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Salvador Borges-Neto

Professor of Radiology
Radiology, Nuclear Medicine
Box 3949 Med Ctr, Durham, NC 27710
Trent Drive - Duke Circle - Duke Medical Pavillion, Rm 1W19, Durham, NC 27710

Selected Publications


Prognostic relevance of gait-related cognitive functions for dementia conversion in amnestic mild cognitive impairment.

Journal Article BMC Geriatr · July 31, 2023 BACKGROUND: Increasing research suggests that gait abnormalities can be a risk factor for Alzheimer's Disease (AD). Notably, there is growing evidence highlighting this risk factor in individuals with amnestic Mild Cognitive Impairment (aMCI), however furt ... Full text Link to item Cite

Mechanical dyssynchrony: How do we measure it, what it means, and what we can do about it.

Journal Article J Nucl Cardiol · October 2021 Left ventricular mechanical dyssynchrony (LVMD) is defined by a difference in the timing of mechanical contraction or relaxation between different segments of the left ventricle (LV). Mechanical dyssynchrony is distinct from electrical dyssynchrony as meas ... Full text Link to item Cite

The prognostic value of diastolic and systolic mechanical left ventricular dyssynchrony among patients with coronary artery disease and heart failure.

Journal Article J Nucl Cardiol · October 2020 BACKGROUND: Prevalence and prognostic value of diastolic and systolic dyssynchrony in patients with coronary artery disease (CAD) + heart failure (HF) or CAD alone are not well understood. METHODS: We included patients with gated single-photon emission com ... Full text Link to item Cite

How low can we go?

Journal Article J Nucl Cardiol · April 2020 Full text Link to item Cite

Moving towards a synchronized left ventricle.

Journal Article J Nucl Cardiol · April 2020 Full text Link to item Cite

Long-Term Outcomes of 125 Patients With Metastatic Pheochromocytoma or Paraganglioma Treated With 131-I MIBG.

Conference J Clin Endocrinol Metab · March 1, 2020 CONTEXT: Prognosis of metastatic pheochromocytoma/paraganglioma following 131-Iodine metaiodobenzylguanidine (MIBG) is incompletely characterized due to small samples and shorter follow-up in these rare, often indolent tumors. OBJECTIVE: To describe long-t ... Full text Link to item Cite

Optimal efficient imaging time for identification of sentinel lymph node with Tc-99m Tilmanocept in breast cancer patients.

Conference Am J Nucl Med Mol Imaging · 2020 We determined the optimal imaging time for axillary lymph node (LN) visualization following Tc-99m Tilmanocept in breast cancer patients to establish imaging guidelines that can allow for a reliable and efficient yet high yield study prior to surgery. Retr ... Link to item Cite

Molecular Imaging and Therapy for Neuroendocrine Tumors.

Journal Article Curr Treat Options Oncol · August 29, 2019 Neuroendocrine tumors (NETs) are relatively rare, with 12,000-15,000 new cases diagnosed annually in the USA. Although NETs are a diverse group of neoplasms, they share common molecular targets that can be exploited using nuclear medicine techniques for bo ... Full text Link to item Cite

The Prognostic Value of Diastolic and Systolic Mechanical Left Ventricular Dyssynchrony Among Patients With Coronary Heart Disease.

Conference JACC Cardiovasc Imaging · July 2019 OBJECTIVES: The goal of this study was to examine whether diastolic dyssynchrony, measured by using gated single-photon emission computed tomography (GSPECT) myocardial perfusion imaging (MPI) in patients with coronary artery disease (CAD), is independentl ... Full text Link to item Cite

Regional Amyloid-β Load and White Matter Abnormalities Contribute to Hypometabolism in Alzheimer's Dementia.

Journal Article Mol Neurobiol · July 2019 We investigated the association between amyloid-β deposition and white matter (WM) integrity as a determinant of brain glucose hypometabolism across the Alzheimer's disease (AD) spectrum. We assessed ninety-six subjects (27 cognitively normal, 49 mild cogn ... Full text Link to item Cite

The BIN1 rs744373 SNP is associated with increased tau-PET levels and impaired memory.

Journal Article Nat Commun · April 16, 2019 The single nucleotide polymorphism (SNP) rs744373 in the bridging integrator-1 gene (BIN1) is a risk factor for Alzheimer's disease (AD). In the brain, BIN1 is involved in endocytosis and sustaining cytoskeleton integrity. Post-mortem and in vitro studies ... Full text Link to item Cite

Trends in cardiorespiratory fitness: The evolution of exercise treadmill testing at a single Academic Medical Center from 1970 to 2012.

Journal Article Am Heart J · April 2019 OBJECTIVE: To identify temporal trends in the use of exercise treadmill testing (ETT) and cardiorespiratory fitness (CRF) estimated by ETT in metabolic equivalents (METs). PATIENTS AND METHODS: We compiled an ETT database of all available treadmill tests-i ... Full text Link to item Cite

White matter in different regions evolves differently during progression to dementia.

Journal Article Neurobiol Aging · April 2019 White matter hyperintensities (WMHs) are common in individuals with mild cognitive impairment (MCI) and Alzheimer's disease. Patients with MCI with high WMH volumes are known to have an increased chance of conversion to Alzheimer's disease compared with th ... Full text Link to item Cite

A concise and persistent feature to study brain resting-state network dynamics: Findings from the Alzheimer's Disease Neuroimaging Initiative.

Journal Article Hum Brain Mapp · March 2019 Alzheimer's disease (AD) is the most common type of dementia in the elderly with no effective treatment currently. Recent studies of noninvasive neuroimaging, resting-state functional magnetic resonance imaging (rs-fMRI) with graph theoretical analysis hav ... Full text Link to item Cite

Prognostic relevance of gait-related cognitive functions for dementia conversion in amnestic mild cognitive impairment.

Journal Article BMC Geriatr · July 31, 2023 BACKGROUND: Increasing research suggests that gait abnormalities can be a risk factor for Alzheimer's Disease (AD). Notably, there is growing evidence highlighting this risk factor in individuals with amnestic Mild Cognitive Impairment (aMCI), however furt ... Full text Link to item Cite

Mechanical dyssynchrony: How do we measure it, what it means, and what we can do about it.

Journal Article J Nucl Cardiol · October 2021 Left ventricular mechanical dyssynchrony (LVMD) is defined by a difference in the timing of mechanical contraction or relaxation between different segments of the left ventricle (LV). Mechanical dyssynchrony is distinct from electrical dyssynchrony as meas ... Full text Link to item Cite

The prognostic value of diastolic and systolic mechanical left ventricular dyssynchrony among patients with coronary artery disease and heart failure.

Journal Article J Nucl Cardiol · October 2020 BACKGROUND: Prevalence and prognostic value of diastolic and systolic dyssynchrony in patients with coronary artery disease (CAD) + heart failure (HF) or CAD alone are not well understood. METHODS: We included patients with gated single-photon emission com ... Full text Link to item Cite

How low can we go?

Journal Article J Nucl Cardiol · April 2020 Full text Link to item Cite

Moving towards a synchronized left ventricle.

Journal Article J Nucl Cardiol · April 2020 Full text Link to item Cite

Long-Term Outcomes of 125 Patients With Metastatic Pheochromocytoma or Paraganglioma Treated With 131-I MIBG.

Conference J Clin Endocrinol Metab · March 1, 2020 CONTEXT: Prognosis of metastatic pheochromocytoma/paraganglioma following 131-Iodine metaiodobenzylguanidine (MIBG) is incompletely characterized due to small samples and shorter follow-up in these rare, often indolent tumors. OBJECTIVE: To describe long-t ... Full text Link to item Cite

Optimal efficient imaging time for identification of sentinel lymph node with Tc-99m Tilmanocept in breast cancer patients.

Conference Am J Nucl Med Mol Imaging · 2020 We determined the optimal imaging time for axillary lymph node (LN) visualization following Tc-99m Tilmanocept in breast cancer patients to establish imaging guidelines that can allow for a reliable and efficient yet high yield study prior to surgery. Retr ... Link to item Cite

Molecular Imaging and Therapy for Neuroendocrine Tumors.

Journal Article Curr Treat Options Oncol · August 29, 2019 Neuroendocrine tumors (NETs) are relatively rare, with 12,000-15,000 new cases diagnosed annually in the USA. Although NETs are a diverse group of neoplasms, they share common molecular targets that can be exploited using nuclear medicine techniques for bo ... Full text Link to item Cite

The Prognostic Value of Diastolic and Systolic Mechanical Left Ventricular Dyssynchrony Among Patients With Coronary Heart Disease.

