemotherapy According to 21-Gene Recurrence Score in Young Women with Breast Cancer.

Journal Article Ann Surg Oncol · April 2023 BACKGROUND: Initial trials evaluating Oncotype DX, reported as a recurrence score (RS) from 0 to 100, were not powered to evaluate overall survival, and premenopausal women were underrepresented. The purpose of this study was to explore the benefit of chem ... Full text Link to item Cite

Abstract P3-05-20: Low 21-Gene Recurrence Score Is Not Associated with a High Axillary Nodal Burden in Post-Menopausal Women Presenting with a Clinically Negative Axilla

Conference Cancer Research · March 1, 2023 AbstractBackground: The predictive and prognostic value of the 21-gene recurrence score (RS) has emphasized the importance of tumor biology and minimized the credence of a limited (1-3 positive) nodal burden ... Full text Cite

Abstract P1-06-02: The effect of race on pathologic complete response rates and overall survival in patients with triple negative breast cancer

Conference Cancer Research · March 1, 2023 AbstractIntroduction: Despite the recent overall improvement in survival for patients with breast cancer, racial disparities in outcomes persist. While studies have demonstrated that socioeconomic factors an ... Full text Cite

Axillary nodal disease burden is not associated with an elevated 21-gene recurrence score in post-menopausal women presenting with a clinically negative axilla.

Journal Article Am J Surg · July 2024 BACKGROUND: The predictive and prognostic value of the recurrence score (RS) has emphasized the importance of tumor biology and has reduced the prognostic implications of limited nodal burden in post-menopausal women with HR+/HER2-invasive breast cancer (I ... Full text Link to item Cite

Racial/Ethnic Disparities in Pathologic Complete Response and Overall Survival in Patients With Triple-Negative Breast Cancer Treated With Neoadjuvant Chemotherapy.

Journal Article J Clin Oncol · May 10, 2024 PURPOSE: Black women have higher rates of death from triple-negative breast cancer (TNBC) than White women. We hypothesized that pathologic complete response (pCR) to neoadjuvant chemotherapy (NAC) and overall survival (OS) may vary by race/ethnicity in pa ... Full text Link to item Cite

Anatomy Versus Biology: What Guides Chemotherapy Decisions in Older Patients With Breast Cancer?

Journal Article J Surg Res · April 2024 INTRODUCTION: With the increasing utilization of genomic assays, such as the Oncotype DX recurrence score (RS), the relevance of anatomic staging has been questioned for select older patients with breast cancer. We sought to evaluate differences in chemoth ... Full text Link to item Cite

Retained Biopsy Site Markers After Breast Lesion Surgical Resection: Associations With Residual Malignancy.

Journal Article AJR Am J Roentgenol · January 2024 BACKGROUND. Biopsy site markers (BSMs) placed during image-guided core needle biopsy (CNB) are typically targeted for surgical excision, along with the breast imaging abnormality. Retained BSMs raise concern of incomplete resection of the breast abnormalit ... Full text Link to item Cite

Chromatin insulation orchestrates matrix metalloproteinase gene cluster expression reprogramming in aggressive breast cancer tumors.

Journal Article Mol Cancer · November 28, 2023 BACKGROUND: Triple-negative breast cancer (TNBC) is an aggressive subtype that exhibits a high incidence of distant metastases and lacks targeted therapeutic options. Here we explored how the epigenome contributes to matrix metalloprotease (MMP) dysregulat ... Full text Link to item Cite

Epigenetic Profiles of Triple-Negative Breast Cancers of African American and White Females.

Journal Article JAMA Netw Open · October 2, 2023 IMPORTANCE: Triple-negative breast cancer (TNBC) is the most aggressive breast cancer subtype and appears to have disproportionately higher incidence and worse outcomes among younger African American females. OBJECTIVE: To investigate whether epigenetic di ... Full text Link to item Cite

Neoadjuvant Chemotherapy and Endocrine Therapy for Older Patients with Estrogen Receptor Positive Breast Cancer: Comparison of Approaches.

Journal Article Ann Surg Oncol · October 2023 BACKGROUND: Benefits of a pathologic complete response (pCR) following neoadjuvant therapy are well established, yet outcomes for older women are understudied. We sought to examine the pCR and overall survival (OS) rates of women with estrogen receptor (ER ... Full text Link to item Cite

A Pilot Study of Neoadjuvant Nivolumab, Ipilimumab, and Intralesional Oncolytic Virotherapy for HER2-negative Breast Cancer.

