Scholars@Duke
Cindy Louise Amundsen

Cindy Louise Amundsen

Roy T. Parker, M.D. Distinguished Professor of Obstetrics and Gynecology, in the School of Medicine
Obstetrics and Gynecology, Urogynecology
cindy.amundsen@duke.edu
5324 McFarland Drive Suite 310, Box 3192, Durham, NC 27617
5324 McFarland Drive Suite 310, Box 3192, Durham, NC 27617

Selected Publications

Symptoms of Lower Urinary Tract Dysfunction Research Network (LURN): An introduction to the Urinary Urgency Phenotyping Protocol LURN II.

Journal Article Neurourol Urodyn · November 2024 AIMS: The Symptoms of Lower Urinary Tract Dysfunction Research Network (LURN) is undertaking a new cohort study in LURN II including cases and controls. METHODS: This new cohort was enrolled to specifically study urinary urgency and urgency urinary inconti ... Full text Link to item Cite

Sacral and Implantable Tibial Neuromodulation for the Management of Overactive Bladder: A Systematic Review and Meta-analysis.

Journal Article Adv Ther · October 30, 2024 INTRODUCTION: Implantable tibial neuromodulation (iTNM) systems have recently become commercially available in the US, and offer a new method of neurostimulation for the treatment of overactive bladder (OAB). In the absence of head-to-head studies, the aim ... Full text Link to item Cite

A prospective study to assess the effectiveness and safety of the BlueWind System in the treatment of patients diagnosed with urgency urinary incontinence.

Journal Article Neurourol Urodyn · September 2024 BACKGROUND: Overactive bladder (OAB) affects one in six adults in Europe and the United States and impairs the quality of life of millions of individuals worldwide. When conservative management fails, third-line treatments including tibial neuromodulation ... Full text Link to item Cite

Structural Changes in Brain White Matter Tracts Associated With Overactive Bladder Revealed by Diffusion Tensor Magnetic Resonance Imaging: Findings From a Symptoms of Lower Urinary Tract Dysfunction Research Network Cross-Sectional Case-Control Study.

Journal Article J Urol · August 2024 PURPOSE: Our objective was to investigate structural changes in brain white matter tracts using diffusion tensor imaging (DTI) in patients with overactive bladder (OAB). MATERIALS AND METHODS: Treatment-seeking OAB patients and matched controls enrolled in ... Full text Link to item Cite

Trial Design for Mixed Urinary Incontinence: Midurethral Sling Versus Botulinum Toxin A.

Journal Article Urogynecology (Phila) · May 1, 2024 IMPORTANCE: Mixed urinary incontinence (MUI) is common and can be challenging to manage. OBJECTIVES: We present the protocol design and rationale of a trial comparing the efficacy of 2 procedures for the treatment of women with MUI refractory to oral treat ... Full text Link to item Cite

Vaginal morphology and position associated with prolapse recurrence after vaginal surgery: A secondary analysis of the DEMAND study.

Journal Article BJOG · February 2024 OBJECTIVE: To identify vaginal morphology and position factors associated with prolapse recurrence following vaginal surgery. DESIGN: Secondary analysis of magnetic resonance images (MRI) of the Defining Mechanisms of Anterior Vaginal Wall Descent cross-se ... Full text Link to item Cite

Intraoperative Predictors of Sacral Neuromodulation Implantation and Treatment Response: Results From the ROSETTA Trial.

Journal Article J Urol · August 2023 PURPOSE: We determined the utility of intraoperative data in predicting sacral neuromodulation outcomes in urgency urinary incontinence. MATERIALS AND METHODS: Intraoperative details of sacral neuromodulation stage 1 were recorded during the prospective, r ... Full text Link to item Cite

Reply by Authors.

Journal Article J Urol · August 2023 Full text Link to item Cite

Development and validation of models predicting treatment patterns in women with urinary urgency and/or urgency incontinence: A Symptoms of Lower Urinary Tract Dysfunction Research Network observational cohort study.

Journal Article Neurourol Urodyn · August 2023 PURPOSE: To develop a tool to predict a woman's treatment pattern for bothersome urinary urgency (UU) and/or UU incontinence over 1 year after presenting for care at urology or urogynecology clinics. METHODS: The Symptoms of Lower Urinary Tract Dysfunction ... Full text Link to item Cite

Neuromodulation in the Older Woman: An Advanced Treatment Option for Urgency Urinary Incontinence

Journal Article Current Geriatrics Reports · June 1, 2023 Purpose of Review: Urgency urinary incontinence (UUI) disproportionately impacts older women, and treatment strategies should minimize known harms while optimizing benefits. In the present review, we seek to provide an overview of the recent literature as ... Full text Cite

Strategies for Difficult Fluoroscopic Landmarking During Sacral Neuromodulation Lead Placement.

Journal Article Urology · April 2023 OBJECTIVES: Fluoroscopic guidance is a key tool used in combination with sensory and motor testing to ensure optimal sacral neuromodulation lead placement. The objectives of this video are to briefly review bony landmarks for fluoroscopic imaging and provi ... Full text Link to item Cite

Longitudinal urinary microbiome characteristics in women with urgency urinary incontinence undergoing sacral neuromodulation.

Journal Article Int Urogynecol J · February 2023 INTRODUCTION AND HYPOTHESIS: The objective was to evaluate the stability of the urinary microbiome communities in women undergoing sacral neuromodulation (SNM) for urgency urinary incontinence (UUI). We hypothesized that clinical response to SNM therapy wo ... Full text Link to item Cite

Phenotyping of Urinary Urgency Patients Without Urgency Incontinence, and Their Comparison to Urgency Incontinence Patients: Findings From the LURN Study.

Journal Article J Urol · January 2023 PURPOSE: We characterize patients with urinary urgency with vs without urgency urinary incontinence who presented to clinics actively seeking treatment for their symptoms. MATERIALS AND METHODS: Participants who enrolled in the Symptoms of Lower Urinary Tr ... Full text Link to item Cite

Reply by Authors.

Journal Article J Urol · January 2023 Full text Link to item Cite

Characterization of the GU microbiome in women with self-perceived bladder health over the life course.

Journal Article Neurourol Urodyn · January 2023 BACKGROUND: A variety of factors influence bladder health, including environmental factors, life experiences, biologic foundations, and coexistent medical conditions. A biologically diverse microbial community exists in the urine that is likely influenced ... Full text Link to item Cite

Treatment patterns in women with urinary urgency and/or urgency urinary incontinence in the symptoms of Lower Urinary Tract Dysfunction Research Network Observational Cohort Study.

Journal Article Neurourol Urodyn · January 2023 BACKGROUND: Limited epidemiological data exist describing how patients engage with various treatments for overactive bladder (OAB). To improve care for patients with OAB, it is essential to gain a better understanding of how patients interface with OAB tre ... Full text Open Access Link to item Cite

Total fluid intake, caffeine, and other bladder irritant avoidance among adults having urinary urgency with and without urgency incontinence: The Symptoms of Lower Urinary Tract Dysfunction Research Network (LURN).

Journal Article Neurourol Urodyn · January 2023 INTRODUCTION: Caffeine has long been vilified as a cause for urinary urgency incontinence (UUI) along with other potential bladder irritants such as carbonation, alcohol, and acidic juices. The objective of this study was to assess the fluid intake behavio ... Full text Link to item Cite

Design and Implementation of a Career Development Program for Physician-Scientists: Lessons Learned.

Journal Article Urogynecology (Phila) · August 1, 2022 IMPORTANCE: Although skills in health services research and data science have great potential to advance the field of urogynecology, few clinical researchers obtain such training. OBJECTIVES: The aim of the R25 UrogynCREST Program is to prepare the next ge ... Full text Open Access Link to item Cite

The Patient Perspective on Adverse Surgical Events After Pelvic Floor Surgery

Journal Article Current Bladder Dysfunction Reports · June 1, 2022 Purpose of Review: To review the present literature describing the patient experience of adverse events (AEs) following pelvic reconstructive surgery (PRS). Recent Findings: Patients’ perceived importance of AEs changes over the short-, medium-, and long-t ... Full text Cite

Postoperative changes in cognition and cerebrospinal fluid neurodegenerative disease biomarkers.

Journal Article Ann Clin Transl Neurol · February 2022 OBJECTIVE: Numerous investigators have theorized that postoperative changes in Alzheimer's disease neuropathology may underlie postoperative neurocognitive disorders. Thus, we determined the relationship between postoperative changes in cognition and cereb ... Full text Open Access Link to item Cite

Experimental Pain and Auditory Sensitivity in Overactive Bladder Syndrome: A Symptoms of the Lower Urinary Tract Dysfunction Research Network (LURN) Study.

Journal Article J Urol · January 2022 PURPOSE: The objective of this study was to investigate the presence of nonbladder sensory abnormalities in participants with overactive bladder syndrome (OAB). MATERIALS AND METHODS: Symptoms of Lower Urinary Tract Dysfunction Research Network (LURN) stud ... Full text Link to item Cite

Reply by Authors.

Journal Article J Urol · January 2022 Full text Link to item Cite

Predicting outcomes after intradetrusor onabotulinumtoxina for non-neurogenic urgency incontinence in women.

Journal Article Neurourol Urodyn · January 2022 AIMS: Develop models to predict outcomes after intradetrusor injection of 100 or 200 units of onabotulinumtoxinA in women with non-neurogenic urgency urinary incontinence (UUI). METHODS: Models were developed using 307 women from two randomized trials asse ... Full text Open Access Link to item Cite

Subtyping of common complex diseases and disorders by integrating heterogeneous data. Identifying clusters among women with lower urinary tract symptoms in the LURN study.

