Scholars@Duke
Daniel P. Barboriak

Daniel P. Barboriak

Professor of Radiology
Radiology, Neuroradiology
barbo013@mc.duke.edu
Box 3808 Med Ctr, Durham, NC 27710
1527 Hosp North, Durham, NC 27710

Selected Publications

Assessing the Performance of Artificial Intelligence Models: Insights from the American Society of Functional Neuroradiology Artificial Intelligence Competition.

Journal Article AJNR Am J Neuroradiol · September 9, 2024 BACKGROUND AND PURPOSE: Artificial intelligence models in radiology are frequently developed and validated using data sets from a single institution and are rarely tested on independent, external data sets, raising questions about their generalizability an ... Full text Link to item Cite

Ethical Considerations and Fairness in the Use of Artificial Intelligence for Neuroradiology.

Journal Article AJNR Am J Neuroradiol · November 2023 In this review, concepts of algorithmic bias and fairness are defined qualitatively and mathematically. Illustrative examples are given of what can go wrong when unintended bias or unfairness in algorithmic development occurs. The importance of explainabil ... Full text Link to item Cite

Early post-bevacizumab change in rCBV from DSC-MRI identifies pseudoresponse in recurrent glioblastoma: Results from ACRIN 6677/RTOG 0625.

Journal Article Front Oncol · 2023 BACKGROUND: Progressive enhancement predicted poor survival in ACRIN 6677/RTOG 0625, a multi-center trial of bevacizumab with irinotecan or temozolomide in recurrent glioblastoma, but pseudoresponse likely limited enhancement-based survival prognostication ... Full text Link to item Cite

Repeatability of Automated Image Segmentation with BraTumIA in Patients with Recurrent Glioblastoma.

Journal Article AJNR Am J Neuroradiol · June 2021 BACKGROUND AND PURPOSE: Despite high interest in machine-learning algorithms for automated segmentation of MRIs of patients with brain tumors, there are few reports on the variability of segmentation results. The purpose of this study was to obtain benchma ... Full text Link to item Cite

Value of dynamic contrast perfusion MRI to predict early response to bevacizumab in newly diagnosed glioblastoma: results from ACRIN 6686 multicenter trial.

Journal Article Neuro Oncol · February 25, 2021 BACKGROUND: In Radiation Therapy Oncology Group (RTOG) 0825, a phase III trial of standard therapy with bevacizumab or without (placebo) in newly diagnosed glioblastoma, 44 patients underwent dynamic contrast enhanced (DCE) and/or dynamic susceptibility co ... Full text Link to item Cite

Response to Letter to Editor.

Journal Article Neuro Oncol · November 26, 2020 Full text Link to item Cite

Consensus recommendations for a dynamic susceptibility contrast MRI protocol for use in high-grade gliomas.

Journal Article Neuro Oncol · September 29, 2020 Despite the widespread clinical use of dynamic susceptibility contrast (DSC) MRI, DSC-MRI methodology has not been standardized, hindering its utilization for response assessment in multicenter trials. Recently, the DSC-MRI Standardization Subcommittee of ... Full text Link to item Cite

Artificial Intelligence in Neuroradiology: Current Status and Future Directions.

Journal Article AJNR Am J Neuroradiol · August 2020 Fueled by new techniques, computational tools, and broader availability of imaging data, artificial intelligence has the potential to transform the practice of neuroradiology. The recent exponential increase in publications related to artificial intelligen ... Full text Link to item Cite

Consensus recommendations for a standardized brain tumor imaging protocol for clinical trials in brain metastases.

Journal Article Neuro Oncol · June 9, 2020 A recent meeting was held on March 22, 2019, among the FDA, clinical scientists, pharmaceutical and biotech companies, clinical trials cooperative groups, and patient advocacy groups to discuss challenges and potential solutions for increasing development ... Full text Link to item Cite

Quantitative Delta T1 (dT1) as a Replacement for Adjudicated Central Reader Analysis of Contrast-Enhancing Tumor Burden: A Subanalysis of the American College of Radiology Imaging Network 6677/Radiation Therapy Oncology Group 0625 Multicenter Brain Tumor Trial.

Journal Article AJNR Am J Neuroradiol · July 2019 BACKGROUND AND PURPOSE: Brain tumor clinical trials requiring solid tumor assessment typically rely on the 2D manual delineation of enhancing tumors by ≥2 expert readers, a time-consuming step with poor interreader agreement. As a solution, we developed qu ... Full text Link to item Cite

Interreader Variability of Dynamic Contrast-enhanced MRI of Recurrent Glioblastoma: The Multicenter ACRIN 6677/RTOG 0625 Study.