Journal Article Cancer Res Commun · August 2023 PURPOSE: Neoadjuvant combination immune checkpoint blockade and intralesional oncolytic virotherapy have the potential to activate antitumor responses in patients with breast cancer. EXPERIMENTAL DESIGN: Eligibility for this pilot phase I trial included pa ... Full text Link to item Cite

Construction and validation of a gene expression classifier to predict immunotherapy response in primary triple-negative breast cancer.

Journal Article Commun Med (Lond) · July 10, 2023 BACKGROUND: Immune checkpoint inhibitors (ICI) improve clinical outcomes in triple-negative breast cancer (TNBC) patients. However, a subset of patients does not respond to treatment. Biomarkers that show ICI predictive potential in other solid tumors, suc ... Full text Link to item Cite

Survival Benefit of Chemotherapy According to 21-Gene Recurrence Score in Young Women with Breast Cancer.

Journal Article Ann Surg Oncol · April 2023 BACKGROUND: Initial trials evaluating Oncotype DX, reported as a recurrence score (RS) from 0 to 100, were not powered to evaluate overall survival, and premenopausal women were underrepresented. The purpose of this study was to explore the benefit of chem ... Full text Link to item Cite

Abstract P3-05-20: Low 21-Gene Recurrence Score Is Not Associated with a High Axillary Nodal Burden in Post-Menopausal Women Presenting with a Clinically Negative Axilla

Conference Cancer Research · March 1, 2023 AbstractBackground: The predictive and prognostic value of the 21-gene recurrence score (RS) has emphasized the importance of tumor biology and minimized the credence of a limited (1-3 positive) nodal burden ... Full text Cite

Abstract P1-06-02: The effect of race on pathologic complete response rates and overall survival in patients with triple negative breast cancer

Conference Cancer Research · March 1, 2023 AbstractIntroduction: Despite the recent overall improvement in survival for patients with breast cancer, racial disparities in outcomes persist. While studies have demonstrated that socioeconomic factors an ... Full text Cite

ShouldStage IA Breast Cancerbe Expanded?

Conference ANNALS OF SURGICAL ONCOLOGY · 2023 Cite

The Influence of Body Mass Index on the Histopathology and Outcomes of Patients Diagnosed with Atypical Breast Lesions.

Conference Ann Surg Oncol · October 2022 BACKGROUND: Multiple studies have demonstrated a link between obesity and breast cancer; however, the potential association between obesity and atypical high-risk breast lesions has not been well characterized. We sought to evaluate the characteristics and ... Full text Link to item Cite

Machine Learning-Based Epigenetic Classifiers for Axillary Staging of Patients with ER-Positive Early-Stage Breast Cancer.

Journal Article Ann Surg Oncol · October 2022 BACKGROUND: In the era of molecular stratification and effective multimodality therapies, surgical staging of the axilla is becoming less relevant for patients with estrogen receptor (ER)-positive early-stage breast cancer (EBC). Therefore, a nonsurgical m ... Full text Link to item Cite

Epigenetic Signatures Predict Pathologic Nodal Stage in Breast Cancer Patients with Estrogen Receptor-Positive, Clinically Node-Positive Disease.

Journal Article Ann Surg Oncol · August 2022 BACKGROUND: Breast cancer patients with clinically positive nodes who undergo upfront surgery are often recommended for axillary lymph node dissection (ALND), yet more than half are found to have limited nodal disease (≤ 3 positive nodes, pN1) at surgery. ... Full text Open Access Link to item Cite

Higher risk tumor features are not associated with higher nodal stage in patients with estrogen receptor-positive, node-positive breast cancer.

Journal Article Breast Cancer Res Treat · June 2022 INTRODUCTION: Studies support omission of axillary lymph node dissection (ALND) for patients with sentinel node-positive disease, with ALND recommended for patients who present with clinically positive nodes. Here, we evaluate patient and tumor characteris ... Full text Open Access Link to item Cite

Updates on treating ductal carcinoma in situ: what's to know in 2021.

Journal Article Curr Opin Obstet Gynecol · February 1, 2022 PURPOSE OF REVIEW: Ductal carcinoma in situ (DCIS) is a noninvasive stage of disease but understood to be a nonobligate precursor to invasive breast cancer. As such, women with DCIS are routinely recommended for standard breast cancer treatment to prevent ... Full text Link to item Cite

SAVI SCOUT® localization of metastatic axillary lymph node prior to neoadjuvant chemotherapy for targeted axillary dissection: a pilot study.