Journal Article PLoS One · 2022 We present a methodology for subtyping of persons with a common clinical symptom complex by integrating heterogeneous continuous and categorical data. We illustrate it by clustering women with lower urinary tract symptoms (LUTS), who represent a heterogene ... Full text Open Access Link to item Cite

Defining mechanisms of recurrence following apical prolapse repair based on imaging criteria.

Journal Article American journal of obstetrics and gynecology · November 2021 BackgroundProlapse recurrence after transvaginal surgical repair is common; however, its mechanisms are ill-defined. A thorough understanding of how and why prolapse repairs fail is needed to address their high rate of anatomic recurrence and to d ... Full text Cite

The Urinary Microbiome in Postmenopausal Women with Recurrent Urinary Tract Infections.

Journal Article The Journal of urology · November 2021 PurposeThe etiology of postmenopausal recurrent urinary tract infection (UTI) is not completely known, but the urinary microbiome is thought to be implicated. We compared the urinary microbiome in menopausal women with recurrent UTIs to age-matche ... Full text Cite

Sacral neuromodulation: sacral anatomy and optimal lead placement.

Journal Article Int Urogynecol J · September 2021 INTRODUCTION AND HYPOSTHESIS: To develop an instructional video that correlates cadaveric anatomy with fluoroscopic images to assist in conceptualization of optimal placement of the foramen needle and lead to complete an efficient and successful sacral neu ... Full text Link to item Cite

Sacral neuromodulation: troubleshooting needle placement.

Journal Article Int Urogynecol J · September 2021 INTRODUCTION AND HYPOTHESIS: The objective was to develop an instructional video that utilizes fluoroscopic images and anatomical landmarks to increase the surgeon's ability to troubleshoot optimal placement of the foramen needle and lead during a stage I ... Full text Link to item Cite

Baseline Characteristics, Evaluation, and Management of Women With Complaints of Recurrent Urinary Tract Infections.

Journal Article Female Pelvic Med Reconstr Surg · May 1, 2021 OBJECTIVE: The aims of this study were to determine the proportion of women presenting for recurrent urinary tract infections (UTIs) who met the diagnostic criteria (culture-proven UTI ≥3 in 1 year or ≥2 in 6 months) and to assess advanced testing utilizat ... Full text Link to item Cite

Does a recent urinary tract infection increase the risk of postprocedure urinary tract infection after onabotulinum toxin a?

Journal Article Obstetrical and Gynecological Survey · May 1, 2021 Onabotulinum toxin A (BTX-A) is commonly used as treatment for refractory overactive bladder (OAB) but is associated with postprocedural urinary tract infection (UTI) in up to 35% of cases despite antibiotic prophylaxis. In women with recent UTI, it is unc ... Full text Cite

Benchmarking DNA isolation kits used in analyses of the urinary microbiome.

Journal Article Sci Rep · March 17, 2021 The urinary microbiome has been increasingly characterized using next-generation sequencing. However, many of the technical methods have not yet been specifically optimized for urine. We sought to compare the performance of several DNA isolation kits used ... Full text Link to item Cite

Comparison of 100 U With 200 U of Intradetrusor OnabotulinumToxinA for Nonneurogenic Urgency Incontinence.

Journal Article Female Pelvic Med Reconstr Surg · March 1, 2021 OBJECTIVES: The objective of this study was to compare efficacy and adverse events between 100 U and 200 U of onabotulinumtoxinA for 6 months in women with nonneurogenic urgency incontinence. METHODS: This is a secondary analysis of 2 multicenter randomize ... Full text Link to item Cite

Does a Recent Urinary Tract Infection Increase the Risk of Postprocedure Urinary Tract Infection After Onabotulinum Toxin A?

Journal Article Female Pelvic Med Reconstr Surg · February 1, 2021 OBJECTIVES: The objective of this study was to evaluate the risk of postprocedure urinary tract infection (UTI) after injection of onabotulinum toxin A (BTX-A) in women who had a UTI within 30 days before procedure. METHODS: This was a retrospective cohort ... Full text Link to item Cite

Prevalence of childhood trauma and its association with lower urinary tract symptoms in women and men in the LURN study.

Conference Neurourol Urodyn · February 2021 AIMS: To describe the association between childhood traumas (death of a family member, severe illness, sexual trauma, parental separation) reported by women and men and lower urinary tract symptoms (LUTS). METHODS: In this secondary analysis of the Lower U ... Full text Link to item Cite

Evaluation of Host Immune Cellular and Extracellular Matrix Responses to Prolapse Mesh With and Without Tension in a Rat Model.

Journal Article Female pelvic medicine & reconstructive surgery · February 2021 ObjectivesWe sought to determine whether vaginal host immune cellular and extracellular matrix responses are altered in a rat sacrocolpopexy model when lightweight polypropylene mesh is attached on tension versus without tension.MethodsWe ... Full text Cite

Polycarbonate Urethane Mesh: A New Material for Pelvic Reconstruction.

Journal Article Female Pelvic Med Reconstr Surg · February 1, 2021 OBJECTIVE: Polycarbonate urethane (PCU) is a new biomaterial, and its mechanical properties can be tailored to match that of vaginal tissue. We aimed to determine whether vaginal host immune and extracellular matrix responses differ after PCU versus lightw ... Full text Link to item Cite

The Design of a Prospective Trial to Evaluate the Role of Preoperative Frailty Assessment in Older Women Undergoing Surgery for the Treatment of Pelvic Organ Prolapse: The FASt Supplemental Trial.

Journal Article Female Pelvic Med Reconstr Surg · January 1, 2021 OBJECTIVE: We present the rationale for and the design of a prospective trial to evaluate the role of preoperative frailty and mobility assessments in older women undergoing surgery for the treatment of pelvic organ prolapse (POP) as a planned prospective ... Full text Link to item Cite

A Blueprint for Creating Mentored, Collaborative Networks for Early-Career Physician-Scientists.

Journal Article Female Pelvic Med Reconstr Surg · January 1, 2021 OBJECTIVES: The objective is to improve the high-quality collaborative research of early-career investigators, the American Urogynecologic Society/Pelvic Floor Disorders Foundation funded and developed the Junior Faculty Research Network (JFRN). The purpos ... Full text Link to item Cite

Streamlining Postoperative Void Trials: A Study Comparing Standard Backfill Versus Backfill in the Operating Room.

Journal Article Female Pelvic Med Reconstr Surg · January 1, 2021 OBJECTIVE: The standard backfill void trial (VT) performed after urogynecologic surgery is time-consuming. We adopted a new VT protocol in which the bladder is backfilled in the operating room (OR). We hypothesized that this protocol would result in (1) sh ... Full text Link to item Cite

Relationship of symptom severity and bother in individuals seeking care for lower urinary tract symptoms.

Journal Article Neurourol Urodyn · November 2020 AIMS: Bother attributed to lower urinary tract symptoms (LUTS) drives care-seeking and treatment aggressiveness. The longitudinal relationship of LUTS severity and bother in a care-seeking cohort, however, is not well understood. We aim to conduct a longit ... Full text Link to item Cite

Outcomes of native tissue transvaginal apical approaches in women with advanced pelvic organ prolapse and stress urinary incontinence.

Journal Article Int Urogynecol J · October 2020 INTRODUCTION AND HYPOTHESIS: Limited data exist comparing different surgical approaches in women with advanced vaginal prolapse. This study compared 2-year surgical outcomes of uterosacral ligament suspension (ULS) and sacrospinous ligament fixation (SSLF) ... Full text Link to item Cite

A protocol to reduce self-reported pain scores and adverse events following lumbar punctures in older adults.

Journal Article J Neurol · July 2020 OBJECTIVE: Lumbar punctures (LPs) are important for obtaining CSF in neurology studies but are associated with adverse events and feared by many patients. We determined adverse event rates and pain scores in patients prospectively enrolled in two cohort st ... Full text Link to item Cite

Cost-Effectiveness of Sacral Neuromodulation versus OnabotulinumtoxinA for Refractory Urgency Urinary Incontinence: Results of the ROSETTA Randomized Trial.

Journal Article J Urol · May 2020 PURPOSE: Sacral neuromodulation and intradetrusor onabotulinumtoxinA injection are therapies for refractory urgency urinary incontinence. Sacral neuromodulation involves surgical implantation of a device that can last 4 to 6 years while onabotulinumtoxinA ... Full text Link to item Cite

Reply by Authors.

Journal Article J Urol · May 2020 Full text Link to item Cite

Prevalence, subtypes, and correlates of nocturia in the symptoms of Lower Urinary Tract Dysfunction Research Network cohort.

Journal Article Neurourol Urodyn · April 2020 AIMS: We determined the prevalence, severity, and correlates of nocturia in a large clinical cohort of patients. METHODS: Patients presenting with lower urinary tract symptoms (LUTS) completed 3-day bladder diaries. Nocturia was quantified based on the mea ... Full text Link to item Cite

Longitudinal changes in symptom-based female and male LUTS clusters.

Journal Article Neurourol Urodyn · January 2020 AIMS: Lower urinary tract symptoms (LUTS) are diverse in type and variable in severity. We examined symptom change within the Symptoms of the Lower Urinary Tract Dysfunction Research Network (LURN) Observational Cohort study identified clusters over time a ... Full text Link to item Cite

The MARBLE Study Protocol: Modulating ApoE Signaling to Reduce Brain Inflammation, DeLirium, and PostopErative Cognitive Dysfunction.

