Scholars@Duke
Cameron Robert Wolfe

Cameron Robert Wolfe

Professor of Medicine
Medicine, Infectious Diseases
cw74@duke.edu
Duke Box 102359, Division of Infectious Diseases, DUMC, Durham, NC 27710
Room 159 Hanes House, Trent Drive, Durham, NC 27710

Selected Publications

Epidemiology of Infections in Lung Transplant Recipients Treated With Belatacept.

Journal Article Transpl Infect Dis · November 4, 2024 BACKGROUND: Belatacept is a costimulatory blocker that can be used to prevent and treat rejection in lung transplant recipients (LuTRs). The epidemiology of infections in belatacept-treated LuTRs has not been systematically evaluated. METHODS: We performed ... Full text Link to item Cite

Donor-derived infections in the United States: Opportunities to learn from the Disease Transmission Advisory Committee's experience.

Journal Article Transpl Infect Dis · November 2024 The Disease Transmission Advisory Committee (DTAC) of the Organ Procurement and Transplantation Network focuses on issues related to the transmission of disease through organ transplantation. Providing a review of potential cases of transmission, translati ... Full text Link to item Cite

Kaposi Sarcoma of the Cardiac Allograft in a Heart Transplant Recipient

Journal Article Annals of Internal Medicine: Clinical Cases · November 1, 2024 Full text Cite

National Institutes of Health COVID-19 Treatment Guidelines Panel: Perspectives and Lessons Learned.

Journal Article Ann Intern Med · November 2024 DESCRIPTION: In March 2020, the White House Coronavirus Task Force determined that clinicians in the United States needed expert treatment guidelines to optimally manage patients with COVID-19, a potentially life-threatening disease caused by a new pathoge ... Full text Link to item Cite

Estimated Median Waiting Time for Organ Procurement and Transplantation Network Human Immunodeficiency Virus Organ Policy Equity Act Variance Kidney Candidates: A Propensity Score Matched Analysis.

Journal Article Transplant infectious disease : an official journal of the Transplantation Society · November 2024 BackgroundPrior to the 2013 HIV Organ Policy Equity (HOPE) Act, which enabled research on the transplantation of solid organs from donors with human immunodeficiency virus (HIV) to candidates living with HIV, it was prohibited for HIV+ individuals ... Full text Cite

Deceased Donor Infectious Diseases Testing and Antimicrobial Use: Surveys of Organ Procurement Organizations and Transplant Professionals.

Journal Article Transplant infectious disease : an official journal of the Transplantation Society · November 2024 BackgroundDonor screening and antimicrobial management processes are inconsistent across organ procurement organizations (OPOs) and transplant centers. As part of a Controversies Conference addressing the evaluation and management of infectious di ... Full text Cite

SARS-CoV-2 RNA and Nucleocapsid Antigen Are Blood Biomarkers Associated With Severe Disease Outcomes That Improve in Response to Remdesivir.

Journal Article J Infect Dis · September 23, 2024 BACKGROUND: Although antivirals remain important for the treatment COVID-19, methods to assess treatment efficacy are lacking. Here, we investigated the impact of remdesivir on viral dynamics and their contribution to understanding antiviral efficacy in th ... Full text Link to item Cite

Longitudinal analysis of viral dynamics in HIV+-to-HIV+ HOPE Act kidney-transplant recipients.

Journal Article J Clin Invest · September 10, 2024 BACKGROUNDThe HIV Organ Policy Equity (HOPE) Act allows individuals living with HIV to accept organs from donors with HIV. This practice widens the pool of available organs, but also presents important virological issues, including the potential for HIV su ... Full text Link to item Cite

Challenging boundaries: Organ transplants from donors with Listeria central nervous system infections.

Journal Article Am J Transplant · July 2024 Pretransplant mortality rates in the US remain high and are connected to effective organ donation and utilization. Thus, there is a need to maximize the utilization of available donors. In some cases, this has been safely achieved using organs from donors ... Full text Link to item Cite

Real-World Experience With Maribavir for Treatment of Cytomegalovirus Infection in High-Risk Solid Organ Transplant Recipients.

Journal Article Open Forum Infect Dis · July 2024 We evaluated use of maribavir (MBV) for treatment of 15 episodes of refractory/resistant cytomegalovirus infection in 13 solid organ transplant recipients. Treatment failure due to treatment-emergent MBV resistance or early virological recurrence after MBV ... Full text Link to item Cite

Management of infectious disease syndromes in thoracic organ transplants and mechanical circulatory device recipients: a Delphi panel.

Journal Article Transpl Infect Dis · June 2024 PURPOSE: Antimicrobial misuse contributes to antimicrobial resistance in thoracic transplant (TTx) and mechanical circulatory support (MCS) recipients. This study uses a modified Delphi method to define the expected appropriate antimicrobial prescribing fo ... Full text Link to item Cite

Risk factors, management, and clinical outcomes of invasive Mycoplasma and Ureaplasma infections after lung transplantation.

Journal Article Am J Transplant · April 2024 Mollicute infections, caused by Mycoplasma and Ureaplasma species, are serious complications after lung transplantation; however, understanding of the epidemiology and outcomes of these infections remains limited. We conducted a single-center retrospective ... Full text Open Access Link to item Cite

A Risk Profile Using Simple Hematologic Parameters to Assess Benefits From Baricitinib in Patients Hospitalized With COVID-19: A Post Hoc Analysis of the Adaptive COVID-19 Treatment Trial-2.

