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Adela Rambi Guanco Cardones

Adjunct Associate Professor in the Department of Dermatology
Dermatology

Selected Publications


S2k guidelines on diagnosis and treatment of linear IgA dermatosis initiated by the European Academy of Dermatology and Venereology.

Journal Article J Eur Acad Dermatol Venereol · June 2024 INTRODUCTION: Linear IgA dermatosis (LAD) is a rare subepidermal autoimmune bullous disease (AIBD) defined by predominant or exclusive immune deposits of immunoglobulin A at the basement membrane zone of skin or mucous membranes. This disorder is a rare, c ... Full text Link to item Cite

Management of Adult Patients With Drug Reaction With Eosinophilia and Systemic Symptoms: A Delphi-Based International Consensus.

Journal Article JAMA Dermatol · January 1, 2024 IMPORTANCE: Drug reaction with eosinophilia and systemic symptoms (DRESS) is a rare but potentially fatal drug hypersensitivity reaction. To our knowledge, there is no international consensus on its severity assessment and treatment. OBJECTIVE: To reach an ... Full text Link to item Cite

Detection of novel therapies using a multi-national, multi-institutional registry of cutaneous immune-related adverse events and management.

Journal Article International journal of dermatology · August 2023 BackgroundCutaneous immune-related adverse events (cirAEs) remain a prevalent and common sequelae of immune checkpoint inhibitor (ICI) therapy, often necessitating treatment interruption and prolonged immune suppression. Treatment algorithms are s ... Full text Cite

Development of a Skin-Directed Scoring System for Stevens-Johnson Syndrome and Epidermal Necrolysis: A Delphi Consensus Exercise.

Journal Article JAMA Dermatol · July 1, 2023 IMPORTANCE: Scoring systems for Stevens-Johnson syndrome and epidermal necrolysis (EN) only estimate patient prognosis and are weighted toward comorbidities and systemic features; morphologic terminology for EN lesions is inconsistent. OBJECTIVES: To estab ... Full text Link to item Cite

Single-cell landscape analysis unravels molecular programming of the human B cell compartment in chronic GVHD.

Journal Article JCI Insight · June 8, 2023 Alloreactivity can drive autoimmune syndromes. After allogeneic hematopoietic stem cell transplantation (allo-HCT), chronic graft-versus-host disease (cGVHD), a B cell-associated autoimmune-like syndrome, commonly occurs. Because donor-derived B cells cont ... Full text Link to item Cite

Cutaneous Vasculopathy and Recalcitrant Lower-Extremity Ulcerations

Journal Article Annals of Internal Medicine Clinical Cases · April 1, 2023 Lower-extremity ulcerations are a frequent cause of hospitalization, and those that persist despite appropriate treatment warrant careful scrutiny. We present a case of chronic, progressive leg ulcerations in a young woman accompanied by oral and genital u ... Full text Cite

A Phase I Trial of SYK Inhibition with Fostamatinib in the Prevention and Treatment of Chronic Graft-Versus-Host Disease.

Journal Article Transplant Cell Ther · March 2023 Despite the exciting advancement of novel therapies, chronic graft-versus-host disease (cGVHD) remains the most common cause of non-relapse mortality after allogeneic hematopoietic stem cell transplantation (HCT). Frontline treatment of cGVHD involves syst ... Full text Link to item Cite

Recrudescence of Severe Carbamazepine- Induced DRESS Syndrome after Initiation of Levetiracetam.

Journal Article Skinmed · 2023 Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a potentially fatal cutaneous hypersensitivity reaction commonly precipitated by antiepileptic drugs (AEDs). Cross-reactivity among aromatic AEDs is well-documented, but between arom ... Link to item Cite

Clinical and direct immunofluorescence characteristics of cutaneous toxicity associated with enfortumab vedotin.

