Scholars@Duke
Ralph Abi Hachem

Ralph Abi Hachem

Associate Professor of Head and Neck Surgery & Communication Sciences
Rhinology and Skull Base Surgery
ralph.abi.hachem@duke.edu
Duke South Yellow Zone 4000, DUMC Box 3805, Durham, NC 27710
40 Duke Medicine Circle, DUMC Box 3805, Durham, NC 27710
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Selected Publications

Patient-derived organoid model of olfactory ensheathing cell tumor.

Journal Article Int Forum Allergy Rhinol · September 27, 2024 We developed a culture model of a human olfactory ensheathing cell tumor. Cultured organoids resemble normal ensheathing cells. Assays suggest that this model provides a tool for studying the roles of these glial cells in the maintenance of the peripheral ... Full text Link to item Cite

Impact of Intra-Phenotypic Nasal Vestibular Variation on Local Airflow Dynamics.

Journal Article Laryngoscope · August 21, 2024 OBJECTIVES: Many individuals with healthy normal nasal anatomy and function exhibit a prominent notch indentation at the junction of the ala and sidewall, specifically around the anterior-superior region of the unilateral nasal vestibule up to the internal ... Full text Link to item Cite

The lateral based nasopharyngeal flap: A novel vascularized flap for skull base reconstruction.

Journal Article Head Neck · August 12, 2024 As the indications for endoscopic skull base approaches have increased, so has the need for more versatile vascularized flaps for skull base reconstruction. Here, we describe a novel lateral based nasopharyngeal flap (LNPF). Two cadaver heads were dissecte ... Full text Link to item Cite

Olfactory neuroblastoma mimics molecular heterogeneity and lineage trajectories of small-cell lung cancer.

Journal Article Cancer Cell · June 10, 2024 The olfactory epithelium undergoes neuronal regeneration from basal stem cells and is susceptible to olfactory neuroblastoma (ONB), a rare tumor of unclear origins. Employing alterations in Rb1/Trp53/Myc (RPM), we establish a genetically engineered mouse m ... Full text Link to item Cite

Predictors of Non-Rhinogenic Facial Pain or Pressure in Otolaryngology Clinic.

Journal Article Otolaryngol Head Neck Surg · May 2024 OBJECTIVES: Identify demographic and clinical characteristics that may help differentiate non-rhinogenic facial pain or pressure (NRFP) from sinusitis. STUDY DESIGN: Retrospective single-institution study. SETTING: Tertiary Care Center Rhinology Clinic. ME ... Full text Link to item Cite

Treatment of unilateral olfactory neuroblastoma: Appropriate extent of surgical resection and potential for olfactory preservation.

Journal Article Int Forum Allergy Rhinol · May 2024 Historically, comprehensive surgical resection for olfactory neuroblastoma has included the bilateral olfactory epithelium, cribriform plate, overlying dura, olfactory bulbs and tracts. This results in postoperative anosmia that may significantly impact a ... Full text Link to item Cite

Barosinusitis due to routine weather changes: A cross-sectional analysis of public websites.

Journal Article World J Otorhinolaryngol Head Neck Surg · March 2024 BACKGROUND: Sinusitis is a common diagnosis that can be erroneously associated with routine weather-related barometric pressure changes. In actuality, these pressure changes likely exacerbate migraine headaches, which can cause facial pain and pressure rat ... Full text Link to item Cite

Safety and Feasibility of Steroid-Eluting Stent as a Bolster in Endoscopic Anterior Skull Base Reconstruction.

Journal Article Ann Otol Rhinol Laryngol · January 2024 BACKGROUND: With a rising incidence of cerebrospinal fluid (CSF) leaks, endoscopic endonasal CSF leak repair is increasingly performed. Current approaches utilize a variety of materials including free mucosal grafts and vascularized flaps, but post-op leak ... Full text Link to item Cite

Preoperative Embolization Techniques in the Treatment of Juvenile Nasopharyngeal Angiofibroma: A Systematic Review.

Journal Article Otolaryngol Head Neck Surg · September 2023 OBJECTIVE: Preoperative embolization has proven beneficial in the surgical treatment of juvenile nasopharyngeal angiofibromas (JNA). However, the consensus for the best embolization practices remains unclear. This systematic review seeks to characterize th ... Full text Link to item Cite

Use of Tympanostomy T-Tube for Endoscopic Endonasal Marsupialization of Small Rathke's Cleft Cysts: A Case Series.

Journal Article J Neurol Surg B Skull Base · August 2023 Objectives  This article describes a novel technique implementing the use of a tympanostomy t-tube to provide long-term marsupialization of small Rathke's cleft cysts (RCCs). Design  A retrospective review of electronic medical records was performed to col ... Full text Link to item Cite

Nasopharyngeal Carcinoma: Case Presentation and Literature Review of Treatment Innovation with Immunotherapy.