Journal Article Ann Intern Med · March 2024 BACKGROUND: The ACTT risk profile, which was developed from ACTT-1 (Adaptive COVID-19 Treatment Trial-1), demonstrated that hospitalized patients with COVID-19 in the high-risk quartile (characterized by low absolute lymphocyte count [ALC], high absolute n ... Full text Link to item Cite

Policies and practice of solid organ donation amongst people living with HIV in Canada: time for education and re-evaluation.

Journal Article HIV Res Clin Pract · February 24, 2024 The numbers of organ donors in Canada and the USA fall short of increasing demand, resulting in increased morbidity, poor health outcomes, higher medical costs and death of many individuals waitlisted for transplantation. In the US, since 2013 when the US ... Link to item Cite

Non-Standard Risk Donors and Risk of Donor-Derived Infections: From Evaluation to Therapeutic Management.

Journal Article Transpl Int · 2024 Expected and unexpected donor-derived infections are a rare complication of solid organ transplantation, but can result in significant morbidity and mortality. Over the last years, the growing gap existing between patients on the waiting list and available ... Full text Link to item Cite

"They paged me what?": A transplant infectious disease guide to donor calls.

Journal Article Transpl Infect Dis · December 2023 Donor-derived infections in solid organ transplantation can be prevented by risk stratification of donors based on available information, and inquiries surrounding possible or diagnosed infection are common questions posed to transplant infectious disease ... Full text Link to item Cite

Real-world Experiences in the Transplantation of Hepatitis C-NAAT-positive Organs.

Journal Article Transplant Direct · November 2023 BACKGROUND: Hepatitis C virus (HCV) nucleic acid amplification test (NAAT)-positive donors have increased the organ pool. Direct-acting antivirals (DAAs) have led to high rates of treatment success and sustained virologic response (SVR) in recipients with ... Full text Link to item Cite

When you need to dive in the deep end-Transplanting SARS-CoV-2 PCR+ recipients.

Journal Article Transpl Infect Dis · October 2023 There is an ongoing need to understand whether transplantation during acute Coronavirus disease 2019 (COVID-19) can be performed safely, especially when urgent transplant is required. We collected retrospective data of all consecutive non-lung transplant r ... Full text Link to item Cite

Antiviral Treatment Failures After Transplantation of Organs From Donors With Hepatitis C Infection: A Report of 4 Cases.

Journal Article Am J Kidney Dis · September 2023 The transplantation of organs from donors with hepatitis C virus (HCV) infection into uninfected recipients has expanded the available organ donor pool. With the advancement of direct-acting antivirals (DAAs), high rates of cure among transplant recipients ... Full text Link to item Cite

Disparities in Mpox Vaccination Among Priority Populations During the 2022 Outbreak.

Journal Article Open Forum Infect Dis · September 2023 BACKGROUND: The 2022 mpox outbreak disproportionately affected men who have sex with men and persons living with HIV (PLWH). A 2-dose mpox vaccine series was deployed in mid-2022. Structural racism and insurance status may have affected equitable vaccinati ... Full text Link to item Cite

Concurrent Sexually Transmitted Infection Testing Among Patients Tested for Mpox at a Tertiary Healthcare System.

Journal Article Open Forum Infect Dis · August 2023 Coinfection with sexually transmitted infections (STIs) and mpox is common. We evaluated concurrent STI testing among Duke Health patients tested for mpox. We found that most patients tested for mpox were not comprehensively tested for STIs, despite concur ... Full text Link to item Cite

Living kidney donors with HIV: experience and outcomes from a case series by the HOPE in Action Consortium.

Journal Article Lancet Reg Health Am · August 2023 BACKGROUND: Living kidney donation is possible for people living with HIV (PLWH) in the United States within research studies under the HIV Organ Policy Equity (HOPE) Act. There are concerns that donor nephrectomy may have an increased risk of end-stage re ... Full text Link to item Cite

Abatacept, Cenicriviroc, or Infliximab for Treatment of Adults Hospitalized With COVID-19 Pneumonia: A Randomized Clinical Trial.

Journal Article JAMA · July 25, 2023 IMPORTANCE: Immune dysregulation contributes to poorer outcomes in COVID-19. OBJECTIVE: To investigate whether abatacept, cenicriviroc, or infliximab provides benefit when added to standard care for COVID-19 pneumonia. DESIGN, SETTING, AND PARTICIPANTS: Ra ... Full text Open Access Link to item Cite

Epidemiology, management, and clinical outcomes of extrapulmonary Mycobacterium abscessus complex infections in heart transplant and ventricular assist device recipients.

Journal Article Am J Transplant · July 2023 Nontuberculous mycobacteria are emerging pathogens, yet data on the epidemiology and management of extrapulmonary nontuberculous mycobacteria infections in orthotopic heart transplantation (OHT) and ventricular assist device (VAD) recipients are scarce. We ... Full text Link to item Cite

Evaluating Demographic Representation in Clinical Trials: Use of the Adaptive Coronavirus Disease 2019 Treatment Trial (ACTT) as a Test Case.

Journal Article Open Forum Infect Dis · June 2023 BACKGROUND: Clinical trials initiated during emerging infectious disease outbreaks must quickly enroll participants to identify treatments to reduce morbidity and mortality. This may be at odds with enrolling a representative study population, especially w ... Full text Link to item Cite

Baricitinib Treatment of Coronavirus Disease 2019 Is Associated With a Reduction in Secondary Infections.