Journal Article Radiology · February 2019 Purpose To evaluate factors contributing to interreader variation (IRV) in parameters measured at dynamic contrast material-enhanced (DCE) MRI in patients with glioblastoma who were participating in a multicenter trial. Materials and Methods A total of 18 ... Full text Link to item Cite

Publisher Correction: A Multi-Institutional Comparison of Dynamic Contrast-Enhanced Magnetic Resonance Imaging Parameter Calculations (Scientific Reports (2017) DOI: 10.1038/s41598-017-11554-w)

Journal Article Scientific Reports · December 1, 2018 The original version of this Article incorrectly listed the authors individually rather than as part of the Joint Head and Neck Radiotherapy-MRI Development Cooperative. This error has now been corrected in the PDF and HTML version of the Article. ... Full text Cite

Prognostic value of contrast enhancement and FLAIR for survival in newly diagnosed glioblastoma treated with and without bevacizumab: results from ACRIN 6686.

Journal Article Neuro Oncol · September 3, 2018 BACKGROUND: ACRIN 6686/RTOG 0825 was a phase III trial of conventional chemoradiation plus adjuvant temozolomide with bevacizumab or without (placebo) in newly diagnosed glioblastoma. This study investigated whether changes in contrast-enhancing and fluid ... Full text Link to item Cite

Erratum: Dynamic contrast-enhanced magnetic resonance imaging for head and neck cancers

Journal Article Scientific Data · March 20, 2018 Scientific Data 5:18008 doi: 10.1038/sdata.2018.8 (2018); Published 13 Feb 2018; Updated 20 March 2018. An additional word was erroneously inserted into the abstract of this Data Descriptor during typesetting. This has now been corrected in the HTM ... Full text Cite

Dynamic contrast-enhanced magnetic resonance imaging for head and neck cancers.

Journal Article Sci Data · February 13, 2018 Dynamic myraidpro contrast-enhanced magnetic resonance imaging (DCE-MRI) has been correlated with prognosis in head and neck squamous cell carcinoma as well as with changes in normal tissues. These studies implement different software, either commercial or ... Full text Link to item Cite

ACRIN 6684: Multicenter, phase II assessment of tumor hypoxia in newly diagnosed glioblastoma using magnetic resonance spectroscopy.

Journal Article PLoS One · 2018 A multi-center imaging trial by the American College of Radiology Imaging Network (ACRIN) "A Multicenter, phase II assessment of tumor hypoxia in glioblastoma using 18F Fluoromisonidazole (FMISO) with PET and MRI (ACRIN 6684)", was conducted to assess hypo ... Full text Link to item Cite

A Multi-Institutional Comparison of Dynamic Contrast-Enhanced Magnetic Resonance Imaging Parameter Calculations.

Journal Article Sci Rep · September 11, 2017 Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) provides quantitative metrics (e.g. Ktrans, ve) via pharmacokinetic models. We tested inter-algorithm variability in these quantitative metrics with 11 published DCE-MRI algorithms, all impleme ... Full text Link to item Cite

ACRIN 6684: Assessment of Tumor Hypoxia in Newly Diagnosed Glioblastoma Using 18F-FMISO PET and MRI.

Journal Article Clin Cancer Res · October 15, 2016 PURPOSE: Structural and functional alterations in tumor vasculature are thought to contribute to tumor hypoxia which is a primary driver of malignancy through its negative impact on the efficacy of radiation, immune surveillance, apoptosis, genomic stabili ... Full text Link to item Cite

Statistical Issues in Testing Conformance with the Quantitative Imaging Biomarker Alliance (QIBA) Profile Claims.

Journal Article Acad Radiol · April 2016 A major initiative of the Quantitative Imaging Biomarker Alliance is to develop standards-based documents called "Profiles," which describe one or more technical performance claims for a given imaging modality. The term "actor" denotes any entity (device, ... Full text Open Access Link to item Cite

Metrology Standards for Quantitative Imaging Biomarkers.

Journal Article Radiology · December 2015 Although investigators in the imaging community have been active in developing and evaluating quantitative imaging biomarkers (QIBs), the development and implementation of QIBs have been hampered by the inconsistent or incorrect use of terminology or metho ... Full text Open Access Link to item Cite

Repeatability of Standardized and Normalized Relative CBV in Patients with Newly Diagnosed Glioblastoma.

Journal Article AJNR Am J Neuroradiol · September 2015 BACKGROUND AND PURPOSE: For more widespread clinical use advanced imaging methods such as relative cerebral blood volume must be both accurate and repeatable. The aim of this study was to determine the repeatability of relative CBV measurements in newly di ... Full text Link to item Cite

Consensus recommendations for a standardized Brain Tumor Imaging Protocol in clinical trials.

Journal Article Neuro Oncol · September 2015 A recent joint meeting was held on January 30, 2014, with the US Food and Drug Administration (FDA), National Cancer Institute (NCI), clinical scientists, imaging experts, pharmaceutical and biotech companies, clinical trials cooperative groups, and patien ... Full text Link to item Cite

Dynamic susceptibility contrast MRI measures of relative cerebral blood volume as a prognostic marker for overall survival in recurrent glioblastoma: results from the ACRIN 6677/RTOG 0625 multicenter trial.