Conference JACC Cardiovasc Imaging · July 2019 OBJECTIVES: The goal of this study was to examine whether diastolic dyssynchrony, measured by using gated single-photon emission computed tomography (GSPECT) myocardial perfusion imaging (MPI) in patients with coronary artery disease (CAD), is independentl ... Full text Link to item Cite

Regional Amyloid-β Load and White Matter Abnormalities Contribute to Hypometabolism in Alzheimer's Dementia.

Journal Article Mol Neurobiol · July 2019 We investigated the association between amyloid-β deposition and white matter (WM) integrity as a determinant of brain glucose hypometabolism across the Alzheimer's disease (AD) spectrum. We assessed ninety-six subjects (27 cognitively normal, 49 mild cogn ... Full text Link to item Cite

The BIN1 rs744373 SNP is associated with increased tau-PET levels and impaired memory.

Journal Article Nat Commun · April 16, 2019 The single nucleotide polymorphism (SNP) rs744373 in the bridging integrator-1 gene (BIN1) is a risk factor for Alzheimer's disease (AD). In the brain, BIN1 is involved in endocytosis and sustaining cytoskeleton integrity. Post-mortem and in vitro studies ... Full text Link to item Cite

Trends in cardiorespiratory fitness: The evolution of exercise treadmill testing at a single Academic Medical Center from 1970 to 2012.

Journal Article Am Heart J · April 2019 OBJECTIVE: To identify temporal trends in the use of exercise treadmill testing (ETT) and cardiorespiratory fitness (CRF) estimated by ETT in metabolic equivalents (METs). PATIENTS AND METHODS: We compiled an ETT database of all available treadmill tests-i ... Full text Link to item Cite

White matter in different regions evolves differently during progression to dementia.

Journal Article Neurobiol Aging · April 2019 White matter hyperintensities (WMHs) are common in individuals with mild cognitive impairment (MCI) and Alzheimer's disease. Patients with MCI with high WMH volumes are known to have an increased chance of conversion to Alzheimer's disease compared with th ... Full text Link to item Cite

A concise and persistent feature to study brain resting-state network dynamics: Findings from the Alzheimer's Disease Neuroimaging Initiative.

Journal Article Hum Brain Mapp · March 2019 Alzheimer's disease (AD) is the most common type of dementia in the elderly with no effective treatment currently. Recent studies of noninvasive neuroimaging, resting-state functional magnetic resonance imaging (rs-fMRI) with graph theoretical analysis hav ... Full text Link to item Cite

Association of CSF CD40 levels and synaptic degeneration across the Alzheimer's disease spectrum.

Journal Article Neurosci Lett · February 16, 2019 The CD40 pathway has been implicated in microglial activation, which is considered as a key factor in the pathogenesis of Alzheimer's disease (AD). However, the association of CSF CD40 and synaptic degeneration in living human is not clear. A total of 294 ... Full text Link to item Cite

Amyloid beta-positive subjects exhibit longitudinal network-specific reductions in spontaneous brain activity.

Journal Article Neurobiol Aging · February 2019 Amyloid beta (Aβ) deposition and cognitive decline are key features of Alzheimer's disease. The relationship between Aβ status and changes in neuronal function over time, however, remains unclear. We evaluated the effect of baseline Aβ status on reference ... Full text Link to item Cite

Translating Alzheimer's disease-associated polymorphisms into functional candidates: a survey of IGAP genes and SNPs.

Journal Article Neurobiol Aging · February 2019 The International Genomics of Alzheimer's Project (IGAP) is a consortium for characterizing the genetic landscape of Alzheimer's disease (AD). The identified and/or confirmed 19 single-nucleotide polymorphisms (SNPs) associated with AD are located on non-c ... Full text Link to item Cite

Functional signature of conversion of patients with mild cognitive impairment.

Journal Article Neurobiol Aging · February 2019 The entorhinal-hippocampal circuit is a strategic hub for cognition and the first site affected by Alzheimer's disease (AD). We investigated magnetic resonance imaging patterns of brain atrophy and functional connectivity in an Alzheimer's Disease Neuroima ... Full text Link to item Cite

Accuracy and generalization capability of an automatic method for the detection of typical brain hypometabolism in prodromal Alzheimer disease.

Journal Article Eur J Nucl Med Mol Imaging · February 2019 PURPOSE: The aim of this study was to verify the reliability and generalizability of an automatic tool for the detection of Alzheimer-related hypometabolic pattern based on a Support-Vector-Machine (SVM) model analyzing 18F-fluorodeoxyglucose (FDG) PET dat ... Full text Link to item Cite

QuickNAT: A fully convolutional network for quick and accurate segmentation of neuroanatomy.

Journal Article Neuroimage · February 1, 2019 Whole brain segmentation from structural magnetic resonance imaging (MRI) is a prerequisite for most morphological analyses, but is computationally intense and can therefore delay the availability of image markers after scan acquisition. We introduce Quick ... Full text Link to item Cite

Disease progression timeline estimation for Alzheimer's disease using discriminative event based modeling.

Journal Article Neuroimage · February 1, 2019 Alzheimer's Disease (AD) is characterized by a cascade of biomarkers becoming abnormal, the pathophysiology of which is very complex and largely unknown. Event-based modeling (EBM) is a data-driven technique to estimate the sequence in which biomarkers for ... Full text Link to item Cite

Accurate risk estimation of β-amyloid positivity to identify prodromal Alzheimer's disease: Cross-validation study of practical algorithms.

Journal Article Alzheimers Dement · February 2019 INTRODUCTION: The aim was to create readily available algorithms that estimate the individual risk of β-amyloid (Aβ) positivity. METHODS: The algorithms were tested in BioFINDER (n = 391, subjective cognitive decline or mild cognitive impairment) and valid ... Full text Link to item Cite

A Novel Method to Estimate Long-Term Chronological Changes From Fragmented Observations in Disease Progression.

Journal Article Clin Pharmacol Ther · February 2019 Clinical observations of patients with chronic diseases are often restricted in terms of duration. Therefore, obtaining a quantitative and comprehensive understanding of the chronology of chronic diseases is challenging, because of the inability to precise ... Full text Link to item Cite

MAPT rs242557 variant is associated with hippocampus tau uptake on 18F-AV-1451 PET in non-demented elders.

Journal Article Aging (Albany NY) · January 31, 2019 The microtubule-associated protein tau gene (MAPT) rs242557 variant is associated with multiple tauopathies and dementia. This study investigated whether it was correlated with brain tau-PET uptake in non-demented elders. Ninety non-demented elders were id ... Full text Link to item Cite

Understanding disease progression and improving Alzheimer's disease clinical trials: Recent highlights from the Alzheimer's Disease Neuroimaging Initiative.

Journal Article Alzheimers Dement · January 2019 INTRODUCTION: The overall goal of the Alzheimer's Disease Neuroimaging Initiative (ADNI) is to validate biomarkers for Alzheimer's disease (AD) clinical trials. ADNI is a multisite, longitudinal, observational study that has collected many biomarkers since ... Full text Link to item Cite

A δ Homolog for Dementia Case Finding with Replication in the Alzheimer's Disease Neuroimaging Initiative.

Journal Article J Alzheimers Dis · 2019 Dementia can be empirically described by the latent dementia phenotype "δ" and its various composite "homologs". We have explored δ's blood-based protein biomarkers in the Texas Alzheimer's Research and Care Consortium (TARCC) study. However, it would be c ... Full text Link to item Cite

The Relationship Between Hippocampal Volumes and Delayed Recall Is Modified by APOE ε4 in Mild Cognitive Impairment.

Journal Article Front Aging Neurosci · 2019 Objective: To investigate whether APOE ε4 affects the association of verbal memory with neurodegeneration presented by the hippocampal volume/intracranial volume ratio (HpVR). Methods: The study sample included 371 individuals with normal cognition (NC), 7 ... Full text Link to item Cite

Evaluating trajectories of episodic memory in normal cognition and mild cognitive impairment: Results from ADNI.

Journal Article PLoS One · 2019 BACKGROUND: Memory assessment is a key factor for the diagnosis of cognitive impairment. However, memory performance over time may be quite heterogeneous within diagnostic groups. METHOD: To identify latent trajectories in memory performance and their asso ... Full text Link to item Cite

Random forest prediction of Alzheimer's disease using pairwise selection from time series data.