Journal Article J Alzheimers Dis · 2020 BACKGROUND: Perioperative neurocognitive disorders (PND) are common complications in older adults associated with increased 1-year mortality and long-term cognitive decline. One risk factor for worsened long-term postoperative cognitive trajectory is the A ... Full text Open Access Link to item Cite

Sacral neuromodulation versus onabotulinumtoxinA for refractory urgency urinary incontinence: impact on fecal incontinence symptoms and sexual function.

Journal Article Am J Obstet Gynecol · November 2019 BACKGROUND: Women with refractory urgency urinary incontinence can be treated with onabotulinumtoxinA or sacral neuromodulation. Little data exists on the comparative effects of treatment of refractory urgency urinary incontinence on other pelvic floor com ... Full text Link to item Cite

Are three-day voiding diaries feasible and reliable? Results from the Symptoms of Lower Urinary Tract Dysfunction Research Network (LURN) cohort.

Journal Article Neurourol Urodyn · November 2019 AIMS: The aims of this study were to assess the completeness of voiding diaries in a research context and to correlate diary data with patient-reported questionnaires. METHODS: Men and women enrolled in the Symptoms of Lower Urinary Tract Dysfunction Resea ... Full text Link to item Cite

Randomized Controlled Trial to Assess the Impact of High Concentration Intraurethral Lidocaine on Urodynamic Voiding Parameters.

Journal Article Urology · November 2019 OBJECTIVE: To assess whether intraurethral anesthesia decreased voiding efficiency (VE), reduced catheterization pain, and impacted urodynamic parameters in healthy adult females. METHODS: In a randomized, double-blind, placebo-controlled trial, participan ... Full text Link to item Cite

Recruitment and retention: A randomized controlled trial of video-enhanced versus standard consent processes within the E-OPTIMAL study.

Journal Article Clin Trials · October 2019 BACKGROUND/AIMS: In this study, we compared two research consent techniques: a standardized video plus usual consent and usual consent alone. METHODS: Individuals who completed 24-month outcomes (completers) in the Operations and Pelvic Muscle Training in ... Full text Link to item Cite

Controlling faecal incontinence in women by performing anal exercises with biofeedback or loperamide: a randomised clinical trial.

Journal Article Lancet Gastroenterol Hepatol · September 2019 BACKGROUND: Well designed, large comparative effectiveness trials assessing the efficacy of primary interventions for faecal incontinence are few in number. The objectives of this study were to compare different combinations of anorectal manometry-assisted ... Full text Open Access Link to item Cite

Patient Characteristics Associated with More Bother from Lower Urinary Tract Symptoms.

Journal Article J Urol · September 2019 PURPOSE: Some patients continue to have bothersome lower urinary tract symptoms despite treatment. We examined characteristics associated with bother from lower urinary tract symptoms in a prospective cohort. MATERIALS AND METHODS: In this 1-year prospecti ... Full text Link to item Cite

EFFECT OF RECURRENT UTI PROPHYLAXIS ON URINARY MICROBES

Conference INTERNATIONAL UROGYNECOLOGY JOURNAL · September 1, 2019 Link to item Cite

COMPARISON OF DNA EXTRACTION KITS IN COMPOSITIONAL ANALYSES OF URINARY MICROBIOME

Conference INTERNATIONAL UROGYNECOLOGY JOURNAL · September 1, 2019 Link to item Cite

Role of β-3 adrenergic receptor polymorphism in overactive bladder.

Journal Article Neurourol Urodyn · June 2019 AIMS: Women with overactive bladder (OAB) have a higher frequency of a single-nucleotide polymorphism (SNP) at codon 64 of the β-3 adrenergic receptor gene (ADRB3). Since the SNP results in an amino acid substitution that could theoretically alter receptor ... Full text Link to item Cite

Gaining the Patient Perspective on Pelvic Floor Disorders' Surgical Adverse Events

Journal Article Obstetrical and Gynecological Survey · June 1, 2019 Full text Cite

The INTUIT Study: Investigating Neuroinflammation Underlying Postoperative Cognitive Dysfunction.

Journal Article J Am Geriatr Soc · April 2019 BACKGROUND/OBJECTIVES: Every year, up to 40% of the more than 16 million older Americans who undergo anesthesia/surgery develop postoperative cognitive dysfunction (POCD) or delirium. Each of these distinct syndromes is associated with decreased quality of ... Full text Open Access Link to item Cite

73: Impact of refractory urgency urinary incontinence treatment on bowel and sexual function

Conference American Journal of Obstetrics and Gynecology · March 2019 Full text Cite

Gaining the patient perspective on pelvic floor disorders' surgical adverse events.

Journal Article Am J Obstet Gynecol · February 2019 BACKGROUND: The Institute for Healthcare Improvement defines an adverse event as an unintended physical injury resulting from or contributed to by medical care that requires additional monitoring, treatment, or hospitalization or that results in death. The ... Full text Link to item Cite

Randomized Controlled Trial to Assess the Impact of Intraurethral Lidocaine on Urodynamic Voiding Parameters.

Journal Article Female Pelvic Med Reconstr Surg · 2019 OBJECTIVES: The aim of the study was to determine whether intraurethral anesthesia decreases voiding efficiency (VE; voided volume/(voided volume + residual volume)) and impacts other urodynamic parameters in healthy female volunteers during urodynamic stu ... Full text Link to item Cite

Bowel function, sexual function, and symptoms of pelvic organ prolapse in women with and without urinary incontinence.

Journal Article Neurourol Urodyn · November 2018 AIMS: Bowel symptoms, pelvic organ prolapse, and sexual dysfunction are common, but their frequency among women with lower urinary tract symptoms (LUTS) has not been well described. Our aims were to describe pelvic floor symptoms among women with and witho ... Full text Link to item Cite

The LURN Research Network Neuroimaging and Sensory Testing (NIST) Study: Design, protocols, and operations.

Journal Article Contemp Clin Trials · November 2018 The Neuroimaging and Sensory Testing (NIST) Study of the Symptoms of Lower Urinary Tract Dysfunction Research Network (LURN) is a cross-sectional, case-control study designed to investigate whether disrupted brain connectivity and sensory processing are as ... Full text Link to item Cite

Sex differences in lower urinary tract biology and physiology.

Journal Article Biol Sex Differ · October 22, 2018 Females and males differ significantly in gross anatomy and physiology of the lower urinary tract, and these differences are commonly discussed in the medical and scientific literature. However, less attention is dedicated to investigating the varied devel ... Full text Link to item Cite

Mental Health, Sleep and Physical Function in Treatment Seeking Women with Urinary Incontinence.

Journal Article J Urol · October 2018 PURPOSE: We examined how mental health measures, sleep and physical function are associated with the presence and type of urinary incontinence and severity in women seeking treatment for lower urinary tract symptoms. MATERIALS AND METHODS: This baseline cr ... Full text Link to item Cite

Two-Year Outcomes of Sacral Neuromodulation Versus OnabotulinumtoxinA for Refractory Urgency Urinary Incontinence: A Randomized Trial.

Journal Article Eur Urol · July 2018 BACKGROUND: Urgency urinary incontinence (UUI) is a chronic condition for which sacral neuromodulation (SNM) (InterStim/Medtronic) and onabotulinumtoxinA (BTX) (BotoxA/Allergan) are utilized. These therapies have not been compared over extended time. OBJEC ... Full text Link to item Cite

Baseline Lower Urinary Tract Symptoms in Patients Enrolled in LURN: A Prospective, Observational Cohort Study.

Journal Article J Urol · April 2018 PURPOSE: We described and compared the frequency and type of lower urinary tract symptoms reported by men and women at the time that they were recruited from urology and urogynecology clinics into the Symptoms of Lower Urinary Tract Dysfunction Research Ne ... Full text Link to item Cite

A genome-scale DNA methylation study in women with interstitial cystitis/bladder pain syndrome.

Journal Article Neurourol Urodyn · April 2018 AIMS: To assess the feasibility of using voided urine samples to perform a DNA methylation study in females with interstitial cystitis/bladder pain syndrome (IC/BPS) as compared to age- and race-matched controls. A unique methylation profile could lead to ... Full text Link to item Cite

In Search of More Sleep.

Journal Article Obstet Gynecol · February 2018 Full text Link to item Cite

PREVALENCE AND CORRELATES OF NOCTURIA IN THE LURN COHORT

Conference NEUROUROLOGY AND URODYNAMICS · February 1, 2018 Link to item Cite

myTIPreport and Training for Independent Practice: A Tool for Real-Time Workplace Feedback for Milestones and Procedural Skills.

Journal Article J Grad Med Educ · February 2018 BACKGROUND: Few tools currently exist for effective, accessible delivery of real-time, workplace feedback in the clinical setting. OBJECTIVE: We developed and implemented a real-time, web-based tool for performance-based feedback in the clinical environmen ... Full text Link to item Cite

Vaginal Uterosacral Ligament Suspension: A Retrospective Cohort of Absorbable and Permanent Suture Groups.

Journal Article Female Pelvic Med Reconstr Surg · 2018 OBJECTIVE: The aim of this study was to compare anatomic results after vaginal uterosacral ligament suspension with absorbable versus permanent suture. METHODS: We performed a retrospective cohort study of women who underwent vaginal uterosacral ligament s ... Full text Link to item Cite

Refractory urgency urinary incontinence treatment in women: impact of age on outcomes and complications.