Journal Article Neuro Oncol · August 2015 BACKGROUND: The study goal was to determine whether changes in relative cerebral blood volume (rCBV) derived from dynamic susceptibility contrast (DSC) MRI are predictive of overall survival (OS) in patients with recurrent glioblastoma multiforme (GBM) whe ... Full text Link to item Cite

Response assessment criteria for brain metastases: proposal from the RANO group.

Journal Article Lancet Oncol · June 2015 CNS metastases are the most common cause of malignant brain tumours in adults. Historically, patients with brain metastases have been excluded from most clinical trials, but their inclusion is now becoming more common. The medical literature is difficult t ... Full text Link to item Cite

Diffusion MRI quality control and functional diffusion map results in ACRIN 6677/RTOG 0625: a multicenter, randomized, phase II trial of bevacizumab and chemotherapy in recurrent glioblastoma.

Journal Article Int J Oncol · May 2015 Functional diffusion mapping (fDM) is a cancer imaging technique that quantifies voxelwise changes in apparent diffusion coefficient (ADC). Previous studies have shown value of fDMs in bevacizumab therapy for recurrent glioblastoma multiforme (GBM). The ai ... Full text Link to item Cite

Quantitative imaging biomarkers: a review of statistical methods for computer algorithm comparisons.

Journal Article Stat Methods Med Res · February 2015 Quantitative biomarkers from medical images are becoming important tools for clinical diagnosis, staging, monitoring, treatment planning, and development of new therapies. While there is a rich history of the development of quantitative imaging biomarker ( ... Full text Link to item Cite

Repeatability of quantitative metrics derived from MR diffusion tractography in paediatric patients with epilepsy.

Journal Article Br J Radiol · May 2014 OBJECTIVE: To quantify the test-retest repeatability of mean diffusivity (MD) and fractional anisotropy (FA) derived from diffusion tensor imaging (DTI) tractography in a cohort of paediatric patients with localization-related epilepsy. METHODS: 30 patient ... Full text Link to item Cite

A fully automatic extraction of magnetic resonance image features in glioblastoma patients.

Journal Article Med Phys · April 2014 PURPOSE: Glioblastoma is the most common malignant brain tumor. It is characterized by low median survival time and high survival variability. Survival prognosis for glioblastoma is very important for optimized treatment planning. Imaging features observed ... Full text Link to item Cite

Magnetic resonance spectroscopy as an early indicator of response to anti-angiogenic therapy in patients with recurrent glioblastoma: RTOG 0625/ACRIN 6677.

Journal Article Neuro Oncol · July 2013 BACKGROUND: The prognosis for patients with recurrent glioblastoma remains poor. The purpose of this study was to assess the potential role of MR spectroscopy as an early indicator of response to anti-angiogenic therapy. METHODS: Thirteen patients with rec ... Full text Link to item Cite

Early post-bevacizumab progression on contrast-enhanced MRI as a prognostic marker for overall survival in recurrent glioblastoma: results from the ACRIN 6677/RTOG 0625 Central Reader Study.

Journal Article Neuro Oncol · July 2013 BACKGROUND: RTOG 0625/ACRIN 6677 is a multicenter, randomized, phase II trial of bevacizumab with irinotecan or temozolomide in recurrent glioblastoma (GBM). This study investigated whether early posttreatment progression on FLAIR or postcontrast MRI asses ... Full text Link to item Cite

Gliosarcoma metastatic to the leptomeninges and dura.

Journal Article J Neuroimaging · April 2013 We describe a rare case of a patient with left frontotemporal gliosarcoma, which metastasized through the cerebrospinal fluid (CSF) to the leptomeninges and pachymeninges. Pathologically confirmed, magnetic resonance imaging-visible leptomeningeal spread o ... Full text Link to item Cite

Apparent diffusion coefficient histogram analysis stratifies progression-free and overall survival in patients with recurrent GBM treated with bevacizumab: a multi-center study.

Journal Article J Neurooncol · July 2012 We have tested the predictive value of apparent diffusion coefficient (ADC) histogram analysis in stratifying progression-free survival (PFS) and overall survival (OS) in bevacizumab-treated patients with recurrent glioblastoma multiforme (GBM) from the mu ... Full text Link to item Cite

A change in the apparent diffusion coefficient after treatment with bevacizumab is associated with decreased survival in patients with recurrent glioblastoma multiforme.