Journal Article Br J Dermatol · July 2022 Enfortumab vedotin (EV), a novel antibody-drug conjugate approved for metastatic urothelial carcinoma, causes a variety of cutaneous adverse reactions. We present two cases of bullous eruptions following treatment with EV, both demonstrating IgG deposition ... Full text Link to item Cite

Ruxolitinib for the treatment of steroid refractory pediatric chronic graft-versus-host disease.

Journal Article Pediatr Dermatol · May 2022 Chronic graft-versus-host disease (cGVHD) of the skin is a serious cause of long-term morbidity and mortality among patients who receive hematopoietic stem cell transplants. Systemic corticosteroids remain first-line treatment for cutaneous cGVHD; however, ... Full text Link to item Cite

Severe Retiform Purpura Associated With COVID-19 Infection

Journal Article Annals of Internal Medicine Clinical Cases · April 1, 2022 A healthy, unvaccinated 44-year-old woman developed a severe, diffusely spread, and intensely painful purpuric rash following mild COVID-19 infection. A punch skin biopsy revealed small vessel inflammation and intravascular thrombi consistent with thrombot ... Full text Cite

Semi-automated weak annotation for deep neural network skin thickness measurement.

Journal Article Ultrason Imaging · July 2021 Correctly calculating skin stiffness with ultrasound shear wave elastography techniques requires an accurate measurement of skin thickness. We developed and compared two algorithms, a thresholding method and a deep learning method, to measure skin thicknes ... Full text Link to item Cite

S2k guidelines on diagnosis and treatment of linear IgA dermatosis initiated by the European Academy of Dermatology and Venereology.

Journal Article J Eur Acad Dermatol Venereol · June 2024 INTRODUCTION: Linear IgA dermatosis (LAD) is a rare subepidermal autoimmune bullous disease (AIBD) defined by predominant or exclusive immune deposits of immunoglobulin A at the basement membrane zone of skin or mucous membranes. This disorder is a rare, c ... Full text Link to item Cite

Management of Adult Patients With Drug Reaction With Eosinophilia and Systemic Symptoms: A Delphi-Based International Consensus.

Journal Article JAMA Dermatol · January 1, 2024 IMPORTANCE: Drug reaction with eosinophilia and systemic symptoms (DRESS) is a rare but potentially fatal drug hypersensitivity reaction. To our knowledge, there is no international consensus on its severity assessment and treatment. OBJECTIVE: To reach an ... Full text Link to item Cite

Detection of novel therapies using a multi-national, multi-institutional registry of cutaneous immune-related adverse events and management.

Journal Article International journal of dermatology · August 2023 BackgroundCutaneous immune-related adverse events (cirAEs) remain a prevalent and common sequelae of immune checkpoint inhibitor (ICI) therapy, often necessitating treatment interruption and prolonged immune suppression. Treatment algorithms are s ... Full text Cite

Development of a Skin-Directed Scoring System for Stevens-Johnson Syndrome and Epidermal Necrolysis: A Delphi Consensus Exercise.

Journal Article JAMA Dermatol · July 1, 2023 IMPORTANCE: Scoring systems for Stevens-Johnson syndrome and epidermal necrolysis (EN) only estimate patient prognosis and are weighted toward comorbidities and systemic features; morphologic terminology for EN lesions is inconsistent. OBJECTIVES: To estab ... Full text Link to item Cite

Single-cell landscape analysis unravels molecular programming of the human B cell compartment in chronic GVHD.

Journal Article JCI Insight · June 8, 2023 Alloreactivity can drive autoimmune syndromes. After allogeneic hematopoietic stem cell transplantation (allo-HCT), chronic graft-versus-host disease (cGVHD), a B cell-associated autoimmune-like syndrome, commonly occurs. Because donor-derived B cells cont ... Full text Link to item Cite

Cutaneous Vasculopathy and Recalcitrant Lower-Extremity Ulcerations

Journal Article Annals of Internal Medicine Clinical Cases · April 1, 2023 Lower-extremity ulcerations are a frequent cause of hospitalization, and those that persist despite appropriate treatment warrant careful scrutiny. We present a case of chronic, progressive leg ulcerations in a young woman accompanied by oral and genital u ... Full text Cite

A Phase I Trial of SYK Inhibition with Fostamatinib in the Prevention and Treatment of Chronic Graft-Versus-Host Disease.