Journal Article Am J Obstet Gynecol · January 2018 BACKGROUND: Women with refractory urgency urinary incontinence (ie, unresponsive to behavioral and pharmacological interventions) are treated with onabotulinumtoxinA or sacral neuromodulation. OBJECTIVE: The objective of the study was to compare treatment ... Full text Link to item Cite

Improving Postoperative Efficiency: An Algorithm for Expedited Void Trials After Urogynecologic Surgery.

Journal Article South Med J · December 2017 OBJECTIVES: To evaluate the relation between voided volume and void trial "success" to create an algorithm that minimizes the need for postvoid residual volume (PVR) assessment in backfill-assisted void trials. METHODS: This article is an ancillary analysi ... Full text Link to item Cite

Multiple Reflex Pathways Contribute to Bladder Activation by Intraurethral Stimulation in Persons With Spinal Cord Injury.

Journal Article Urology · November 2017 OBJECTIVE: To measure the urodynamic effects of electrical co-stimulation of 2 individual sites in the proximal and distal urethra in persons with spinal cord injury (SCI). This work was motivated by preclinical findings that selective co-stimulation of th ... Full text Link to item Cite

Perioperative Behavioral Therapy and Pelvic Muscle Strengthening Do Not Enhance Quality of Life After Pelvic Surgery: Secondary Report of a Randomized Controlled Trial.

Journal Article Phys Ther · November 1, 2017 BACKGROUND: There is significant need for trials evaluating the long-term effectiveness of a rigorous program of perioperative behavioral therapy with pelvic floor muscle training (BPMT) in women undergoing transvaginal reconstructive surgery for prolapse. ... Full text Link to item Cite

Characteristics Associated with Treatment Response and Satisfaction in Women Undergoing OnabotulinumtoxinA and Sacral Neuromodulation for Refractory Urgency Urinary Incontinence.

Journal Article J Urol · October 2017 PURPOSE: We sought to identify clinical and demographic characteristics associated with treatment response and satisfaction in women undergoing onabotulinumtoxinA and sacral neuromodulation therapies. MATERIALS AND METHODS: We analyzed data from the ROSETT ... Full text Open Access Link to item Cite

Urinary Biomarkers in Women with Refractory Urgency Urinary Incontinence Randomized to Sacral Neuromodulation versus OnabotulinumtoxinA Compared to Controls.

Journal Article J Urol · June 2017 PURPOSE: We measured urinary biomarker levels in women with refractory urgency urinary incontinence and controls at baseline and 6 months after treatment with sacral neuromodulation or intradetrusor injection of onabotulinumtoxinA. We also assessed the ass ... Full text Link to item Cite

Do Mixed-Flora Preoperative Urine Cultures Matter?

Journal Article South Med J · June 2017 OBJECTIVES: To determine whether mixed-flora preoperative urine cultures, as compared with no-growth preoperative urine cultures, are associated with a higher prevalence of postoperative urinary tract infections (UTIs). METHODS: This was a retrospective co ... Full text Link to item Cite

Neuroprosthetic control of lower urinary tract function

Chapter · March 10, 2017 Lower urinary tract dysfunction is highly prevalent, leads to a decreased quality of life, and is associated with a high economic burden. In the past decade electrical stimulation has emerged as a valid treatment modality for those with lower urinary tract ... Full text Cite

Expert Panel Recommendations on Lower Urinary Tract Health of Women Across Their Life Span.

Journal Article J Womens Health (Larchmt) · November 2016 Urologic and kidney problems are common in women across their life span and affect their daily life, including physical activity, sexual relations, social life, and future health. Urological health in women is still understudied and the underlying mechanis ... Full text Open Access Link to item Cite

OnabotulinumtoxinA vs Sacral Neuromodulation on Refractory Urgency Urinary Incontinence in Women: A Randomized Clinical Trial.

Journal Article JAMA · October 4, 2016 IMPORTANCE: Women with refractory urgency urinary incontinence are treated with sacral neuromodulation and onabotulinumtoxinA with limited comparative information. OBJECTIVE: To assess whether onabotulinumtoxinA is superior to sacral neuromodulation in con ... Full text Open Access Link to item Cite

Methods for a multicenter randomized trial for mixed urinary incontinence: rationale and patient-centeredness of the ESTEEM trial.

Journal Article Int Urogynecol J · October 2016 INTRODUCTION AND HYPOTHESIS: Mixed urinary incontinence (MUI) can be a challenging condition to manage. We describe the protocol design and rationale for the Effects of Surgical Treatment Enhanced with Exercise for Mixed Urinary Incontinence (ESTEEM) trial ... Full text Open Access Link to item Cite

Symptoms of Lower Urinary Tract Dysfunction Research Network.

Journal Article J Urol · July 2016 PURPOSE: To address gaps in understanding and treating lower urinary tract symptoms, the NIDDK created the Symptoms of Lower Urinary Tract Dysfunction Research Network (LURN). The goals of LURN are to work collaboratively to 1) identify and explain the imp ... Full text Link to item Cite

Microhematuria in Postmenopausal Women: Adherence to Guidelines in a Tertiary Care Setting.

Journal Article J Urol · April 2016 PURPOSE: In 2012 the AUA (American Urological Association) released a revision of the asymptomatic microscopic hematuria guidelines. Our study objectives were to assess adherence to these guidelines and describe the prevalence of urinary tract malignancy i ... Full text Link to item Cite

Controlling anal incontinence in women by performing anal exercises with biofeedback or loperamide (CAPABLe) trial: Design and methods.

Journal Article Contemp Clin Trials · September 2015 The goals of this trial are to determine the efficacy and safety of two treatments for women experiencing fecal incontinence. First, we aim to compare the use of loperamide to placebo and second, to compare the use of anal sphincter exercises with biofeedb ... Full text Open Access Link to item Cite

Posterior tibial nerve stimulation for the treatment of fecal incontinence: a systematic evidence review.

Journal Article Obstet Gynecol Surv · May 2015 IMPORTANCE AND OBJECTIVES: Posterior tibial nerve stimulation (PTNS) is a potential emerging therapy for fecal incontinence (FI). The aim of this study was to systematically review the literature regarding the efficacy of PTNS as a treatment of FI. EVIDENC ... Full text Link to item Cite

Electrical stimulation for the treatment of lower urinary tract dysfunction after spinal cord injury.

Journal Article J Spinal Cord Med · March 2015 Electrical stimulation for bladder control is an alternative to traditional methods of treating neurogenic lower urinary tract dysfunction (NLUTD) resulting from spinal cord injury (SCI). In this review, we systematically discuss the neurophysiology of bla ... Full text Link to item Cite

Sexual activity and vaginal topography in women with symptomatic pelvic floor disorders.

Journal Article J Sex Med · February 2015 INTRODUCTION: Pelvic floor disorders affect vaginal anatomy and may affect sexual function. AIMS: The aims of this study were to explore the relationship between vaginal anatomy and sexual activity in women with symptomatic pelvic floor disorders and to as ... Full text Link to item Cite

Optimizing Urine Processing Protocols for Protein and Metabolite Detection.

Journal Article J Proteomics Bioinform · 2015 BACKGROUND: In urine, factors such as timing of voids, and duration at room temperature (RT) may affect the quality of recovered protein and metabolite data. Additives may aid with detection, but can add more complexity in sample collection or analysis. We ... Link to item Cite

UNDERACTIVE BLADDER IN OBESE-PRONE RATS FED A HIGH FAT DIET

Conference NEUROUROLOGY AND URODYNAMICS · August 1, 2014 Link to item Cite

Findings of universal cystoscopy at incontinence surgery and their sequelae.

Journal Article Am J Obstet Gynecol · May 2014 OBJECTIVE: The purpose of this study was to report the frequency of abnormal cystoscopy at incontinence surgery and to identify risk factors and sequelae of injury. STUDY DESIGN: Findings of cystoscopy were collected prospectively in 3 multicenter surgical ... Full text Link to item Cite

The Refractory Overactive Bladder: Sacral NEuromodulation vs. BoTulinum Toxin Assessment: ROSETTA trial.

Journal Article Contemp Clin Trials · March 2014 We present the rationale for and design of a randomized, open-label, active-control trial comparing the effectiveness of 200 units of onabotulinum toxin A (Botox A®) versus sacral neuromodulation (InterStim®) therapy for refractory urgency urinary incontin ... Full text Link to item Cite

Oral antibiotics to prevent postoperative urinary tract infection: a randomized controlled trial.

Journal Article Obstet Gynecol · January 2014 OBJECTIVE: To evaluate whether nitrofurantoin prophylaxis prevents postoperative urinary tract infection (UTI) in patients receiving transurethral catheterization after pelvic reconstructive surgery. METHODS: In a randomized, double-blind, placebo-controll ... Full text Link to item Cite

Psychosocial factors related to the use of InterStim® for the treatment of refractory overactive bladder.

Journal Article Female Pelvic Med Reconstr Surg · 2014 OBJECTIVES: Sacral neuromodulation is a well-established treatment of refractory overactive bladder (OAB). Although literature exists on the psychosocial impact of other implanted medical devices, data do not exist for InterStim therapy. We aim to evaluate ... Full text Link to item Cite

Impact of staged InterStim implantation on the postoperative activities of daily living and pain.