Journal Article Br J Radiol · April 2012 OBJECTIVES: The aim of this study was to determine the prognostic significance of changes in parameters derived from diffusion tensor imaging (DTI) that occur in response to treatment with bevacizumab and irinotecan in patients with recurrent glioblastoma ... Full text Link to item Cite

Dynamic contrast-enhanced MRI in head-and-neck cancer: the impact of region of interest selection on the intra- and interpatient variability of pharmacokinetic parameters.

Journal Article Int J Radiat Oncol Biol Phys · March 1, 2012 PURPOSE: Dynamic contrast-enhanced (DCE) MRI-extracted parameters measure tumor microvascular physiology and are usually calculated from an intratumor region of interest (ROI). Optimal ROI delineation is not established. The valid clinical use of DCE-MRI r ... Full text Link to item Cite

Colocalization of gadolinium-diethylene triamine pentaacetic acid with high-molecular-weight molecules after intracerebral convection-enhanced delivery in humans.

Journal Article Neurosurgery · September 2011 BACKGROUND: Convection-enhanced delivery (CED) permits site-specific therapeutic drug delivery within interstitial spaces at increased dosages through circumvention of the blood-brain barrier. CED is currently limited by suboptimal methodologies for monito ... Full text Link to item Cite

Prognostic significance of parameters derived from co-registered 18F-fluorodeoxyglucose PET and contrast-enhanced MRI in patients with high-grade glioma.

Journal Article Br J Radiol · April 2011 OBJECTIVE: The aim of this study was to determine the prognostic significance of the volume and intensity of abnormal (18)F-fluorodeoxyglucose positron emission tomography (FDG-PET) accumulation within areas of contrast enhancement on post-therapeutic volu ... Full text Link to item Cite

Noncompartmental kinetic analysis of DCE-MRI data from malignant tumors: Application to glioblastoma treated with bevacizumab.

Journal Article Magn Reson Med · August 2010 Dynamic contrast enhanced MRI contrast agent kinetics in malignant tumors are typically complex, requiring multicompartment tumor models for adequate description. For consistent comparisons among tumors or among successive studies of the same tumor, we pro ... Full text Link to item Cite

Dynamic contrast enhanced-MRI in head and neck cancer patients: Variability of the precontrast longitudinal relaxation time (T10).

Journal Article Med Phys · June 2010 PURPOSE: Calculation of the precontrast longitudinal relaxation times (T10) is an integral part of the Tofts-based pharmacokinetic (PK) analysis of dynamic contrast enhanced-magnetic resonance images. The purpose of this study was to investigate the interp ... Full text Link to item Cite

An automated method for nonparametric kinetic analysis of clinical DCE-MRI data: application to glioblastoma treated with bevacizumab.

Journal Article Magn Reson Med · May 2010 Here, we describe an automated nonparametric method for evaluating gadolinium-diethylene triamine pentaacetic acid (Gd-DTPA) kinetics, based on dynamic contrast-enhanced-MRI scans of glioblastoma patients taken before and after treatment with bevacizumab; ... Full text Link to item Cite

Trichothiodystrophy with dysmyelination and central osteosclerosis.

Journal Article AJNR Am J Neuroradiol · January 2010 Trichothiodystrophy (TTD) is a rare group of autosomal recessive disorders of DNA repair unified by the presence of sulfur-deficient brittle hair. We report a 3-year-old boy with classic clinical features of TTD, including ichthyosis, alopecia, development ... Full text Link to item Cite

Applications of the repeatability of quantitative imaging biomarkers: a review of statistical analysis of repeat data sets.

Journal Article Transl Oncol · December 2009 Repeat imaging data sets performed on patients with cancer are becoming publicly available. The potential utility of these data sets for addressing important questions in imaging biomarker development is vast. In particular, these data sets may be useful t ... Full text Link to item Cite

Quantitative imaging to assess tumor response to therapy: common themes of measurement, truth data, and error sources.

Journal Article Transl Oncol · December 2009 RATIONALE: Early detection of tumor response to therapy is a key goal. Finding measurement algorithms capable of early detection of tumor response could individualize therapy treatment as well as reduce the cost of bringing new drugs to market. On an indiv ... Full text Link to item Cite

Magnetic resonance assessment of response to therapy: tumor change measurement, truth data and error sources.

Journal Article Transl Oncol · December 2009 This article describes methods and issues that are specific to the assessment of change in tumor characteristics as measured using quantitative magnetic resonance (MR) techniques and how this relates to the establishment of quantitative MR imaging (MRI) bi ... Full text Link to item Cite

Synchronous Chemoradiation and Multiple Targeted Drugs for Advanced Head and Neck Cancer

Conference International Journal of Radiation Oncology*Biology*Physics · November 2009 Full text Cite

Ruptured maxillary retention cyst: cause of unilateral rhinorrhea after trauma.