Journal Article PLoS One · 2019 Time-dependent data collected in studies of Alzheimer's disease usually has missing and irregularly sampled data points. For this reason time series methods which assume regular sampling cannot be applied directly to the data without a pre-processing step. ... Full text Link to item Cite

Prognosis of conversion of mild cognitive impairment to Alzheimer's dementia by voxel-wise Cox regression based on FDG PET data.

Journal Article Neuroimage Clin · 2019 AIM: The value of 18F-fluorodeoxyglucose (FDG) PET for the prognosis of conversion from mild cognitive impairment (MCI) to Alzheimer's dementia (AD) is controversial. In the present work, the identification of cerebral metabolic patterns with significant p ... Full text Link to item Cite

Correction to: Clinical Quantification of Myocardial Blood Flow Using PET: Joint Position Paper of the SNMMI Cardiovascular Council and the ASNC.

Journal Article J Nucl Cardiol · December 2018 The above position statement originally published containing errors in the author metadata; specifically, the Expert Content Reviewers-Andrew Einstein, Raymond Russell and James R. Corbett-were tagged as full authors of the paper. The article metadata has ... Full text Link to item Cite

Predictors of Survival in 211 Patients with Stage IV Pulmonary and Gastroenteropancreatic MIBG-Positive Neuroendocrine Tumors Treated with 131I-MIBG.

Journal Article J Nucl Med · November 2018 This retrospective analysis identifies predictors of survival in a cohort of patients with meta-iodobenzylguanidine (MIBG)-positive stage IV pulmonary and gastroenteropancreatic neuroendocrine tumor (P/GEP-NET) treated with 131I-MIBG therapy, to inform tre ... Full text Open Access Link to item Cite

Variability in Ejection Fraction Measured By Echocardiography, Gated Single-Photon Emission Computed Tomography, and Cardiac Magnetic Resonance in Patients With Coronary Artery Disease and Left Ventricular Dysfunction.

Journal Article JAMA Netw Open · August 3, 2018 IMPORTANCE: Clinical decisions are frequently based on measurement of left ventricular ejection fraction (LVEF). Limited information exists regarding inconsistencies in LVEF measurements when determined by various imaging modalities and the potential impac ... Full text Link to item Cite

Multimodal and Multiscale Deep Neural Networks for the Early Diagnosis of Alzheimer's Disease using structural MR and FDG-PET images.

Journal Article Sci Rep · April 9, 2018 Alzheimer's Disease (AD) is a progressive neurodegenerative disease where biomarkers for disease based on pathophysiology may be able to provide objective measures for disease diagnosis and staging. Neuroimaging scans acquired from MRI and metabolism image ... Full text Link to item Cite

18F-florbetapir Positron Emission Tomography-determined Cerebral β-Amyloid Deposition and Neurocognitive Performance after Cardiac Surgery.

Journal Article Anesthesiology · April 2018 BackgroundAmyloid deposition is a potential contributor to postoperative cognitive dysfunction. The authors hypothesized that 6-week global cortical amyloid burden, determined by F-florbetapir positron emission tomography, would be greater in thos ... Full text Cite

Brain multiplexes reveal morphological connectional biomarkers fingerprinting late brain dementia states.

Journal Article Sci Rep · March 7, 2018 Accurate diagnosis of mild cognitive impairment (MCI) before conversion to Alzheimer's disease (AD) is invaluable for patient treatment. Many works showed that MCI and AD affect functional and structural connections between brain regions as well as the sha ... Full text Link to item Cite

Dual-Model Radiomic Biomarkers Predict Development of Mild Cognitive Impairment Progression to Alzheimer's Disease.

Journal Article Front Neurosci · 2018 Predicting progression of mild cognitive impairment (MCI) to Alzheimer's disease (AD) is clinically important. In this study, we propose a dual-model radiomic analysis with multivariate Cox proportional hazards regression models to investigate promising ri ... Full text Link to item Cite

Pattern Discovery in Brain Imaging Genetics via SCCA Modeling with a Generic Non-convex Penalty.

Journal Article Sci Rep · October 25, 2017 Brain imaging genetics intends to uncover associations between genetic markers and neuroimaging quantitative traits. Sparse canonical correlation analysis (SCCA) can discover bi-multivariate associations and select relevant features, and is becoming popula ... Full text Link to item Cite

Comparison of Bayesian penalized likelihood reconstruction versus OS-EM for characterization of small pulmonary nodules in oncologic PET/CT.

Journal Article Ann Nucl Med · October 2017 OBJECTIVE: To determine whether the recently introduced Bayesian penalized likelihood PET reconstruction (Q.Clear) increases the visual conspicuity and SUVmax of small pulmonary nodules near the PET resolution limit, relative to ordered subset expectation ... Full text Link to item Cite

Cascaded Multi-view Canonical Correlation (CaMCCo) for Early Diagnosis of Alzheimer's Disease via Fusion of Clinical, Imaging and Omic Features.

Journal Article Sci Rep · August 15, 2017 The introduction of mild cognitive impairment (MCI) as a diagnostic category adds to the challenges of diagnosing Alzheimer's Disease (AD). No single marker has been proven to accurately categorize patients into their respective diagnostic groups. Thus, pr ... Full text Link to item Cite

Association of Plasma Neurofilament Light With Neurodegeneration in Patients With Alzheimer Disease.

Journal Article JAMA Neurol · May 1, 2017 IMPORTANCE: Existing cerebrospinal fluid (CSF) or imaging (tau positron emission tomography) biomarkers for Alzheimer disease (AD) are invasive or expensive. Biomarkers based on standard blood test results would be useful in research, drug development, and ... Full text Link to item Cite

The prognostic value of mechanical left ventricular dyssynchrony defined by phase analysis from gated single-photon emission computed tomography myocardial perfusion imaging among patients with coronary heart disease.

Journal Article J Nucl Cardiol · April 2017 BACKGROUND: The prognostic value of left ventricular dyssynchrony measured by gated single-photon emission computed tomography (GSPECT) myocardial perfusion imaging (MPI) and its relationship to electrical dyssynchrony measured by QRS duration are incomple ... Full text Link to item Cite

Longitudinal measurement and hierarchical classification framework for the prediction of Alzheimer's disease.

Journal Article Sci Rep · January 12, 2017 Accurate prediction of Alzheimer's disease (AD) is important for the early diagnosis and treatment of this condition. Mild cognitive impairment (MCI) is an early stage of AD. Therefore, patients with MCI who are at high risk of fully developing AD should b ... Full text Link to item Cite

A practical method of I-131 thyroid cancer therapy dose optimization using estimated effective renal clearance.

Journal Article SAGE Open Med Case Rep · 2017 In thyroid cancer patients with renal impairment or other complicating factors, it is important to maximize I-131 therapy efficacy while minimizing bone marrow and lung damage. We developed a web-based calculator based on a modified Benua and Leeper method ... Full text Open Access Link to item Cite

Prognostic value of the cadmium-zinc-telluride camera: A comparison with a conventional (Anger) camera.

Journal Article J Nucl Cardiol · December 2016 BACKGROUND: New multipinhole cadmium-zinc-telluride (CZT) cameras allow for faster imaging and lower radiation doses for single photon emission computed tomography (SPECT) studies, but assessment of prognostic ability is necessary. METHODS AND RESULTS: We ... Full text Link to item Cite

Chagas’ Disease: Update on Current Diagnosis

Journal Article Current Cardiovascular Imaging Reports · December 1, 2016 Purpose of Review: Chagas’ disease has become an emerging health problem due to increased migration. In the present review, we have summarized the usefulness of non-invasive imaging tools for the diagnosis of cardiac involvement in Chagas’ disease, with em ... Full text Cite

Association Between Anticholinergic Medication Use and Cognition, Brain Metabolism, and Brain Atrophy in Cognitively Normal Older Adults.

Journal Article JAMA Neurol · June 1, 2016 IMPORTANCE: The use of anticholinergic (AC) medication is linked to cognitive impairment and an increased risk of dementia. To our knowledge, this is the first study to investigate the association between AC medication use and neuroimaging biomarkers of br ... Full text Link to item Cite

Difference in appearance between prone and supine myocardial perfusion images obtained on a high-efficiency cadmium zinc telluride SPECT camera.

Journal Article Nucl Med Commun · May 2016 OBJECTIVE: The recent introduction of high-efficiency solid-state gamma cameras for myocardial perfusion single photon emission computed tomography has enabled lower patient radiation dose, faster imaging, and improved image quality. However, artifacts sti ... Full text Link to item Cite

Comparison of stress cardiovascular magnetic resonance imaging (CMR) with stress nuclear perfusion for the diagnosis of coronary artery disease.