Journal Article Breast Cancer Res Treat · January 2022 PURPOSE: In clinically node-positive breast cancer, axillary staging after neoadjuvant chemotherapy (NAC) is optimized with targeted axillary dissection (TAD), which includes removal of the biopsy-proven metastatic lymph node (LN) in addition to sentinel l ... Full text Link to item Cite

SARS-CoV-2 infection and venous thromboembolism after surgery: an international prospective cohort study.

Journal Article Anaesthesia · January 2022 SARS-CoV-2 has been associated with an increased rate of venous thromboembolism in critically ill patients. Since surgical patients are already at higher risk of venous thromboembolism than general populations, this study aimed to determine if patients wit ... Full text Link to item Cite

ACR Appropriateness Criteria® Transgender Breast Cancer Screening.

Journal Article J Am Coll Radiol · November 2021 Breast cancer screening recommendations for transgender and gender nonconforming individuals are based on the sex assigned at birth, risk factors, and use of exogenous hormones. Insufficient evidence exists to determine whether transgender people undergoin ... Full text Link to item Cite

Effects of pre-operative isolation on postoperative pulmonary complications after elective surgery: an international prospective cohort study.

Journal Article Anaesthesia · November 2021 We aimed to determine the impact of pre-operative isolation on postoperative pulmonary complications after elective surgery during the global SARS-CoV-2 pandemic. We performed an international prospective cohort study including patients undergoing elective ... Full text Link to item Cite

National trends and predictors of mastectomy with immediate breast reconstruction.

Journal Article Am J Surg · October 2021 PURPOSE: This study aimed to evaluate national trends in utilization, resource use, and predictors of immediate breast reconstruction (IR) after mastectomy. METHODS: The 2005-2014 National Inpatient Sample database was used to identify adult women undergoi ... Full text Link to item Cite

SARS-CoV-2 vaccination modelling for safe surgery to save lives: data from an international prospective cohort study.

Journal Article Br J Surg · September 27, 2021 BACKGROUND: Preoperative SARS-CoV-2 vaccination could support safer elective surgery. Vaccine numbers are limited so this study aimed to inform their prioritization by modelling. METHODS: The primary outcome was the number needed to vaccinate (NNV) to prev ... Full text Link to item Cite

Epigenetic Regulation of Immunotherapy Response in Triple-Negative Breast Cancer.

Journal Article Cancers (Basel) · August 17, 2021 Triple-negative breast cancer (TNBC) is defined by the absence of estrogen receptor and progesterone receptor and human epidermal growth factor receptor 2 (HER2) overexpression. This malignancy, representing 15-20% of breast cancers, is a clinical challeng ... Full text Link to item Cite

Timing of surgery following SARS-CoV-2 infection: an international prospective cohort study.

Journal Article Anaesthesia · June 2021 Peri-operative SARS-CoV-2 infection increases postoperative mortality. The aim of this study was to determine the optimal duration of planned delay before surgery in patients who have had SARS-CoV-2 infection. This international, multicentre, prospective c ... Full text Link to item Cite

Assessing the Burden of Nodal Disease for Breast Cancer Patients with Clinically Positive Nodes: Hope for More Limited Axillary Surgery.

Journal Article Ann Surg Oncol · May 2021 BACKGROUND: Omission of axillary lymph node dissection (ALND) is accepted for patients with one or two positive sentinel nodes, and studies are focusing on clinically node-positive patients who have been downstaged with neoadjuvant chemotherapy (NAC). Evid ... Full text Link to item Cite

"Going Flat" After Mastectomy: Patient-Reported Outcomes by Online Survey.

Journal Article Ann Surg Oncol · May 2021 BACKGROUND: The Going Flat movement aims to increase awareness and acceptance of mastectomy alone as a viable option for patients. Little is known about motivations and satisfaction with surgical outcomes in this population. METHODS: An online survey was a ... Full text Link to item Cite

ASO Visual Abstract: "Going Flat" After Mastectomy: Patient-Reported Outcomes by Online Survey.