Journal Article Int Urogynecol J · July 2013 Featured Publication OBJECTIVES: To evaluate the short-term effects of staged InterStim implantation on activities of daily living (ADL) and pain. METHODS: This prospective study assessed women undergoing staged InterStim implantation. The Older Americans Resources and Service ... Full text Link to item Cite

Comparison of diary-derived bladder and sleep measurements across OAB individuals, primary insomniacs, and healthy controls.

Journal Article Int Urogynecol J · March 2013 Featured Publication INTRODUCTION AND HYPOTHESIS: Can diary-derived bladder and sleep measurements differentiate individuals with overactive bladder syndrome (OAB) from individuals with primary insomnia and healthy controls? METHODS: Bladder- and sleep-diary data were compared ... Full text Link to item Cite

Vaginal prolapse recurrence after uterosacral ligament suspension in normal-weight compared with overweight and obese women.

Journal Article Obstet Gynecol · March 2013 Featured Publication OBJECTIVE: To compare recurrent prolapse after vaginal uterosacral ligament suspension in normal-weight compared with overweight or obese women. METHODS: We performed a retrospective cohort study of the risk of recurrent prolapse after uterosacral ligament ... Full text Link to item Cite

Sling revision/removal for mesh erosion and urinary retention: long-term risk and predictors.

Journal Article Am J Obstet Gynecol · January 2013 Featured Publication OBJECTIVE: The objective of the study was to estimate the long-term risk of sling revision/removal after an initial sling and to assess indications (mesh erosion and urinary retention) and predictors of sling revision/removal. STUDY DESIGN: Using a populat ... Full text Link to item Cite

The efficacy of posterior tibial nerve stimulation for the treatment of overactive bladder in women: a systematic review.

Journal Article Int Urogynecol J · November 2012 Featured Publication INTRODUCTION AND HYPOTHESIS: Posterior tibial nerve stimulation (PTNS) is a percutaneous method of peripheral, sacral neuromodulation. Its current use is limited; however, published data suggest PTNS may be an effective treatment for overactive bladder (OA ... Full text Link to item Cite

A randomized trial of urodynamic testing before stress-incontinence surgery

Journal Article Obstetrical and Gynecological Survey · October 1, 2012 Full text Cite

Do urodynamic parameters predict persistent postoperative stress incontinence after midurethral sling? A systematic review.

Journal Article Int Urogynecol J · July 2012 Featured Publication INTRODUCTION AND HYPOTHESIS: It is unclear whether preoperative urodynamic study (UDS) values are predictive of outcomes after midurethral sling. MATERIALS AND METHODS: We systematically reviewed multiple databases from January 1989 to October 2011 for Eng ... Full text Link to item Cite

A midurethral sling to reduce incontinence after vaginal prolapse repair.

Journal Article N Engl J Med · June 21, 2012 Featured Publication BACKGROUND: Women without stress urinary incontinence undergoing vaginal surgery for pelvic-organ prolapse are at risk for postoperative urinary incontinence. A midurethral sling may be placed at the time of prolapse repair to reduce this risk. METHODS: We ... Full text Link to item Cite

A randomized trial of urodynamic testing before stress-incontinence surgery.

Journal Article N Engl J Med · May 24, 2012 Featured Publication BACKGROUND: Urodynamic studies are commonly performed in women before surgery for stress urinary incontinence, but there is no good evidence that they improve outcomes. METHODS: We performed a multicenter, randomized, noninferiority trial involving women w ... Full text Link to item Cite

Comprehensive analysis of LAMC1 genetic variants in advanced pelvic organ prolapse.

Journal Article Am J Obstet Gynecol · May 2012 Featured Publication OBJECTIVE: We sought to comprehensively evaluate the association of laminin gamma-1 (LAMC1) and advance pelvic organ prolapse. STUDY DESIGN: We conducted a candidate gene association of patients (n = 239) with stages III-IV prolapse and controls (n = 197) ... Full text Link to item Cite

Single-incision mini-sling compared with tension-free vaginal tape for the treatment of stress urinary incontinence: a randomized controlled trial.

Journal Article Obstet Gynecol · February 2012 Featured Publication OBJECTIVE: To compare the efficacy of a single-incision mini-sling, placed in the "U" position, with tension-free vaginal tape (TVT) in the treatment of stress urinary incontinence. METHODS: Women with urodynamic stress incontinence with or without genital ... Full text Link to item Cite

Treatment for urinary tract infection after midurethral sling: a retrospective study comparing patients who receive short-term postoperative catheterization and patients who pass a void trial on the day of surgery.

Journal Article Female Pelvic Med Reconstr Surg · 2012 Featured Publication INTRODUCTION: This is a retrospective cohort study comparing the risk of treatment for postoperative urinary tract infection (UTI) in patients who receive short-term postoperative catheterization versus those who pass a void trial on the day of surgery aft ... Full text Link to item Cite

Does obesity impact the success of an InterStim test phase for the treatment of refractory urge urinary incontinence in female patients?

Journal Article Female Pelvic Med Reconstr Surg · 2012 Featured Publication OBJECTIVES: Some providers believe obesity may be a relative contraindication for InterStim; however, the relationship between obesity and treatment outcome has not been evaluated. Our objectives were to compare the test phase (stage 1) success and complic ... Full text Link to item Cite

Pelvic floor symptoms improve similarly after pessary and behavioral treatment for stress incontinence.

Journal Article Female Pelvic Med Reconstr Surg · 2012 Featured Publication OBJECTIVE: The objective of this study was to determine if differences exist in pelvic symptom distress and impact on women randomized to pessary versus behavioral therapy for treatment of stress urinary incontinence (SUI). METHODS: Change in symptom and c ... Full text Link to item Cite

Patient preferences for different severities of and treatments for overactive bladder.

Journal Article Female Pelvic Med Reconstr Surg · July 2011 Featured Publication OBJECTIVE: : Symptoms of overactive bladder (OAB) can have profound effects on women's quality of life. However, quantitative data on how women value these symptoms and their treatments are limited. We sought to assess women's preferences, which are referr ... Full text Link to item Cite

Lead migration after sacral neuromodulation: surgical revision in fascial versus tined anchoring systems.

Journal Article Int Urogynecol J · April 2011 Featured Publication INTRODUCTION AND HYPOTHESIS: Our objective was to compare risk of surgical revision after sacral neuromodulator lead migration based on the type of anchoring system. METHODS: We performed a retrospective cohort study of patients receiving sacral neuromodul ... Full text Link to item Cite

Multiple pudendal sensory pathways reflexly modulate bladder and urethral activity in patients with spinal cord injury.

Journal Article J Urol · February 2011 Featured Publication PURPOSE: Electrical stimulation of pudendal afferents can evoke reflex bladder contractions with relaxation of the external urethral sphincter in cats. This voiding reflex is mediated by pudendal sensory fibers innervating the penile and prostatic urethra ... Full text Link to item Cite

AUTONOMIC NERVOUS SYSTEM ACTIVITY PRECEDING NOCTURIA IN OLDER ADULTS

Conference SLEEP · January 1, 2011 Featured Publication Link to item Cite

Detrusor overactivity persisting at night and preceding nocturia in patients with overactive bladder syndrome: a nocturnal cystometrogram and polysomnogram study.

Journal Article J Urol · August 2010 Featured Publication PURPOSE: Nocturia, a common symptom of overactive bladder syndrome, is associated with substantial adverse consequences and yet its pathophysiology has hardly been studied and the capacity to treat it remains limited. We established methods to study the ph ... Full text Link to item Cite

Conditional and continuous electrical stimulation increase cystometric capacity in persons with spinal cord injury.

Journal Article Neurourol Urodyn · March 2010 Featured Publication AIMS: Individuals with spinal cord injury (SCI) exhibit neurogenic detrusor overactivity (NDO) causing high intravesicle pressures and incontinence. The first aim was to measure changes in maximum cystometric capacity (MCC) evoked by electrical stimulation ... Full text Link to item Cite

Efficacy and adverse events of sacral nerve stimulation for overactive bladder: A systematic review.

Journal Article Neurourol Urodyn · 2010 Featured Publication AIMS: To systematically review the literature regarding efficacy and adverse events of sacral nerve stimulation (SNS) via the InterStim device for treatment of women with refractory overactive bladder (OAB). METHODS: We searched MEDLINE, Embase, Web of Sci ... Full text Link to item Cite

Intraurethral activation of excitatory bladder reflexes in persons with spinal cord injury.

Journal Article Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference · December 1, 2009 Electrical activation of an excitatory reflex between sensory fibers in the pudendal nerve and the bladder has been demonstrated in cats and is a potential means of restoring micturition function in persons with spinal cord injury. We investigated the clin ... Cite

Cost-effectiveness of sacral neuromodulation versus intravesical botulinum A toxin for treatment of refractory urge incontinence.

Journal Article J Urol · December 2009 Featured Publication PURPOSE: We determined the cost-effectiveness of sacral neuromodulation vs intravesical botulinum toxin A for the treatment of refractory urge incontinence. MATERIALS AND METHODS: We developed a Markov decision model using a societal perspective to compare ... Full text Link to item Cite

Design of the Value of Urodynamic Evaluation (ValUE) trial: A non-inferiority randomized trial of preoperative urodynamic investigations.

Journal Article Contemp Clin Trials · November 2009 Featured Publication BACKGROUND AND PURPOSE: Urodynamic studies (UDS) are routinely obtained prior to surgery for stress urinary incontinence (SUI) despite a lack of evidence that UDS information has an actual impact on outcome. The primary aim of this non-inferiority randomiz ... Full text Link to item Cite

Outcome of a randomized, double-blind, placebo controlled trial of botulinum A toxin for refractory overactive bladder.