Journal Article J Neurol Surg Rep · July 2023 Nasopharyngeal carcinoma (NPC), a rare head and neck malignancy, arises from the epithelial lining of nasopharyngeal mucosa. The confluence of various risk factors, such as latent Epstein-Barr virus infection, genetic susceptibility, smoking, alcohol consu ... Full text Link to item Cite

Nasopharyngeal Carcinoma: Case Presentation and Literature Review of Treatment Innovation with Immunotherapy

Journal Article Journal of Neurological Surgery Reports · July 2023 AbstractNasopharyngeal carcinoma (NPC), a rare head and neck malignancy, arises from the epithelial lining of nasopharyngeal mucosa. The confluence of various risk factors, such as latent Epstein–Barr virus infection, genet ... Full text Cite

Deconstructing Olfactory Epithelium Developmental Pathways in Olfactory Neuroblastoma.

Journal Article Cancer Res Commun · June 2023 UNLABELLED: Olfactory neuroblastoma is a rare tumor arising from the olfactory cleft region of the nasal cavity. Because of the low incidence of this tumor, as well as an absence of established cell lines and murine models, understanding the mechanisms dri ... Full text Link to item Cite

Nasal Cavity Squamous Cell Carcinoma: Factors Associated With Treatment Outcomes and Potential Organ Preservation.

Journal Article Am J Rhinol Allergy · January 2023 BACKGROUND: Squamous cell carcinoma of the nasal cavity (NCSCC) is a rare, challenging malignancy. Surgical resection of this tumor can cause significant facial deformity, and indications for adjuvant or organ preservation therapies are not well-described. ... Full text Link to item Cite

Characterizing Olfactory Dysfunction in Patients with Unilateral Cleft Lip Nasal Deformities.

Journal Article Facial Plast Surg Aesthet Med · 2023 Background: Unilateral cleft lip nasal deformity (uCLND) is associated with olfactory dysfunction, but the underlying etiology remains poorly understood. Objective: To investigate the etiology of uCLND-associated olfactory dysfunction using clinical, compu ... Full text Open Access Link to item Cite

Preparation of Human Olfactory Epithelial Biopsies for Downstream Analysis.

Journal Article Methods Mol Biol · 2023 The olfactory mucosa, lining a portion of the nasal cavity, houses the primary olfactory sensory neurons responsible for odor transduction, along with supporting cell populations. Tremendous advances have come from studying the peripheral olfactory system ... Full text Link to item Cite

Persistent post-COVID-19 smell loss is associated with immune cell infiltration and altered gene expression in olfactory epithelium.

Journal Article Sci Transl Med · December 21, 2022 SARS-CoV-2 causes profound changes in the sense of smell, including total smell loss. Although these alterations are often transient, many patients with COVID-19 exhibit olfactory dysfunction that lasts months to years. Although animal and human autopsy st ... Full text Link to item Cite

Retrospective Review of Surgical Site Infections after Endoscopic Endonasal Sellar and Parasellar Surgery: Multicenter Quality Data from the North American Skull Base Society.

Journal Article J Neurol Surg B Skull Base · December 2022 Introduction  Transnasal access to the anterior skull base provides a minimally invasive approach for sellar and parasellar masses compared with its open counterparts. The unique microbiome of the sinonasal mucosa provides distinct challenges not encounter ... Full text Link to item Cite

Rapid tissue prototyping with micro-organospheres.

Journal Article Stem Cell Reports · September 13, 2022 In vitro tissue models hold great promise for modeling diseases and drug responses. Here, we used emulsion microfluidics to form micro-organospheres (MOSs), which are droplet-encapsulated miniature three-dimensional (3D) tissue models that can be establish ... Full text Open Access Link to item Cite

Patient-derived organoid model of olfactory ensheathing cell tumor.

Journal Article Int Forum Allergy Rhinol · September 27, 2024 We developed a culture model of a human olfactory ensheathing cell tumor. Cultured organoids resemble normal ensheathing cells. Assays suggest that this model provides a tool for studying the roles of these glial cells in the maintenance of the peripheral ... Full text Link to item Cite

Impact of Intra-Phenotypic Nasal Vestibular Variation on Local Airflow Dynamics.

Journal Article Laryngoscope · August 21, 2024 OBJECTIVES: Many individuals with healthy normal nasal anatomy and function exhibit a prominent notch indentation at the junction of the ala and sidewall, specifically around the anterior-superior region of the unilateral nasal vestibule up to the internal ... Full text Link to item Cite

The lateral based nasopharyngeal flap: A novel vascularized flap for skull base reconstruction.