Journal Article Ann Surg Oncol · May 2021 The "Going Flat" movement aims to increase awareness and acceptance of mastectomy alone as a viable option for patients. Little is known about the motivation for and satisfaction with surgical outcomes in this population. Among 931 women surveyed in online ... Full text Link to item Cite

How patients experience endocrine therapy for breast cancer: an online survey of side effects, adherence, and medical team support.

Journal Article J Cancer Surviv · February 2021 PURPOSE: Many patients with hormone receptor-positive (HR+) breast cancer do not adhere to endocrine therapy (ET), and treatment-related side effects are often discussed by participants in online breast cancer forums. Our aim was to survey this unique grou ... Full text Link to item Cite

Current Triple-Negative Breast Cancer Subtypes: Dissecting the Most Aggressive Form of Breast Cancer.

Journal Article Front Oncol · 2021 Triple-negative breast cancer (TNBC) is a highly heterogeneous disease defined by the absence of estrogen receptor (ER) and progesterone receptor (PR) expression, and human epidermal growth factor receptor 2 (HER2) overexpression that lacks targeted treatm ... Full text Link to item Cite

Locoregional Management of Inflammatory Breast Cancer

Journal Article Current Breast Cancer Reports · December 1, 2020 Purpose of Review: Inflammatory breast cancer (IBC) is a biologically aggressive subtype with a high risk for rapid local progression and early distant metastasis. We review the updated data for optimal locoregional management of IBC, including areas of ac ... Full text Cite

National Trends in Immediate Breast Reconstruction: An Analysis of Implant-Based Versus Autologous Reconstruction After Mastectomy.

Journal Article Ann Surg Oncol · November 2020 BACKGROUND: Many factors affect access to immediate breast reconstruction (IR) after mastectomy. The present study was performed to assess trends, outcomes, and predictors of IR techniques using a nationally representative cohort. METHODS: The 2009-2014 Na ... Full text Link to item Cite

Anaphylactic Reaction to Lymphazurin 1% during Breast Reconstruction Surgery: An Uncommon but Serious Complication.

Journal Article Plast Reconstr Surg Glob Open · September 2020 Lymphazurin 1% (isosulfan blue dye) is the most frequently used blue dye in the United States, and it is commonly used for sentinel node biopsy in breast cancer patients. Although cases of allergic reaction to lymphazurin have been reported in the general ... Full text Link to item Cite

Disparities in Risk Reduction Therapy Recommendations for Young Women With Lobular Carcinoma In-Situ.

Journal Article Clin Breast Cancer · August 2020 BACKGROUND: Endocrine therapy (ET) significantly reduces the risk of breast cancer development in high-risk patients diagnosed with lobular carcinoma in situ (LCIS). However, the variables impacting recommendation and use of ET in young adults (YAs) is not ... Full text Link to item Cite

A comparison of two non-radioactive alternatives to wire for the localization of non-palpable breast cancers.

Journal Article Breast Cancer Res Treat · July 2020 PURPOSE: Multiple wire-free technologies for localization of non-palpable breast cancers have emerged as satisfactory alternatives to wire. However, no study has compared two non-radioactive wire-free approaches to one another. The purpose of this study wa ... Full text Link to item Cite

Clinicopathological Features of Triple-Negative Breast Cancer Epigenetic Subtypes.

Journal Article Ann Surg Oncol · October 2019 BACKGROUND/OBJECTIVE: Triple-negative breast cancer (TNBC) is a heterogeneous collection of breast tumors with numerous differences including morphological characteristics, genetic makeup, immune-cell infiltration, and response to systemic therapy. DNA met ... Full text Link to item Cite

Microchipping the breast: an effective new technology for localizing non-palpable breast lesions for surgery.

Journal Article Breast Cancer Res Treat · May 2019 PURPOSE: Use of a wire to localize a non-palpable breast lesion for surgery is standard but archaic. We sought to evaluate a new radiofrequency localization system (RFLS) as an effective, non-radioactive alternative to the wire. METHODS: Patients who requi ... Full text Link to item Cite

Impact of port site scar on perception of patients with breast cancer: patient-reported outcomes.

Journal Article Breast Cancer Res Treat · August 2018 PURPOSE: As the number of survivors continues to increase with improvements in breast cancer treatment, greater emphasis has been placed on the aesthetic outcome following breast surgery. Effort is made to minimize scarring on the breast, yet patients who ... Full text Link to item Cite

Variations in cancer care for adolescents and young adults (AYAs) with ductal carcinoma in situ.

