Scholars@Duke
Angelique Boutzoukas

Angelique Boutzoukas

Assistant Professor of Pediatrics
Pediatrics, Infectious Diseases
300 W. Morgan Street, Suite 772, Durham, NC 27701

Selected Publications

Carbapenem-resistant Enterobacterales in solid organ transplant recipients.

Journal Article Am J Transplant · April 2025 Carbapenem-resistant Enterobacterales (CRE) are an important threat to the health of solid organ transplant recipients (SOTr); data comparing outcomes of SOTr with CRE to non-SOTr with CRE are lacking. A matched cohort study was performed within 2 prospect ... Full text Link to item Cite

Population Pharmacokinetics of Meropenem Across the Adult Lifespan.

Journal Article Clin Pharmacokinet · February 2025 BACKGROUND AND OBJECTIVE: We conducted an opportunistic pharmacokinetic study to evaluate the population pharmacokinetics of meropenem, an antimicrobial commonly used to treat Gram-negative infections in adults of different ages, including older adults, an ... Full text Link to item Cite

Predictors of Potentially Inappropriate Stimulant Prescribing Among Adults.

Journal Article Pharmacoepidemiol Drug Saf · January 2025 PURPOSE: Increases in adult stimulant prescribing pose a potential risk due to the higher prevalence of contraindicated conditions among this population. We sought to identify patient, provider, and visit characteristics predictive of potentially inappropr ... Full text Link to item Cite

Molecular epidemiology and clinical characterization of carbapenemase-producing Enterobacter spp. from an international cohort.

Journal Article J Infect Dis · December 12, 2024 BACKGROUND: Despite the global public health threat posed by carbapenem-resistant Enterobacter spp., clinical and molecular epidemiological studies on international isolates remain scarce. Historically, the taxonomy of Enterobacter has been challenging, li ... Full text Link to item Cite

Increased mortality in hospital- compared to community-onset carbapenem-resistant enterobacterales infections.

Journal Article J Antimicrob Chemother · November 4, 2024 BACKGROUND: The CDC reported a 35% increase in hospital-onset (HO) carbapenem-resistant Enterobacterales (CRE) infections during the COVID-19 pandemic. We evaluated patient outcomes following HO and community-onset (CO) CRE bloodstream infections (BSI). ME ... Full text Link to item Cite

Postdiscontinuation Antibiotic Exposure in Hospitalized Infants at Risk for Late-onset Sepsis in the Neonatal Intensive Care Unit.

Journal Article Pediatr Infect Dis J · October 1, 2024 BACKGROUND: In the neonatal intensive care unit, infants are at risk for late-onset sepsis. When blood cultures are negative, antibiotic stewardship efforts encourage stopping antibiotics, yet the duration of therapeutic exposure after the last dose is unk ... Full text Link to item Cite

Urinary Tract Infection Epidemiology in NICUs in the United States.

Journal Article Am J Perinatol · May 2024 OBJECTIVE: Our objective was to characterize the incidence, associated clinical factors, timing of infection, microbiology, and incidence of concordant blood culture of urinary tract infections (UTIs) in very low birth weight (VLBW <1,500g) infants. STUDY ... Full text Link to item Cite

Trends in Pediatric Emergency and Inpatient Healthcare Use for Mental and Behavioral Health Among North Carolinians During the Early COVID-19 Pandemic.

Journal Article J Pediatric Infect Dis Soc · December 26, 2023 BACKGROUND: Widespread school closures and health care avoidance during the COVID-19 pandemic led to disruptions in access to pediatric mental health care. METHODS: We conducted a retrospective study of emergency and inpatient administrative claims from pr ... Full text Link to item Cite

Leveraging School Infection Data to Address Community COVID-19 Data Gaps.

Journal Article J Pediatric Infect Dis Soc · December 26, 2023 BACKGROUND: At-home COVID-19 tests became available in the USA in April 2021 with widespread use by January 2022; however, the lack of infrastructure to report test results to public health agencies created a gap in public health data. Kindergarten through ... Full text Link to item Cite

School Absenteeism as a Marker for Community COVID-19 Rates.

Journal Article J Pediatric Infect Dis Soc · December 26, 2023 BACKGROUND: Reported community transmission rates of coronavirus disease 2019 (COVID-19) may not be accurate, particularly since at-home testing has become widely available. School absenteeism may serve as a marker of broader community COVID-19 transmissio ... Full text Link to item Cite

Impact of the COVID-19 Pandemic on Pediatric Preventive Health Care Among North Carolina Children Enrolled in Medicaid.

Journal Article Journal of the Pediatric Infectious Diseases Society · December 2023 BackgroundChildren enrolled in private insurance had reduced preventive health care during the coronavirus disease 2019 (COVID-19) pandemic. However, the impact of the pandemic on children enrolled in Medicaid has been minimally described.Meth ... Full text Cite

International Epidemiology of Carbapenemase-Producing Escherichia coli.