Journal Article Head Neck · August 12, 2024 As the indications for endoscopic skull base approaches have increased, so has the need for more versatile vascularized flaps for skull base reconstruction. Here, we describe a novel lateral based nasopharyngeal flap (LNPF). Two cadaver heads were dissecte ... Full text Link to item Cite

Olfactory neuroblastoma mimics molecular heterogeneity and lineage trajectories of small-cell lung cancer.

Journal Article Cancer Cell · June 10, 2024 The olfactory epithelium undergoes neuronal regeneration from basal stem cells and is susceptible to olfactory neuroblastoma (ONB), a rare tumor of unclear origins. Employing alterations in Rb1/Trp53/Myc (RPM), we establish a genetically engineered mouse m ... Full text Link to item Cite

Predictors of Non-Rhinogenic Facial Pain or Pressure in Otolaryngology Clinic.

Journal Article Otolaryngol Head Neck Surg · May 2024 OBJECTIVES: Identify demographic and clinical characteristics that may help differentiate non-rhinogenic facial pain or pressure (NRFP) from sinusitis. STUDY DESIGN: Retrospective single-institution study. SETTING: Tertiary Care Center Rhinology Clinic. ME ... Full text Link to item Cite

Treatment of unilateral olfactory neuroblastoma: Appropriate extent of surgical resection and potential for olfactory preservation.

Journal Article Int Forum Allergy Rhinol · May 2024 Historically, comprehensive surgical resection for olfactory neuroblastoma has included the bilateral olfactory epithelium, cribriform plate, overlying dura, olfactory bulbs and tracts. This results in postoperative anosmia that may significantly impact a ... Full text Link to item Cite

Barosinusitis due to routine weather changes: A cross-sectional analysis of public websites.

Journal Article World J Otorhinolaryngol Head Neck Surg · March 2024 BACKGROUND: Sinusitis is a common diagnosis that can be erroneously associated with routine weather-related barometric pressure changes. In actuality, these pressure changes likely exacerbate migraine headaches, which can cause facial pain and pressure rat ... Full text Link to item Cite

Safety and Feasibility of Steroid-Eluting Stent as a Bolster in Endoscopic Anterior Skull Base Reconstruction.

Journal Article Ann Otol Rhinol Laryngol · January 2024 BACKGROUND: With a rising incidence of cerebrospinal fluid (CSF) leaks, endoscopic endonasal CSF leak repair is increasingly performed. Current approaches utilize a variety of materials including free mucosal grafts and vascularized flaps, but post-op leak ... Full text Link to item Cite

Preoperative Embolization Techniques in the Treatment of Juvenile Nasopharyngeal Angiofibroma: A Systematic Review.

Journal Article Otolaryngol Head Neck Surg · September 2023 OBJECTIVE: Preoperative embolization has proven beneficial in the surgical treatment of juvenile nasopharyngeal angiofibromas (JNA). However, the consensus for the best embolization practices remains unclear. This systematic review seeks to characterize th ... Full text Link to item Cite

Use of Tympanostomy T-Tube for Endoscopic Endonasal Marsupialization of Small Rathke's Cleft Cysts: A Case Series.

Journal Article J Neurol Surg B Skull Base · August 2023 Objectives  This article describes a novel technique implementing the use of a tympanostomy t-tube to provide long-term marsupialization of small Rathke's cleft cysts (RCCs). Design  A retrospective review of electronic medical records was performed to col ... Full text Link to item Cite

Nasopharyngeal Carcinoma: Case Presentation and Literature Review of Treatment Innovation with Immunotherapy.

Journal Article J Neurol Surg Rep · July 2023 Nasopharyngeal carcinoma (NPC), a rare head and neck malignancy, arises from the epithelial lining of nasopharyngeal mucosa. The confluence of various risk factors, such as latent Epstein-Barr virus infection, genetic susceptibility, smoking, alcohol consu ... Full text Link to item Cite

Nasopharyngeal Carcinoma: Case Presentation and Literature Review of Treatment Innovation with Immunotherapy

Journal Article Journal of Neurological Surgery Reports · July 2023 AbstractNasopharyngeal carcinoma (NPC), a rare head and neck malignancy, arises from the epithelial lining of nasopharyngeal mucosa. The confluence of various risk factors, such as latent Epstein–Barr virus infection, genet ... Full text Cite

Deconstructing Olfactory Epithelium Developmental Pathways in Olfactory Neuroblastoma.

