Scholars@Duke
Devon James Godfrey

Devon James Godfrey

Associate Professor of Radiation Oncology
Radiation Oncology
devon.godfrey@duke.edu
Box 3295 Med Ctr, DUMC, Durham, NC 27710
Radiation Oncology, Physics, Box 3295, DUMC, Durham, NC 27710
Manage Profile
Embed Profile Data

Selected Publications

A multi-institutional meningioma MRI dataset for automated multi-sequence image segmentation.

Journal Article Sci Data · May 15, 2024 Meningiomas are the most common primary intracranial tumors and can be associated with significant morbidity and mortality. Radiologists, neurosurgeons, neuro-oncologists, and radiation oncologists rely on brain MRI for diagnosis, treatment planning, and l ... Full text Link to item Cite

Incidence and imaging characteristics of difficult to detect retrospectively identified brain metastases in patients receiving repeat courses of stereotactic radiosurgery.

Journal Article J Neurooncol · March 2024 PURPOSE: During stereotactic radiosurgery (SRS) planning for brain metastases (BM), brain MRIs are reviewed to select appropriate targets based on radiographic characteristics. Some BM are difficult to detect and/or definitively identify and may go untreat ... Full text Link to item Cite

A Deep Learning-Based Computer Aided Detection (CAD) System for Difficult-to-Detect Brain Metastases.

Journal Article Int J Radiat Oncol Biol Phys · March 1, 2023 PURPOSE: We sought to develop a computer-aided detection (CAD) system that optimally augments human performance, excelling especially at identifying small inconspicuous brain metastases (BMs), by training a convolutional neural network on a unique magnetic ... Full text Link to item Cite

Impact of Race on Outcomes of High-Risk Patients With Prostate Cancer Treated With Moderately Hypofractionated Radiotherapy in an Equal Access Setting.

Journal Article Fed Pract · August 2022 BACKGROUND: Moderately hypofractionated radiotherapy (MHRT) is an accepted treatment for localized prostate cancer; however, limited MHRT data address high-risk prostate cancer (HRPC) and/or African American patients. We report clinical outcomes and toxici ... Full text Link to item Cite

Effect of Large Prostate Volume on Efficacy and Toxicity of Moderately Hypofractionated Radiation Therapy in Patients With Prostate Cancer.

Journal Article Adv Radiat Oncol · 2022 PURPOSE: To evaluate the effect of prostate volume on outcomes after moderately hypofractionated radiation therapy (mHFRT) for prostate cancer. METHODS AND MATERIALS: Prostate cancer patients treated with mHFRT at a Veteran's Affairs Medical Center from Au ... Full text Link to item Cite

A Deep Learning-Based Computer Aided Detection (CAD) System for Difficult-to-Detect Brain Metastases (BM)

Conference INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS · 2022 Cite

Dosimetric Predictors of Toxicity in Patients With Early-Stage Prostate Cancer Treated With Moderately Hypofractionated IMRT or PBT: A Multi-Institutional Analysis.

Conference International journal of radiation oncology, biology, physics · November 2021 Purpose/objective(s)Limited published data address modifiable risk factors for significant toxicity complicating moderately hypofractionated schedules of intensity-modulated radiation therapy (IMRT) and proton-beam therapy (PBT) in patients with e ... Full text Cite

A Pooled Toxicity Analysis of Moderately Hypofractionated Proton Beam Therapy and Intensity Modulated Radiation Therapy in Early-Stage Prostate Cancer Patients.

Journal Article Int J Radiat Oncol Biol Phys · July 15, 2021 PURPOSE: Data comparing moderately hypofractionated intensity modulated radiation therapy (IMRT) and proton beam therapy (PBT) are lacking. We aim to compare late toxicity profiles of patients with early-stage prostate cancer treated with moderately hypofr ... Full text Link to item Cite

Local Tumor Control and Patient Outcome Using Stereotactic Body Radiation Therapy for Hepatocellular Carcinoma: iRECIST as a Potential Substitute for Traditional Criteria.

