Scholars@Duke
Beiyu Liu

Beiyu Liu

Biostatistician III
Biostatistics & Bioinformatics
beiyu.liu@duke.edu
Duke Box 2721, Durham, NC 27710
2424 Erwin Road Ste 1106, 11028B Hock Plaza, Durham, NC 27705

Selected Publications

Ratios of head circumference to ventricular size vary over time and predict eventual need for CSF diversion in intraventricular hemorrhage of prematurity.

Journal Article Childs Nerv Syst · March 2024 PURPOSE: Intraventricular hemorrhage (IVH) of prematurity can lead to hydrocephalus, sometimes necessitating permanent cerebrospinal fluid (CSF) diversion. We sought to characterize the relationship between head circumference (HC) and ventricular size in I ... Full text Open Access Link to item Cite

Methodology of a Natural History Study of a Rare Neurodevelopmental Disorder: Alternating Hemiplegia of Childhood as a Prototype Disease.

Journal Article J Child Neurol · October 2023 Here, we describe the process of development of the methodology for an international multicenter natural history study of alternating hemiplegia of childhood as a prototype disease for rare neurodevelopmental disorders. We describe a systematic multistep a ... Full text Link to item Cite

Chronological trends in the causation of malignant mesothelioma: Fiber burden analysis of 619 cases over four decades.

Journal Article Environ Res · August 1, 2023 Malignant mesothelioma is a relatively rare malignancy with a strong association with prior asbestos exposure. A percentage of cases is not related to asbestos, and fiber analysis of lung tissue is a useful methodology for identifying idiopathic or spontan ... Full text Link to item Cite

A Nationwide Analysis of Aneurysmal Subarachnoid Hemorrhage Mortality, Complications, and Health Economics in the USA.

Journal Article Transl Stroke Res · June 2023 Aneurysmal subarachnoid hemorrhage (aSAH) is a devastating neurological condition. Endovascular coiling or surgical clipping have equivocal success rates, but relatively little is known regarding the health economics and complications of these procedures a ... Full text Link to item Cite

Clinicopathologic Characteristics of Melanoma in Patients with Parkinson Disease.

Journal Article JID Innov · March 2023 Patients with Parkinson disease (PD) are at high risk for developing melanoma, although current literature lacks details on the associated clinicopathologic characteristics. Our retrospective case-control study aimed to guide skin cancer surveillance recom ... Full text Link to item Cite

Teledermatology May Benefit Marginalized Populations: National and Institutional Trends during the COVID-19 Pandemic.

Journal Article Dermatol Ther (Heidelb) · March 2023 INTRODUCTION: Limited data exist regarding demographic-specific teledermatology (TD) utilization during the coronavirus disease 2019 (COVID-19) pandemic. This study aimed to determine TD utilization trends during the pandemic. METHODS: A retrospective coho ... Full text Link to item Cite

Evaluation of Dosing Regimens of Vancomycin and Aminoglycosides in Pediatric Patients on Continuous Renal Replacement Therapy

Journal Article Journal of Pediatric Pharmacology and Therapeutics · January 1, 2023 OBJECTIVE To determine the optimal empiric dosing regimen to achieve therapeutic serum concentrations of vancomycin and aminoglycosides in pediatric patients who are receiving continuous renal replacement therapy (CRRT). METHODS This retrospective study in ... Full text Cite

Medical adhesive allergens: Retrospective analysis of cross-sectional data from the North American Contact Dermatitis Group, 2001-2018.

Journal Article J Am Acad Dermatol · November 2022 BACKGROUND: Identification of allergens causing medical adhesive contact allergy is difficult. OBJECTIVE: To characterize the demographics, clinical characteristics, patch test results, and occupational data for North American Contact Dermatitis Group pati ... Full text Link to item Cite

Treatment Patterns and Health Care Resource Utilization of Iatrogenic Spinal Cerebrospinal Fluid Leaks in the United States.

Journal Article Clin Spine Surg · November 1, 2022 STUDY DESIGN: Retrospective cohort study. OBJECTIVE: We aimed to characterize the treatment patterns and the associated costs in patients with cerebrospinal fluid (CSF) leak after spine procedures in the United States. BACKGROUND: CSF leak is a common comp ... Full text Link to item Cite

Outcomes With a Mobile Digital Health Platform for Patients Undergoing Spine Surgery: Retrospective Analysis.