Journal Article Cancer Res Commun · June 2023 UNLABELLED: Olfactory neuroblastoma is a rare tumor arising from the olfactory cleft region of the nasal cavity. Because of the low incidence of this tumor, as well as an absence of established cell lines and murine models, understanding the mechanisms dri ... Full text Link to item Cite

Nasal Cavity Squamous Cell Carcinoma: Factors Associated With Treatment Outcomes and Potential Organ Preservation.

Journal Article Am J Rhinol Allergy · January 2023 BACKGROUND: Squamous cell carcinoma of the nasal cavity (NCSCC) is a rare, challenging malignancy. Surgical resection of this tumor can cause significant facial deformity, and indications for adjuvant or organ preservation therapies are not well-described. ... Full text Link to item Cite

Characterizing Olfactory Dysfunction in Patients with Unilateral Cleft Lip Nasal Deformities.

Journal Article Facial Plast Surg Aesthet Med · 2023 Background: Unilateral cleft lip nasal deformity (uCLND) is associated with olfactory dysfunction, but the underlying etiology remains poorly understood. Objective: To investigate the etiology of uCLND-associated olfactory dysfunction using clinical, compu ... Full text Open Access Link to item Cite

Preparation of Human Olfactory Epithelial Biopsies for Downstream Analysis.

Journal Article Methods Mol Biol · 2023 The olfactory mucosa, lining a portion of the nasal cavity, houses the primary olfactory sensory neurons responsible for odor transduction, along with supporting cell populations. Tremendous advances have come from studying the peripheral olfactory system ... Full text Link to item Cite

Persistent post-COVID-19 smell loss is associated with immune cell infiltration and altered gene expression in olfactory epithelium.

Journal Article Sci Transl Med · December 21, 2022 SARS-CoV-2 causes profound changes in the sense of smell, including total smell loss. Although these alterations are often transient, many patients with COVID-19 exhibit olfactory dysfunction that lasts months to years. Although animal and human autopsy st ... Full text Link to item Cite

Retrospective Review of Surgical Site Infections after Endoscopic Endonasal Sellar and Parasellar Surgery: Multicenter Quality Data from the North American Skull Base Society.

Journal Article J Neurol Surg B Skull Base · December 2022 Introduction  Transnasal access to the anterior skull base provides a minimally invasive approach for sellar and parasellar masses compared with its open counterparts. The unique microbiome of the sinonasal mucosa provides distinct challenges not encounter ... Full text Link to item Cite

Rapid tissue prototyping with micro-organospheres.

Journal Article Stem Cell Reports · September 13, 2022 In vitro tissue models hold great promise for modeling diseases and drug responses. Here, we used emulsion microfluidics to form micro-organospheres (MOSs), which are droplet-encapsulated miniature three-dimensional (3D) tissue models that can be establish ... Full text Open Access Link to item Cite

Endoscopic Sinus Surgery in Older Patients With Significant Medical Comorbidities.

Journal Article Am J Rhinol Allergy · September 2022 BACKGROUND: Endoscopic sinus surgery (ESS) offers excellent outcomes for patients with chronic rhinosinusitis (CRS) in the general population. It is unclear whether older patients with significant medical comorbidities experience similar benefits. OBJECTIV ... Full text Link to item Cite

Endoscopic Sinus Surgery for Cystic Fibrosis: Variables Influencing Sinonasal and Pulmonary Outcomes.

Journal Article Am J Rhinol Allergy · May 2022 BACKGROUND: Endoscopic sinus surgery is a well-established treatment for chronic rhinosinusitis in patients with cystic fibrosis, though its benefits seem to be limited to improving sinonasal symptoms rather than affecting lung function. OBJECTIVE: This st ... Full text Link to item Cite

Persistent post-COVID-19 smell loss is associated with inflammatory infiltration and altered olfactory epithelial gene expression.

Journal Article bioRxiv · April 18, 2022 Most human subjects infected by SARS-CoV-2 report an acute alteration in their sense of smell, and more than 25% of COVID patients report lasting olfactory dysfunction. While animal studies and human autopsy tissues have suggested mechanisms underlying acu ... Full text Link to item Cite

Aging-related olfactory loss is associated with olfactory stem cell transcriptional alterations in humans.

Journal Article J Clin Invest · February 15, 2022 BACKGROUNDPresbyosmia, or aging-related olfactory loss, occurs in a majority of humans over age 65 years, yet remains poorly understood, with no specific treatment options. The olfactory epithelium (OE) is the peripheral organ for olfaction and is subject ... Full text Link to item Cite

Sinus headache: changing the treatment paradigm.

