Scholars@Duke
Maria Cristina Segovia

Maria Cristina Segovia

Associate Professor of Medicine
Medicine, Gastroenterology
Office hours Monday - Friday 8AM - 5PM  
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Selected Publications

Endoscopic Surveillance of the Intestinal Allograft: Recommendations From the Intestinal Rehabilitation and Transplant Association Working Group.

Journal Article Transplantation · April 1, 2024 Intestinal transplant (ITx) rejection lacks a reliable noninvasive biomarker and rejection surveillance relies on serial endoscopies and mucosal biopsies followed by histologic assessment. Endoscopic biopsies are also essential for identifying other ITx-re ... Full text Link to item Cite

When you need to dive in the deep end-Transplanting SARS-CoV-2 PCR+ recipients.

Journal Article Transpl Infect Dis · October 2023 There is an ongoing need to understand whether transplantation during acute Coronavirus disease 2019 (COVID-19) can be performed safely, especially when urgent transplant is required. We collected retrospective data of all consecutive non-lung transplant r ... Full text Link to item Cite

Evolving challenges with long-term care of liver transplant recipients.

Journal Article Clin Transplant · October 2023 The number of liver transplants (LT) performed worldwide continues to rise, and LT recipients are living longer post-transplant. This has led to an increasing number of LT recipients requiring lifelong care. Optimal care post-LT requires careful attention ... Full text Link to item Cite

The First Collective Examination of Immunosuppressive Practices Among American Intestinal Transplant Centers.

Journal Article Transplant Direct · September 2023 BACKGROUND: Unlike other solid organs, no standardized treatment algorithms exist for intestinal transplantation (ITx). We established a consortium of American ITx centers to evaluate current practices. METHODS: All American centers performing ITx during t ... Full text Link to item Cite

Medical intestinal rehabilitation.

Journal Article Curr Opin Organ Transplant · August 1, 2023 PURPOSE OF REVIEW: Medical intestinal rehabilitation is a part of the very complex management of patients with intestinal failure. The goal is to achieve enteral autonomy and minimize need for parenteral nutrition and hydration. In this manuscript, we will ... Full text Link to item Cite

Cytomegalovirus Infection Management in Multivisceral and Intestinal Transplant: A Dual Institution Study.

Journal Article Transplant Proc · March 2023 Intestinal transplant and multivisceral transplant were originally in pediatric populations and are relatively new procedures in adults. Despite increasing success rates in the immediate post-transplant period, infectious complications and acute and chroni ... Full text Link to item Cite

An analysis of the outcomes of Clostridioides difficile occurring in intestinal transplant recipients requiring hospitalization.

Journal Article Transpl Infect Dis · February 2023 BACKGROUND: Organ transplantation is a known risk factor for Clostridioides difficile infection (CDI). There is limited published data on the impact of CDI in the intestinal transplant population. METHODS: We utilized the National Readmission Database (201 ... Full text Link to item Cite

When You Need to Dive in the Deep End - Transplanting SARS-COV-2 PCR+ Recipients

Conference AMERICAN JOURNAL OF TRANSPLANTATION · 2023 Cite

When You Need to Dive in the Deep End - Transplanting SARS-COV-2 PCR+ Recipients

Conference AMERICAN JOURNAL OF TRANSPLANTATION · 2023 Cite

Consensus recommendations for use of maintenance immunosuppression in solid organ transplantation: Endorsed by the American College of Clinical Pharmacy, American Society of Transplantation, and International Society for Heart and Lung Transplantation: An executive summary.

Journal Article Pharmacotherapy · August 2022 Advances in maintenance immunosuppression over the past three decades have improved solid organ transplantation outcomes dramatically. Uninterrupted access to immunosuppression is paramount to minimize rejection and maintain allograft and patient survival. ... Full text Link to item Cite

Consensus recommendations for use of maintenance immunosuppression in solid organ transplantation: Endorsed by the American College of Clinical Pharmacy, American Society of Transplantation, and the International Society for Heart and Lung Transplantation.