Journal Article Breast J · July 2018 NCCN guidelines recommend tamoxifen (TAM) for adjuvant treatment of ductal carcinoma in situ (DCIS). TAM has side effects that can potentially complicate treatment recommendations and patient acceptance. It is unknown how well-accepted this recommended the ... Full text Link to item Cite

Assessing the Effect of Lifetime Contralateral Breast Cancer Risk on the Selection of Contralateral Prophylactic Mastectomy for Unilateral Breast Cancer.

Journal Article Clin Breast Cancer · April 2018 INTRODUCTION: Contralateral prophylactic mastectomy (CPM) rates are rising, with fear implicated as a contributing factor. This study used a contralateral breast cancer (CBC) risk stratification tool to assess whether the selection of CPM is reflective of ... Full text Link to item Cite

Predictors associated with MRI surveillance screening in women with a personal history of unilateral breast cancer but without a genetic predisposition for future contralateral breast cancer.

Journal Article Breast Cancer Res Treat · November 2017 PURPOSE: For women with a personal history of breast cancer (PHBC), no validated mechanisms exist to calculate future contralateral breast cancer (CBC) risk. The Manchester risk stratification guidelines were developed to evaluate CBC risk in women with a ... Full text Link to item Cite

Genome-wide chromatin accessibility, DNA methylation and gene expression analysis of histone deacetylase inhibition in triple-negative breast cancer.

Journal Article Genom Data · June 2017 Triple-negative breast cancer (TNBC), especially the subset with a basal phenotype, represents the most aggressive subtype of breast cancer. Unlike other solid tumors, TNBCs harbor a low number of driver mutations. Conversely, we and others have demonstrat ... Full text Link to item Cite

Histological assessment of breast lesions identified exclusively by magnetic resonance.

Journal Article Am Surg · October 2014 Radiologic-pathologic correlation of lesions diagnosed by magnetic resonance (MR) is precluded by insufficient data on histological characteristics of lesions suspicious on MR but not visible on concurrent mammogram or ultrasound. The objective of this stu ... Link to item Cite

Microbial dysbiosis is associated with human breast cancer.

Journal Article PLoS One · 2014 Breast cancer affects one in eight women in their lifetime. Though diet, age and genetic predisposition are established risk factors, the majority of breast cancers have unknown etiology. The human microbiota refers to the collection of microbes inhabiting ... Full text Link to item Cite

Prognostic impact of micrometastases in colon cancer: interim results of a prospective multicenter trial.

Journal Article Ann Surg · October 2007 OBJECTIVE: The 25% rate of recurrence after complete resection of stage II colon cancer (CC) suggests the presence of occult nodal metastases not identified by hematoxylin and eosin staining (H&E). Interim data from our ongoing prospective multicenter tria ... Full text Link to item Cite

Prospective multicenter trial of staging adequacy in colon cancer: preliminary results.

Journal Article Arch Surg · June 2006 HYPOTHESIS: Lymph node evaluation is an important prognostic factor in colorectal cancer (CRC). A 25% recurrence rate in patients with node-negative CRC suggests that current staging practices are inadequate. Focused analysis of the sentinel node (SN) by m ... Full text Link to item Cite

Myoepithelial-specific CD44 shedding is mediated by a putative chymotrypsin-like sheddase.

Journal Article Biochem Biophys Res Commun · December 9, 2000 Our previous studies have demonstrated that myoepithelial cells, which surround incipient carcinomas in situ of the breast and other organs, exert antiinvasive and antiangiogenic effects in vitro through the elaboration of a number of different suppressor ... Full text Link to item Cite

Myoepithelial-specific CD44 shedding contributes to the anti-invasive and antiangiogenic phenotype of myoepithelial cells.

Journal Article Exp Cell Res · November 25, 2000 Myoepithelial cells surround incipient ductal carcinomas of the breast and exert anti-invasive and antiangiogenic effects in vitro through the elaboration of suppressor molecules. This study examines one putative molecule, solubilized CD44 produced by myoe ... Full text Link to item Cite

The human myoepithelial cell displays a multifaceted anti-angiogenic phenotype.

Journal Article Oncogene · July 20, 2000 Human myoepithelial cells which surround ducts and acini of certain organs such as the breast form a natural border separating epithelial cells from stromal angiogenesis. Myoepithelial cell lines (HMS-1-6), derived from diverse benign myoepithelial tumors, ... Full text Link to item Cite

Immune deviation and Fas-mediated deletion limit antitumor activity after multiple dendritic cell vaccinations in mice.