Journal Article AJR Am J Roentgenol · December 2019 OBJECTIVE. The purpose of this study was to investigate whether, compared with traditional criteria, the modified Response Evaluation Criteria in Solid Tumors version 1.1 for immune-based therapeutics (iRECIST) improves prediction of local tumor control an ... Full text Link to item Cite

Radiation Therapy for Pancreatic Cancer: Executive Summary of an ASTRO Clinical Practice Guideline.

Journal Article Pract Radiat Oncol · 2019 PURPOSE: This guideline systematically reviews the evidence for treatment of pancreatic cancer with radiation in the adjuvant, neoadjuvant, definitive, and palliative settings and provides recommendations on indications and technical considerations. METHOD ... Full text Link to item Cite

The role of external beam radiotherapy in the treatment of hepatocellular cancer.

Journal Article Cancer · September 1, 2018 Hepatocellular carcinoma (HCC) is increasing in incidence and mortality. Although the prognosis remains poor, long-term survival has improved from 3% in 1970 to an 18% 5-year survival rate today. This is likely because of the introduction of well tolerated ... Full text Link to item Cite

The Impact of Biologically Equivalent Dose on Tumor Control in Unresectable Hepatocellular Carcinoma

Conference International Journal of Radiation Oncology*Biology*Physics · October 2017 Full text Cite

A multi-institutional meningioma MRI dataset for automated multi-sequence image segmentation.

Journal Article Sci Data · May 15, 2024 Meningiomas are the most common primary intracranial tumors and can be associated with significant morbidity and mortality. Radiologists, neurosurgeons, neuro-oncologists, and radiation oncologists rely on brain MRI for diagnosis, treatment planning, and l ... Full text Link to item Cite

Incidence and imaging characteristics of difficult to detect retrospectively identified brain metastases in patients receiving repeat courses of stereotactic radiosurgery.

Journal Article J Neurooncol · March 2024 PURPOSE: During stereotactic radiosurgery (SRS) planning for brain metastases (BM), brain MRIs are reviewed to select appropriate targets based on radiographic characteristics. Some BM are difficult to detect and/or definitively identify and may go untreat ... Full text Link to item Cite

A Deep Learning-Based Computer Aided Detection (CAD) System for Difficult-to-Detect Brain Metastases.

Journal Article Int J Radiat Oncol Biol Phys · March 1, 2023 PURPOSE: We sought to develop a computer-aided detection (CAD) system that optimally augments human performance, excelling especially at identifying small inconspicuous brain metastases (BMs), by training a convolutional neural network on a unique magnetic ... Full text Link to item Cite

Impact of Race on Outcomes of High-Risk Patients With Prostate Cancer Treated With Moderately Hypofractionated Radiotherapy in an Equal Access Setting.

Journal Article Fed Pract · August 2022 BACKGROUND: Moderately hypofractionated radiotherapy (MHRT) is an accepted treatment for localized prostate cancer; however, limited MHRT data address high-risk prostate cancer (HRPC) and/or African American patients. We report clinical outcomes and toxici ... Full text Link to item Cite

Effect of Large Prostate Volume on Efficacy and Toxicity of Moderately Hypofractionated Radiation Therapy in Patients With Prostate Cancer.

Journal Article Adv Radiat Oncol · 2022 PURPOSE: To evaluate the effect of prostate volume on outcomes after moderately hypofractionated radiation therapy (mHFRT) for prostate cancer. METHODS AND MATERIALS: Prostate cancer patients treated with mHFRT at a Veteran's Affairs Medical Center from Au ... Full text Link to item Cite

A Deep Learning-Based Computer Aided Detection (CAD) System for Difficult-to-Detect Brain Metastases (BM)

Conference INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS · 2022 Cite

Dosimetric Predictors of Toxicity in Patients With Early-Stage Prostate Cancer Treated With Moderately Hypofractionated IMRT or PBT: A Multi-Institutional Analysis.

Conference International journal of radiation oncology, biology, physics · November 2021 Purpose/objective(s)Limited published data address modifiable risk factors for significant toxicity complicating moderately hypofractionated schedules of intensity-modulated radiation therapy (IMRT) and proton-beam therapy (PBT) in patients with e ... Full text Cite

A Pooled Toxicity Analysis of Moderately Hypofractionated Proton Beam Therapy and Intensity Modulated Radiation Therapy in Early-Stage Prostate Cancer Patients.