Journal Article Pharmacotherapy · August 2022 Advances in maintenance immunosuppression over the past three decades have improved solid organ transplantation outcomes dramatically. Uninterrupted access to immunosuppression is paramount to minimize rejection and maintain allograft and patient survival. ... Full text Link to item Cite

Adenovirus Enteritis Following Intestinal Transplantation.

Conference AMERICAN JOURNAL OF TRANSPLANTATION · 2022 Cite

Efficacy and safety of mammalian target of rapamycin inhibitors following intestinal and multivisceral transplantation.

Journal Article Clin Transplant · July 2021 This is a descriptive study reviewing the outcomes of mammalian target of rapamycin inhibitors (mTORs) in intestinal (IT) and multivisceral transplantation (MVT). This study included 22 patients, 20 adults, and two children, and an overall mean age of 46 y ... Full text Link to item Cite

Endoscopic Surveillance of the Intestinal Allograft: Recommendations From the Intestinal Rehabilitation and Transplant Association Working Group.

Journal Article Transplantation · April 1, 2024 Intestinal transplant (ITx) rejection lacks a reliable noninvasive biomarker and rejection surveillance relies on serial endoscopies and mucosal biopsies followed by histologic assessment. Endoscopic biopsies are also essential for identifying other ITx-re ... Full text Link to item Cite

When you need to dive in the deep end-Transplanting SARS-CoV-2 PCR+ recipients.

Journal Article Transpl Infect Dis · October 2023 There is an ongoing need to understand whether transplantation during acute Coronavirus disease 2019 (COVID-19) can be performed safely, especially when urgent transplant is required. We collected retrospective data of all consecutive non-lung transplant r ... Full text Link to item Cite

Evolving challenges with long-term care of liver transplant recipients.

Journal Article Clin Transplant · October 2023 The number of liver transplants (LT) performed worldwide continues to rise, and LT recipients are living longer post-transplant. This has led to an increasing number of LT recipients requiring lifelong care. Optimal care post-LT requires careful attention ... Full text Link to item Cite

The First Collective Examination of Immunosuppressive Practices Among American Intestinal Transplant Centers.

Journal Article Transplant Direct · September 2023 BACKGROUND: Unlike other solid organs, no standardized treatment algorithms exist for intestinal transplantation (ITx). We established a consortium of American ITx centers to evaluate current practices. METHODS: All American centers performing ITx during t ... Full text Link to item Cite

Medical intestinal rehabilitation.

Journal Article Curr Opin Organ Transplant · August 1, 2023 PURPOSE OF REVIEW: Medical intestinal rehabilitation is a part of the very complex management of patients with intestinal failure. The goal is to achieve enteral autonomy and minimize need for parenteral nutrition and hydration. In this manuscript, we will ... Full text Link to item Cite

Cytomegalovirus Infection Management in Multivisceral and Intestinal Transplant: A Dual Institution Study.

Journal Article Transplant Proc · March 2023 Intestinal transplant and multivisceral transplant were originally in pediatric populations and are relatively new procedures in adults. Despite increasing success rates in the immediate post-transplant period, infectious complications and acute and chroni ... Full text Link to item Cite

An analysis of the outcomes of Clostridioides difficile occurring in intestinal transplant recipients requiring hospitalization.

Journal Article Transpl Infect Dis · February 2023 BACKGROUND: Organ transplantation is a known risk factor for Clostridioides difficile infection (CDI). There is limited published data on the impact of CDI in the intestinal transplant population. METHODS: We utilized the National Readmission Database (201 ... Full text Link to item Cite

When You Need to Dive in the Deep End - Transplanting SARS-COV-2 PCR+ Recipients

Conference AMERICAN JOURNAL OF TRANSPLANTATION · 2023 Cite

When You Need to Dive in the Deep End - Transplanting SARS-COV-2 PCR+ Recipients

Conference AMERICAN JOURNAL OF TRANSPLANTATION · 2023 Cite

Consensus recommendations for use of maintenance immunosuppression in solid organ transplantation: Endorsed by the American College of Clinical Pharmacy, American Society of Transplantation, and International Society for Heart and Lung Transplantation: An executive summary.