Journal Article Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · August 2023 BackgroundCarbapenemase-producing (CP) Escherichia coli (CP-Ec) are a global public health threat. We aimed to describe the clinical and molecular epidemiology and outcomes of patients from several countries with CP-Ec isolates obtained from a pro ... Full text Cite

In-Person Instruction and Educational Outcomes of K-8 Students During the COVID-19 Pandemic.

Journal Article Pediatrics · July 1, 2023 OBJECTIVES: Quantify the relationship between district policy permitting in-person instruction and educational outcomes during the 2020 to 2021 academic year for kindergarten through eighth grade students. METHODS: An ecological, repeated cross-sectional a ... Full text Link to item Cite

Defining Variability in Evaluation and Management of Children with Chronic Osteomyelitis.

Journal Article J Pediatric Infect Dis Soc · April 28, 2023 Pediatric chronic osteomyelitis is a rare, debilitating condition lacking management guidelines. In a national survey of 162 pediatric infectious disease physicians through the Emerging Infections Network, tremendous variability in diagnostic approaches an ... Full text Link to item Cite

SARS-CoV-2 Screening Testing Programs for Safe In-person Learning in K-12 Schools.

Journal Article J Pediatric Infect Dis Soc · February 27, 2023 BACKGROUND: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) screening testing is a recommended mitigation strategy for schools, although few descriptions of program implementation are available. METHODS: Kindergarten through 12th grade (K-12) ... Full text Link to item Cite

La Crosse Virus Neuroinvasive Disease in Children: A Contemporary Analysis of Clinical/Neurobehavioral Outcomes and Predictors of Disease Severity.

Journal Article Clin Infect Dis · February 8, 2023 BACKGROUND: La Crosse virus (LACV) is the most common neuroinvasive arboviral infection in children in the United States. However, data regarding predictors of disease severity and neurologic outcome are limited. Additionally, long-term neurologic and neur ... Full text Link to item Cite

Mechanisms to expedite pediatric clinical trial site activation: The DOSE trial experience.

Journal Article Contemp Clin Trials · February 2023 BACKGROUND: Timely trial start-up is a key determinant of trial success; however, delays during start-up are common and costly. Moreover, data on start-up metrics in pediatric clinical trials are sparse. To expedite trial start-up, the Trial Innovation Net ... Full text Link to item Cite

Test-to-Stay After SARS-CoV-2 Exposure: A Mitigation Strategy for Optionally Masked K-12 Schools.

Journal Article Pediatrics · November 1, 2022 OBJECTIVES: We evaluated the impact of a test-to-stay (TTS) program on within-school transmission and missed school days in optionally masked kindergarten through 12th grade schools during a period of high community severe acute respiratory syndrome corona ... Full text Open Access Link to item Cite

Improving Hepatitis B Vaccination Rates among At-risk Children and Adolescents with Inflammatory Bowel Disease

Journal Article Pediatric Quality and Safety · July 23, 2022 Introduction: Patients with inflammatory bowel disease (IBD) receiving tumor necrosis factor alpha inhibitors (TNFai) may be at higher risk for hepatitis B virus (HBV) infection. We conducted a quality improvement (QI) initiative to improve HBV vaccination ... Full text Cite

School Masking Policies and Secondary SARS-CoV-2 Transmission.

Journal Article Pediatrics · June 1, 2022 OBJECTIVES: Throughout the COVID-19 pandemic, masking has been a widely used mitigation practice in kindergarten through 12th grade (K-12) school districts to limit within-school transmission. Prior studies attempting to quantify the impact of masking have ... Full text Link to item Cite

Test-to-Stay After Exposure to SARS-CoV-2 in K-12 Schools.

Journal Article Pediatrics · May 1, 2022 OBJECTIVES: We evaluated the safety and efficacy of a test-to-stay program for unvaccinated students and staff who experienced an unmasked, in-school exposure to someone with confirmed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. ... Full text Open Access Link to item Cite

Secondary Transmission of COVID-19 in K-12 Schools: Findings From 2 States.

Journal Article Pediatrics · February 1, 2022 OBJECTIVES: We evaluated the impact of distancing practices on secondary transmission of severe acute respiratory syndrome coronavirus 2 and the degree of sports-associated secondary transmission across a large diverse cohort of schools during spring 2021. ... Full text Link to item Cite

Masking Adherence in K-12 Schools and SARS-CoV-2 Secondary Transmission.

Journal Article Pediatrics · February 1, 2022 OBJECTIVES: Masking is an essential coronavirus 2019 mitigation tool assisting in the safe return of kindergarten through 12th grade children and staff to in-person instruction; however, masking adherence, compliance evaluation methods, and potential conse ... Full text Link to item Cite

Building a National Framework to Pair Scientists and Schools During a Global Pandemic.