Journal Article Transplant Cell Ther · March 2023 Despite the exciting advancement of novel therapies, chronic graft-versus-host disease (cGVHD) remains the most common cause of non-relapse mortality after allogeneic hematopoietic stem cell transplantation (HCT). Frontline treatment of cGVHD involves syst ... Full text Link to item Cite

Recrudescence of Severe Carbamazepine- Induced DRESS Syndrome after Initiation of Levetiracetam.

Journal Article Skinmed · 2023 Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a potentially fatal cutaneous hypersensitivity reaction commonly precipitated by antiepileptic drugs (AEDs). Cross-reactivity among aromatic AEDs is well-documented, but between arom ... Link to item Cite

Clinical and direct immunofluorescence characteristics of cutaneous toxicity associated with enfortumab vedotin.

Journal Article Br J Dermatol · July 2022 Enfortumab vedotin (EV), a novel antibody-drug conjugate approved for metastatic urothelial carcinoma, causes a variety of cutaneous adverse reactions. We present two cases of bullous eruptions following treatment with EV, both demonstrating IgG deposition ... Full text Link to item Cite

Ruxolitinib for the treatment of steroid refractory pediatric chronic graft-versus-host disease.

Journal Article Pediatr Dermatol · May 2022 Chronic graft-versus-host disease (cGVHD) of the skin is a serious cause of long-term morbidity and mortality among patients who receive hematopoietic stem cell transplants. Systemic corticosteroids remain first-line treatment for cutaneous cGVHD; however, ... Full text Link to item Cite

Severe Retiform Purpura Associated With COVID-19 Infection

Journal Article Annals of Internal Medicine Clinical Cases · April 1, 2022 A healthy, unvaccinated 44-year-old woman developed a severe, diffusely spread, and intensely painful purpuric rash following mild COVID-19 infection. A punch skin biopsy revealed small vessel inflammation and intravascular thrombi consistent with thrombot ... Full text Cite

Semi-automated weak annotation for deep neural network skin thickness measurement.

Journal Article Ultrason Imaging · July 2021 Correctly calculating skin stiffness with ultrasound shear wave elastography techniques requires an accurate measurement of skin thickness. We developed and compared two algorithms, a thresholding method and a deep learning method, to measure skin thicknes ... Full text Link to item Cite

Management of Infectious Emergencies for the Inpatient Dermatologist.

Journal Article Curr Dermatol Rep · 2021 PURPOSE OF REVIEW: There are various dermatologic emergencies stemming from bacterial, viral, and fungal etiologies that can present in the inpatient setting. This review summarizes the pathogenesis and diagnosis of infections with cutaneous involvement an ... Full text Link to item Cite

Th17 cell inhibition in a costimulation blockade-based regimen for vascularized composite allotransplantation using a nonhuman primate model.

Journal Article Transpl Int · October 2020 Vascularized composite allotransplantation (VCA) is challenged by the morbidity of immunosuppression required to prevent rejection. The use of highly specific biologics has not been well explored in VCA. Given that psoriasis is T-cell mediated, as is rejec ... Full text Link to item Cite

Data from: Quantifying skin stiffness in graft-versus-host disease, morphea and systemic sclerosis using acoustic radiation force impulse imaging and shear wave elastography

Dataset · July 2, 2020 There is a need for objective, sensitive and reproducible methods of assessing skin sclerosis. We performed a cross sectional, non-interventional study to evaluate the utility of accoustic radiation force impulse (ARFI) and shear wave elasticity imaging (S ... Full text Cite

Society of Dermatology Hospitalists supportive care guidelines for the management of Stevens-Johnson syndrome/toxic epidermal necrolysis in adults.