Journal Article AJNR Am J Neuroradiol · June 2009 This study describes a case of a patient with traumatic rupture of a maxillary sinus retention cyst, which had an interesting clinical presentation of unilateral rhinorrhea, mimicking a CSF leak. The diagnosis was made fortuitously by comparison of a postt ... Full text Link to item Cite

Prognostic significance of early changes in the apparent diffusion coefficient that occurs after treatment of patients with glioblastoma multiforme with bevacizumab.

Journal Article J Clin Oncol · May 20, 2009 2058 Background: To determine the prognostic significance of changes in parameters derived from diffusion tensor imaging (DTI) that occur in response to combination chemotherapy with the antiangiogenesis agent bevacizumab (BEV) in patients with recurrent g ... Link to item Cite

Fundamentals of quantitative dynamic contrast-enhanced MR imaging.

Journal Article Magn Reson Imaging Clin N Am · May 2009 Featured Publication Quantitative analysis of dynamic contrast-enhanced MR imaging (DCE-MR imaging) has the power to provide information regarding physiologic characteristics of the microvasculature and is, therefore, of great potential value to the practice of oncology. In pa ... Full text Link to item Cite

Repeatability of quantitative parameters derived from diffusion tensor imaging in patients with glioblastoma multiforme.

Journal Article J Magn Reson Imaging · May 2009 Featured Publication PURPOSE: To quantify the repeatability of apparent diffusion coefficient (ADC) and fractional anisotropy (FA) in patients with glioblastoma multiforme. MATERIALS AND METHODS: IRB approval and informed consent were obtained for this Health Insurance Portabi ... Full text Link to item Cite

The Reference Image Database to Evaluate Response to therapy in lung cancer (RIDER) project: a resource for the development of change-analysis software.

Journal Article Clin Pharmacol Ther · October 2008 Critical to the clinical evaluation of effective novel therapies for lung cancer is the early and accurate determination of tumor response, which requires an understanding of the sources of uncertainty in tumor measurement and subsequent attempts to minimi ... Full text Link to item Cite

Comparison of three physiologically-based pharmacokinetic models for the prediction of contrast agent distribution measured by dynamic MR imaging.

Journal Article J Magn Reson Imaging · June 2008 Featured Publication PURPOSE: To compare the performance of three physiologically-based pharmacokinetic (PBPK) models for predicting gadolinium contrast agent concentration-time curves (Gd-CTCs) obtained in superior sagittal sinus (SSS), cerebral cortex, and psoas muscle. MATE ... Full text Link to item Cite

Hippocampal MRI signal hyperintensity after febrile status epilepticus is predictive of subsequent mesial temporal sclerosis.

Journal Article AJR Am J Roentgenol · April 2008 OBJECTIVE: The objective of our study was to test the hypothesis that the finding of hyperintense hippocampal signal intensity on T2-weighted MR images soon after febrile status epilepticus is associated with subsequent hippocampal volume loss and persiste ... Full text Link to item Cite

SU‐GG‐J‐181: The Role of Voxel‐Based T10 Calculations in Determining Correct Pharmacokinetic Parameters for Head and Neck Tumors

Conference Medical Physics · January 1, 2008 Purpose: To determine the optimal flip angle combination (oFAc) that generates voxel‐based T10 values, the median T10 for primary and nodes [formula omitted], and its implications on vascular permeability (PERM) and extracellular volume fraction (EVF) in H ... Full text Cite

Gain in signal-to-noise for first-pass contrast-enhanced abdominal MR angiography at 3 Tesla over standard 1.5 Tesla: prediction with a computer model.

Journal Article Acad Radiol · July 2007 RATIONALE AND OBJECTIVES: To estimate the gain in signal-to-noise ratio (SNR) in first-pass contrast-enhanced (CE) abdominal magnetic resonance angiography (MRA) at 3.0 T compared with 1.5 T. MATERIALS AND METHODS: Three protocols were simulated using six ... Full text Link to item Cite

TH‐E‐M100J‐02: Potential of Dynamic Contrast Enhanced‐Magnetic Resonance Imaging (DCE‐MRI) Extracted Parameters to Estimate Treatment Response in Locally Advanced Head and Neck (LAHN) Cancer Patients

Conference Medical Physics · January 1, 2007 Purpose: To evaluate the use of DCE‐MRI to measure changes in tumor physiology in LAHN cancer patients receiving TT and cisplatin based concurrent chemoradiation (ChemoRT). Material and Methods: Eligible patients with LAHN were enrolled on an IRB approved ... Full text Cite

Chemodosimetry of in vivo tumor liposomal drug concentration using MRI.

Journal Article Magn Reson Med · November 2006 Featured Publication Effective cancer chemotherapy depends on the delivery of therapeutic drugs to cancer cells at cytotoxic concentrations. However, physiologic barriers, such as variable vessel permeability, high interstitial fluid pressure, and heterogeneous perfusion, make ... Full text Link to item Cite

Diffusion-weighted and perfusion MR imaging for brain tumor characterization and assessment of treatment response.