Journal Article Int J Radiat Oncol Biol Phys · July 15, 2021 PURPOSE: Data comparing moderately hypofractionated intensity modulated radiation therapy (IMRT) and proton beam therapy (PBT) are lacking. We aim to compare late toxicity profiles of patients with early-stage prostate cancer treated with moderately hypofr ... Full text Link to item Cite

Local Tumor Control and Patient Outcome Using Stereotactic Body Radiation Therapy for Hepatocellular Carcinoma: iRECIST as a Potential Substitute for Traditional Criteria.

Journal Article AJR Am J Roentgenol · December 2019 OBJECTIVE. The purpose of this study was to investigate whether, compared with traditional criteria, the modified Response Evaluation Criteria in Solid Tumors version 1.1 for immune-based therapeutics (iRECIST) improves prediction of local tumor control an ... Full text Link to item Cite

Radiation Therapy for Pancreatic Cancer: Executive Summary of an ASTRO Clinical Practice Guideline.

Journal Article Pract Radiat Oncol · 2019 PURPOSE: This guideline systematically reviews the evidence for treatment of pancreatic cancer with radiation in the adjuvant, neoadjuvant, definitive, and palliative settings and provides recommendations on indications and technical considerations. METHOD ... Full text Link to item Cite

The role of external beam radiotherapy in the treatment of hepatocellular cancer.

Journal Article Cancer · September 1, 2018 Hepatocellular carcinoma (HCC) is increasing in incidence and mortality. Although the prognosis remains poor, long-term survival has improved from 3% in 1970 to an 18% 5-year survival rate today. This is likely because of the introduction of well tolerated ... Full text Link to item Cite

The Impact of Biologically Equivalent Dose on Tumor Control in Unresectable Hepatocellular Carcinoma

Conference International Journal of Radiation Oncology*Biology*Physics · October 2017 Full text Cite

Triphasic contrast enhanced CT simulation with bolus tracking for pancreas SBRT target delineation.

Journal Article Pract Radiat Oncol · 2017 PURPOSE: Bolus-tracked multiphasic contrast computed tomography (CT) is often used in diagnostic radiology to enhance the visibility of pancreas tumors, but is uncommon in radiation therapy pancreas CT simulation, and its impact on gross tumor volume (GTV) ... Full text Link to item Cite

Advances in Medical Physics: 2014

Book · July 1, 2014 Advances in Medical Physics (AMP) is designed to help medical physicists and technically inclined physicians stay current in medical radiation science and technology, especially in sub-fields of medical physics other than their own. AMP 2014 contains an ex ... Cite

Intensity-modulated radiotherapy

Chapter · July 1, 2013 Intensity-modulated radiotherapy (IMRT) is a radiation delivery technique that allows dose sculpting to improve target coverage while sparing normal tissues. In an IMRT plan, the number of photons delivered (or fluence) varies within a field. Such variabil ... Full text Cite

The effect of averaging adjacent planes for artifact reduction in matrix inversion tomosynthesis.

Journal Article Med Phys · February 2013 PURPOSE: Matrix inversion tomosynthesis (MITS) uses linear systems theory and knowledge of the imaging geometry to remove tomographic blur that is present in conventional backprojection tomosynthesis reconstructions, leaving in-plane detail rendered clearl ... Full text Link to item Cite

SU-E-J-16: Prostate Bed Motion during Post-Prostatectomy Radiotherapy.

Journal Article Med Phys · June 2012 PURPOSE: To report the inter-fractional prostate bed motion (PBM) during post-prostatectomy radiotherapy using cone-beam CT (CBCT). The correlations between PBM, anterior rectal wall and posterior bladder wall shifts were also investigated. METHODS: Sevent ... Full text Link to item Cite

On-Board Digital Tomosynthesis: An Emerging New Technology for Image-Guided Radiation Therapy

Chapter · January 1, 2012 External-beam radiation therapy is a common treatment modality for cancers. e treatment course typically consists of 30-40 daily fractions of 180-200 cGy over several weeks. On-board imaging (OBI) guidance is oen designed to track shis in patient positioni ... Full text Cite

SU‐E‐J‐153: Tracking Respiratory Motion in CBCT Projection Images Using an Integrated Optical Flow (IOF) Method