Journal Article Curr Opin Otolaryngol Head Neck Surg · February 1, 2022 PURPOSE OF REVIEW: Although the majority of patients with sinus headache do not have rhinosinusitis, many patients will unnecessarily undergo work-up and treatment for rhinosinusitis. This leads to a significant cost burden to the healthcare system. In the ... Full text Link to item Cite

Sinus Irrigation Penetration After Proposed Modified Draf IIa Technique in a Side-to-Side Cadaveric Model.

Journal Article Am J Rhinol Allergy · July 2021 BACKGROUND: Endoscopic sinus surgery (ESS) is an effective intervention for patients with medically refractory chronic rhinosinusitis. Frontal sinusotomy is the most challenging part of ESS, with one of the key outcomes being access for topical irrigations ... Full text Link to item Cite

Healthcare Resource Utilization for Chronic Rhinosinusitis in Older Adults.

Journal Article Healthcare (Basel) · June 25, 2021 OBJECTIVES: Chronic rhinosinusitis (CRS) is a common and costly health problem in the United States. While often associated with younger adults, CRS can affect the elderly. As the aging population increases in the United States, the cost burden of CRS in o ... Full text Open Access Link to item Cite

General Complications after Endoscopic Sinus Surgery in Smokers: A 2005-2016 NSQIP Analysis.

Journal Article Ann Otol Rhinol Laryngol · April 2021 BACKGROUND: Exposure to cigarette smoke has been associated with a higher incidence of postoperative complications across a variety of surgical specialties. However, it is unclear if smoking increases this risk after endoscopic sinus surgery (ESS). Because ... Full text Link to item Cite

Survival Outcomes in Sinonasal Poorly Differentiated Squamous Cell Carcinoma.

Journal Article Laryngoscope · April 2021 OBJECTIVE: Sinonasal squamous cell carcinoma (SCC) is rare with no consensus on treatment regimen. Our goal is to analyze treatment outcomes in poorly differentiated SCC (PDSCC) using a large national database. STUDY DESIGN: Retrospective database study. M ... Full text Link to item Cite

Survival outcomes in sinonasal carcinoma with neuroendocrine differentiation: A NCDB analysis.

Journal Article Am J Otolaryngol · 2021 BACKGROUND: Sinonasal carcinoma with neuroendocrine differentiation (SCND) is a rare group of tumors with poor prognosis. Treatment and sequence of therapies are still unclear. The goal of this study is to analyze treatment outcomes in SCND using a nationa ... Full text Link to item Cite

Analysis of Self- and 360-Evaluation Scores of the Professionalism Intelligence Model Within an Academic Otolaryngology-Head and Neck Surgery Department.

Journal Article J Healthc Leadersh · 2021 PURPOSE: To analyze self and 360-evaluation scores of the professionalism intelligence model domains within an academic Otolaryngology-Head and Neck Surgery Department. METHODS: A leadership course was introduced within the Department of Head and Neck Surg ... Full text Link to item Cite

Olfactory-Specific Quality of Life Outcomes after Endoscopic Endonasal Surgery of the Sella.

Journal Article Allergy Rhinol (Providence) · 2021 OBJECTIVE: To assess olfactory outcomes as measured by an olfactory-specific quality of life (QOL) questionnaire in patients undergoing EESBS for sellar lesions. DESIGN: Retrospective case series. SETTING: Tertiary academic medical center. PARTICIPANTS: In ... Full text Link to item Cite

Sinonasal Squamous Cell Carcinoma Outcomes: Does Treatment at a High-Volume Center Confer Survival Benefit?

Journal Article Otolaryngol Head Neck Surg · November 2020 OBJECTIVE: To determine whether treatment of sinonasal squamous cell carcinoma (SCC) at a high-volume facility affects survival. STUDY DESIGN: Retrospective database analysis. SETTING: National Cancer Database (2004-2014). SUBJECTS AND METHODS: The Nationa ... Full text Link to item Cite

The use of balloon dilation in revision sinus surgery.

Journal Article Int Forum Allergy Rhinol · October 2020 BACKGROUND: Recent studies have demonstrated a dramatic increase in the use of balloon sinus dilation (BSD) in the United States. However, the use of BSD specifically in revision sinus surgery has not been investigated. This study addresses the question of ... Full text Link to item Cite

Non-neuronal expression of SARS-CoV-2 entry genes in the olfactory system suggests mechanisms underlying COVID-19-associated anosmia.

Journal Article Sci Adv · July 31, 2020 Altered olfactory function is a common symptom of COVID-19, but its etiology is unknown. A key question is whether SARS-CoV-2 (CoV-2) - the causal agent in COVID-19 - affects olfaction directly, by infecting olfactory sensory neurons or their targets in th ... Full text Link to item Cite

The MARBLE Study Protocol: Modulating ApoE Signaling to Reduce Brain Inflammation, DeLirium, and PostopErative Cognitive Dysfunction.