Journal Article JMIR Perioper Med · October 26, 2022 BACKGROUND: Digital health solutions have been shown to enhance outcomes for individuals with chronic medical illnesses, but few have been validated for surgical patients. The digital health platform ManageMySurgery (MMS) has been validated for spine surge ... Full text Link to item Cite

Quality and Perceived Usefulness of Patient-Submitted Store-and-Forward Teledermatology Images.

Journal Article JAMA Dermatol · October 1, 2022 IMPORTANCE: Patient-submitted images vary considerably in quality and usefulness. Studies that characterize patient-submitted images in a real-life setting are lacking. OBJECTIVE: To evaluate the quality and perceived usefulness of patient-submitted images ... Full text Link to item Cite

Impact of Education and Data Feedback on Antibiotic Prescribing for Urinary Tract Infections in the Emergency Department: An Interrupted Time-Series Analysis.

Journal Article Clin Infect Dis · September 30, 2022 BACKGROUND: Urinary tract infections (UTIs) are often misdiagnosed or treated with exceedingly broad-spectrum antibiotics, leading to negative downstream effects. We aimed to implement antimicrobial stewardship (AS) strategies targeting UTI prescribing in ... Full text Link to item Cite

High-dose, high-frequency ustekinumab therapy for patients with severe hidradenitis suppurativa.

Journal Article Br J Dermatol · September 2022 In this case series, ustekinumab therapy demonstrated efficacy in some patients with severe hidradenitis suppurativa previously treated with adalimumab and/or infliximab. Larger prospective studies are needed to evaluate ustekinumab as a treatment option f ... Full text Link to item Cite

Impact of Education and Data Feedback on Guideline-Concordant Prescribing for Urinary Tract Infections in the Outpatient Setting.

Journal Article Open Forum Infect Dis · March 2022 BACKGROUND: Urinary tract infections (UTIs) are the most common outpatient indication for antibiotics and an important target for antimicrobial stewardship (AS) activities. With The Joint Commission standards now requiring outpatient AS, data supporting ef ... Full text Link to item Cite

Comparison of intermittent versus continuous infusion antihypertensives in acute ischemic stroke.

Journal Article Am J Emerg Med · February 2022 BACKGROUND: The optimal approach to blood pressure (BP) management in acute ischemic stroke remains unclear. The purpose of this study was to determine if an intermittent (labetalol or hydralazine) or continuous infusion (nicardipine or clevidipine) antihy ... Full text Link to item Cite

Impact of pharmacist outreach on glucagon prescribing.

Journal Article J Am Pharm Assoc (2003) · 2022 BACKGROUND: Hypoglycemia is a major limiting factor in the glycemic management of diabetes. As a method of treating hypoglycemia, the American Diabetes Association recommends glucagon to be prescribed for all individuals at increased risk of clinically imp ... Full text Link to item Cite

Contact Allergy in Canada Versus United States: Analysis of the North American Contact Dermatitis Group Data 2005-2016.

Journal Article Dermatitis · November 2021 OBJECTIVE: The aim of the study was to describe the differences in contact allergy between the United States (US) and Canada. METHODS: This is a retrospective cross-sectional analysis of the North American Contact Dermatitis Group data from 2005 to 2016. F ... Full text Link to item Cite

Ventriculomegaly and postoperative lateral/third ventricular blood as predictors of cerebrospinal fluid diversion following posterior fossa tumor resection.

Journal Article J Neurosurg Pediatr · November 1, 2021 OBJECTIVE: Postoperative hydrocephalus occurs in one-third of children after posterior fossa tumor resection. Although models to predict the need for CSF diversion after resection exist for preoperative variables, it is unknown which postoperative variable ... Full text Link to item Cite

Retrospective Analysis of Quality Control Data Using Pooled Blood to Compare Agreement within Two Models of Blood Gas Analyzers.

Journal Article J Appl Lab Med · September 1, 2021 BACKGROUND: Two previous reports from the same group concluded that the analytical reliability of Instrumentation Laboratory GEM4000 analyzers (GEM4K) deteriorated during a 24-hour period, based on results between samples from the same patient but collecte ... Full text Link to item Cite

Atopic dermatitis is associated with hidradenitis suppurativa diagnosis: A single institution retrospective cohort study.