Journal Article Open Forum Infect Dis · May 2023 We performed a secondary analysis of the National Institutes of Health-sponsored Adaptive COVID-19 Treatment Trial (ACTT-2) randomized controlled trial and found that baricitinib was associated with a 50% reduction in secondary infections after controlling ... Full text Link to item Cite

When You Need to Dive in the Deep End - Transplanting SARS-COV-2 PCR+ Recipients

Conference AMERICAN JOURNAL OF TRANSPLANTATION · 2023 Cite

When You Need to Dive in the Deep End - Transplanting SARS-COV-2 PCR+ Recipients

Conference AMERICAN JOURNAL OF TRANSPLANTATION · 2023 Cite

Temporal Improvements in COVID-19 Outcomes for Hospitalized Adults: A Post Hoc Observational Study of Remdesivir Group Participants in the Adaptive COVID-19 Treatment Trial.

Journal Article Ann Intern Med · December 2022 BACKGROUND: The COVID-19 standard of care (SOC) evolved rapidly during 2020 and 2021, but its cumulative effect over time is unclear. OBJECTIVE: To evaluate whether recovery and mortality improved as SOC evolved, using data from ACTT (Adaptive COVID-19 Tre ... Full text Link to item Cite

Severe Monkeypox in Hospitalized Patients - United States, August 10-October 10, 2022.

Journal Article MMWR Morb Mortal Wkly Rep · November 4, 2022 As of October 21, 2022, a total of 27,884 monkeypox cases (confirmed and probable) have been reported in the United States.§ Gay, bisexual, and other men who have sex with men have constituted a majority of cases, and persons with HIV infection and those f ... Full text Open Access Link to item Cite

Transplanting thoracic COVID-19 positive donors: An institutional protocol and report of the first 14 cases.

Journal Article J Heart Lung Transplant · October 2022 We present our institution's protocol for evaluating and transplanting thoracic organs from COVID-19 positive donors and report the outcomes to date. Hearts from donors testing positive for COVID-19 on any test were eligible for transplantation at our inst ... Full text Link to item Cite

Infliximab for Treatment of Adults Hospitalized with Moderate or Severe Covid-19.

Journal Article medRxiv · September 26, 2022 BACKGROUND: Immune dysregulation contributes to poorer outcomes in severe Covid-19. Immunomodulators targeting various pathways have improved outcomes. We investigated whether infliximab provides benefit over standard of care. METHODS: We conducted a maste ... Full text Link to item Cite

Baricitinib versus dexamethasone for adults hospitalised with COVID-19 (ACTT-4): a randomised, double-blind, double placebo-controlled trial.

Journal Article Lancet Respir Med · September 2022 BACKGROUND: Baricitinib and dexamethasone have randomised trials supporting their use for the treatment of patients with COVID-19. We assessed the combination of baricitinib plus remdesivir versus dexamethasone plus remdesivir in preventing progression to ... Full text Open Access Link to item Cite

Infectious Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Virus in Symptomatic Coronavirus Disease 2019 (COVID-19) Outpatients: Host, Disease, and Viral Correlates.

Journal Article Clin Infect Dis · August 24, 2022 BACKGROUND: Although severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infectious virus isolation in outpatients with coronavirus disease 2019 (COVID-19) has been associated with viral RNA levels and symptom duration, little is known about the h ... Full text Link to item Cite

National Landscape of Human Immunodeficiency Virus-Positive Deceased Organ Donors in the United States.

Journal Article Clin Infect Dis · June 10, 2022 BACKGROUND: Organ transplantation from donors with human immunodeficiency virus (HIV) to recipients with HIV (HIV D+/R+) presents risks of donor-derived infections. Understanding clinical, immunologic, and virologic characteristics of HIV-positive donors i ... Full text Link to item Cite

Remdesivir for the Prevention of Invasive Mechanical Ventilation or Death in Coronavirus Disease 2019 (COVID-19): A Post Hoc Analysis of the Adaptive COVID-19 Treatment Trial-1 Cohort Data.

Journal Article Clin Infect Dis · April 9, 2022 This post hoc analysis of the Adaptive Coronavirus Disease 2019 (COVID-19) Treatment Trial-1 (ACTT-1) shows a treatment effect of remdesivir (RDV) on progression to invasive mechanical ventilation (IMV) or death. Additionally, we create a risk profile that ... Full text Link to item Cite

Cytomegalovirus prevention in thoracic organ transplantation: A single-center evaluation of letermovir prophylaxis.

Journal Article J Heart Lung Transplant · April 2022 BACKGROUND: Cytomegalovirus (CMV) infection is common following thoracic organ transplantation and causes substantial morbidity and mortality. Letermovir is a novel antiviral agent used off-label in this population for CMV prevention. Our goal was to under ... Full text Link to item Cite

Donor-derived tuberculosis among solid organ transplant recipients in the United States-2008 to 2018.

Journal Article Transpl Infect Dis · April 2022 Mycobacterium tuberculosis can be transmitted via organ donation and result in severe outcomes. To better understand donor-derived tuberculosis (DDTB), all potential transmissions reported to the Organ Procurement and Transplantation Network (OPTN) Ad Hoc ... Full text Link to item Cite

HOPE in action: A prospective multicenter pilot study of liver transplantation from donors with HIV to recipients with HIV.

Journal Article American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · March 2022 Liver transplantation (LT) from donors-with-HIV to recipients-with-HIV (HIV D+/R+) is permitted under the HOPE Act. There are only three international single-case reports of HIV D+/R+ LT, each with limited follow-up. We performed a prospective multicenter ... Full text Cite

A phase 2a clinical trial of molnupiravir in patients with COVID-19 shows accelerated SARS-CoV-2 RNA clearance and elimination of infectious virus.