Journal Article J Am Acad Dermatol · June 2020 Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are life-threatening conditions with high morbidity and mortality. Supportive care management of SJS/TEN is highly variable. A systematic review of the literature was performed by dermatol ... Full text Link to item Cite

Evaluation of the Effectiveness and Tolerability of Mycophenolate Mofetil and Mycophenolic Acid for the Treatment of Morphea.

Journal Article JAMA Dermatol · May 1, 2020 IMPORTANCE: First-line systemic therapy for morphea includes methotrexate with or without systemic corticosteroids. When this regimen is ineffective, not tolerated, or contraindicated, a trial of mycophenolate mofetil (MMF) or mycophenolic acid (MPA)-refer ... Full text Link to item Cite

Diagnosis and management of pemphigus: Recommendations of an international panel of experts.

Journal Article J Am Acad Dermatol · March 2020 BACKGROUND: Several European countries recently developed international diagnostic and management guidelines for pemphigus, which have been instrumental in the standardization of pemphigus management. OBJECTIVE: We now present results from a subsequent Del ... Full text Link to item Cite

Developing classification criteria for skin-predominant dermatomyositis: the Delphi process.

Journal Article Br J Dermatol · February 2020 BACKGROUND: The European League Against Rheumatism/American College of Rheumatology classification criteria for inflammatory myopathies are able to classify patients with skin-predominant dermatomyositis (DM). However, approximately 25% of patients with sk ... Full text Link to item Cite

Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome.

Journal Article Clin Dermatol · 2020 Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a severe cutaneous drug reaction characterized by fever, lymphadenopathy, hematologic abnormalities, multisystem involvement, and viral reactivation. Although most patients with DRES ... Full text Link to item Cite

Management of Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis: a Review and Update

Journal Article Current Dermatology Reports · December 1, 2019 Purpose of Review: This review highlights current concepts in the management of Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN). Recent Findings: A new scoring system, the ABCD-10, was recently developed to better estimate mortality among SJS ... Full text Cite

Inpatient Management of Autoimmune Blistering Diseases: an Update, Review, and Practical Guide

Journal Article Current Dermatology Reports · December 1, 2019 Purpose of Review: Review the evaluation, management, and treatment of hospitalized autoimmune blistering diseases (AIBD) patients based on the current literature and expert opinion. Recent Findings: The cost and prevalence of hospitalization for AIBD pati ... Full text Cite

Updates on Merkel Cell Carcinoma.

Journal Article Dermatol Clin · October 2019 Merkel cell carcinoma (MCC) is a rare but aggressive skin cancer associated with the Merkel cell Polyomavirus. Its incidence and mortality are increasing. There have been many advances in the last several decades in the etiology, detection, and management ... Full text Link to item Cite

Comparison of Deep Learning and Classical Image Processing for Skin Segmentation

Conference IEEE International Ultrasonics Symposium, IUS · October 1, 2019 Skin stiffness correlates with the progression of sclerotic skin diseases. Ultrasound shear wave elasticity imaging techniques can measure skin stiffness, but an accurate skin thickness measurement is required to compute the elastic modulus. We explored di ... Full text Cite

Analysis of Factors Affecting Shear Wave Speed in in vivo Skin

Conference IEEE International Ultrasonics Symposium, IUS · October 1, 2019 In 10 patients with cutaneous sclerotic skin conditions, shear wave elasticity imaging (SWEI) was used to measure shear wave speed in the skin in vivo. The dermis was segmented using an thresholding-based algorithm and group speeds were found in both the d ... Full text Cite

Subacute cutaneous lupus erythematosus and dermatomyositis associated with anti-programmed cell death 1 therapy.