Journal Article J Nucl Cardiol · April 2016 OBJECTIVES: To assess the diagnostic performance of stress cardiac magnetic resonance (stress CMR) vs stress single-photon emission computed tomography (SPECT) in patients presenting to the emergency department (ED) with chest pain. BACKGROUND: SPECT imagi ... Full text Link to item Cite

Technical aspects of resolution recovery reconstruction.

Journal Article J Nucl Cardiol · February 2016 Technological advances in processing have allowed nuclear cardiology labs to increase efficiency as well as reduce radiation exposure to both patients and staff. With increased awareness on reduced radiation exposure, efficiency and quality resolution reco ... Full text Link to item Cite

Comparison of the prognostic value of regadenoson and adenosine myocardial perfusion imaging.

Journal Article J Nucl Cardiol · August 2015 BACKGROUND: Regadenoson is now widely used in single-photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI). However, the prognostic value of abnormal stress perfusion findings with regadenoson vs adenosine are unclear. The aim of t ... Full text Link to item Cite

Definitive diagnosis of cerebrospinal fluid leak into the pleural space using 111In-DTPA cisternography.

Journal Article Clin Nucl Med · March 2015 A 58-year-old woman with a calcified disk extrusion causing severe spinal stenosis underwent T8 to T9 diskectomy and spinal fusion. A postoperative pseudomeningocele was treated with lumbar drain and fibrin glue. Performed for persistent right pleural effu ... Full text Link to item Cite

Ischaemia change with revascularisation versus medical therapy in reduced ejection fraction.

Journal Article Open Heart · 2015 OBJECTIVE: Nuclear imaging data demonstrate that revascularisation leads to favourable effects on ischaemia burden and improved outcomes compared with medical therapy (MT). In patients with heart failure (HF), the effects of MT versus revascularisation on ... Full text Open Access Link to item Cite

Two-day lymphoscintigraphic imaging for melanoma.

Journal Article Nucl Med Commun · August 2014 OBJECTIVES: Sentinel lymph node mapping has a long history of successful use in the staging and management of cutaneous melanoma. Most practitioners inject the primary site with radiocolloid the evening before or on the day of lymphoscintigraphy. We have f ... Full text Link to item Cite

Comparative definitions for moderate-severe ischemia in stress nuclear, echocardiography, and magnetic resonance imaging.

Journal Article JACC Cardiovasc Imaging · June 2014 The lack of standardized reporting of the magnitude of ischemia on noninvasive imaging contributes to variability in translating the severity of ischemia across stress imaging modalities. We identified the risk of coronary artery disease (CAD) death or myo ... Full text Link to item Cite

Prognostic value of CZT SPECT camera in cardiac imaging

Conference JOURNAL OF NUCLEAR MEDICINE · May 1, 2014 Link to item Cite

Pulmonary venous stenosis on ventilation-perfusion scintigraphy: a correlation with dynamic magnetic resonance pulmonary angiography.

Journal Article Clin Nucl Med · March 2014 A case of pulmonary vein stenosis as a result of prior atrial fibrillation focus procedures for atrial fibrillation, correlated with magnetic resonance (MR) pulmonary angiography, is presented. Restricted flow to the right lung in similar quantities measur ... Full text Link to item Cite

Pulmonary venous stenosis on ventilation-perfusion scintigraphy: a correlation with dynamic magnetic resonance pulmonary angiography.

Journal Article Clinical nuclear medicine · January 1, 2014 A case of pulmonary vein stenosis as a result of prior atrial fibrillation focus procedures for atrial fibrillation, correlated with magnetic resonance (MR) pulmonary angiography, is presented. Restricted flow to the right lung in similar quantities measur ... Cite

Inducible myocardial ischemia and outcomes in patients with coronary artery disease and left ventricular dysfunction.

Journal Article J Am Coll Cardiol · May 7, 2013 OBJECTIVES: The study objectives were to test the hypotheses that ischemia during stress testing has prognostic value and identifies those patients with coronary artery disease (CAD) with left ventricular (LV) dysfunction who derive the greatest benefit fr ... Full text Link to item Cite

Ischemia change in stable coronary artery disease is an independent predictor of death and myocardial infarction.

Journal Article JACC Cardiovasc Imaging · July 2012 OBJECTIVES: The aim of this study was to evaluate the independent prognostic significance of ischemia change in stable coronary artery disease (CAD). BACKGROUND: Recent randomized trials in stable CAD have suggested that revascularization does not improve ... Full text Link to item Cite

Comparison of Clinical characteristics and long-term outcomes of patients with ischemic cardiomyopathy with versus without angina pectoris (from the Duke Databank for Cardiovascular Disease).

Journal Article Am J Cardiol · May 1, 2012 Myocardial ischemic origin is a significant independent predictor of mortality in patients with heart failure (HF). The implications of angina pectoris (AP) in HF are less well characterized. The aim of this study was to compare the clinical characteristic ... Full text Link to item Cite

Nomograms for estimating coronary artery disease prognosis with gated stress myocardial perfusion SPECT.

Journal Article J Nucl Cardiol · February 2012 BACKGROUND: Nomograms can be useful tools for estimating coronary artery disease (CAD) risk. We sought to devise risk-based nomograms for stress myocardial perfusion SPECT to include measures of % ischemic myocardium and left ventricular function. METHODS: ... Full text Link to item Cite

Patient management after noninvasive cardiac imaging results from SPARC (Study of myocardial perfusion and coronary anatomy imaging roles in coronary artery disease).

Journal Article J Am Coll Cardiol · January 31, 2012 OBJECTIVES: This study examined short-term cardiac catheterization rates and medication changes after cardiac imaging. BACKGROUND: Noninvasive cardiac imaging is widely used in coronary artery disease, but its effects on subsequent patient management are u ... Full text Link to item Cite

Nuclear medicine

Chapter · January 19, 2012 Cite

Nuclear medicine: Case 18

Chapter · January 19, 2012 Cite

Nuclear medicine: Case 3

Chapter · January 19, 2012 Cite

Nuclear medicine: Case 2

Chapter · January 19, 2012 Cite

Imaging surrogate end points in heart failure trials.

Journal Article Heart Fail Clin · October 2011 Despite the epidemiologic importance, large investments, and careful design, recent results of heart failure (HF) trials have been unable to demonstrate significant treatment improvements. This shortcoming has led to a reassessment of research methodology, ... Full text Link to item Cite

SPECT myocardial perfusion imaging for the assessment of left ventricular mechanical dyssynchrony.

Journal Article J Nucl Cardiol · August 2011 Phase analysis of gated single-photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI) is an evolving technique for measuring LV mechanical dyssynchrony. Since its inception in 2005, it has undergone considerable technical developmen ... Full text Link to item Cite

Relationship of technetium-99m tetrofosmin-gated rest single-photon emission computed tomography myocardial perfusion imaging to death and hospitalization in heart failure patients: results from the nuclear ancillary study of the HF-ACTION trial.

Journal Article Am Heart J · June 2011 BACKGROUND: We hypothesized that the severity of resting perfusion abnormalities assessed by the summed rest score (SRS) would be associated with a higher rate of adverse outcomes in patients with heart failure (HF) and reduced left ventricular (LV) ejecti ... Full text Link to item Cite

Prevalence and predictors of mechanical dyssynchrony as defined by phase analysis in patients with left ventricular dysfunction undergoing gated SPECT myocardial perfusion imaging.

Journal Article J Nucl Cardiol · February 2011 BACKGROUND: A novel method to quantify dyssynchrony using phase analysis of single-photon emission computed tomography (SPECT) myocardial perfusion imaging has been developed. We sought to determine the prevalence of SPECT-derived mechanical dyssynchrony, ... Full text Link to item Cite

Utility of FDG PET/CT in inflammatory cardiovascular disease.

Journal Article Radiographics · 2011 Inflammatory disorders of the cardiovascular system can affect the myocardium, pericardium, or vessel walls. Patients with myocardial and pericardial disease may present with chest pain, palpitations, and shortness of breath, symptoms resembling myocardial ... Full text Link to item Cite

Improved near-term coronary artery disease risk classification with gated stress myocardial perfusion SPECT.

