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Wonjae Lee

Assistant Professor of Neurosurgery
3 Genome Ct. MSRB3 Rm-5138, Box 3807, Durham, NC 27710
3 Genome Ct. MSRB3 Rm-5138, Box 3807, Durham, NC 27710

Selected Publications

Cell-adhesive double network self-healing hydrogel capable of cell and drug encapsulation: New platform to construct biomimetic environment with bottom-up approach.

Journal Article Carbohydr Polym · August 15, 2024 This study presents the development and characterization of a novel double-network self-healing hydrogel based on N-carboxyethyl chitosan (CEC) and oxidized dextran (OD) with the incorporation of crosslinked collagen (CEC-OD/COL-GP) to enhance its biologic ... Full text Link to item Cite

Engineering Three-Dimensional Vascularized Cardiac Tissues.

Journal Article Tissue Eng Part B Rev · April 2022 Heart disease is one of the largest burdens to human health worldwide and has very limited therapeutic options. Engineered three-dimensional (3D) vascularized cardiac tissues have shown promise in rescuing cardiac function in diseased hearts and may serve ... Full text Link to item Cite

A neurovascular-unit-on-a-chip for the evaluation of the restorative potential of stem cell therapies for ischaemic stroke.

Journal Article Nat Biomed Eng · August 2021 The therapeutic efficacy of stem cells transplanted into an ischaemic brain depends primarily on the responses of the neurovascular unit. Here, we report the development and applicability of a functional neurovascular unit on a microfluidic chip as a micro ... Full text Open Access Link to item Cite

A versatile system to record cell-cell interactions.

Journal Article Elife · October 7, 2020 Cell-cell interactions influence all aspects of development, homeostasis, and disease. In cancer, interactions between cancer cells and stromal cells play a major role in nearly every step of carcinogenesis. Thus, the ability to record cell-cell interactio ... Full text Link to item Cite

3D patterned stem cell differentiation using thermo-responsive methylcellulose hydrogel molds.

Journal Article Sci Rep · July 6, 2016 Tissue-specific patterned stem cell differentiation serves as the basis for the development, remodeling, and regeneration of the multicellular structure of the native tissues. We herein proposed a cytocompatible 3D casting process to recapitulate this patt ... Full text Link to item Cite

Directed axonal outgrowth using a propagating gradient of IGF-1.

Journal Article Adv Mater · August 6, 2014 The temporospatial regulation of axon outgrowth is useful for guiding de novo connectivity or re-connectivity of neurons in neurological injury or disease. Here we report the successful construction of a biocompatible guidance device, in which a linear pro ... Full text Link to item Cite

The design of a heterocellular 3D architecture and its application to monitoring the behavior of cancer cells in response to the spatial distribution of endothelial cells.

Journal Article Adv Mater · October 9, 2012 The spatial cell distribution is one of the critical features for governing cellular interactions and their consequent behaviors. Here we suggest a novel method of building a hierarchical cellular structure by stacking cell-attached microplate structures w ... Full text Link to item Cite

Hydrophobic nanoparticles improve permeability of cell-encapsulating poly(ethylene glycol) hydrogels while maintaining patternability.

Journal Article Proc Natl Acad Sci U S A · November 30, 2010 Cell encapsulating poly(ethylene glycol) hydrogels represent a promising approach for constructing 3D cultures designed to more closely approximate in vivo tissue environment. Improved strategies are needed, however, to optimally balance hydrogel permeabil ... Full text Link to item Cite

The reliable targeting of specific drug release profiles by integrating arrays of different albumin-encapsulated microsphere types.

Journal Article Biomaterials · December 2009 Biodegradable polymer microspheres have been successfully utilized as a medium for controlled protein or peptide-based drug release. Because the release kinetics has been typically controlled by modulating physical or chemical properties of the medium, the ... Full text Link to item Cite

Viral infection of human progenitor and liver-derived cells encapsulated in three-dimensional PEG-based hydrogel.

Journal Article Biomed Mater · February 2009 We have studied the encapsulation of human progenitor cells into 3D PEG hydrogels. Replication-incompetent lentivirus promoter reporter vectors were found to efficiently detect the in vivo expression of human hepatic genes in hydrogel-encapsulated liver pr ... Full text Link to item Cite