Journal Article Cancer Res · April 15, 2000 Genetic immunization with a single injection of dendritic cells (DCs) expressing a model melanoma antigen generates antigen-specific, MHC-restricted, protective immune responses. After initiating the immune response, additional vaccinations may increase th ... Link to item Cite

Human colon cancer cells express multiple glycoprotein ligands for E-selectin.

Journal Article Int J Oncol · February 2000 The interaction between the colon tumor cell surface and the endothelial cell layer is an important component of tumor intravasation, extravasation, and metastasis. Multiple studies suggest that tumor cells may bind to E-selectin expressed on endothelial c ... Full text Link to item Cite

Different patterns of angiogenesis in sarcomas and carcinomas.

Journal Article Clin Cancer Res · November 1999 Solid tumors depend on angiogenesis for growth and metastasis. It has been shown that blood vessel density, as determined by counting the number of capillaries in clustered bursts, is a significant prognostic factor in carcinomas. It is unclear, however, w ... Link to item Cite

Alpha-fetoprotein-specific genetic immunotherapy for hepatocellular carcinoma.

Journal Article Cancer Res · July 1, 1999 The majority of human hepatocellular carcinomas overexpress alpha-fetoprotein (AFP). Two genetic immunization strategies were used to determine whether AFP could serve as a target for T-cell immune responses. Dendritic cells engineered to express AFP produ ... Link to item Cite

Regression of metastatic breast cancer in a patient treated with the anti-angiogenic drug TNP-470.

Journal Article Tumori · 1999 BACKGROUND: Solid tumors in general, and breast cancer in particular, depend on angiogenesis to grow and metastasize. Multiple agents have been developed in order to inhibit this phenomenon of tumor-induced angiogenesis. TNP-470 is one of the most potent o ... Full text Link to item Cite

Early operative intervention after thrombolytic therapy for primary subclavian vein thrombosis: an effective treatment approach.

Journal Article J Vasc Surg · June 1998 PURPOSE: Effective treatment of primary subclavian vein thrombosis focuses on restoration of venous patency, relief of intrinsic stenosis, and decompression of the thoracic inlet. The appropriate method and timing for surgery, however, have not been not we ... Full text Link to item Cite

Total parenteral nutrition alters NPY/PYY receptor levels in the rat brain.

Journal Article Physiol Behav · December 1997 The regulation of appetite and satiety is complex and may involve peptide mediators such as cholecystokinin (CCK) and neuropeptide Y (NPY). Studies have indicated that calories administered enterally and parenterally impact on feeding, and possibly via the ... Full text Link to item Cite

Neuropeptide Y functions as a physiologic regulator of cephalic phase acid secretion.

Journal Article Regul Pept · August 4, 1994 Neuropeptide Y (NPY) has been established as a potent orexigenic peptide, and recent studies suggest that NPY stimulates cephalic phase secretion as well. However, it is not known whether NPY's effects are pharmacologic or physiologic. In order to determin ... Full text Link to item Cite

Role of neuropeptides in the regulation of feeding behavior: a review of cholecystokinin, bombesin, neuropeptide Y, and galanin.

Journal Article Neurosci Biobehav Rev · 1994 The purpose of this report is to provide a review of four peptides (cholecystokinin, bombesin, neuropeptide Y, galanin) and their role in feeding behavior. Cholecystokinin (CCK) and bombesin (BBS) are considered satiety peptides, and neuropeptide Y (NPY) a ... Full text Link to item Cite

Regionally specific effects of atypical antipsychotic drugs on striatal Fos expression: The nucleus accumbens shell as a locus of antipsychotic action.

Journal Article Mol Cell Neurosci · August 1992 The mechanisms by which atypical antipsychotic drugs such as clozapine exert therapeutic effects but do not induce extrapyramidal side effects are not clear. We have examined the effects of acute administration of three antipsychotic drugs on Fos protein e ... Full text Link to item Cite

Stress selectively increases fos protein in dopamine neurons innervating the prefrontal cortex.

Journal Article Cereb Cortex · 1991 Stress-induced alterations in expression of c-fos protein (Fos) in mesencephalic dopamine (DA) neurons of the rat were examined in order to discern which midbrain DA neurons are metabolically activated by stress. Restraint stress for 30 min increased the n ... Full text Link to item Cite