Journal Article JACC Cardiovasc Imaging · November 2010 OBJECTIVES: We compared analytical approaches to estimate the added value of myocardial perfusion single-photon emission computed tomography (MPS) variables in estimating coronary artery disease (CAD) outcomes. BACKGROUND: Stress MPS markers of regional is ... Full text Link to item Cite

Single-photon emission computed tomography myocardial perfusion imaging and the risk of sudden cardiac death in patients with coronary disease and left ventricular ejection fraction>35%.

Journal Article J Am Coll Cardiol · July 13, 2010 OBJECTIVES: The aim of this study was to determine whether single-photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI) is an effective method of risk stratification for sudden cardiac death (SCD) in patients with coronary artery d ... Full text Link to item Cite

Does myocardial perfusion imaging provide incremental prognostic information to left ventricular ejection fraction?

Journal Article Curr Cardiol Rep · March 2010 Cardiac nuclear imaging studies such as gated single photon emission computed tomography can offer assessment of myocardial perfusion and ventricular function. These two types of data can provide valuable information for the diagnosis of coronary artery di ... Full text Link to item Cite

Myocardial perfusion, function, and dyssynchrony in patients with heart failure: baseline results from the single-photon emission computed tomography imaging ancillary study of the Heart Failure and A Controlled Trial Investigating Outcomes of Exercise TraiNing (HF-ACTION) Trial.

Journal Article Am Heart J · October 2009 Featured Publication BACKGROUND: There are currently limited data on the relationships between resting perfusion abnormalities, left ventricular ejection fraction (LVEF), New York Heart Association (NYHA) functional class, and exercise capacity as defined by peak VO(2) and 6-m ... Full text Link to item Cite

Single photon emission computed tomography myocardial imaging: clinical applications and future directions.

Journal Article Minerva Cardioangiol · June 2009 Featured Publication Single photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI) has proven to be an invaluable tool in the non-invasive assessment of patients with cardiovascular diseases. Exercise and pharmacologic stress SPECT MPI has been extensiv ... Link to item Cite

Use of phase analysis of gated SPECT perfusion imaging to quantify dyssynchrony in patients with mild-to-moderate left ventricular dysfunction.

Journal Article J Nucl Cardiol · 2009 Featured Publication BACKGROUND: CRT has been shown to be beneficial in the majority of patients with NYHA class III-IV symptoms, prolonged QRS duration, and an EF < or =35%. The use of imaging modalities to quantify dyssynchrony may help identify patients who may benefit from ... Full text Link to item Cite

Prognostic validation of an algorithm to convert myocardial perfusion SPECT imaging data from a 12-segment model to a 17-segment model.

Journal Article J Nucl Cardiol · 2009 Featured Publication BACKGROUND: A 17-segment model has become the standard for interpreting myocardial perfusion single-photon emission computed tomography (SPECT). Methods for converting pre-existing databases from 12-segment models to the 17-segment model are needed for ong ... Full text Link to item Cite

Left ventricular mechanical dyssynchrony as assessed by phase analysis of ECG-gated SPECT myocardial perfusion imaging.

Journal Article Echocardiography · November 2008 Featured Publication Cardiac resynchronization therapy (CRT) has shown benefits in patients with severe heart failure. The traditional criteria to select patients for CRT (NYHA class III or IV, depressed left ventricular (LV) ejection fraction, and prolonged QRS duration) resu ... Full text Link to item Cite

Single-photon emission computed tomography myocardial perfusion defects are associated with an increased risk of all-cause death, cardiovascular death, and sudden cardiac death.

Journal Article Circ Cardiovasc Imaging · November 2008 Featured Publication BACKGROUND: Single-photon emission computed tomography myocardial perfusion imaging defects are associated with increased all-cause mortality and cardiovascular death. However, it is unknown whether single-photon emission computed tomography myocardial per ... Full text Link to item Cite

Emerging role of myocardial perfusion imaging to evaluate patients for cardiac resynchronization therapy.

Journal Article Am J Cardiol · July 15, 2008 Featured Publication Left ventricular (LV) dyssynchrony is an increasingly important consideration in the evaluation and management of patients with LV systolic dysfunction. Improvements in clinical status, LV remodeling, and survival have been demonstrated with the use of car ... Full text Link to item Cite

Evaluation of combined cardiac positron emission tomography and coronary computed tomography angiography for the detection of coronary artery disease.

Journal Article Nucl Med Commun · July 2008 Featured Publication BACKGROUND: Coronary artery disease is a leading cause of morbidity and mortality. Multiple imaging modalities are used to screen for significant coronary artery disease. We report the concordance between coronary computed tomography angiography (CTA) and ... Full text Link to item Cite

Repeatability and reproducibility of phase analysis of gated single-photon emission computed tomography myocardial perfusion imaging used to quantify cardiac dyssynchrony.

Journal Article Nucl Med Commun · April 2008 Featured Publication BACKGROUND: A novel method to quantify dyssynchrony has been developed using phase analysis of gated single-photon emission computed tomography perfusion imaging. We report on the effect of variability in image reconstruction on the phase analysis results ... Full text Link to item Cite

Measuring left ventricular mechanical dyssynchrony from ECG-gated SPECT myocardial perfusion imaging.

Journal Article Minerva Cardioangiol · April 2008 Featured Publication Cardiac resynchronization therapy (CRT) has shown benefits in patients with severe heart failure. The traditional criteria to select patients for CRT (New York Heart Association [NYHA] class III or IV, depressed left ventricular [LV] ejection fraction, and ... Link to item Cite

Impact of stress SPECT imaging after revascularization: Evaluating the appropriateness criteria

Conference JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY · March 11, 2008 Link to item Cite

WE‐C‐AUD B‐05: Predicting Radiation‐Induced Cardiac Perfusion Defects Using a Fusion Model

Conference Medical Physics · January 1, 2008 Purpose: To predict radiation‐induced cardiac perfusion defects using a fusion model that combines the results of four separate models: feed‐forward neural networks (NNET), self‐organizing maps (SOM), support vector machines (SVM), and multivariate adaptiv ... Full text Cite

Prognostic estimation of coronary artery disease risk with resting perfusion abnormalities and stress ischemia on myocardial perfusion SPECT.

Journal Article J Nucl Cardiol · 2008 Featured Publication BACKGROUND: The extent and severity of stress ischemia are strong predictors of coronary artery disease (CAD) events. Prognosis associated with myocardial perfusion single photon emission computed tomography (MPS) abnormalities on the resting scan as it re ... Full text Link to item Cite

Prognosis by coronary computed tomographic angiography: matched comparison with myocardial perfusion single-photon emission computed tomography.

Journal Article J Cardiovasc Comput Tomogr · 2008 Featured Publication BACKGROUND: The diagnostic accuracy of coronary computed tomographic angiography (CTA) is high with few reports noting its ability to stratify risk. The quantity and quality of prognostic evidence with myocardial perfusion single-photon emission computed t ... Full text Link to item Cite

Assessment of left ventricular mechanical dyssynchrony by phase analysis of ECG-gated SPECT myocardial perfusion imaging.

Journal Article J Nucl Cardiol · 2008 Featured Publication Cardiac resynchronization therapy (CRT) has shown benefits in patients with severe heart failure. However, at least 30% of patients selected for CRT by use of traditional criteria (New York Heart Association class III or IV, depressed left ventricular [LV] ... Full text Link to item Cite

Evaluation of mechanical dyssynchrony and myocardial perfusion using phase analysis of gated SPECT imaging in patients with left ventricular dysfunction.

Journal Article J Nucl Cardiol · 2008 Featured Publication BACKGROUND: Using phase analysis of gated single photon emission computed tomography (SPECT) imaging, we examined the relation between myocardial perfusion, degree of electrical dyssynchrony, and degree of SPECT-derived mechanical dyssynchrony in patients ... Full text Link to item Cite

PET/CT in cardiology

Journal Article · December 1, 2007 The high incidence of cardiovascular disease and the resultant morbidity associated with the sequelae of acute cardiovascular events continue to be major issues of medical concern. To assist in the clinical evaluation of patients with known or suspected ca ... Full text Cite

Training cardiovascular specialists in imaging: a curriculum based on fundamental concepts required for multimodal imaging.

Journal Article Am Heart J · November 2007 BACKGROUND: Training cardiovascular (CV) imaging specialists is becoming increasingly complex owing to rapidly emerging technological advances and the growing recognition that single modality training is inefficient and results in suboptimal education and ... Full text Link to item Cite

Prospective assessment of radiotherapy-associated cardiac toxicity in breast cancer patients: analysis of data 3 to 6 years after treatment.