Journal Article Sci Transl Med · January 19, 2022 There is an urgent need for an effective, oral, direct-acting therapeutic to block transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and prevent progression to severe coronavirus disease 2019 (COVID-19). In a phase 2a double-blin ... Full text Link to item Cite

Antibodies, boosters, and optimizing SARS-CoV-2 vaccines for transplantation: A call for more research.

Journal Article Am J Transplant · January 2022 Despite emerging data suggesting reduced antibody responses among solid organ transplant recipients following SARS-CoV-2 vaccine, critical unanswered questions remain. The clinical implications of the reduced humoral response need to be assessed through pr ... Full text Link to item Cite

Transplanting Thoracic COVID-19 Positive Donors: Overcoming the Pandemic

Conference JOURNAL OF HEART AND LUNG TRANSPLANTATION · 2022 Cite

COVID-19 in Lung Transplant Recipients: Outcomes and Long-Term Follow Up

Conference JOURNAL OF HEART AND LUNG TRANSPLANTATION · 2022 Cite

Rapid test to assess the escape of SARS-CoV-2 variants of concern.

Journal Article Sci Adv · December 3, 2021 Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants are concerning in the ongoing coronavirus disease 2019 (COVID-19) pandemic. Here, we developed a rapid test, termed CoVariant-SCAN, that detects neutralizing antibodies (nAbs) capable of ... Full text Link to item Cite

Buyer beware: The risks of donor-derived vaccine-induced thrombosis and thrombocytopenia.

Journal Article Am J Transplant · December 2021 The authors discuss two Letters to the Editor describing outcomes of transplantation using organs from donors who died with COVID-19 vaccine-induced thrombosis and thrombocytopenia and outline an evaluation algorithm for such donors and a management algori ... Full text Link to item Cite

Efficacy of interferon beta-1a plus remdesivir compared with remdesivir alone in hospitalised adults with COVID-19: a double-bind, randomised, placebo-controlled, phase 3 trial.

Journal Article Lancet Respir Med · December 2021 BACKGROUND: Functional impairment of interferon, a natural antiviral component of the immune system, is associated with the pathogenesis and severity of COVID-19. We aimed to compare the efficacy of interferon beta-1a in combination with remdesivir compare ... Full text Open Access Link to item Cite

Assessment of Simulated Surveillance Testing and Quarantine in a SARS-CoV-2-Vaccinated Population of Students on a University Campus.

Journal Article JAMA Health Forum · October 2021 IMPORTANCE: The importance of surveillance testing and quarantine on university campuses to limit SARS-CoV-2 transmission needs to be reevaluated in the context of a complex and rapidly changing environment that includes vaccines, variants, and waning immu ... Full text Open Access Link to item Cite

DAS181 Treatment of Severe Lower Respiratory Tract Parainfluenza Virus Infection in Immunocompromised Patients: A Phase 2 Randomized, Placebo-Controlled Study.

Journal Article Clin Infect Dis · August 2, 2021 BACKGROUND: There are no antiviral therapies for parainfluenza virus (PIV) infections. DAS181, a sialidase fusion protein, has demonstrated activity in in vitro and in animal models of PIV. METHODS: Adult immunocompromised patients diagnosed with PIV lower ... Full text Link to item Cite

The limits of refusal: An ethical review of solid organ transplantation and vaccine hesitancy.

Journal Article Am J Transplant · August 2021 Patients pursuing solid organ transplantation are encouraged to receive many vaccines on an accelerated timeline. Vaccination prior to transplantation offers the best chance of developing immunity and may expand the pool of donor organs that candidates can ... Full text Link to item Cite

Letermovir treatment of cytomegalovirus infection or disease in solid organ and hematopoietic cell transplant recipients.

Journal Article Transpl Infect Dis · August 2021 BACKGROUND: Few options are available for cytomegalovirus (CMV) treatment in transplant recipients resistant, refractory, or intolerant to approved agents. Letermovir (LET) is approved for prophylaxis in hematopoietic cell transplant (HCT) recipients, but ... Full text Link to item Cite

Infectious SARS-CoV-2 Virus in Symptomatic COVID-19 Outpatients: Host, Disease, and Viral Correlates.

Journal Article medRxiv · June 25, 2021 BACKGROUND: While SARS-CoV-2 infectious virus isolation in outpatients with COVID-19 has been associated with viral RNA levels and symptom duration, little is known about the host, disease and viral determinants of infectious virus detection. METHODS: COVI ... Full text Link to item Cite

A prospective multicenter pilot study of HIV-positive deceased donor to HIV-positive recipient kidney transplantation: HOPE in action.

Journal Article Am J Transplant · May 2021 HIV-positive donor to HIV-positive recipient (HIV D+/R+) transplantation is permitted in the United States under the HIV Organ Policy Equity Act. To explore safety and the risk attributable to an HIV+ donor, we performed a prospective multicenter pilot stu ... Full text Link to item Cite

Cryptococcus transmission through solid organ transplantation in the United States: A report from the Ad Hoc Disease Transmission Advisory Committee.

Journal Article Am J Transplant · May 2021 Cryptococcus species can cause serious life-threatening infection in solid organ transplant recipients by reactivation of prior infection, posttransplant de novo infection, or donor transmission from the transplanted organ. Although previously reported in ... Full text Link to item Cite

Invasive Mycobacterium abscessus Complex Infection After Cardiac Surgery: Epidemiology, Management, and Clinical Outcomes.