Journal Article Radiology · June 2006 Featured Publication Diffusion-weighted magnetic resonance (MR) imaging and perfusion MR imaging are advanced techniques that provide information not available from conventional MR imaging. In particular, these techniques have a number of applications with regard to characteri ... Full text Link to item Cite

Creation of DICOM--aware applications using ImageJ.

Journal Article J Digit Imaging · June 2005 Featured Publication The demand for image-processing software for radiology applications has been increasing, fueled by advancements in both image-acquisition and image-analysis techniques. The utility of existing image-processing software is often limited by cost, lack of fle ... Full text Link to item Cite

Dosimetry and radiographic analysis of 131I-labeled anti-tenascin 81C6 murine monoclonal antibody in newly diagnosed patients with malignant gliomas: a phase II study.

Journal Article J Nucl Med · June 2005 UNLABELLED: The objective was to perform dosimetry and evaluate dose-response relationships in newly diagnosed patients with malignant brain tumors treated with direct injections of (131)I-labeled anti-tenascin murine 81C6 monoclonal antibody (mAb) into su ... Link to item Cite

Association of internal carotid artery injury with carotid canal fractures in patients with head trauma.

Journal Article AJR Am J Roentgenol · May 2005 OBJECTIVE: The purpose of our study was to determine the degree to which carotid canal fracture and other CT findings are associated with internal carotid artery (ICA) injury in patients with head trauma. MATERIALS AND METHODS: Three neuroradiologists retr ... Full text Link to item Cite

Assessment of apparent diffusion coefficient in normal and degenerated intervertebral lumbar disks: initial experience.

Journal Article Radiology · May 2005 PURPOSE: To determine prospectively the diffusibility of water in normal lumbar disks in adults by using the mean apparent diffusion coefficient (ADC) and to determine if a relationship exists between disk ADC and magnetic resonance (MR) findings of disk d ... Full text Link to item Cite

A lethal association of congenital apnea with brainstem tegmental necrosis.

Journal Article Pediatr Neurol · March 2004 We present a female with premature birth, polyhydramnios, congenital apnea, cranial nerve palsies, orofacial and limb anomalies. Neuroimaging revealed calcifications along the vental margin of the caudal fourth ventricle. Neuropathologic findings at postmo ... Full text Link to item Cite

Correlation of early dynamic CT perfusion imaging with whole-brain MR diffusion and perfusion imaging in acute hemispheric stroke.

Journal Article AJNR Am J Neuroradiol · October 2003 BACKGROUND AND PURPOSE: Compared with MR imaging, dynamic CT perfusion imaging covers only a fraction of the whole brain. An important assumption is that CT perfusion abnormalities correlate with total ischemic volume. The purpose of our study was to measu ... Link to item Cite

Imaging of brain tumors with diffusion-weighted and diffusion tensor MR imaging.

Journal Article Magn Reson Imaging Clin N Am · August 2003 Featured Publication The advent of diffusion-weighted MR imaging and diffusion tensor MR imaging has had little impact on brain tumor detection. Diffusion-weighted imaging has been effective in characterizing specific types of masses, particularly in distinguishing epidermoids ... Full text Link to item Cite

Screening for cerebral metastases with FDG PET in patients undergoing whole-body staging of non-central nervous system malignancy.

Journal Article Radiology · January 2003 PURPOSE: To compare fluorine 18 fluorodeoxyglucose (FDG) positron emission tomography (PET) with the current standard, magnetic resonance (MR) imaging, to determine the sensitivity and specificity of FDG PET for detection of cerebral metastases and to dete ... Full text Link to item Cite

MR signal intensity of gray matter/white matter contrast and intracranial fat: effects of age and sex.

Journal Article Psychiatry Res · July 1, 2002 Signal intensity (SI) values of gray- and white-matter brain regions of interest (ROIs) were obtained from T(2)- and proton density-weighted magnetic resonance (MR) images of 58 normal subjects aged 22-82 years (31 females, 52.3+/-18.8 years; 27 males, 54. ... Full text Link to item Cite

Evaluation of software for registration of contrast-enhanced brain MR images in patients with glioblastoma multiforme.

Journal Article AJR Am J Roentgenol · July 2002 Featured Publication OBJECTIVE: We evaluated commercially available software that rapidly and automatically registers brain MR images on a clinical workstation, and we studied the accuracy of these registrations. SUBJECTS AND METHODS: Ten patients with a diagnosis of glioblast ... Full text Link to item Cite

CT perfusion scanning with deconvolution analysis: pilot study in patients with acute middle cerebral artery stroke.

Journal Article Radiology · January 2002 PURPOSE: To measure mean cerebral blood flow (CBF) in ischemic and nonischemic territories and in low-attenuation regions in patients with acute stroke by using deconvolution-derived hemodynamic imaging. MATERIALS AND METHODS: Twelve patients with acute mi ... Full text Link to item Cite

Do prolonged febrile seizures produce medial temporal sclerosis? Hypotheses, MRI evidence and unanswered questions.