Journal Article Br J Dermatol · September 2019 Programmed cell death 1 (PD-1) blockade has rapidly emerged as an effective therapy for a wide variety of metastatic malignancies. It has been associated with multiple immune-related adverse effects, including cutaneous eruptions. We describe two patients ... Full text Link to item Cite

Interrater Reliability of Clinical Grading Measures for Cutaneous Chronic Graft-vs-Host Disease.

Journal Article JAMA Dermatol · July 1, 2019 IMPORTANCE: Cutaneous chronic graft-vs-host disease (cGVHD) is common after allogeneic hematopoietic stem cell transplant and is often associated with poor patient outcomes. A reliable and practical method for assessing disease severity and response to the ... Full text Link to item Cite

The impact of transplant rejection on cutaneous squamous cell carcinoma in renal transplant recipients.

Journal Article Clin Exp Dermatol · April 2019 BACKGROUND: The incidence of cutaneous squamous cell carcinoma (cSCC) is markedly increased in renal transplant recipients compared with that of the nontransplant population. AIM: To investigate whether there is a relationship between transplant rejection ... Full text Link to item Cite

Development and Validation of a Risk Prediction Model for In-Hospital Mortality Among Patients With Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis-ABCD-10.

Journal Article JAMA Dermatol · April 1, 2019 IMPORTANCE: Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) is a spectrum of severe mucocutaneous drug reaction associated with significant morbidity and mortality. A previously developed SJS/TEN-specific severity-of-illness model (Score of T ... Full text Link to item Cite

How I treat refractory chronic graft-versus-host disease.

Journal Article Blood · March 14, 2019 Approximately 35% to 50% of patients otherwise cured of hematologic malignancies after allogeneic hematopoietic stem cell transplantation will develop the pleomorphic autoimmune-like syndrome known as chronic graft-versus-host disease (cGVHD). Since in 200 ... Full text Link to item Cite

Bullous Diseases of the Skin and Mucous Membranes

Chapter · January 1, 2019 Autoimmune blistering diseases are characterized by epidermal or subepidermal blistering of the skin and mucosal surfaces. Both genetic and environmental factors play a role in their development. Pathogenic autoantibodies against epidermal and basement mem ... Full text Cite

Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis: A Multicenter Retrospective Study of 377 Adult Patients from the United States.

Journal Article J Invest Dermatol · November 2018 Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) is a rare, severe mucocutaneous reaction with few large cohorts reported. This multicenter retrospective study included patients with SJS/TEN seen by inpatient consultative dermatologists at 18 ... Full text Link to item Cite

DRESS syndrome: clinical myths and pearls.

Journal Article Cutis · November 2018 Drug rash with eosinophilia and systemic symptoms (DRESS syndrome), also known as drug-induced hypersensitivity syndrome, is an uncommon severe systemic hypersensitivity drug reaction. It typically develops 2 to 6 weeks after exposure to a culprit medicati ... Link to item Cite

SYK inhibitor entospletinib prevents ocular and skin GVHD in mice.

Journal Article JCI Insight · October 4, 2018 Graft-versus-host disease (GVHD) is a major complication of hematopoietic stem cell transplantation (HCT). The tyrosine kinase SYK contributes to both acute and chronic GVHD development, making it an attractive target for GVHD prevention. Entospletinib (EN ... Full text Link to item Cite

Nodular amyloidosis in a patient with systemic scleroderma.

Journal Article Dermatol Online J · September 15, 2018 Primary cutaneous amyloidosis may be characterized as macular amyloidosis, lichenoid amyloidosis, or nodular amyloidosis. Nodular amyloidosis results from the deposition of immunoglobulin light chains and may rarely be associated with systemic amyloidosis. ... Open Access Link to item Cite

De novo belatacept in clinical vascularized composite allotransplantation.