Journal Article Pharmacotherapy · August 2022 Advances in maintenance immunosuppression over the past three decades have improved solid organ transplantation outcomes dramatically. Uninterrupted access to immunosuppression is paramount to minimize rejection and maintain allograft and patient survival. ... Full text Link to item Cite

Consensus recommendations for use of maintenance immunosuppression in solid organ transplantation: Endorsed by the American College of Clinical Pharmacy, American Society of Transplantation, and the International Society for Heart and Lung Transplantation.

Journal Article Pharmacotherapy · August 2022 Advances in maintenance immunosuppression over the past three decades have improved solid organ transplantation outcomes dramatically. Uninterrupted access to immunosuppression is paramount to minimize rejection and maintain allograft and patient survival. ... Full text Link to item Cite

Adenovirus Enteritis Following Intestinal Transplantation.

Conference AMERICAN JOURNAL OF TRANSPLANTATION · 2022 Cite

Efficacy and safety of mammalian target of rapamycin inhibitors following intestinal and multivisceral transplantation.

Journal Article Clin Transplant · July 2021 This is a descriptive study reviewing the outcomes of mammalian target of rapamycin inhibitors (mTORs) in intestinal (IT) and multivisceral transplantation (MVT). This study included 22 patients, 20 adults, and two children, and an overall mean age of 46 y ... Full text Link to item Cite

Peri-covid Trends on the Intestinal Transplant Waiting List

Conference AMERICAN JOURNAL OF TRANSPLANTATION · 2021 Cite

A National Survey of Immunosuppression Strategies in Intestinal Transplantation.

Conference AMERICAN JOURNAL OF TRANSPLANTATION · April 1, 2019 Link to item Cite

Temporal and Geographical Trends of Intestinal Transplantation in the USA.

Conference AMERICAN JOURNAL OF TRANSPLANTATION · June 1, 2018 Link to item Cite

A Case of Drug-Induced Liver Injury due to Designer Steroid Use

Conference American Journal of Gastroenterology · October 2017 Full text Cite

Use of Everolimus After Multivisceral Transplantation: A Report of Two Cases.

Journal Article Transplant Proc · March 2016 Inhibitors of mechanistic target of rapamycin are used in solid organ transplant procedures to avoid calcineurin inhibitor complications, including nephrotoxicity and malignancy. We present 2 cases of multivisceral transplantation for neuroendocrine tumor ... Full text Link to item Cite

A Case Report of Acute Cellular Rejection Following Intestinal Transplantation Managed With Adalimumab.

Journal Article Transplant Proc · March 2016 There is a higher incidence of acute cellular rejection (ACR) in small bowel transplantation (SBT) compared with transplantation of other solid organs. Although there are reports on the use of infliximab to successfully treat ACR refractory to other treatm ... Full text Link to item Cite

Intestine Transplantation Across a Positive Crossmatch With Preformed Donor-Specific Antibodies.

Journal Article Transplant Proc · March 2016 BACKGROUND: We describe our experience using a modified protocol for immunosuppression for intestine transplantation across a positive crossmatch. Patients who underwent transplantation in 2013 were evaluated over a 12-month period for rejection and infect ... Full text Link to item Cite

Adefovir dipivoxil in chronic hepatitis B: history and current uses.

Journal Article Expert Opin Pharmacother · February 2012 INTRODUCTION: The nucleotide analogue adefovir dipivoxil (ADV) was approved in 2002 for the treatment of chronic infection with hepatitis B virus (HBV), in both hepatitis B e antigen (HBeAg)-positive and -negative patients. ADV 10 mg daily has been associa ... Full text Link to item Cite

Significance of complement split product C4d in ABO-compatible liver allograft: diagnosing utility in acute antibody mediated rejection.

Journal Article Transpl Immunol · January 2012 Diagnosis of liver allograft antibody-mediated rejection (AMR) is difficult and requires a constellation of clinical, laboratory and histologic features that support the disease and exclude other causes. Histologic features of AMR may intermix with those o ... Full text Link to item Cite