Journal Article Prog Brain Res · 2002 Whether or not severe febrile seizures in infancy cause hippocampal injury and subsequent medial temporal sclerosis is an often debated question in epilepsy. Recent magnetic resonance imaging (MRI) of infants suffering from febrile seizures has provided pr ... Full text Link to item Cite

Learning and recall in subjects at genetic risk for Alzheimer's disease.

Journal Article J Neuropsychiatry Clin Neurosci · 2002 Deficits in delayed recall of learned information may be an early marker of Alzheimer's disease (AD). The apolipoprotein E E4 allele and a positive family history (FH) are both genetic risk factors for AD. The authors cross-sectionally compared performance ... Full text Link to item Cite

Quantitative assessment of diffusion abnormalities in posterior reversible encephalopathy syndrome.

Journal Article AJNR Am J Neuroradiol · September 2001 BACKGROUND AND PURPOSE: Previous studies have shown that lesions in posterior reversible encephalopathy syndrome are often isointense on diffusion-weighted MR images. We hypothesized that 1) apparent diffusion coefficient (ADC) maps using various threshold ... Link to item Cite

Serial MR imaging of pineal cysts: implications for natural history and follow-up.

Journal Article AJR Am J Roentgenol · March 2001 OBJECTIVE: The purpose of this study was to examine the frequency of change in size of pineal cysts on serial MR studies. MATERIALS AND METHODS: Thirty-two patients (19 females, 13 males) with a diagnosis of pineal cyst at any time who underwent brain MR i ... Full text Link to item Cite

Vertex epidural hematomas: imaging findings and diagnostic pitfalls.

Journal Article Eur J Radiol · December 2000 PURPOSE: Our purpose was to show the computed tomography (CT) and magnetic resonance (MR) imaging features of vertex epidural hematomas (EDHs) and emphasize pitfalls in the diagnosis of this entity. SUBJECTS AND METHODS: The neuroradiologic studies of four ... Full text Link to item Cite

Detection of cerebral metastases by FDG imaging and MRI

Journal Article RADIOLOGY · November 1, 2000 Link to item Cite

Hippocampal sulcal cavities on MRI: relationship to age and apolipoprotein E genotype.

Journal Article Neurology · June 13, 2000 Hippocampal sulcal cavities are usually considered incidental findings on brain MRI. In a group of 92 elderly volunteers, the authors graded the number and size of hippocampal sulcal cavities with brain MRI to obtain a cavity score. Cavity scores increased ... Full text Link to item Cite

Comparison of patient age with MR imaging features of gangliogliomas.

Journal Article AJR Am J Roentgenol · March 2000 OBJECTIVE: The purpose of this study was to compare MR imaging features of gangliogliomas in children less than 10 years old with those seen in patients at least 10 years old. MATERIALS AND METHODS: Our study population consisted of 15 female patients and ... Full text Link to item Cite

Magnetic resonance spectroscopy in Alzheimer's disease: focus on N-acetylaspartate.

Journal Article Acta Neurol Scand Suppl · 2000 This paper reviews published post-mortem brain and in-vivo proton magnetic resonance spectroscopy (1H-MRS) studies in Alzheimer's disease (AD) and focuses on the emerging role of N-acetylaspartate (NAA) as a prognostic marker of neuronal function. Post-mor ... Full text Link to item Cite

White matter lesion contrast in fast spin-echo fluid-attenuated inversion recovery imaging: effect of varying effective echo time and echo train length.

Journal Article AJR Am J Roentgenol · October 1999 OBJECTIVE: Our aim was to determine whether the contrast between white matter lesions and normal-appearing white matter in fast spin-echo fluid-attenuated inversion recovery (FLAIR) images can be improved by lengthening the effective TE and the echo train ... Full text Link to item Cite

MR arteriography of intracranial circulation.

Journal Article AJR Am J Roentgenol · December 1998 Full text Link to item Cite

Cerebrovascular disease risk factors: neuroradiologic findings in patients with activated protein C resistance.

Journal Article Radiology · April 1998 PURPOSE: To assess the patterns of abnormal neuroradiologic findings in patients with a hypercoagulable state related to activated protein C (APC) resistance. MATERIALS AND METHODS: Records in 23 patients with a hypercoagulable state related to APC resista ... Full text Link to item Cite

Antiphospholipid antibodies: findings at arteriography.

Journal Article AJNR Am J Neuroradiol · April 1998 PURPOSE: The purpose of this study was to determine the frequency and types of abnormalities at arteriography in patients with antiphospholipid antibodies (APA) and ischemic cerebrovascular events. METHODS: Twenty-three patients with APA and ischemic cereb ... Link to item Cite

Dural sinus thrombosis associated with activated protein C resistance: MR imaging findings and proband identification.