Journal Article Cancer · October 15, 2007 BACKGROUND: Radiation therapy (RT) to the left breast/chest wall has been linked with cardiac dysfunction. Previously, the authors identified cardiac perfusion defects in approximately 50% to 60% of patients 0.5 to 2 years post-RT. In the current study, th ... Full text Link to item Cite

Effect of exercise training on ventricular function, dyssynchrony, resting myocardial perfusion, and clinical outcomes in patients with heart failure: a nuclear ancillary study of Heart Failure and A Controlled Trial Investigating Outcomes of Exercise TraiNing (HF-ACTION); design and rationale.

Journal Article Am Heart J · July 2007 BACKGROUND: Technetium Tc 99m gated single photon emission computed tomography (SPECT) has become the cornerstone of noninvasive risk stratification in patients with ischemic heart disease, but its role in patients with heart failure is not as well establi ... Full text Link to item Cite

Clinical results of a novel wide beam reconstruction method for shortening scan time of Tc-99m cardiac SPECT perfusion studies.

Journal Article J Nucl Cardiol · July 2007 BACKGROUND: Newly developed reconstruction algorithms enable the acquisition of images at half of the scan time while maintaining image quality. The purpose of this investigation was to evaluate a novel wide beam reconstruction (WBR) method developed by Ul ... Full text Link to item Cite

Prediction of mortality in patients with coronary artery disease undergoing vasodilator stress testing: a comparison between 99mTc-tetrofosmin and 99mTc-sestamibi.

Journal Article Nucl Med Commun · June 2007 PURPOSE: To compare the prognostic ability of the imaging agents 99mTc-sestamibi versus 99mTc-tetrofosmin to predict mortality outcomes in patients with documented coronary artery disease and undergoing vasodilator stress testing. MATERIALS AND METHODS: Th ... Full text Link to item Cite

Mortality risk associated with ejection fraction differs across resting nuclear perfusion findings.

Journal Article J Nucl Cardiol · April 2007 BACKGROUND: Left ventricular ejection fraction (LVEF) is a significant predictor of morbidity and death. The nuclear summed rest score (SRS) measures myocardial perfusion defects and provides prognostic information, but its effects on long-term outcomes ar ... Full text Link to item Cite

Evaluation of left ventricular mechanical dyssynchrony as determined by phase analysis of ECG-gated SPECT myocardial perfusion imaging in patients with left ventricular dysfunction and conduction disturbances.

Journal Article J Nucl Cardiol · 2007 BACKGROUND: Cardiac resynchronization therapy (CRT) is approved for the treatment of patients with advanced systolic heart failure and evidence of dyssynchrony on electrocardiograms. However, a significant percentage of patients do not demonstrate improvem ... Full text Link to item Cite

First-pass radionuclide angiography.

Journal Article J Nucl Cardiol · November 2006 Full text Link to item Cite

Predicting significant coronary artery disease in patients with left ventricular dysfunction.

Journal Article Am Heart J · August 2006 BACKGROUND: Because coronary artery disease (CAD) is a prevalent comorbidity in patients with low ejection function (EF), a number of patients with heart failure undergo diagnostic cardiac catheterization. The objective of this study was to develop a model ... Full text Link to item Cite

Relation of ventricular premature complexes during recovery from a myocardial perfusion exercise stress test to myocardial ischemia.

Journal Article Am J Cardiol · June 1, 2006 Ventricular premature complexes (VPCs) during exercise have long been believed to be harbingers of increased mortality. A recent study has shown that VPCs during the recovery phase of a treadmill exercise test are more predictive of mortality than VPCs tha ... Full text Link to item Cite

Cardiovascular disease risk stratification with stress single-photon emission computed tomography technetium-99m tetrofosmin imaging in patients with the metabolic syndrome and diabetes mellitus.

Journal Article Am J Cardiol · May 15, 2006 The metabolic syndrome represents a constellation of risk factors caused by insulin resistance, dyslipidemia, hypertension, and obesity, resulting in elevated coronary disease risk. From a multicenter prospective registry of 7,849 patients, the relation am ... Full text Link to item Cite

The incidence and functional consequences of RT-associated cardiac perfusion defects.

Journal Article Int J Radiat Oncol Biol Phys · September 1, 2005 PURPOSE: Radiation therapy (RT) for left-sided breast cancer has been associated with cardiac dysfunction. We herein assess the temporal nature and volume dependence of RT-induced left ventricular perfusion defects and whether these perfusion defects are r ... Full text Link to item Cite

Ethnic differences in the prognostic value of stress technetium-99m tetrofosmin gated single-photon emission computed tomography myocardial perfusion imaging.

Journal Article J Am Coll Cardiol · May 3, 2005 OBJECTIVES: This study was designed to evaluate the differential prognostic value of gated single-photon emission computed tomographic imaging (SPECT) imaging in an ethnically diverse multicenter registry. BACKGROUND: Ethnic minority patient populations ha ... Full text Link to item Cite

Cardiac imaging impaired by a silicone breast implant.

Journal Article Clin Nucl Med · April 2005 The authors report a case of a left-sided silicone breast implant interfering with nuclear imaging of the myocardium. Cardiac SPECT imaging of a woman documented widespread infarct in the anterolateral, inferior, and posterolateral walls, as well as mixed ... Full text Link to item Cite

Incremental prognostic power of single-photon emission computed tomographic myocardial perfusion imaging in patients with known or suspected coronary artery disease.

Journal Article Am J Cardiol · January 15, 2005 Noninvasive stress testing provides prognostic information in patients who have suspected coronary artery disease, but limited data are available on the incremental value of myocardial perfusion testing in high-risk patients. We studied 3,275 patients who ... Full text Link to item Cite

Predicting radiotherapy-induced cardiac perfusion defects.

Journal Article Med Phys · January 2005 The purpose of this work is to compare the efficacy of mathematical models in predicting the occurrence of radiotherapy-induced left ventricular perfusion defects assessed using single-photon emission computed tomography (SPECT). The basis of this study is ... Full text Link to item Cite

Prediction of death and nonfatal myocardial infarction in high-risk patients: a comparison between the Duke treadmill score, peak exercise radionuclide angiography, and SPECT perfusion imaging.

Journal Article J Nucl Med · January 2005 UNLABELLED: Radionuclide exercise testing provides prognostic information in patients with known or suspected coronary artery disease (CAD). The relative contribution of 3 noninvasive tests--the Duke treadmill score (DTS), first-pass radionuclide angiograp ... Link to item Cite

Optimizing sequential dual tracer P.E.T. studies using a combined 2D/3D imaging protocol

Journal Article IEEE Nuclear Science Symposium Conference Record · December 1, 2004 We have investigated a combined 2D/3D protocol for minimizing contamination in dual tracer P.E.T. studies in which the tracers are administered on a timescale that is short compared to the half-lives. We have performed a series of phantom studies on an Adv ... Cite

The additive value of combined assessment of myocardial perfusion and ventricular function studies.

Journal Article J Nucl Med · October 2004 In addition to providing quantitative ventricular function information, gated SPECT and radionuclide angiocardiographic studies can evaluate regional wall motion and ventricular volumes. This review focuses on the combined assessment of myocardial perfusio ... Link to item Cite

Outcome prediction in patients at high risk for coronary artery disease: comparison between 99mTc tetrofosmin and 99mTc sestamibi.

Journal Article Radiology · July 2004 PURPOSE: To determine if there was any difference in the ability of physicians to predict prognosis with technetium 99m ((99m)Tc) sestamibi or (99m)Tc tetrofosmin in a large consecutive series of patients at high risk for coronary artery disease who underw ... Full text Link to item Cite

1126-110 Predicting significant coronary artery disease in heart failure patients

Conference Journal of the American College of Cardiology · March 2004 Full text Cite

Clinical characteristics and referral pattern of patients with left ventricular dysfunction and significant coronary artery disease undergoing radionuclide imaging.

Journal Article J Nucl Cardiol · 2004 BACKGROUND: Many observational studies that predict patient outcomes have examined the use of myocardial perfusion imaging results. However, a referral pattern for radionuclide testing could bias these analyses and should be determined. These patients may ... Full text Link to item Cite

Revascularization in patients with coronary artery disease, left ventricular dysfunction, and viability: a meta-analysis.

Journal Article Am Heart J · October 2003 BACKGROUND: The effects of viability status and treatment allocation on long-term mortality in patients with left ventricular dysfunction and coronary artery disease have not been determined. Several observational studies with significant limitations have ... Full text Link to item Cite

Symptomatic cardiac events following radiation therapy for left-sided breast cancer: possible association with radiation therapy-induced changes in regional perfusion.