Journal Article Clin Infect Dis · April 8, 2021 BACKGROUND: We recently mitigated a clonal outbreak of hospital-acquired Mycobacterium abscessus complex (MABC), which included a large cluster of adult patients who developed invasive infection after exposure to heater-cooler units during cardiac surgery. ... Full text Link to item Cite

COVID-19 Response Strategies at Large Institutes of Higher Education in the United States: A Landscape Analysis, Fall 2020.

Journal Article J Adolesc Health · April 2021 PURPOSE: To examine the pandemic response plans of institutes of higher education (i.e., colleges and universities), including COVID-19 prevention, enforcement, and testing strategies. METHOD: Data from the largest public (n = 50) and private (n = 50) US i ... Full text Link to item Cite

Baricitinib plus Remdesivir for Hospitalized Adults with Covid-19.

Journal Article N Engl J Med · March 4, 2021 Featured Publication BACKGROUND: Severe coronavirus disease 2019 (Covid-19) is associated with dysregulated inflammation. The effects of combination treatment with baricitinib, a Janus kinase inhibitor, plus remdesivir are not known. METHODS: We conducted a double-blind, rando ... Full text Link to item Cite

Early experience with universal preprocedural testing for SARS-CoV-2 in a relatively low-prevalence area.

Journal Article Infect Control Hosp Epidemiol · March 2021 We implemented universal severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) testing of patients undergoing surgical procedures as a means to conserve personal protective equipment (PPE). The rate of asymptomatic coronavirus disease 2019 (COVID-19 ... Full text Open Access Link to item Cite

COVID-19 vaccination in our transplant recipients: The time is now.

Journal Article J Heart Lung Transplant · March 2021 We are entering 2021 with an expanding and effective COVID-19 vaccine armamentarium. Recent interim results from COVID-19 vaccine trials, including more than 80,000 participants worldwide, demonstrate remarkable efficacy and low rate of serious adverse eve ... Full text Link to item Cite

Ten years of donor-derived disease: A report of the disease transmission advisory committee.

Journal Article Am J Transplant · February 2021 Despite clinical and laboratory screening of potential donors for transmissible disease, unexpected transmission of disease from donor to recipient remains an inherent risk of organ transplantation. The Disease Transmission Advisory Committee (DTAC) was cr ... Full text Link to item Cite

Donor derived hepatitis B virus infection: Analysis of the Organ Procurement & Transplantation Network/United Network for Organ Sharing Ad Hoc Disease Transmission Advisory Committee.

Journal Article Transpl Infect Dis · February 2021 Hepatitis B virus (HBV) can be transmitted from organ donor to recipient, but details of transmission events are not widely published. The Disease Transmission Advisory Committee (DTAC) evaluated 105 cases of potential donor derived transmission events of ... Full text Link to item Cite

Time from Start of Quarantine to SARS-CoV-2 Positive Test Among Quarantined College and University Athletes - 17 States, June-October 2020.

Journal Article MMWR Morb Mortal Wkly Rep · January 8, 2021 To safely resume sports, college and university athletic programs and regional athletic conferences created plans to mitigate transmission of SARS-CoV-2, the virus that causes coronavirus disease 2019 (COVID-19). Mitigation measures included physical dista ... Full text Link to item Cite

The Emerging Chronic Sequelae of COVID-19 and Implications for North Carolina.

Journal Article N C Med J · 2021 The acute morbidity and mortality of COVID-19 have been well described. Evidence is emerging that COVID-19 may also result in negative long-term medical and psychiatric outcomes. A broad response from the public health community in North Carolina that incl ... Full text Link to item Cite

Incidence and Outcomes of COVID-19 in Kidney and Liver Transplant Recipients With HIV: Report From the National HOPE in Action Consortium.

Journal Article Transplantation · January 1, 2021 BACKGROUND: Transplant recipients with HIV may have worse outcomes with coronavirus disease 2019 (COVID-19) due to impaired T-cell function coupled with immunosuppressive drugs. Alternatively, immunosuppression might reduce inflammatory complications and/o ... Full text Link to item Cite

Introduction to Immunosuppression, Tolerance, and Infection Risk

Chapter · January 1, 2021 Over the last half a century, there have been innumerable advances in our understanding of the human immune system. We now have a better understanding not only of the ways our innate and adaptive immune pathways interact to seek out and control infection a ... Full text Cite

Preface

Book · January 1, 2021 Cite

Emerging Transplant Infections: Clinical Challenges and Implications

Book · January 1, 2021 The field of transplant medicine has evolved significantly since the first kidney transplant was performed in 1954. Innovations in transplant immunosuppression have lowered the risk of organ rejection so that infectious complications are now the leading ca ... Full text Cite

Direct-Acting Antivirals and Organ Transplantation: Is There Anything We Can't Do?

Journal Article J Infect Dis · November 27, 2020 The opioid epidemic has resulted in an increase in organ donors with hepatitis C virus (HCV) infection in the United States. With the development of direct-acting antiviral regimens that offer high sustained virologic response rates even in the setting of ... Full text Link to item Cite

Implementation of a Pooled Surveillance Testing Program for Asymptomatic SARS-CoV-2 Infections on a College Campus - Duke University, Durham, North Carolina, August 2-October 11, 2020.

Journal Article MMWR Morb Mortal Wkly Rep · November 20, 2020 On university campuses and in similar congregate environments, surveillance testing of asymptomatic persons is a critical strategy (1,2) for preventing transmission of SARS-CoV-2, the virus that causes coronavirus disease 2019 (COVID-19). All students at D ... Full text Open Access Link to item Cite

Remdesivir for the Treatment of Covid-19 - Final Report.