Journal Article J Urol · June 2009 Featured Publication PURPOSE: We determined the effectiveness of cystoscopic administration of botulinum-A toxin compared to placebo for the treatment of urinary incontinence in subjects with idiopathic overactive bladder. MATERIALS AND METHODS: Subjects were recruited from th ... Full text Link to item Cite

Cost-effectiveness of botulinum toxin a versus anticholinergic medications for idiopathic urge incontinence.

Journal Article J Urol · May 2009 Featured Publication PURPOSE: We assessed the cost-effectiveness of botulinum toxin A injection compared to anticholinergic medications for the treatment of idiopathic urge incontinence. MATERIALS AND METHODS: A Markov decision analysis model was developed to compare the costs ... Full text Link to item Cite

Early vs late midline sling lysis results in greater improvement in lower urinary tract symptoms.

Journal Article Am J Obstet Gynecol · May 2009 Featured Publication OBJECTIVE: Lower urinary tract symptoms (LUTS) occur in 5-20% of women after antiincontinence procedures. Symptoms include complete urinary retention or storage, voiding, and postmicturition symptoms. The goal of this study was to determine the effect of t ... Full text Link to item Cite

Outcomes following vaginal prolapse repair and mid urethral sling (OPUS) trial--design and methods.

Journal Article Clin Trials · April 2009 Featured Publication BACKGROUND: The primary aims of this trial are to determine whether the use of a concomitant prophylactic anti-incontinence procedure may prevent stress urinary incontinence symptom development in women undergoing vaginal prolapse surgery and to evaluate t ... Full text Link to item Cite

Intraurethral activation of excitatory bladder reflexes in persons with spinal cord injury.

Journal Article Annu Int Conf IEEE Eng Med Biol Soc · 2009 Featured Publication Electrical activation of an excitatory reflex between sensory fibers in the pudendal nerve and the bladder has been demonstrated in cats and is a potential means of restoring micturition function in persons with spinal cord injury. We investigated the clin ... Full text Link to item Cite

Complications of Vaginal Surgery

Journal Article · December 1, 2008 Featured Publication Full text Cite

Dorsal genital nerve stimulation for the treatment of overactive bladder symptoms.

Journal Article Neurourol Urodyn · 2008 Featured Publication AIM: To evaluate percutaneous placement of electrodes adjacent to the dorsal genital nerve (DGN) and measure the effects of electrical stimulation on symptoms of urge incontinence during 1 week of home use. METHODS: Prospective, multicenter study. Subjects ... Full text Link to item Cite

Bladder diary measurements in asymptomatic males: frequency, volume per void, and 24-hr volume.

Journal Article Neurourol Urodyn · 2008 Featured Publication AIMS: To collect bladder diary frequency and volume measurements from asymptomatic males and to use these data to develop clinical reference values. MATERIALS AND METHODS: Computer processed three-day bladder diaries were collected from 92 males (median ag ... Full text Link to item Cite

Detrusor overactivity does not predict outcome of sacral neuromodulation test stimulation.

Journal Article Int Urogynecol J Pelvic Floor Dysfunct · December 2007 Featured Publication The aim of this study is to determine if urodynamic findings in patients with urge incontinence predicts response to sacral neuromodulation test stimulation. One hundred four patients with refractory urinary urge incontinence who had undergone sacral neuro ... Full text Link to item Cite

Surgical excision of eroded mesh after prior abdominal sacrocolpopexy.

Journal Article Am J Obstet Gynecol · December 2007 Featured Publication OBJECTIVE: We previously described an endoscopic-assisted transvaginal mesh excision technique. This study compares surgical outcomes after transvaginal mesh excision vs endoscopic-assisted transvaginal mesh excision. In addition, we reviewed our postopera ... Full text Link to item Cite

Pelvic organ prolapse: a review of the current literature.

Journal Article Minerva Ginecol · December 2007 Featured Publication Pelvic organ prolapse has afflicted women since the beginning of mankind. Even though we have been faced with this problem for so many centuries, we still have not found a way to overcome gravity and prevent prolapse. We continue to make efforts to manage ... Link to item Cite

A randomized, controlled trial evaluating 2 techniques of postoperative bladder testing after transvaginal surgery.

Journal Article Am J Obstet Gynecol · December 2007 Featured Publication OBJECTIVE: The purpose of this pilot study was to compare the efficacy of 2 techniques for evaluating bladder function after transvaginal surgery. STUDY DESIGN: Subjects scheduled for transvaginal, outpatient surgery were consecutively enrolled and randomi ... Full text Link to item Cite

Current and future techniques of neuromodulation for bladder dysfunction

Journal Article Current Bladder Dysfunction Reports · December 1, 2007 Featured Publication Recent increase in the use of neuromodulation for the treatment of urinary urgency and frequency, urge incontinence, and nonobstructive urinary retention has coincided with an improved knowledge of micturition physiology and concurrent technologic advances ... Full text Cite

Current and future techniques of neuromodulation for bladder dysfunction.

Journal Article Curr Urol Rep · November 2007 Featured Publication Recent increase in the use of neuromodulation for the treatment of urinary urgency and frequency, urge incontinence, and nonobstructive urinary retention has coincided with improved knowledge of micturition physiology and concurrent technologic advances in ... Full text Link to item Cite

Lack of psychological resilience: an important correlate for urinary incontinence.

Journal Article Int Urogynecol J Pelvic Floor Dysfunct · October 2007 Featured Publication Our study evaluated medical conditions, level of physical functioning, and psychological health as correlates of urinary continence (UI) for four different age groups of women. Survey questions from the 1996 MIDUS survey were used in three domains of healt ... Full text Link to item Cite

Quality of life after surgery for genital prolapse in elderly women: obliterative and reconstructive surgery.

Journal Article Int Urogynecol J Pelvic Floor Dysfunct · July 2007 Featured Publication The objective of this study was to determine if obliterative and reconstructive vaginal surgery for advanced pelvic organ prolapse improve quality of life in elderly women. Women age 65 years or older with stage 3 or 4 pelvic organ prolapse who desired sur ... Full text Link to item Cite

A prospective assessment of overactive bladder symptoms in a cohort of elderly women who underwent transvaginal surgery for advanced pelvic organ prolapse.

Journal Article Am J Obstet Gynecol · July 2007 Featured Publication OBJECTIVE: The objective of this study was to evaluate the impact of transvaginal prolapse surgery on overactive bladder symptoms in elderly women. STUDY DESIGN: Women (> or = 65 years old) with stage III or IV prolapse who enrolled in a prospective study ... Full text Link to item Cite

Sexual dysfunction in women with polycystic ovary syndrome: The effects of testosterone, obesity, and depression

Journal Article Journal of Pelvic Medicine and Surgery · May 1, 2007 OBJECTIVES: We examine the relationship among sexual function, obesity, psychologic depression, and serum total (totT) and bioavailable (bioT) testosterone levels in a group of premenopausal women with polycystic ovary syndrome (PCOS). METHODS: Women with ... Full text Cite

The PESSRI study: symptom relief outcomes of a randomized crossover trial of the ring and Gellhorn pessaries.

Journal Article Am J Obstet Gynecol · April 2007 Featured Publication OBJECTIVE: The aim of this randomized crossover trial was to compare symptom relief and change in life impact for women using the ring with support and Gellhorn pessaries. STUDY DESIGN: Subjects were randomized to use each pessary for 3 months. Outcome dat ... Full text Link to item Cite

Overt rectal prolapse following repair of stage IV vaginal vault prolapse.

Journal Article Int Urogynecol J Pelvic Floor Dysfunct · April 2007 Pelvic organ prolapse is an increasingly common problem as women are living longer. With the growing numbers of surgeries performed to correct this problem, further research is needed to understand the long-term success as well as possible complications of ... Full text Link to item Cite

The utility of magnetic resonance imaging for diagnosis and surgical planning before transvaginal periurethral diverticulectomy in women.

Journal Article Int Urogynecol J Pelvic Floor Dysfunct · March 2007 Featured Publication The objective of this paper is to report the value of magnetic resonance imaging (MRI) in the evaluation of urethral diverticulum in women. Medical records were identified by a query of urethral diverticulectomy billing data from January 1, 2000 through De ... Full text Link to item Cite

Bladder diary patterns in detrusor overactivity and urodynamic stress incontinence.

Journal Article Neurourol Urodyn · 2007 Featured Publication AIMS: Our aims were: (1) to describe and compare frequency-volume and incontinence episode patterns in patients with urodynamic stress incontinence (USI) and detrusor overactivity (DO) as measured by a hand-written and computer-analyzed bladder diary and ( ... Full text Link to item Cite

Predicting implantation with a neuromodulator using two different test stimulation techniques: A prospective randomized study in urge incontinent women.

Journal Article Neurourol Urodyn · 2007 Featured Publication AIMS: The purpose of this study was to determine whether a percutaneous needle electrode (PNE) technique or a surgical first stage lead placement (FSLP) better predicted whether a patient would progress to implantation of a pulse generator (IPG) in older u ... Full text Link to item Cite

In patients undergoing neuromodulation for intractable urge incontinence a reduction in 24-hr pad weight after the initial test stimulation best predicts long-term patient satisfaction.