Journal Article Am J Transplant · July 2018 Most immunosuppressive regimens used in clinical vascularized composite allotransplantation (VCA) have been calcineurin inhibitor (CNI)-based. As such, most recipients have experienced CNI-related side effects. Costimulation blockade, specifically CD28/B7 ... Full text Link to item Cite

Data from: Comparison of rituximab and conventional adjuvant therapy for pemphigus vulgaris: A retrospective analysis

Dataset · June 5, 2018 Background: Rituximab is a promising steroid sparing agent used in the treatment of moderate to severe pemphigus vulgaris. Its exact place in the algorithm of pemphigus treatment, vis-a-vis other, conventional adjuvant therapy (CAT) is not known. Objectiv ... Full text Cite

Timing and Number of Cutaneous Squamous Cell Carcinomas in Transplant Recipients.

Journal Article JAMA Dermatol · June 1, 2018 This cohort study of 3652 recipients of solid organ transplants examines the timing and number of cutaneous squamous cell carcinomas that developed after transplantation. ... Full text Link to item Cite

Examining the Incidence and Presentation of Melanoma in the Cardiothoracic Transplant Population.

Journal Article JAMA Dermatol · May 1, 2018 IMPORTANCE: The immunosuppression vital to maintaining transplanted organs comes with an increased incidence of cutaneous neoplasms. Understanding the genesis of malignant melanoma (MM) in transplant subpopulations is necessary for adequate disease surveil ... Full text Link to item Cite

Comparison of rituximab and conventional adjuvant therapy for pemphigus vulgaris: A retrospective analysis.

Journal Article PLoS One · 2018 BACKGROUND: Rituximab is a promising steroid sparing agent used in the treatment of moderate to severe pemphigus vulgaris. Its exact place in the algorithm of pemphigus treatment, vis-√†-vis other, conventional adjuvant therapy (CAT) is not known. OBJECTIVE ... Full text Link to item Cite

Concepts and controversies in the treatment of cutaneous lichen planus.

Journal Article G Ital Dermatol Venereol · December 2017 Cutaneous lichen planus (CLP) is a chronic autoimmune disease classically associated with severely pruritic, polygonal, violaceous, flat-topped papules and plaques. Subtypes such as hypertrophic and bullous lichen planus and lichen planus pigmentosus have ... Full text Link to item Cite

Fever, Joint Pain, Seizures, and Rash in a 53-Year-Old Woman.

Journal Article Arthritis Care Res (Hoboken) · September 2017 Full text Link to item Cite

Amicrobial Pustulosis of the Folds and Autoimmunity.

Journal Article J Low Genit Tract Dis · October 2016 Full text Link to item Cite

Vascularized composite allotransplantation: a closer look at the banff working classification.

Journal Article Transpl Int · June 2016 The first Banff vascularized composite allotransplantation meeting was held in 2007 to standardize criteria for the characterization and reporting of severity and types of rejection. As a result, the 2007 Banff VCA working classification for skin allograft ... Full text Link to item Cite

Characterizing sclerotic skin stiffness with Acoustic Radiation Force Impulse (ARFI) and Shear Wave Elasticity Imaging (SWEI)

Conference 2015 IEEE International Ultrasonics Symposium, IUS 2015 · November 13, 2015 Sclerotic skin diseases are associated with inflammation and fibrosis in the dermis, and these changes in collagen content with disease progression make this pathology amenable to being characterized with Acoustic Radiation Force Impulse (ARFI) and Shear W ... Full text Cite

Preliminary Results on the Feasibility of Using ARFI/SWEI to Assess Cutaneous Sclerotic Diseases.

Journal Article Ultrasound Med Biol · November 2015 In this study, acoustic radiation force impulse (ARFI) and shear wave elasticity imaging (SWEI) were applied to the skin to investigate the feasibility of their use in assessing sclerotic skin diseases. Our motivation was to develop a non-invasive imaging ... Full text Link to item Cite

Long-term Efficacy of Topical Fluorouracil Cream, 5%, for Treating Actinic Keratosis: A Randomized Clinical Trial.