Journal Article JAAD Int · September 2021 BACKGROUND: Hidradenitis suppurativa (HS) and atopic dermatitis (AD) are both chronic inflammatory skin diseases. An association between these 2 conditions can have important potential implications for elucidating pathogenesis, disease course, and treatmen ... Full text Link to item Cite

Decreasing tracheostomy placement in hospitalized pediatric patients with subglottic stenosis - Kids' Inpatient Database (KID) analysis.

Journal Article Int J Pediatr Otorhinolaryngol · July 2021 OBJECTIVES: We aimed to assess procedural trends for tracheostomy placement in the management of children with subglottic stenosis. We hypothesize that with increased use of less invasive airway interventions for subglottic stenosis, tracheostomy may be pe ... Full text Link to item Cite

Multisite Quality Improvement Study of a Patient-Pathologist Consultation Program.

Journal Article Am J Clin Pathol · May 18, 2021 OBJECTIVES: The aim of this multisite quality improvement study was to evaluate patients' experiences with the patient-centered pathology (PCP) consultation program and to determine whether PCP enhanced their care experience. METHODS: Patients were invited ... Full text Link to item Cite

Characterization of Isavuconazole serum concentrations after enteral feeding tube administration in a hospitalized cohort: A case series.

Journal Article J Clin Pharm Ther · April 2021 WHAT IS KNOWN AND OBJECTIVE: Invasive fungal infections often occur in patients with comorbidities that complicate oral administration. Serum concentrations of isavuconazole were characterized after enteral tube administration. CASE DESCRIPTION: Thirteen o ... Full text Link to item Cite

Contact dermatitis associated with preservatives: Retrospective analysis of North American Contact Dermatitis Group data, 1994 through 2016.

Journal Article J Am Acad Dermatol · April 2021 BACKGROUND: Preservatives are often necessary components of commercial products. Large-scale North American studies on preservative allergy are limited. OBJECTIVE: To evaluate demographics, positive patch test reactions (PPTRs), clinical relevance, and tre ... Full text Link to item Cite

Outcomes and Health Care Resource Utilization of Adult Bacterial Meningitis in the United States.

Journal Article Neurol Clin Pract · April 2021 OBJECTIVE: To examine the longitudinal health care resource utilization, in-hospital mortality, and incidence of downstream complications of bacterial meningitis in the United States. METHODS: Using IBM MarketScan, we retrieved data on adult patients with ... Full text Link to item Cite

Reduced MFAP5 expression in stroma of gallbladder adenocarcinoma and its potential diagnostic utility.

Journal Article Virchows Arch · March 2021 The diagnosis of invasive adenocarcinoma of the gallbladder can sometimes be challenging. The presence of true desmoplastic reaction facilitates the diagnosis of invasion. However, desmoplasia-like changes can be observed in benign gallbladder conditions, ... Full text Link to item Cite

Paediatric bacterial meningitis in the USA: outcomes and healthcare resource utilization of nosocomial versus community-acquired infection.

Journal Article Journal of medical microbiology · January 2021 Introduction. Paediatric bacterial meningitis remains a costly disease, both financially and clinically.Hypothesis/Gap Statement. Previous epidemiological and cost studies of bacterial meningitis (BM) have largely focused on adult populations ... Full text Cite

Fragrance- and Botanical-Related Allergy and Associated Concomitant Reactions: A Retrospective Analysis of the North American Contact Dermatitis Group Data 2007-2016.

Journal Article Dermatitis · January 2021 IMPORTANCE: When fragrance- and botanical-related (F/BR) allergy is identified, concomitant reaction (CR) frequencies can help direct avoidance recommendations. OBJECTIVE: This study aimed to determine the CR rates for F/BR allergens. DESIGN: A retrospecti ... Full text Link to item Cite

Withdrawal of Life-supporting Treatment in Severe Traumatic Brain Injury.

Journal Article JAMA Surg · August 1, 2020 IMPORTANCE: There are limited data on which factors affect the critical and complex decision to withdraw life-supporting treatment (LST) in patients with severe traumatic brain injury (sTBI). OBJECTIVE: To determine demographic and clinical factors associa ... Full text Link to item Cite

Meta-analysis of number needed to treat for diagnosis of melanoma by clinical setting.