Journal Article Neurourol Urodyn · 2007 Featured Publication AIMS: To evaluate long-term patient satisfaction of sacral neuromodulation and to correlate satisfaction with incontinence parameters. METHODS: Patients at least 1-year remote from sacral neuromodulation were mailed a questionnaire to evaluate satisfaction ... Full text Link to item Cite

A statistical comparison of pad numbers versus pad weights in the quantification of urinary incontinence.

Journal Article Neurourol Urodyn · 2007 Featured Publication AIMS: Pad per day (PPD) usage is a frequently utilized measure of urinary incontinence. The 24-hour pad weight test (24PWT) is a reproducible test for quantifying incontinence volumes. We investigated whether PPD validly reports the magnitude of urinary in ... Full text Link to item Cite

Bladder diary measurements in asymptomatic females: functional bladder capacity, frequency, and 24-hr volume.

Journal Article Neurourol Urodyn · 2007 Featured Publication AIMS: To study the effects of age and 24-h volume (V(24)) on bladder diary measurements of voiding frequency (F(24)) and functional bladder capacity (FBC) from an asymptomatic female population. Also, to use these data to develop clinical reference values. ... Full text Link to item Cite

Normative bladder diary measurements: night versus day.

Journal Article Neurourol Urodyn · 2007 Featured Publication AIMS: To investigate bladder diary measurements from asymptomatic subjects in separate night and day periods, including their relationships to age and total volume voided. A major objective of this study was to generate age-adjusted reference values agains ... Full text Link to item Cite

Pudendal nerve stimulation evokes reflex bladder contractions in persons with chronic spinal cord injury.

Journal Article Neurourol Urodyn · 2007 Featured Publication AIMS: Although electrical stimulation of the pudendal nerve has been shown to evoke reflex micturition-like bladder contractions in both intact and spinalized cats, there is little evidence to suggest that an analogous excitatory reflex exists in humans, p ... Full text Link to item Cite

Dorsal genital nerve stimulation for the treatment of refractory overactive bladder symptoms

Conference NEUROUROLOGY AND URODYNAMICS · January 1, 2007 Featured Publication Link to item Cite

Bladder diary volume per void measurements in detrusor overactivity.

Journal Article J Urol · December 2006 Featured Publication PURPOSE: We investigated the clinical usefulness of adjusting reference volume per void values for a recently reported strong tendency for volume per void to increase with increasing 24-hour volume in asymptomatic individuals. Our approach was to 1) test w ... Full text Link to item Cite

Sensory nerve injury after uterosacral ligament suspension.

Journal Article Am J Obstet Gynecol · December 2006 Featured Publication OBJECTIVE: Uterosacral ligament suspension is a technique that is performed commonly to suspend the prolapsed vaginal apex. This case series describes our experience with the clinical evaluation and management of lower extremity sensory nerve symptoms afte ... Full text Link to item Cite

Diagnosis of Pelvic Organ Prolapse

Journal Article · December 1, 2006 Featured Publication Full text Cite

Obstruction after Burch colposuspension: a return to retropubic urethrolysis.

Journal Article Int Urogynecol J Pelvic Floor Dysfunct · September 2006 Featured Publication We compare our postoperative outcomes of a vaginal vs abdominal urethrolysis after an obstructed Burch colposuspension. We performed a retrospective review of all women who had undergone a Burch urethrolysis from 1997 through 2003. Data collected included ... Full text Link to item Cite

The current use of neuromodulation for bladder dysfunction.

Journal Article Minerva Ginecol · August 2006 Neuromodulation utilizes electrical stimulation to alter the function of an organ. Recent advances in technology and improved knowledge of micturition physiology have coincided with the growth of neuromodulation for the treatment of urinary urgency/frequen ... Link to item Cite

Sacral neuromodulation for the treatment of refractory urinary urge incontinence after stress incontinence surgery.

Journal Article Am J Obstet Gynecol · December 2005 Featured Publication OBJECTIVE: This study was undertaken to evaluate the response to sacral neuromodulation in women with refractory, nonobstructive urinary urge incontinence after stress incontinence surgery. STUDY DESIGN: We reviewed the medical records of women in whom sac ... Full text Link to item Cite

The 1-hour pad test is a valuable tool in the initial evaluation of women with urinary incontinence

Journal Article Journal of Pelvic Medicine and Surgery · November 25, 2005 Featured Publication Aim: The urinary pad weight test is an objective measure of severity of urine loss. The purpose of this study was an attempt to determine the correlation among the 1-hour pad weight test, number of pads used per day, reported magnitude of incontinence, 24- ... Full text Cite

Sacral neuromodulation for intractable urge incontinence: are there factors associated with cure?

Journal Article Urology · October 2005 Featured Publication OBJECTIVES: To determine the variables that affect the cure rate in patients with urge incontinence treated with sacral neuromodulation. METHODS: This prospective analysis of patients with refractory urinary urge incontinence who underwent placement of a n ... Full text Link to item Cite

Vascular anatomy of the presacral space: a fresh tissue cadaver dissection.

Journal Article Am J Obstet Gynecol · May 2005 Featured Publication OBJECTIVE: To assess variability in the vascular structures of the presacral space and to estimate the risk of injury because of blind suture placement during sacral colpopexy. STUDY DESIGN: Ten fresh frozen female cadavers were evaluated. Three 0-polyeste ... Full text Link to item Cite

Nocturnal polyuria in women with overactive bladder symptoms and nocturia.

Journal Article Am J Obstet Gynecol · May 2005 Featured Publication OBJECTIVE: This study was undertaken to determine the prevalence of nocturnal polyuria in women complaining of nocturia and overactive bladder (OAB) symptoms and to identify clinical and health characteristics associated with nocturnal polyuria. STUDY DESI ... Full text Link to item Cite

Abdominal sacral colpopexy with allograft fascia lata: one-year outcomes.

Journal Article Am J Obstet Gynecol · May 2005 Featured Publication OBJECTIVE: The purpose of this study was to assess 1-year outcomes of sacral colpopexy with the use of allograft fascia lata. STUDY DESIGN: Records of all subjects who underwent sacral colpopexy with allograft fascia lata from May 1, 2001, to April 30, 200 ... Full text Link to item Cite

Patient characteristics and management of dermal allograft extrusions.

Journal Article Int Urogynecol J Pelvic Floor Dysfunct · 2005 Featured Publication The objective of this study was to describe our rate of extrusion of dermal allograft material when used in anterior or posterior colporrhaphy and to review our success in treating extrusions with conservative management. A retrospective review of all subj ... Full text Link to item Cite

The effect of botulinum-A toxin on patients with severe urge urinary incontinence.

Journal Article J Urol · December 2004 Featured Publication PURPOSE: We determined the effect of 150 units of botulinum-A toxin (Botox, Allergan, Irvine, California) on subjects with severe urge urinary incontinence (UUI). MATERIALS AND METHODS: This was an open label uncontrolled clinical trial. Subjects were recr ... Full text Link to item Cite

Transvaginal endoscopic removal of eroded mesh after abdominal sacral colpopexy.

Journal Article Obstet Gynecol · May 2004 Featured Publication BACKGROUND: Abdominal sacral colpopexy with permanent mesh has become the preferred abdominal technique for correcting posthysterectomy vaginal vault prolapse. Although rare, mesh erosion after sacral colpopexy is often challenging to manage. We report on ... Full text Link to item Cite

Delayed presentation and successful repair of a recurrent vesicovaginal fistula after hysterectomy and primary abdominal repair.

Journal Article Int Urogynecol J Pelvic Floor Dysfunct · 2004 Featured Publication Urogenital fistulae are an uncommon consequence of gynecologic surgery. Vesicovaginal fistulae due to gynecologic surgery generally appear 1-6 weeks after surgery and recurrent fistulae within 3 months of their repair. The pathogenesis of vesicovaginal fis ... Full text Link to item Cite

Functional outcomes of primary and secondary repairs of vesicovaginal fistulae via vaginal cuff scar excision.

Journal Article Int Urogynecol J Pelvic Floor Dysfunct · 2004 Featured Publication Hospital and office charts of patients who underwent vaginal cuff scar excision for vesicovaginal fistula (VVF) repair from February 1998 to December 2002 at our institution were reviewed. Preoperative demographics and fistula characteristics were gathered ... Full text Link to item Cite

Urethral erosion after synthetic and nonsynthetic pubovaginal slings: differences in management and continence outcome.

Journal Article J Urol · July 2003 Featured Publication PURPOSE: We present a series of urethral erosion following a pubovaginal sling procedure due to synthetic and nonsynthetic materials and discuss their management and continence outcome. MATERIALS AND METHODS: During a 3-year period 57 patients underwent ur ... Full text Link to item Cite

Preoperative urodynamic evaluation may predict voiding dysfunction in women undergoing pubovaginal sling.

Journal Article J Urol · June 2003 Featured Publication PURPOSE: We determine which urodynamic parameters can best predict postoperative voiding dysfunction following pubovaginal sling surgery. MATERIALS AND METHODS: The records of 98 consecutive women who had undergone pubovaginal sling surgery with allograft ... Full text Link to item Cite

Anatomical correction of vaginal vault prolapse by uterosacral ligament fixation in women who also require a pubovaginal sling.

Journal Article J Urol · May 2003 Featured Publication PURPOSE: We describe the anatomical and functional outcome in patients who underwent vaginal vault fixation to the proximal uterosacral ligaments for the treatment of vault prolapse and who also required a concomitant pubovaginal sling for associated stres ... Full text Link to item Cite

Giant pelvic retroperitoneal leiomyoma arising from the rectal wall.