Journal Article N Engl J Med · November 5, 2020 BACKGROUND: Although several therapeutic agents have been evaluated for the treatment of coronavirus disease 2019 (Covid-19), no antiviral agents have yet been shown to be efficacious. METHODS: We conducted a double-blind, randomized, placebo-controlled tr ... Full text Link to item Cite

Donor evaluation in the era of HIV-positive organ transplantation: The importance of the infectious diseases specialist.

Journal Article Am J Transplant · September 2020 A 61-year-old female with well-controlled human immunodeficiency virus (HIV) and end-stage renal disease was on the kidney transplant waitlist awaiting an organ offer, including from HIV-positive donors through the HIV Organ Policy Equity (HOPE) Act. We pr ... Full text Link to item Cite

Infectious complications of vascularized composite allograft transplantation.

Journal Article Curr Opin Organ Transplant · August 2020 PURPOSE OF REVIEW: Vascularized composite allograft (VCA) transplants constitute multiple tissues transplanted together as one functional unit. These procedures are increasing in frequency and complexity, yet data about graft survival, quality of life, and ... Full text Link to item Cite

Coronavirus disease 2019: Implications of emerging infections for transplantation.

Journal Article Am J Transplant · July 2020 The recent identification of an outbreak of 2019- novel Coronavirus is currently evolving, and the impact on transplantation is unknown. However, it is imperative that we anticipate the potential impact on the transplant community in order to avert severe ... Full text Link to item Cite

Response to Apewokin and Onyishi.

Journal Article Clin Infect Dis · June 10, 2020 Full text Link to item Cite

Utilization of hepatitis C virus-infected organ donors in cardiothoracic transplantation: An ISHLT expert consensus statement.

Journal Article J Heart Lung Transplant · May 2020 The advent of therapies for successful treatment of hepatitis C virus has allowed the heart and lung transplant community to re-explore the use of hepatitis C virus-positive donors for organ transplantation, with a benefit for many terminally ill patients. ... Full text Link to item Cite

Viremic Hepatitis B Donors: A Case of Why It's Time to Further Expand the Donor Pool for Thoracic Transplant

Conference The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · April 1, 2020 INTRODUCTION: In light of a national shortage of thoracic organs, patients with end stage lung disease need an expanded donor pool. There are approximately 847,000 persons with chronic hepatitis B virus (HBV) in the U.S. Previously, transplantation of HBV ... Full text Cite

Reply to Verweij et al.

Journal Article Clin Infect Dis · January 2, 2020 Full text Link to item Cite

Real-World Experiences in the Transplantation of Hepatitis C Positive Kidneys

Conference AMERICAN JOURNAL OF TRANSPLANTATION · 2020 Cite

Anti-influenza hyperimmune intravenous immunoglobulin for adults with influenza A or B infection (FLU-IVIG): a double-blind, randomised, placebo-controlled trial.

Journal Article Lancet Respir Med · November 2019 BACKGROUND: Since the 1918 influenza pandemic, non-randomised studies and small clinical trials have suggested that convalescent plasma or anti-influenza hyperimmune intravenous immunoglobulin (hIVIG) might have clinical benefit for patients with influenza ... Full text Link to item Cite

Solid organ transplantation in older adults. Infectious and other age-related considerations.

Journal Article OBM Transplant · November 2019 In the U.S., older adults aged 65 or above comprise nearly one quarter of the solid organ transplant (SOT) waitlists, and the number of transplants performed in this age group continues to increase. There are no specific guidelines for the assessment and f ... Full text Link to item Cite

Perspectives on Scedosporium species and Lomentospora prolificans in lung transplantation: Results of an international practice survey from ESCMID fungal infection study group and study group for infections in compromised hosts, and European Confederation of Medical Mycology.

Journal Article Transpl Infect Dis · October 2019 BACKGROUND: Scedosporium species and Lomentospora prolificans (S/L) are the second most common causes of invasive mold infections following Aspergillus in lung transplant recipients. METHODS: We assessed the current practices on management of S/L colonizat ... Full text Link to item Cite

Donor-derived infections: Guidelines from the American Society of Transplantation Infectious Diseases Community of Practice.

Journal Article Clin Transplant · September 2019 These updated guidelines from the Infectious Diseases Community of Practice of the American Society of Transplantation will review the current state of the art of donor-derived infections. Specifically, the guideline will summarize standardized definitions ... Full text Link to item Cite

Renal cell carcinoma suspected at time of organ donation 2008-2016: A report of the OPTN ad hoc Disease Transmission Advisory Committee Registry.

Journal Article Clin Transplant · July 2019 All 179 reports to the OPTN of potential renal cell carcinoma (RCC) transmission from 1/1/2008 through 12/31/2016 were reviewed. Cases were divided into those with donor tumor known or suspected at time of transplant (N = 147 donors), and those in which tu ... Full text Link to item Cite

Hepatitis and Thoracic Transplantation - No More Virus Non-Grata

Conference The Journal of Heart and Lung Transplantation · April 2019 Full text Cite

Opening the Doors of Hope: HIV-Positive Living Kidney Donation.

Conference AMERICAN JOURNAL OF TRANSPLANTATION · April 1, 2019 Link to item Cite

Clinical Practice Guidelines by the Infectious Diseases Society of America: 2018 Update on Diagnosis, Treatment, Chemoprophylaxis, and Institutional Outbreak Management of Seasonal Influenzaa.