Journal Article J Am Acad Dermatol · May 2020 OBJECTIVE: To provide a formal statistical comparison of the efficacy of melanoma detection among different clinical settings. METHODS: A systematic review and meta-analysis of all relevant observational studies on number needed to treat (NNT) in relation ... Full text Link to item Cite

Malignant Diffuse Mesothelioma in Women: A Study of 354 Cases.

Journal Article Am J Surg Pathol · March 2020 We reviewed 354 cases of malignant diffuse mesothelioma (MM) in women from a database of 2858 histologically confirmed MM cases. There was a pleural predominance with 78% pleural MM and 22% peritoneal MM. The pleural tumors consisted of 72% epithelioid, 19 ... Full text Link to item Cite

Evaluation of thiamine for the prevention of ifosfamide-induced encephalopathy.

Journal Article Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners · March 2020 Study objectiveTo determine whether thiamine prophylaxis decreases the incidence of ifosfamide-induced encephalopathy in patients receiving ifosfamide for the treatment of lymphoma.DesignRetrospective, multi-center, cohort study.Patie ... Full text Cite

The longitudinal health economic impact of viral encephalitis in the United States.

Journal Article J Med Microbiol · February 2020 Introduction. Previous studies of viral encephalitis have focused on acute costs, estimating incidence at 7.3 per 100 000 and total US annual charges at $2 billion in 2010.Aim. We aim to quantify the most updated longitudinal health economic impact of vira ... Full text Link to item Cite

Patch Test Practice Patterns of Members of the American Contact Dermatitis Society.

Journal Article Dermatitis · 2020 BACKGROUND: Patch testing is the criterion standard for diagnosis and management of allergic contact dermatitis. Limitations on the number of allergens tested can negatively impact patient care. OBJECTIVE: This study reports clinical practice patterns of A ... Full text Link to item Cite

A comparison of knowledge acquisition and perceived efficacy of a traditional vs flipped classroom-based dermatology residency curriculum.

Journal Article Cutis · January 2020 Flipped and traditional classroom models were compared in the Duke University Medical Center (Durham, North Carolina) dermatology residency program for the 2014-2015 academic year. The residents participated in 12 lectures-6 traditional and 6 flipped-that ... Link to item Cite

Duration of Dermatitis Before Patch Test Appointment Is Associated With Distance to Clinic and County Poverty Rate.

Journal Article Dermatitis · 2020 BACKGROUND: Contact dermatitis is a common disease that is associated with impaired quality of life. OBJECTIVE: We examined the effect of travel distance and other socioeconomic factors on duration of dermatitis before presentation at the Duke Contact Derm ... Full text Link to item Cite

EBUS-FNA cytologic-histologic correlation of PD-L1 immunohistochemistry in non-small cell lung cancer.

Journal Article J Am Soc Cytopathol · 2020 INTRODUCTION: Immune checkpoint pathway markers induce immune tolerance to non-small cell lung cancer (NSCLC). Therapeutic antibodies targeting the programmed cell death 1 (PD-1)/programmed cell death ligand 1 (PD-L1) pathway have demonstrated efficacy in ... Full text Link to item Cite

Healthcare Economics of Hydrocephalus After Aneurysmal Subarachnoid Hemorrhage in the United States.

Journal Article Transl Stroke Res · December 2019 Hydrocephalus is one of the most common sequelae after aneurysmal subarachnoid hemorrhage (aSAH), and it is a large contributor to the condition's high rates of readmission and mortality. Our objective was to quantify the healthcare resource utilization (H ... Full text Link to item Cite

National estimations of airway foreign bodies in children in the United States, 2000 to 2009.

Journal Article Clin Otolaryngol · May 2019 OBJECTIVE: Identify risk factors associated with airway foreign bodies in children in the United States and report observed trends over time. DATA SOURCE: KID database (2000-2009). METHODS: ICD-9-CM codes for airway foreign bodies were used to identify pat ... Full text Link to item Cite

Flow cytometry immunophenotyping of vitreous specimens does not contribute to diagnosis of lymphoma without supporting morphologic features.

Journal Article Diagn Cytopathol · April 2019 BACKGROUND: Diagnostic vitrectomy with flow cytometry immunophenotyping (FCI) is being increasingly used as part of screening for diagnostically challenging cases. We aim to evaluate the utility of combined cytopathology and FCI in diagnostic pars plana vi ... Full text Link to item Cite

30-Day outcomes analysis of NSQIP-pediatric for surgical management of head and neck lymphatic malformations in children.