Journal Article Clin Breast Cancer · August 2003 Our group has demonstrated that tangential radiation therapy (RT) to the left breast or chest wall can cause perfusion changes in the anterior myocardium. We assess if RT-induced perfusion changes are associated with the development of symptoms consistent ... Link to item Cite

Radionuclide viability testing: should it affect treatment strategy in patients with cardiomyopathy and significant coronary artery disease?

Journal Article Am Heart J · May 2003 BACKGROUND: Ischemic heart failure is a significant source of morbidity and mortality, yet it has an unclear treatment strategy. The assessment of viable myocardium by nuclear imaging studies has shown promise in predicting improvements in ejection fractio ... Full text Link to item Cite

Myocardial perfusion changes in patients irradiated for left-sided breast cancer and correlation with coronary artery distribution.

Journal Article Int J Radiat Oncol Biol Phys · March 15, 2003 PURPOSE: To evaluate postradiation regional heart perfusion changes with single photon emission tomography (SPECT) myocardial perfusion imaging in 69 patients treated with tangential photon beams radiation therapy (RT) for left-sided breast cancer. To corr ... Full text Link to item Cite

Prognostic value of normal exercise and adenosine (99m)Tc-tetrofosmin SPECT imaging: results from the multicenter registry of 4,728 patients.

Journal Article J Nucl Med · February 2003 UNLABELLED: Event rates associated with a normal or low-risk myocardial perfusion SPECT imaging study have been shown by numerous investigators to be associated with <1%/y of follow-up. Thus, the aim of this study was to evaluate the prognostic value of a ... Link to item Cite

Gated 99mTc-tetrofosmin and 18F-FDG studies: a comparison of single-acquisition and separate-acquisition protocols.

Journal Article J Nucl Med Technol · December 2002 UNLABELLED: 18F-FDG is a well-established tracer for evaluating myocardial viability, as is (99m)Tc-tetrofosmin (TET) for evaluating myocardial perfusion. Dual-isotope single-acquisition (DISA) studies using a (99m)Tc perfusion agent and (18)F-FDG have bee ... Link to item Cite

Efficiency comparison between 99m Tc-tetrofosmin and 99m Tc-sestamibi myocardial perfusion studies.

Journal Article Nucl Med Commun · March 2002 The purpose of this investigation was to compare the efficiency of two different imaging protocols using two different clinically available 99mTc labelled myocardial perfusion tracers. One thousand one hundred and thirty-four imaging studies were performed ... Full text Link to item Cite

Quantification of myocardial hypoperfusion with 99m Tc-sestamibi in patients undergoing prolonged coronary artery balloon occlusion.

Journal Article Nucl Med Commun · March 2002 Percutaneous transluminal coronary angioplasty provides an excellent opportunity to investigate the location and quantity of hypoperfusion during sudden complete occlusion of one of the major coronary arteries. Thirty-five patients referred for elective pe ... Full text Link to item Cite

Impact of diabetes on the risk stratification using stress single-photon emission computed tomography myocardial perfusion imaging in patients with symptoms suggestive of coronary artery disease.

Journal Article Circulation · January 1, 2002 BACKGROUND: Coronary artery disease can develop prematurely and is the leading cause of death among diabetics, making noninvasive risk stratification desirable. METHODS AND RESULTS: Patients with symptoms of coronary artery disease who were undergoing stre ... Full text Link to item Cite

Doxorubicin-based chemotherapy and radiation increase cardiac perfusion changes in patients treated for left-sided breast cancer

Journal Article Breast Cancer Research and Treatment · December 1, 2001 Purpose: To determine the incidence/severity of regional cardiac perfusion abnormalities in patients treated with radiation therapy (RT) to the left breast/chest wall +/- chemotherapy (CTx). Methods: 80 patients with left-sided breast cancer underwent rest ... Cite

Incremental prognostic value of RNA ejection fraction measurements during pharmacologic stress testing: a comparison with clinical and perfusion variables.

Journal Article J Nucl Med · June 2001 UNLABELLED: This investigation examined the prognostic power of first-pass radionuclide angiocardiography (RNA) ejection fraction compared with clinical information and myocardial perfusion imaging in patients undergoing pharmacologic stress testing. The v ... Link to item Cite

Cardiac perfusion changes in patients treated for breast cancer with radiation therapy and doxorubicin: preliminary results.

Journal Article Int J Radiat Oncol Biol Phys · March 15, 2001 PURPOSE: To determine the incidence and dose dependence of regional cardiac perfusion abnormalities in patients with left-sided breast cancer treated with radiation therapy (RT) with and without doxorubicin (Dox). METHODS: Twenty patients with left-sided b ... Full text Link to item Cite

Noninvasive strategies for the estimation of cardiac risk in stable chest pain patients. The Economics of Noninvasive Diagnosis (END) Study Group.

Journal Article Am J Cardiol · July 1, 2000 Effective allocation of medical resources in stable chest pain patients requires the accurate diagnosis of coronary artery disease and the stratification of future cardiac risk. We studied the relative predictive value for cardiac death of 3 commonly appli ... Full text Link to item Cite

27. PET Image Interpretation. Attenuation-Corrected (ATN) Vs Non-Attenuation Corrected (NATN) Images.

Journal Article Clin Positron Imaging · July 2000 Purpose: The purpose of this study was to evaluate the difference, if any, in lesion detection in ATN and NATN images.Methods: Sixty-one consecutive patients having clinical whole body FDG PET scans for oncologic indications were included. The patients wer ... Full text Link to item Cite

Whole-body Tc-99m sestamibi scintigraphy in the follow-up of differentiated thyroid carcinoma.

Journal Article Clin Nucl Med · June 2000 PURPOSE: This study evaluated the potential of Tc-99m sestamibi whole-body scan (WBMIBI) as an alternative to whole-body I-131 scan (WBI) for the follow-up of patients with differentiated thyroid carcinoma. MATERIALS AND METHODS: We evaluated 99 consecutiv ... Full text Link to item Cite

Poststress measurements of left ventricular function with gated perfusion SPECT: comparison with resting measurements by using a same-day perfusion-function protocol.

Journal Article Radiology · May 2000 PURPOSE: To investigate the relationship between the development of ischemia during stress testing and the changes in left ventricular ejection fraction (LVEF) measurements obtained after stress and at rest with a same-day perfusion-function imaging protoc ... Full text Link to item Cite

Complementary nature of radiotracer parathyroid imaging and intraoperative parathyroid hormone assays in the surgical management of primary hyperparathyroid disease: case report and review.

Journal Article Clin Nucl Med · March 2000 PURPOSE: This article illustrates the complementary nature of preoperative radionuclide parathyroid imaging and intraoperative rapid parathyroid hormone (PTH) assays in primary hyperparathyroid disease. The authors review the literature on these procedures ... Full text Link to item Cite

Prediction of myocardial perfusion abnormalities by quantitative regional function using a radionuclide angiography database: a comparison with wall motion analysis.

Journal Article Clin Nucl Med · February 2000 PURPOSE: Myocardial perfusion and functional information during the same study is now feasible. A new assessment of regional ejection fraction at rest and peak exercise by first-pass radionuclide angiography using a "normal" database file has been develope ... Full text Link to item Cite

The added value of simultaneous myocardial perfusion and left ventricular function.

Journal Article Curr Opin Cardiol · November 1999 The focus of this review is the advantages of simultaneously assessing myocardial perfusion and left ventricular function. Nuclear cardiology imaging techniques as well as the development of technetium-labeled perfusion tracers now permit combined myocardi ... Full text Link to item Cite

Imaging guidelines for nuclear cardiology procedures. Part 2

Journal Article Journal of Nuclear Cardiology · April 28, 1999 Cite

The economic consequences of available diagnostic and prognostic strategies for the evaluation of stable angina patients: an observational assessment of the value of precatheterization ischemia. Economics of Noninvasive Diagnosis (END) Multicenter Study Group.

Journal Article J Am Coll Cardiol · March 1999 OBJECTIVES: The study aim was to determine observational differences in costs of care by the coronary disease diagnostic test modality. BACKGROUND: A number of diagnostic strategies are available with few data to compare the cost implications of the initia ... Full text Link to item Cite

The noninvasive prediction of cardiac mortality in men and women with known or suspected coronary artery disease. Economics of Noninvasive Diagnosis (END) Study Group.