Journal Article J Alzheimers Dis · 2020 BACKGROUND: Perioperative neurocognitive disorders (PND) are common complications in older adults associated with increased 1-year mortality and long-term cognitive decline. One risk factor for worsened long-term postoperative cognitive trajectory is the A ... Full text Open Access Link to item Cite

Novel Application of Steroid Eluting Stent in Petrous Apex Cholesterol Granuloma.

Journal Article J Neurol Surg B Skull Base · October 2019 Objective  This study describes the safety and efficacy of mometasone furoate eluting stents in the management of petrous apex cholesterol granuloma approached through an endonasal endoscopic route and assesses the restenosis rate. Methods  Consecutive pat ... Full text Link to item Cite

Symptom Profile of Chronic Rhinosinusitis Versus Obstructive Sleep Apnea in a Tertiary Rhinology Clinic.

Journal Article Ann Otol Rhinol Laryngol · October 2019 OBJECTIVES: Patients with undiagnosed obstructive sleep apnea (OSA) often present to an otolaryngologist with symptoms of chronic rhinosinusitis (CRS). This study analyzes symptom profiles of such patients to help identify those who may benefit from polyso ... Full text Link to item Cite

Factors associated with opioid use after endoscopic sinus surgery.

Journal Article Laryngoscope · August 2019 OBJECTIVES/HYPOTHESIS: Responsible prescribing of postoperative pain medications is necessary in combatting the current opioid epidemic in the United States. The goal of this study was to determine which clinical factors affect opioid usage following funct ... Full text Link to item Cite

Sinonasal Quality of Life Outcomes After Extended Endonasal Approaches to the Skull Base.

Journal Article J Neurol Surg B Skull Base · August 2019 Introduction  Endoscopic endonasal skull base surgery (EESBS) leads to significant alterations in sinonasal anatomy and physiology. However, there is limited data available on quality of life (QOL) outcomes following EESBS. Methods  A retrospective review ... Full text Link to item Cite

Factors Associated with Revision Surgery after Balloon Sinuplasty.

Journal Article Otolaryngol Head Neck Surg · April 2019 OBJECTIVE: Although balloon sinuplasty (BSP) is increasing in popularity, little is known about which patients are the ideal candidates. The objective of this study is to investigate factors that may be associated with BSP failure. STUDY DESIGN: Retrospect ... Full text Link to item Cite

Role of induction chemotherapy in sinonasal malignancies: a systematic review.

Journal Article Int Forum Allergy Rhinol · February 2019 BACKGROUND: Cancers of the paranasal sinuses are rare tumors that tend to be aggressive and usually are diagnosed at an advanced stage. Despite being rare, these tumors include a wide spectrum of histological subtypes with different biological behaviors. C ... Full text Link to item Cite

Balloon Catheter Dilation of the Sinuses: A 2011-2014 MarketScan Analysis.

Journal Article Otolaryngol Head Neck Surg · December 2018 OBJECTIVE: This study uses a large national claims-based database to analyze recent practice patterns related to balloon catheter dilation (BCD) of the sinuses. STUDY DESIGN: Retrospective study. SETTING: Academic. SUBJECTS AND METHODS: Patients with chron ... Full text Link to item Cite

Low-Grade Papillary Schneiderian Carcinoma of the Sinonasal Cavity and Temporal Bone.

Journal Article Ann Otol Rhinol Laryngol · December 2018 OBJECTIVES:: The aim of this study was to further characterize a newly described neoplasm, low-grade papillary Schneiderian carcinoma, occurring simultaneously in the sinonasal cavity and mastoid. Additionally, the authors review the only 2 similar cases w ... Full text Link to item Cite

Management of epistaxis in patients with ventricular assist device: a retrospective review.

Journal Article J Otolaryngol Head Neck Surg · August 2, 2018 BACKGROUND: Patients with a ventricular assist device (VAD) are at risk for epistaxis due to the need for anticoagulation. Additionally, these patients develop acquired von Willebrand syndrome (AvWS) due to these devices. Management is complicated by the r ... Full text Link to item Cite

Middle ear irrigation using a hydrodebrider decreases biofilm surface area in an animal model of otitis media.

Journal Article Laryngoscope Investig Otolaryngol · June 2018 OBJECTIVE: To compare the safety and efficacy of manual and powered irrigation of the middle ear using saline or 1% baby shampoo to treat biofilm-forming bacterial middle ear infections. BACKGROUND: Biofilms play a major role in recalcitrant otitis media a ... Full text Link to item Cite

Salvage skull base reconstruction in the endoscopic era: Vastus lateralis free tissue transfer.