Journal Article Clin Infect Dis · March 5, 2019 These clinical practice guidelines are an update of the guidelines published by the Infectious Diseases Society of America (IDSA) in 2009, prior to the 2009 H1N1 influenza pandemic. This document addresses new information regarding diagnostic testing, trea ... Full text Link to item Cite

Early experience with the use of hepatitis C antibody-positive, nucleic acid testing-negative donors in lung transplantation.

Journal Article Clin Transplant · March 2019 Historically, potential lung donors who have detectable antibodies to hepatitis C virus have been declined by most centers due to concern for possible disease transmission. We sought to evaluate hepatitis C viral transmission rates from donors who were kno ... Full text Link to item Cite

Use of Letermovir as Salvage Therapy for Drug-Resistant Cytomegalovirus Retinitis.

Journal Article Antimicrob Agents Chemother · March 2019 Treatment options for drug-resistant cytomegalovirus (CMV) are limited. Letermovir is a novel antiviral recently approved for CMV prophylaxis following hematopoietic cell transplantation, but its efficacy in other settings is unknown. We recently used lete ... Full text Open Access Link to item Cite

Implications of declining donor offers with increased risk of disease transmission on waiting list survival in lung transplantation.

Journal Article J Heart Lung Transplant · March 2019 BACKGROUND: Donors with characteristics that may increase the likelihood of disease transmission with transplantation are noted as increased risk via Public Health Service criteria. This study aimed to establish the implications of declining an increased-r ... Full text Link to item Cite

Genomic characterization of recurrent mold infections in thoracic transplant recipients.

Journal Article Transpl Infect Dis · October 2018 Invasive mold disease in thoracic organ transplant recipients is a well-recognized complication, but the long-term persistence of molds within the human body and evasion of host defenses has not been well-described. We present 2 cases of invasive mold dise ... Full text Link to item Cite

Donor-derived hepatitis C in the era of increasing intravenous drug use: A report of the Disease Transmission Advisory Committee.

Journal Article Clin Transplant · October 2018 The opioid epidemic has resulted in a potential increase in donors in the testing window period for hepatitis C virus (HCV). We analyzed HCV reports to the Disease Transmission Advisory Committee (DTAC) between 2008 and 2016 to estimate the risk of HCV tra ... Full text Link to item Cite

Early Rhinovirus Infection After Lung Transplantation - Simply the Innocent Bystander?

Conference The Journal of Heart and Lung Transplantation · April 2018 Full text Cite

Transplant Drug Interactions and a Word of Caution for the HIV Provider. A Case Report.

Journal Article Open Forum Infect Dis · April 2018 Electronic medical record platforms fail to support provider alerts when a drug is discontinued. Protease inhibitors, often boosted by ritonavir or cobicistat, increase the serum concentration of calcineurin inhibitors. This case demonstrates acute liver t ... Full text Open Access Link to item Cite

Don’t Pass the Peanuts: Donor-Derived Nut Allergy in Lung Transplant

Conference The Journal of Heart and Lung Transplantation · April 2018 Full text Cite

Brincidofovir - Finally an Option for PML?

Conference The Journal of Heart and Lung Transplantation · April 2018 Full text Cite

Pediatrics and donor-derived disease transmission: The US OPTN experience.

Journal Article Pediatr Transplant · February 2018 PDDTE are tracked by the OPTN Ad Hoc DTAC. Specific evaluation of potential transmissions from pediatric deceased donors or the impact of donor-derived disease transmissions to pediatric organ recipients has not been previously undertaken. PDDTE reported t ... Full text Link to item Cite

Increased indoleamine-2,3-dioxygenase activity is associated with poor clinical outcome in adults hospitalized with influenza in the INSIGHT FLU003Plus study

Journal Article Open Forum Infectious Diseases · January 1, 2018 Background. Indoleamine-2,3-dioxygenase (IDO) mediated tryptophan (TRP) depletion has antimicrobial and immuno-regulatory effects. Increased kynurenine (KYN)-to-TRP (KT) ratios, reflecting increased IDO activity, have been associated with poorer outcomes f ... Full text Cite

Oseltamivir, amantadine, and ribavirin combination antiviral therapy versus oseltamivir monotherapy for the treatment of influenza: a multicentre, double-blind, randomised phase 2 trial.

Journal Article Lancet Infect Dis · December 2017 BACKGROUND: Influenza continues to have a substantial socioeconomic and health impact despite a long established vaccination programme and approved antivirals. Preclinical data suggest that combining antivirals might be more effective than administering os ... Full text Link to item Cite

Donor-derived infections in solid organ transplant patients: toward a holistic approach.

Journal Article Curr Opin Infect Dis · August 2017 PURPOSE OF REVIEW: Solid organ demand far exceeds organ supply. Strategies to increase the donor pool include the liberalization of selection criteria without increasing the risk of unexpected donor-derived infection (DDI), a rare complication of transplan ... Full text Link to item Cite

The "PHS Increased Risk" Label Is Associated With Nonutilization of Hundreds of Organs per Year.

Journal Article Transplantation · July 2017 BACKGROUND: The Public Health Service "Increased Risk" (PHS IR) designation identifies donors at increased risk of transmitting hepatitis B, C, and human immunodeficiency virus. Although the risk remains very low in the era of nucleic acid testing, we hypo ... Full text Link to item Cite

Two-Phase Hospital-Associated Outbreak of Mycobacterium abscessus: Investigation and Mitigation.