Journal Article Obstet Gynecol · May 2003 BACKGROUND: Pelvic retroperitoneal leiomyomas arising from the rectal wall are rare. We present a case of a giant retroperitoneal leiomyoma mimicking bilateral solid adnexal masses in a postmenopausal woman. CASE: A 54-year-old postmenopausal woman present ... Full text Link to item Cite

Sacral neuromodulation in an older, urge-incontinent population.

Journal Article Am J Obstet Gynecol · December 2002 Featured Publication OBJECTIVE: The success of sacral neuromodulation in the treatment of urge incontinence has been reported in young populations. Herein we report the success in an older, urge-incontinent population. STUDY DESIGN: A cohort of 25 patients older than 55 years ... Full text Link to item Cite

Long-term results of Ingelman-Sundberg denervation procedure for urge incontinence refractory to medical therapy.

Journal Article J Urol · September 2002 PURPOSE: Urge incontinence refractory to anticholinergic medication and behavioral techniques is a therapeutic challenge. We evaluated the durability of the modified Ingelman-Sundberg detrusor denervation procedure as minimally invasive surgical therapy fo ... Full text Link to item Cite

Functional success of vaginal-cuff excision as a technique for transvaginal repair of vesicovaginal fistulae after hysterectomy

Journal Article Journal of Pelvic Surgery · January 1, 2001 Objective To examine the surgical and functional success of complete vaginal-cuff excision for transvaginal repair of vesicovaginal fistulae. Material and Methods Thirty-four women with posthysterectomy vesicovaginal fistulae presented for repair. Surgical ... Cite

Outcome in 104 pubovaginal slings using freeze-dried allograft fascia lata from a single tissue bank.

Journal Article Urology · December 4, 2000 Featured Publication We describe our experience with the use of allograft fascia lata for the treatment of stress urinary incontinence. One hundred and four patients underwent allograft fascia lata pubovaginal slings. Preoperatively, all were evaluated by a detailed urogynecol ... Full text Link to item Cite

Bilateral uterosacral ligament vaginal vault suspension with site-specific endopelvic fascia defect repair for treatment of pelvic organ prolapse.

Journal Article Am J Obstet Gynecol · December 2000 Featured Publication OBJECTIVE: The anatomic and functional success of suspension of the vaginal cuff to the proximal uterosacral ligaments is described. STUDY DESIGN: Forty-six women underwent vaginal site-specific repair of endopelvic fascia defects with suspension of the va ... Full text Link to item Cite

Variations in strategy for the treatment of urethral obstruction after a pubovaginal sling procedure.

Journal Article J Urol · August 2000 Featured Publication PURPOSE: We evaluated the success of several techniques for treating urethral obstruction and erosion after a pubovaginal sling procedure. MATERIALS AND METHODS: Between April 1998 and June 1999, 32 women 33 to 79 years old (average age 62) who underwent a ... Link to item Cite

Bladder endometriosis: conservative management.

Journal Article J Urol · June 2000 PURPOSE: We evaluate the characteristics of women with bladder endometriosis successfully treated with hormonal therapy. MATERIALS AND METHODS: The records of 14 patients with a mean age of 48.7 years (range 26 to 71) diagnosed with bladder endometriosis o ... Full text Link to item Cite

Use of the martius labial fat pad as an adjunct in the management of urinary fistulae and urethral obstruction following antiincontinence procedures

Journal Article Journal of Pelvic Surgery · January 1, 2000 Conclusion: Transvaginal surgery involving a Martius rotational flap should be considered in reconstructive surgery for complications after urogynecologic surgery. Results: One patient developed a postoperative cellulitis. Two patients reported decreased s ... Cite

The incidence of uterovaginal prolapse after pubovaginal sling

Journal Article Journal of Pelvic Surgery · January 1, 2000 Conclusion: In neurologically intact women with a well-suspended uterus preoperatively, postoperative uterovaginal prolapse is not a significant complication after pubovaginal sling. Results: Pelvic examinations were performed on 24 of 28 patients. Uterine ... Cite

Do urinary symptoms correlate with urodynamic findings?

Journal Article J Urol · June 1999 Featured Publication PURPOSE: We determined whether urinary symptomatology correlates with video urodynamic findings. MATERIALS AND METHODS: A total of 115 women with complaints of urinary incontinence completed a 27-item questionnaire. Pelvic examination and video urodynamic ... Link to item Cite

Bladder neck competency at rest in women with incontinence.

Journal Article J Urol · February 1999 Featured Publication PURPOSE: We determine the presence of an open bladder neck during video urodynamic studies and relate that finding to the presence of stress urinary incontinence. MATERIALS AND METHODS: Patients presenting with urinary incontinence, voiding dysfunction or ... Link to item Cite

Management of female genitourinary fistulas: transvesical or transvaginal approach?

Journal Article J Urol · December 1998 Featured Publication PURPOSE: We reviewed 25 female genitourinary fistula repairs performed at our institution from 1993 to 1997. MATERIALS AND METHODS: Our series comprised 7 primary vesicovaginal, 6 recurrent vesicovaginal, 7 complex, 1 ureterovaginal and 4 urethrovaginal fi ... Full text Link to item Cite

Pelvic prolapse: diagnosing and treating cystoceles, rectoceles, and enteroceles.

Journal Article Medscape Womens Health · July 1998 The current generation of women is maintaining a healthier and more active lifestyle into an older age. Treatable conditions such as stress urinary incontinence and pelvic prolapse detract from this active lifestyle. In many cases, an improved quality of l ... Link to item Cite

Pelvic prolapse: diagnosing and treating uterine and vaginal vault prolapse.

Journal Article Medscape Womens Health · July 1998 Uterine prolapse is often associated with a concomitant rectocele, cystocele, and/or an enterocele. Moderate degrees of prolapse are often associated with a feeling of pelvic heaviness or fullness or low back pain. The symptoms usually worsen with exertion ... Link to item Cite

Our experience with pubovaginal slings in patients with stress urinary incontinence.

Journal Article J Urol · April 1998 PURPOSE: Pubovaginal slings successfully treat stress urinary incontinence in women with intrinsic sphincter deficiency. Because of its durability, it has been an attractive procedure in select patients with urethral hypermobility. We examine our experienc ... Link to item Cite

Transvaginal urethrolysis for urethral obstruction after anti-incontinence surgery.

Journal Article J Urol · April 1998 PURPOSE: Urethral obstruction following a stress incontinence procedure occurs in 5 to 20% of patients. We examine the success of transvaginal urethrolysis in resolving voiding dysfunction. MATERIALS AND METHODS: A retrospective chart review was performed ... Link to item Cite

The incidence of Helicobacter pylori in patients with interstitial cystitis.

Journal Article J Urol · March 1998 PURPOSE: The cause of interstitial cystitis is unknown. We evaluated the incidence of Helicobacter pylori antibodies in patients with interstitial cystitis to determine whether such infection may be a causative factor. MATERIALS AND METHODS: We obtained se ... Link to item Cite

A followup on transurethral collagen injection therapy for urinary incontinence.

Journal Article J Urol · January 1998 PURPOSE: Transurethral collagen injection therapy has been used successfully in treating stress urinary incontinence due to intrinsic sphincter deficiency since United States Food and Drug Administration approval in October 1993. MATERIALS AND METHODS: Tel ... Full text Link to item Cite

Ovarian abscess 15 months after vaginal hysterectomy. A case report.

Journal Article J Reprod Med · October 1997 BACKGROUND: Ovarian abscess is a primary infection of ovarian parenchyma. Since 1869, only 44 cases after vaginal hysterectomy have been reported in the medical literature. The pathophysiology of bacterial infection in these cases is different from the tra ... Link to item Cite

Treatment results using pubovaginal slings in patients with large cystoceles and stress incontinence.

Journal Article J Urol · August 1997 PURPOSE: We determined the efficacy of performing a pubovaginal sling concurrently with a formal cystocele repair in patients with grade III to IV cystoceles. MATERIALS AND METHODS: We studied 42 women with grade III to IV cystoceles diagnosed by physical ... Link to item Cite

Pelvic floor support in women with a gystocele

Journal Article Journal of Pelvic Surgery · January 1, 1997 Objectives It has been proposed that pelvic prolapse occurs because of failure of the levator ani muscles to function. To investigate this, we assessed the capability of the levator ani muscles to elevate the bladder base in women with a cystocele. Methods ... Cite

Pubovaginal fascial slings.

Journal Article Tech Urol · 1997 The first pubovaginal fascial sling was reported in 1907, however, until recently this procedure was rarely utilized except after other incontinence procedures had failed. Currently, a pubovaginal sling is indicated as the primary incontinence procedure if ... Link to item Cite

Modified Ingelman-Sundberg bladder denervation procedure for intractable urge incontinence.

Journal Article J Urol · November 1996 PURPOSE: We determined the efficacy of the modified Ingelman-Sundberg procedure in women with urge incontinence and intractable detrusor instability. MATERIALS AND METHODS: Women with urge incontinence and detrusor instability, in whom medical and behavior ... Link to item Cite

Videourodynamic studies.

Journal Article Urol Clin North Am · May 1996 Videourodynamic evaluation that incorporates radiographic imaging with simultaneous measurement of bladder and urethral pressure is the most precise method available for diagnosing complex incontinence and voiding disorders. In addition, videourodynamics h ... Full text Link to item Cite