Conference JAMA Dermatol · September 2015 IMPORTANCE: Topical fluorouracil was demonstrated to be effective in reducing the number of actinic keratoses (AKs) for up to 6 months, but no randomized trials studied its long-term efficacy. OBJECTIVE: To evaluate the long-term efficacy of a single cours ... Full text Link to item Cite

Treatment of Dermatitis Herpetiformis

Chapter · January 1, 2015 Dapsone, a sulfone, was synthesized in the early twentieth century and has held longtime FDA approval to treat dermatitis herpetiformis and leprosy. However, unlabeled uses of dapsone have become prevalent among dermatologist, especially in autoimmune bull ... Full text Cite

Updates on the management of autoimmune blistering diseases.

Journal Article Skin Therapy Lett · 2014 Autoimmune blistering diseases are rare, but potentially debilitating cutaneous disorders characterized by varying degrees of mucosal and cutaneous bullae formation. Topical therapy is appropriate for mild and even some moderate disease activity, but syste ... Link to item Cite

Cutaneous squamous cell carcinoma and human papillomavirus: is there an association?

Journal Article Dermatol Surg · January 2013 BACKGROUND: The role of human papillomavirus (HPV) in the induction and maintenance of cervical, anogenital, and some oropharyngeal carcinomas is well recognized, but its role in cutaneous squamous cell carcinoma (SCC) remains to be elucidated. HPV is thou ... Full text Link to item Cite

WHIM syndrome caused by a single amino acid substitution in the carboxy-tail of chemokine receptor CXCR4.

Journal Article Blood · July 5, 2012 WHIM syndrome is a rare, autosomal dominant, immunodeficiency disorder so-named because it is characterized by warts, hypogammaglobulinemia, infections, and myelokathexis (defective neutrophil egress from the BM). Gain-of-function mutations that truncate t ... Full text Link to item Cite

Management of dermatitis herpetiformis.

Journal Article Immunol Allergy Clin North Am · May 2012 The major treatment strategies for DH are gluten restriction or medical treatment with sulfones. Control of the cutaneous manifestations, but not the gastrointestinal changes, is rapid with dapsone. In addition to control of the cutaneous signs and symptom ... Full text Link to item Cite

Pathophysiology of dermatitis herpetiformis: a model for cutaneous manifestations of gastrointestinal inflammation.

Journal Article Immunol Allergy Clin North Am · May 2012 Dermatitis herpetiformis (DH) is an autoimmune blistering skin disease in which antigen presentation in the gastrointestinal mucosa results in cutaneous IgA deposition and distinct, neutrophil-driven cutaneous lesions. Our findings suggest that the qualita ... Full text Link to item Cite

Management of dermatitis herpetiformis.

Journal Article Dermatol Clin · October 2011 The major treatment strategies for DH are gluten restriction or medical treatment with sulfones. Control of the cutaneous manifestations, but not the gastrointestinal changes, is rapid with dapsone. In addition to control of the cutaneous signs and symptom ... Full text Link to item Cite

Pathophysiology of dermatitis herpetiformis: a model for cutaneous manifestations of gastrointestinal inflammation.

Journal Article Dermatol Clin · July 2011 Dermatitis herpetiformis (DH) is an autoimmune blistering skin disease in which antigen presentation in the gastrointestinal mucosa results in cutaneous IgA deposition and distinct, neutrophil-driven cutaneous lesions. Our findings suggest that the qualita ... Full text Link to item Cite

alpha-Melanocyte-stimulating hormone-induced eruptive nevi.

Journal Article Arch Dermatol · April 2009 BACKGROUND: Synthetic peptides that target proopiomelanocortin receptors are being investigated as a novel and safe way to tan. It has been postulated that synthetic alpha-melanocyte-stimulating hormone (alpha-MSH) peptides may have protective effects agai ... Full text Link to item Cite

Oncostatin M enhances CCL21 expression by microvascular endothelial cells and increases the efficiency of dendritic cell trafficking to lymph nodes.