Journal Article Pediatrics · February 1, 2022 The coronavirus disease 2019 (COVID-19) pandemic forced the suspension of in-person education in schools serving students in kindergarten through 12th grade (K-12) across the United States. As time passed, teachers, students, and parents struggled with rem ... Full text Link to item Cite

Quarantine Elimination for K-12 Students With Mask-on-Mask Exposure to SARS-CoV-2.

Journal Article Pediatrics · February 1, 2022 OBJECTIVES: With layered mitigation strategies, there are low rates of secondary transmission of severe acute respiratory syndrome coronavirus 2; therefore, quarantine after close-contact exposure to severe acute respiratory syndrome coronavirus 2 in the k ... Full text Link to item Cite

A School-Based SARS-CoV-2 Testing Program: Testing Uptake and Quarantine Length After In-School Exposures.

Journal Article Pediatrics · February 2022 ObjectivesSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-related quarantines, which are required after close contact with infected individuals, have substantially disrupted in-person education for kindergarten through 12th grade (K-1 ... Full text Open Access Cite

School Safety, Masking, and the Delta Variant.

Journal Article Pediatrics · October 8, 2021 Full text Link to item Cite

Community SARS-CoV-2 Surge and Within-School Transmission.

Journal Article Pediatrics · October 2021 OBJECTIVES: When the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic began, experts raised concerns about in-person instruction in the setting of high levels of community transmission. We describe secondary transmission of SARS-CoV-2 ... Full text Link to item Cite

Antibiotic Safety and Effectiveness in Premature Infants With Complicated Intraabdominal Infections.

Journal Article Pediatr Infect Dis J · June 1, 2021 BACKGROUND: In premature infants, complicated intraabdominal infections (cIAIs) are a leading cause of morbidity and mortality. Although universally prescribed, the safety and effectiveness of commonly used antibiotic regimens have not been established in ... Full text Link to item Cite

Disseminated Toxoplasmosis in a Child Following Allogeneic Hematopoietic Cell Transplantation.

Journal Article J Pediatric Infect Dis Soc · May 28, 2021 A 23-month old female with hypoplastic myelodysplastic syndrome underwent allogenic hematopoietic cell transplantation (HCT), complicated by development of acute exotropia. Bilateral chorioretinal scars and a ring enhancing brain lesion were identified in ... Full text Link to item Cite

Incidence and Secondary Transmission of SARS-CoV-2 Infections in Schools.

Journal Article Pediatrics · April 2021 BackgroundIn an effort to mitigate the spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), North Carolina closed prekindergarten through grade 12 public schools to in-person instruction on March 14, 2020. On July 15, 2020, Nort ... Full text Cite

Impact of COVID-19-related School Closures on the Drivers of Child Health.

Journal Article N C Med J · 2021 The COVID-19 pandemic resulted in large-scale school closures in an effort to reduce the spread of disease. This article reviews the potential impact of COVID-19-related school closures on the health of children in North Carolina, with particular attention ... Full text Link to item Cite

Increasing Adherence to Acute Otitis Media Treatment Duration Guidelines using a Quality Improvement Approach.

Journal Article Pediatr Qual Saf · 2021 UNLABELLED: This quality improvement initiative aimed to improve American Academy of Pediatrics acute otitis media (AOM) guideline adherence in pediatric urgent care sites by increasing the percentage of patients 2 years and older with AOM who received a s ... Full text Link to item Cite

Temporal lobe epilepsy affects spatial organization of entorhinal cortex connectivity.

Journal Article Epilepsy Behav · November 2018 Evidence for structural connectivity patterns within the medial temporal lobe derives primarily from postmortem histological studies. In humans and nonhuman primates, the parahippocampal gyrus (PHg) is subdivided into parahippocampal (PHc) and perirhinal ( ... Full text Link to item Cite

Test-retest reliability of high angular resolution diffusion imaging acquisition within medial temporal lobe connections assessed via tract based spatial statistics, probabilistic tractography and a novel graph theory metric.

Journal Article Brain Imaging Behav · June 2016 This study examined the reliability of high angular resolution diffusion tensor imaging (HARDI) data collected on a single individual across several sessions using the same scanner. HARDI data was acquired for one healthy adult male at the same time of day ... Full text Link to item Cite

High-field magnetic resonance imaging of the human temporal lobe.

Journal Article Neuroimage Clin · 2015 BACKGROUND: Emerging high-field diffusion weighted MR imaging protocols, along with tractography, can elucidate microstructural changes associated with brain disease at the sub-millimeter image resolution. Epilepsy and other neurological disorders are acco ... Full text Link to item Cite

Methodological issues in clinical drug development for essential tremor

Journal Article Tremor and Other Hyperkinetic Movements · January 1, 2012 Essential tremor (ET) is one of the most common tremor disorders in the world. Despite this, only two medications have received Level A recommendations from the American Academy of Neurology to treat it (primidone and propranolol). Even though these medica ... Full text Cite