Journal Article AJR Am J Roentgenol · February 1998 OBJECTIVE: The purpose of this study was to report the association of dural sinus thrombosis with a hypercoagulable state associated with activated protein C resistance. CONCLUSION: In our small study population, hemorrhagic venous infarction was common (t ... Full text Link to item Cite

Brain infarction in young adults: etiology and imaging findings.

Journal Article AJR Am J Roentgenol · October 1997 The causes of stroke in young adults differ substantially from those in older adults. In many instances, the diagnosis can be made by taking a clinical history and performing laboratory studies (e.g., in patients who have multiple thromboses associated wit ... Full text Link to item Cite

Pictorial review: magnetic resonance angiography of arterial variants at the Circle of Willis.

Journal Article Clin Radiol · June 1997 As intracranial MR angiography becomes more widely used and spatial resolution improves, anomalies at the Circle of Willis which have been previously well described on angiographic studies and anatomic dissections will become more frequently appreciated by ... Full text Link to item Cite

Patients with antiphospholipid antibodies: CT and MR findings of the brain.

Journal Article AJR Am J Roentgenol · December 1996 OBJECTIVE: The purpose of this study was to determine the spectrum of neuroradiologic findings in patients with antiphospholipid antibodies (APA) and to compare findings in systemic lupus erythematosus (SLE) and non-SLE patients. MATERIALS AND METHODS: We ... Full text Link to item Cite

Neuroradiologic findings in fucosidosis, a rare lysosomal storage disease.

Journal Article AJNR Am J Neuroradiol · April 1995 Fucosidosis is a rare lysosomal storage disorder with the clinical features of mental retardation, cardiomegaly, dysostosis multiplex, progressive neurologic deterioration, and early death. The neuroradiologic findings in two patients are reported, and inc ... Link to item Cite

NEURORADIOLOGIC FINDINGS IN FUCOSIDOSIS, A RARE LYSOSOMAL STORAGE DISEASE

Journal Article AMERICAN JOURNAL OF NEURORADIOLOGY · April 1, 1995 Link to item Cite

Exercise-related dissection of craniocervical arteries: CT, MR, and angiographic findings.

Journal Article J Comput Assist Tomogr · 1995 OBJECTIVE: Our goal was to demonstrate the spectrum of neuroradiologic (CT, MR, and angiographic) findings in craniocervical arterial dissection (CAD) related to exercise or sporting activities and compare the diagnostic utility of CT, MRI, and MR angiogra ... Full text Link to item Cite

Neuroradiologic findings in fucosidosis, a rare lysosomal storage disease

Journal Article American Journal of Neuroradiology · January 1, 1995 Fucosidosis is a rare lysosomal storage disorder with the clinical features of mental retardation, cardiomegaly, dysostosis multiplex, progressive neurologic deterioration, and early death. The neuroradiologic findings in two patients are reported, and inc ... Cite

Lupus-related myelitis: serial MR findings.

Journal Article AJNR Am J Neuroradiol · November 1994 PURPOSE: To correlate the MR findings in transverse myelitis secondary to systemic lupus erythematosus with clinical findings during disease exacerbation and remission. METHODS: Four patients (ages 33 to 47 years) with episodes of transverse myelitis secon ... Link to item Cite

MR diagnosis of Creutzfeldt-Jakob disease: significance of high signal intensity of the basal ganglia.

Journal Article AJR Am J Roentgenol · January 1994 OBJECTIVE: Creutzfeldt-Jakob disease is a rare dementing illness that usually affects older adults. Currently, neuroradiologic examinations play a minor role in the diagnosis of Creutzfeldt-Jakob disease. Several single case reports have noted a distinctiv ... Full text Link to item Cite

Sacral neurofibroma.

Journal Article AJR Am J Roentgenol · September 1992 Full text Link to item Cite

Candidal splenic abscesses.

Journal Article AJR Am J Roentgenol · March 1991 Full text Link to item Cite

Drinking patterns and preferences among heart patients.

Journal Article Curr Alcohol · 1981 The pattern of alcohol consumption and beverage preferences of heart patients were investigated in 3026 men and 760 women who have had coronary arteriography due to symptoms of coronary heart disease. The younger male heart patients (less than 40 years old ... Link to item Cite

DRINKING PATTERNS OF PATIENTS WITH HEART-DISEASE

Conference ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH · January 1, 1980 Link to item Cite

Risk factors in patients undergoing a second aorta-coronary bypass procedure.

Journal Article J Thorac Cardiovasc Surg · July 1978 A group of 38 patients with a second revascularization procedure was studied for factors which may have contributed to the reappearance of angina after the first operation. Our data indicate that these patients usually have the first operation at an earlie ... Link to item Cite