Journal Article Head Neck · April 2018 BACKGROUND: When locoregional flaps fail to reconstruct the skull base, the microvascular surgeon faces several reconstructive challenges. We present our technique and results of salvage anterior skull base reconstruction utilizing the vastus lateralis fre ... Full text Link to item Cite

Correlation between sinus and lung cultures in lung transplant patients with cystic fibrosis.

Journal Article Int Forum Allergy Rhinol · March 2018 BACKGROUND: Lung transplantation has revolutionized the treatment of end-stage pulmonary disease due to cystic fibrosis. However, infection of the transplanted lungs can lead to serious complications, including graft failure and death. Although many of the ... Full text Link to item Cite

Endoscopic Endonasal Approaches to the Orbit.

Journal Article Int Ophthalmol Clin · 2018 Full text Link to item Cite

Skull base reconstruction following resection of skull base chordomas and chondrosarcomas

Chapter · January 1, 2018 Resection of skull base chordomas and chondrosarcomas can create large dural defects that involve multiple cisterns or the third ventricle leading to high-flow cerebrospinal fluid leaks. Reconstruction of the skull base is essential to an uncomplicated pos ... Full text Cite

Radiodensity of the Ostiomeatal Complex in Recurrent Acute Rhinosinusitis.

Journal Article Otolaryngol Head Neck Surg · November 2017 Objective Recurrent acute rhinosinusitis (RARS) can be an elusive diagnosis due to the lack of clinical and radiographic findings in between acute episodes. This study aims to identify objective computed tomography (CT) characteristics in RARS. Study Desig ... Full text Link to item Cite

Rapidly Progressive Maxillary Atelectasis.

Journal Article J Craniofac Surg · July 2017 OBJECTIVE: Report of a patient with rapidly progressive maxillary atelectasis documented by sequential imaging. CLINICAL REPORT: A 51-year-old man, presented with left periorbital and retro-orbital pain associated with left nasal obstruction. An initial co ... Full text Link to item Cite

Robotics in Sinus and Skull Base Surgery.

Journal Article Otolaryngol Clin North Am · June 2017 Featured Publication Transoral robotic surgery (TORS) has been proven to be safe and to yield acceptable oncological and functional outcomes for surgery of the oropharynx, hypopharynx, supraglottis, and glottis. TORS has been successful at reducing morbidity, improving quality ... Full text Link to item Cite

The Role of Robotic Surgery in Sinonasal and Ventral Skull Base Malignancy.

Journal Article Otolaryngol Clin North Am · April 2017 Featured Publication Over the past decade, robotic surgery has gained wide popularity, making a significant impact on multiple surgical specialties. In the head and neck arena, transoral robotic surgery has proven to be safe and associated with acceptable oncological and super ... Full text Link to item Cite

Surgical Management of Pituitary Apoplexy

Chapter · March 7, 2017 Pituitary apoplexy (PA) is an acute event related to abrupt degeneration of a pituitary adenoma. Typically the tumor infarcts and undergoes hemorrhage. The authors believe that PA occurs due to venous infarction of an adenoma and as such, there is a variab ... Full text Cite

Role of 18 F-FDG PET/CT differentiating olfactory neuroblastoma from sinonasal undifferentiated carcinoma.

Journal Article Laryngoscope · February 2017 Featured Publication OBJECTIVES: The purpose of this study is to demonstrate the potential contribution of positron emission tomography (PET)/computed tomography (CT) to help differentiate olfactory neuroblastoma (ONB) from sinonasal undifferentiated carcinoma (SNUC). METHODS: ... Full text Link to item Cite

Endoscopic trans-sphenoidal surgery for petroclival and clival meningiomas.

Journal Article J Neurosurg Sci · December 2016 Featured Publication Petroclival meningiomas are challenging lesions to manage independently of the selected surgical approach and are unique tumors in the type of pathological displacement of the surrounding anatomy. They also represent one of the most controversial entities ... Link to item Cite

ndoscopic trans-sphenoidal surgery for petroclival and clival meningiomas

Journal Article JOURNAL OF NEUROSURGICAL SCIENCES · December 1, 2016 Link to item Cite

Letter: Radiation-Induced Malignant Transformation of Craniopharyngiomas.

Journal Article Neurosurgery · August 2016 Featured Publication Full text Link to item Cite

Reconstructive techniques in skull base surgery after resection of malignant lesions: a wide array of choices.

Journal Article Curr Opin Otolaryngol Head Neck Surg · April 2016 Featured Publication PURPOSE OF REVIEW: In this manuscript, we will provide a panorama of the current status of skull base reconstruction following endoscopic endonasal or open resection of malignant lesions, focusing on novel options and recent modifications of previously des ... Full text Link to item Cite

Comparison of packing material in an animal model of middle ear trauma.