Journal Article Int J Pediatr Otorhinolaryngol · March 2019 OBJECTIVE: Identify adverse events associated with surgical management of head and neck lymphatic malformations in children by investigating a US national database. DATA SOURCE: Pediatric American College of Surgeons (ACS) National Surgical Quality Improve ... Full text Link to item Cite

Outcomes of surgical treatment for hemangiomas.

Journal Article Pediatr Dermatol · March 2019 OBJECTIVE: To quantify complications and rates of adverse events associated with surgical excision of hemangiomas in children using a national surgical database. DATA SOURCE: Pediatric American College of Surgeons (ACS) National Surgical Quality Improvemen ... Full text Link to item Cite

Creating a small anchor to eliminate large knots in mesh and tape suture

Journal Article Journal of Medical Devices, Transactions of the ASME · September 1, 2018 Wide mesh or tape sutures are used to close high-tension wounds such as in hernia or tendon repair. However, wide sutures produce large knots that are susceptible to increased palpability, infection, and foreign body response. To prevent such adverse event ... Full text Cite

Geospatial Analysis of Risk Factors Contributing to Loss to Follow-up in Cleft Lip/Palate Care.

Journal Article Plast Reconstr Surg Glob Open · September 2018 BACKGROUND: Multidisciplinary cleft care depends on follow-up at specified time points to monitor and address functional or aesthetic concerns that may arise during a child's development. However, loss to follow-up (LTFU) is common and can lead to missed o ... Full text Link to item Cite

Areas for Quality Improvement for Airway Dilation in Children: NSQIP-Pediatric 30-Day Outcomes.

Journal Article Otolaryngol Head Neck Surg · June 2018 Objective To identify predictors of adverse events and highlight areas for quality improvement for children who underwent laryngeal or tracheal dilation, without prior tracheostomy placement. Study Design Cross-sectional analysis using a US national databa ... Full text Link to item Cite

National Characteristics of Lymphatic Malformations in Children: Inpatient Estimates and Trends in the United States, 2000 to 2009.

Journal Article J Pediatr Hematol Oncol · April 2018 With ever increasing demands to manage finite resources for health care utilization, we performed an investigation to identify inpatient clinical characteristics and trends in children with lymphatic malformations using the Kids' Inpatient Database, years ... Full text Link to item Cite

Adverse Events in Endoscopic Sinus Surgery for Infectious Orbital Complications of Sinusitis: 30-Day NSQIP Pediatric Outcomes.

Journal Article Otolaryngol Head Neck Surg · October 2017 Objective Identify predictors of adverse events for children who underwent endoscopic sinus surgery for treatment of orbital complications associated with sinusitis. Study Design Cross-sectional analysis of a US national database. Setting American College ... Full text Link to item Cite

The Public Health Burden of Lymphatic Malformations in Children: National Estimates in the United States, 2000-2009.

Journal Article Lymphat Res Biol · September 2017 OBJECTIVE: Describe inpatient resource utilization trends in children with lymphatic malformations using a national database. DATA SOURCE: Kids' inpatient database, years 2000-2009. METHODS: Subjects included children 18 years and under with International ... Full text Link to item Cite

The public health resource utilization impact of airway foreign bodies in children.

Journal Article Int J Pediatr Otorhinolaryngol · May 2017 OBJECTIVE: Quantify the resource utilization associated with airway foreign bodies in children in the United States using a national database and report observed trends over time. STUDY TYPE: Cross-sectional analysis of national inpatient database with wei ... Full text Link to item Cite

Contact Allergy to Hydroperoxides of Linalool and D-Limonene in a US Population.

Journal Article Dermatitis · 2017 BACKGROUND: Linalool and D-limonene are common fragrance ingredients that readily oxidize on exposure to air. The resulting hydroperoxides of linalool and D-limonene have been shown to have high frequencies of positive patch test reactions in several Europ ... Full text Link to item Cite

RNAi libraries and kinetoplast DNA

Journal Article Biochemical Society Transactions · October 26, 2005 African trypanosomes have a remarkable mitochondrial DNA termed kDNA (kinetoplast DNA) that contains several thousands of topologically interlocked DNA rings. Because of its highly unusual structure, kDNA has a complex replication mechanism. Our ap ... Full text Cite