Journal Article Am J Med · February 1999 PURPOSE: The association between myocardial perfusion imaging defects and cardiac mortality in women is undefined. We examined whether myocardial perfusion imaging predicted cardiac mortality in men and women and compared this with other variables influenc ... Full text Link to item Cite

Combined Tc-99m sestamibi first-pass radionuclide angiography and cardiac SPECT imaging during arbutamine infusion delivered by a computerized closed-loop system.

Journal Article Clin Nucl Med · January 1999 PURPOSE: This study evaluated the feasibility, hemodynamic responses, and relation of combined Tc-99m sestamibi SPECT imaging and first-pass radionuclide angiography during the infusion of a new beta agonist arbutamine. METHODS: Arbutamine was administered ... Full text Link to item Cite

Prognosis by measurements of left ventricular function during exercise. Duke Noninvasive Research Working Group.

Journal Article J Nucl Med · January 1998 UNLABELLED: This study was performed to determine whether gated equilibrium radionuclide angiogram measurements of left ventricular function during rest and exercise add independent information to clinical and catheterization data in predicting cardiac dea ... Link to item Cite

Prognosis by measurements of left ventricular function during exercise

Journal Article Journal of Nuclear Medicine · January 1, 1998 This study was performed to determine whether gated equilibrium radionuclide angiogram measurements of left ventricular function during rest and exercise add independent information to clinical and catheterization data in predicting cardiac death. Methods ... Cite

Cost implications of selective preoperative risk screening in the care of candidates for peripheral vascular operations.

Journal Article Am J Manag Care · December 1997 The preoperative identification that patients are at high risk for adverse postoperative outcomes is the first step toward preventing costly in-hospital complications. The economic implications of noninvasive screening strategies in the care of patients un ... Link to item Cite

Perfusion and function assessment by nuclear cardiology techniques.

Journal Article Curr Opin Cardiol · November 1997 This review focuses on the currently available nuclear cardiology techniques for assessing simultaneously myocardial perfusion and left-ventricular function information. The ability to obtain both types of information in the same patient has been considere ... Full text Link to item Cite

Usefulness of serial radionuclide angiography in predicting cardiac death after coronary artery bypass grafting and comparison with clinical and cardiac catheterization data.

Journal Article Am J Cardiol · April 1, 1997 This investigation assesses the prognostic value of radionuclide measurements of cardiac function in patients undergoing coronary artery bypass grafting (CABG). Radionuclide angiograms during exercise and at rest were obtained in 182 patients before (< or ... Full text Link to item Cite

Prediction of severe coronary artery disease by combined rest and exercise radionuclide angiocardiography and tomographic perfusion imaging with technetium 99m-labeled sestamibi: a comparison with clinical and electrocardiographic data.

Journal Article J Nucl Cardiol · 1997 BACKGROUND: The purpose of this study was to compare the incremental value of clinical information, electrocardiographic data, myocardial perfusion imaging, and radionuclide angiography for predicting severe coronary artery disease at a single testing inte ... Full text Link to item Cite

Analysis of cardiac arrhythmias during dobutamine pharmacologic stress testing in nuclear cardiology as related to the presence or absence of baseline arrhythmias.

Journal Article J Nucl Cardiol · 1997 BACKGROUND: Intravenous dobutamine is an acceptable pharmacologic stress agent for evaluation of myocardial ischemia, but it has the undesirable side effect of precipitating cardiac arrhythmias. All patients are susceptible to the arrhythmogenic potential ... Full text Link to item Cite

Tc-99m sestamibi cardiac SPECT imaging during coronary artery occlusion in humans: comparison with dipyridamole stress studies.

Journal Article Radiology · March 1996 PURPOSE: To compare the magnitude of change in regional myocardial perfusion during dipyridamole stress with that during coronary occlusion. MATERIALS AND METHODS: The authors prospectively studied 14 men with more than 50% diameter stenosis in at least on ... Full text Link to item Cite

Myocardial perfusion and ventricular function measurements during total coronary artery occlusion in humans. A comparison with rest and exercise radionuclide studies.

Journal Article Circulation · January 1994 BACKGROUND: The purpose of this investigation was to compare the magnitude of change in myocardial perfusion and function during exercise with that obtained during total coronary artery occlusion. Radionuclide studies are widely used for the diagnosis and ... Full text Link to item Cite

Radionuclide ventricular function analysis.

Journal Article Radiol Clin North Am · July 1993 The information available from ventricular function studies is important in the management of patients with cardiovascular disease. Radionuclide measurements of ventricular function are closely related to the presence and extent of myocardial damage second ... Link to item Cite

Comparison of bicycle and treadmill radionuclide angiocardiography.

Journal Article J Nucl Med · October 1991 The purpose of this study was to test motion-correction algorithms for initial-transit radionuclide angiocardiograms acquired at rest and during bicycle and treadmill exercise. Treadmill data was spatially reoriented by computer software designed to elimin ... Link to item Cite

Combined exercise radionuclide angiocardiography and single photon emission computed tomography perfusion studies for assessment of coronary artery disease.

Journal Article Semin Nucl Med · July 1991 Although there is widespread use of exercise thallium 201 scintigraphy and radionuclide angiocardiography in patients with coronary artery disease (CAD), little is known about the independence, concordance, or relative importance of these studies in the di ... Full text Link to item Cite

Simultaneous measurement of myocardial perfusion and ventricular function during exercise from a single injection of technetium-99m sestamibi in coronary artery disease.

Journal Article Am J Cardiol · October 16, 1990 New radiopharmaceuticals permit simultaneous assessment of myocardial perfusion and left ventricular function using a single tracer injection. The purpose of this study was to quantitate the relation between myocardial perfusion and function at rest and du ... Full text Link to item Cite

Perfusion and function at rest and treadmill exercise using technetium-99m-sestamibi: comparison of one- and two-day protocols in normal volunteers.

Journal Article J Nucl Med · July 1990 The purpose of this study was to explore the feasibility of performing rest and exercise technetium-99m-sestamibi (99mTc-sestamibi) studies on the same day. We prospectively studied 34 asymptomatic volunteers using two different protocols (17 patients stud ... Link to item Cite

Quantification of myocardial infarction during coronary occlusion and myocardial salvage after reperfusion using cardiac imaging with technetium-99m hexakis 2-methoxyisobutyl isonitrile.

Journal Article J Am Coll Cardiol · December 1988 Myocardial imaging with technetium-99m hexakis 2-methoxyisobutyl isonitrile was investigated as a means to assess myocardial infarct size during coronary occlusion and to quantify the extent of salvaged myocardium after coronary occlusion followed by reper ... Full text Link to item Cite

Quantification of infarct size by 201Tl single-photon emission computed tomography during acute myocardial infarction in humans. Comparison with enzymatic estimates.

Journal Article Circulation · October 1988 We prospectively investigated whether 201Tl single-photon emission computed tomography (SPECT) could accurately diagnose the presence and quantify the extent of acute myocardial infarction when compared with infarct size assessed by plasma MB-creatine kina ... Full text Link to item Cite

Transient platelet aggregation as a mechanism of unstable angina. Aggressive treatment with coronary angioplasty.

Journal Article Jpn Heart J · July 1988 Decreased oxygen supply rather than increased demand may be the primary pathogenic mechanism of myocardial ischemia in patients with unstable angina. Coronary artery spasm and in vivo platelet aggregation may play an important role in the mechanism by whic ... Full text Link to item Cite

Clinical significance of perfusion defects by thallium-201 single photon emission tomography following oral dipyridamole early after coronary angioplasty.

Journal Article J Am Coll Cardiol · May 1988 The clinical significance of myocardial perfusion defects present early after angiographically successful percutaneous transluminal coronary angioplasty was assessed in 53 patients using thallium-201 single photon emission computed tomography combined with ... Full text Link to item Cite

Quantitative thallium-201 single photon emission computed tomography after oral dipyridamole for assessing the presence, anatomic location and severity of coronary artery disease.

Journal Article J Am Coll Cardiol · May 1988 The objective of this investigation was to determine whether analysis of thallium-201 images as detected by quantitative single photon emission computed tomography after a single high oral dose of dipyridamole (300 mg) would accurately detect the presence ... Full text Link to item Cite

Dissociation between global and regional systolic and diastolic ventricular function during coronary occlusion and reperfusion.

Journal Article Am Heart J · October 1987 Indexes of global ventricular function such as the ejection fraction (EF) and the peak diastolic filling rate (PDFR) are often used to assess the effects of coronary recanalization in patients with myocardial infarction. In this investigation we assessed t ... Full text Link to item Cite