Journal Article J Immunol · December 1, 2006 CCL21, a lymphatic endothelial cell (LEC)-derived chemokine, and its receptor CCR7 regulate dendritic cell (DC) trafficking to lymph nodes (LN), but it is unclear how CCL21 expression is regulated. Oncostatin M (OSM) is an IL-6-like cytokine synthesized by ... Full text Link to item Cite

Genetic immunization with LYVE-1 cDNA yields function-blocking antibodies against native protein.

Journal Article Microvasc Res · January 2006 LYVE-1 is a surface bound hyaluronic acid (HA) receptor that is preferentially expressed by lymphatic endothelial cells (LEC). cDNA encoding full-length human LYVE-1 was coated onto gold particles that were then delivered via helium-assisted jet propulsion ... Full text Link to item Cite

VEGF inhibitors in cancer therapy.

Journal Article Curr Pharm Des · 2006 Vascular endothelial growth factor (VEGF)-mediated angiogenesis is thought to play a critical role in tumor growth and metastasis. Consequently, anti-VEGF therapies are being actively investigated as potential anti-cancer treatments, either as alternatives ... Full text Link to item Cite

Central memory self/tumor-reactive CD8+ T cells confer superior antitumor immunity compared with effector memory T cells.

Journal Article Proc Natl Acad Sci U S A · July 5, 2005 Central memory CD8+ T cells (T(CM)) and effector memory CD8+ T cells (T(EM)) are found in humans and mice; however, their relative contributions to host immunity have only recently been examined in vivo. Further, the ability of T(CM) to treat an establishe ... Full text Link to item Cite

Chemokine receptors and melanoma metastasis.

Journal Article J Dermatol Sci · November 2004 Cancer metastasis is the end result of a complex series of biologic events that leads to the formation of clinically significant secondary tumors at distant sites. The sites of distant metastasis are not random since certain tumors show a tendency to devel ... Full text Link to item Cite

Selective expression of stromal-derived factor-1 in the capillary vascular endothelium plays a role in Kaposi sarcoma pathogenesis.

Journal Article Blood · December 1, 2003 Kaposi sarcoma (KS), the most common neoplasm in patients with AIDS, typically presents with multiple skin lesions characterized by "spindle cells," the vast majority of which are infected with KSHV (Kaposi sarcoma herpes virus, also named HHV-8). In patie ... Full text Link to item Cite

Immune evasion by murine melanoma mediated through CC chemokine receptor-10.

Journal Article J Exp Med · November 3, 2003 Human melanoma cells frequently express CC chemokine receptor (CCR)10, a receptor whose ligand (CCL27) is constitutively produced by keratinocytes. Compared with B16 murine melanoma, cells rendered more immunogenic via overexpression of luciferase, B16 cel ... Full text Link to item Cite

CXCR4 enhances adhesion of B16 tumor cells to endothelial cells in vitro and in vivo via beta(1) integrin.

Journal Article Cancer Res · October 15, 2003 The chemokine receptor, CXCR4, is expressed by human melanomas, and its ligand, CXCL12, is frequently produced at sites of melanoma metastasis. Herein, we examine CXCR4-enhanced binding of B16 murine melanoma cells to endothelial cells (ECs) and recombinan ... Link to item Cite

Expression of CXC chemokine receptor-4 enhances the pulmonary metastatic potential of murine B16 melanoma cells.

Journal Article Cancer Res · December 15, 2002 The chemokine receptors CC chemokine receptor (CCR) 7 and CXC chemokine receptor (CXCR) 4 have been implicated in cancer metastasis. To evaluate whether CXCR4 is sufficient to increase tumor metastasis in an organ-specific manner, we transduced murine B16 ... Link to item Cite