Journal Article Am J Otolaryngol · 2016 PURPOSE: To compare the performance of absorbable gelatin sponge (AGS) with polyurethane foam (PUF) as middle ear packing material after mucosal trauma. MATERIALS AND METHODS: Using a randomized, controlled and blinded study design fifteen guinea pigs unde ... Full text Link to item Cite

Base of Tongue Mass. Mucoepidermoid carcinoma.

Journal Article JAMA Otolaryngol Head Neck Surg · October 2015 Full text Link to item Cite

Pediatric and adult sinonasal disorders

Book · April 1, 2015 Featured Publication The past two decades have witnessed enormous advances in the field of rhinology and sinonasal diseases. Chronic Sinusitis is one of the most common chronic illnesses. The introduction of functional endoscopic sinus surgery in the late eighties has revoluti ... Cite

Preface

Book · April 1, 2015 Cite

Congenital nasal and paranasal masses

Chapter · April 1, 2015 Featured Publication Congenital nasal and paranasal masses are rare occurring in 1 in 20000 to 1 in 40000 live births. Commonly encountered masses are nasal dermoids, encephalocele and gliomas, the most common being nasal dermoids. They are due to developmental errors in embry ... Cite

Choanal atresia: Anatomy, etiology, pathophysiology and management

Chapter · April 1, 2015 Featured Publication Choanal atresia is a common cause of congenital nasal obstruction. It is more frequently unilateral in presentation, and always has a variable degree of bony component. Bilateral choanal atresia is a relative emergency due to nasal airway obstruction in ne ... Cite

Juvenile nasopharyngeal angiofibroma: Anatomy, pathophysiology and management

Chapter · April 1, 2015 Juvenile Nasopharyngeal Angiofibromas (JNA) are rare tumors found exclusively in adolescent boys. There are multiple approaches available for resection of these tumors, and the approach used depends largely on tumor extension. Endoscopic resection is the f ... Cite

Association of parathyroid pathology with well-differentiated thyroid carcinoma.

Journal Article Presse Med · June 2012 OBJECTIVE: The objective was to evaluate the association of well-differentiated thyroid carcinoma and parathyroid pathology. METHODS: The medical records of 14 patients with concomitant pathologies were retrospectively reviewed. RESULTS: Parathyroidectomie ... Full text Link to item Cite

L-N-Acetylcysteine treatment is associated with improved hearing outcome in sudden idiopathic sensorineural hearing loss.

Journal Article Acta Otolaryngol · April 2012 CONCLUSION: Combination therapy corticosteroids plus an oral antioxidant L-N-acetylcysteine (LNAC) was associated with improved hearing over corticosteroids alone, particularly at the 6-month follow-up and at high frequencies (i.e. 4000 Hz). This is the fi ... Full text Link to item Cite

Middle ear packing: comparison of materials in an animal model of mucosal trauma.

Journal Article Otolaryngol Head Neck Surg · May 2011 OBJECTIVE: To compare absorbable gelatin sponge (AGS) with an injectable esterified hyaluronic acid (EHA) as middle ear packing material after mucosal trauma. STUDY DESIGN: Randomized, blinded, and controlled study. SETTING: Tertiary university-based hospi ... Full text Link to item Cite

Conservation of hearing and protection of auditory hair cells against trauma-induced losses by local dexamethasone therapy: molecular and genetic mechanisms.

Journal Article Cochlear Implants Int · June 2010 HYPOTHESIS: Dexamethasone (DXM) protects hearing against trauma-induced loss. MATERIALS: in vivo: A guinea pig model of electrode induced trauma (EIT)-induced hearing loss was used to locally deliver dexamethasone. In vitro: TNF-α-challenged organ of Corti ... Full text Link to item Cite

The injured cochlea as a target for inflammatory processes, initiation of cell death pathways and application of related otoprotectives strategies.

Journal Article Recent Pat CNS Drug Discov · June 2010 One of the causes of sensorineural hearing loss is the loss of auditory hair cells following exposure to environmental stresses. Auditory hair cell death in response to cochlear trauma occurs via both necrosis and apoptosis. Apoptosis of hair cells involve ... Full text Link to item Cite

Single-stage total endoscopic resection of a plexiform neurofibroma of the maxillary sinus in a child with type 1 neurofibromatosis.

Journal Article Int J Pediatr Otorhinolaryngol · April 2010 Plexiform neurofibromas are peripheral nerve sheath tumors associated with neurofibromatosis type 1. The maxillary sinus is an extremely rare location of the plexiform neurofibroma and only two adult cases have been previously reported. We report the first ... Full text Link to item Cite