Journal Article Clin Infect Dis · April 1, 2017 BACKGROUND: Nontuberculous mycobacteria (NTM) commonly colonize municipal water supplies and cause healthcare-associated outbreaks. We investigated a biphasic outbreak of Mycobacterium abscessus at a tertiary care hospital. METHODS: Case patients had recen ... Full text Link to item Cite

Mycobacterium Abscessus Infection in Patients with Ventricular Assist Devices

Conference JOURNAL OF HEART AND LUNG TRANSPLANTATION · April 1, 2017 Link to item Cite

Invasive Mycobacterium abscessus Infection in Heart Transplant Recipients

Conference JOURNAL OF HEART AND LUNG TRANSPLANTATION · April 1, 2017 Link to item Cite

Coccidioidomycosis Transmission Through Organ Transplantation: A Report of the OPTN Ad Hoc Disease Transmission Advisory Committee.

Journal Article Am J Transplant · December 2016 Donor-derived coccidioidomycosis has caused unexpected morbidity and mortality in transplant recipients. All proven or probable reports of donor-derived coccidioidomycosis to the Disease Transmission Advisory Committee between 2005 and August 2012 were rev ... Full text Link to item Cite

Aerosolized ribavirin: the most expensive drug for pneumonia.

Journal Article Transpl Infect Dis · August 2016 Dramatic, overnight cost increases of important orphan and generic medications have recently come under public and government scrutiny. We highlight the case of aerosolized ribavirin, an important antiviral agent in hematopoietic stem cell transplantation ... Full text Link to item Cite

Early Nosocomial Adenovirus Infection Is Associated With Worse Outcomes Following Lung Transplantation

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · January 1, 2016 Link to item Cite

Donor-derived transmission events in 2013: a report of the Organ Procurement Transplant Network Ad Hoc Disease Transmission Advisory Committee.

Journal Article Transplantation · February 2015 BACKGROUND: The Organ Procurement Transplant Network Disease Transmission Advisory Committee (DTAC), a multidisciplinary committee, evaluates potential donor-derived transmission events (PDDTE), including infections and malignancies, to assess for donor tr ... Full text Link to item Cite

Bronchomediastinal fistula caused by endobronchial aspergilloma.

Journal Article Ann Am Thorac Soc · January 2015 RATIONALE: Endobronchial aspergilloma is a rare condition affecting immunocompromised patients. We present three cases resulting in airway fistulae. CASE PRESENTATIONS: A 68-year-old male with orthotopic heart transplantation presented with fatigue, cough, ... Full text Link to item Cite

In vitro activity of amikacin against isolates of Mycobacterium avium complex with proposed MIC breakpoints and finding of a 16S rRNA gene mutation in treated isolates.

Journal Article J Clin Microbiol · October 2013 Amikacin is a major drug used for the treatment of Mycobacterium avium complex (MAC) disease, but standard laboratory guidelines for susceptibility testing are not available. This study presents in vitro amikacin MICs for 462 consecutive clinical isolates ... Full text Link to item Cite

Disseminated Mycobacterium immunogenum infection presenting with septic shock and skin lesions in a renal transplant recipient.

Journal Article Transpl Infect Dis · August 2012 Mycobacterium immunogenum is a relatively new species within the Mycobacterium chelonae-Mycobacterium abscessus group of rapidly growing mycobacteria (RGM). M. immunogenum was first characterized in 2001 and, similar to other RGM, is an ubiquitous environm ... Full text Link to item Cite

Response

Journal Article Chest · June 1, 2011 Full text Cite

Case report: treatment of chronic osteomyelitis.

Journal Article Clin Infect Dis · June 2011 Presented is a case of chronic methicillin-resistant Staphylococcus aureus osteomyelitis, which was unsuccessfully treated with multiple courses of debridement and potent antibiotic therapies. Amputation of the patient's lower limb was believed to be the o ... Full text Link to item Cite

Cluster of oseltamivir-resistant 2009 pandemic influenza A (H1N1) virus infections on a hospital ward among immunocompromised patients--North Carolina, 2009.

Journal Article J Infect Dis · March 15, 2011 BACKGROUND: Oseltamivir resistance among 2009 pandemic influenza A (H1N1) viruses (pH1N1) is rare. We investigated a cluster of oseltamivir-resistant pH1N1 infections in a hospital ward. METHODS: We reviewed patient records and infection control measures a ... Full text Link to item Cite

Rescue therapy in adult and pediatric patients with pH1N1 influenza infection: a tertiary center intensive care unit experience from April to October 2009.

Journal Article Crit Care Med · November 2010 OBJECTIVE: Severe respiratory failure is a well-recognized complication of pH1N1 influenza infection. Limited data regarding the efficacy of rescue therapies, including high-frequency oscillatory ventilation and extracorporeal membrane oxygenation, have be ... Full text Link to item Cite

Reversible cardiac dysfunction associated with pandemic 2009 influenza A(H1N1).

Journal Article Chest · May 2010 Historical influenza A epidemics have carried elevated rates of cardiovascular disease, including transient cardiac dysfunction. Whether such an association holds for the novel influenza A strain, pandemic 2009 influenza A(H1N1) [A(H1N1)], remains unknown. ... Full text Link to item Cite

Wound botulism complicating internal fixation of a complex radial fracture.

Journal Article J Clin Microbiol · February 2010 Botulism developed in a patient following surgical repair of an open radial fracture. Symptoms resolved after treatment with antitoxin and antibiotics, and hardware excision was deferred. Subsequent osteomyelitis necessitated hardware exchange, and wound c ... Full text Link to item Cite

Rheumatic fever

Chapter · January 1, 2010 Full text Cite