Conference Medical Physics · January 1, 2011 Purpose: To introduce and evaluate a new method for automatically extracting respiratory phase information directly from CBCT or tomosynthesis projection data. Methods: In the proposed method, the Black and Anandan dense optical flow is computed in the lon ... Full text Cite

MO‐D‐BRC‐07: Reducing Artifacts in Cone‐Beam CT Images Caused by the Presence of An Array Used for Tracking Transponders during Radiotherapy

Conference Medical Physics · January 1, 2011 Purpose: To compare two methods for reducing artifacts in cone‐beam CT (CBCT) images caused by the presence of an electromagnetic array used for tracking transponders during radiotherapy. Methods: A pelvis phantom was imaged using a gantry mounted CBCT sys ... Full text Cite

Digital tomosynthesis for respiratory gated liver treatment: clinical feasibility for daily image guidance.

Journal Article Int J Radiat Oncol Biol Phys · January 1, 2011 PURPOSE: Breath-hold (BH) treatment minimizes internal target volumes (ITV) when treating sites prone to motion. Digital tomosynthesis (DTS) imaging has advantages over cone-beam CT (CBCT) for BH imaging: BH-DTS scan can be completed during a single breath ... Full text Link to item Cite

SU‐GG‐I‐24: Improving IGRT Efficiency Using GPU‐Based Ultrafast Reconstruction of DTS/CBCT and DRR

Conference Medical Physics · January 1, 2010 Purpose: One challenge of on‐line image‐guided radiation therapy is requirement of immediate availability of reconstructed 3D or 4D images for evaluation. This study is to develop a highly data‐parallel version and platform of accelerating reconstruction f ... Full text Cite

Stochastic noise characteristics in matrix inversion tomosynthesis (MITS).

Journal Article Med Phys · May 2009 Matrix inversion tomosynthesis (MITS) uses known imaging geometry and linear systems theory to deterministically separate in-plane detail from residual tomographic blur in a set of conventional tomosynthesis ("shift-and-add") planes. A previous investigati ... Full text Link to item Cite

Comparing digital tomosynthesis to cone-beam CT for position verification in patients undergoing partial breast irradiation.

Journal Article Int J Radiat Oncol Biol Phys · March 1, 2009 PURPOSE: To evaluate digital tomosynthesis (DTS) technology for daily positioning of patients receiving accelerated partial breast irradiation (APBI) and to compare the positioning accuracy of DTS to three-dimensional cone-beam computed tomography (CBCT). ... Full text Link to item Cite

TH‐A‐211A‐01: Digital Tomosynthesis for Target Localization

Conference Medical Physics · January 1, 2009 Any deviation between treated and planned volumes for 3‐D conformal therapy, such as IMRT, may cause an adverse clinical outcome. It is therefore critical to minimize all potential deviations using an on‐board (or real‐time) imaging procedure immediately p ... Full text Cite

Clinical evaluation of positioning verification using digital tomosynthesis and bony anatomy and soft tissues for prostate image-guided radiotherapy.

Journal Article Int J Radiat Oncol Biol Phys · January 1, 2009 PURPOSE: To evaluate on-board digital tomosynthesis (DTS) for patient positioning vs. two-dimensional (2D) radiography and three-dimensional cone beam (CBCT). METHODS AND MATERIALS: A total of 92 image sessions from 9 prostate cancer patients were analyzed ... Full text Link to item Cite

A Novel Digital Tomosynthesis (DTS) Reconstruction Method using Prior Information and a Deformation Model

Conference International Journal of Radiation Oncology*Biology*Physics · September 2008 Full text Cite

On-board four-dimensional digital tomosynthesis: first experimental results.

Journal Article Med Phys · August 2008 The purpose of this study is to propose four-dimensional digital tomosynthesis (4D-DTS) for on-board analysis of motion information in three dimensions. Images of a dynamic motion phantom were reconstructed using acquisition scan angles ranging from 20 deg ... Full text Link to item Cite

A novel digital tomosynthesis (DTS) reconstruction method using a deformation field map.

Journal Article Med Phys · July 2008 We developed a novel digital tomosynthesis (DTS) reconstruction method using a deformation field map to optimally estimate volumetric information in DTS images. The deformation field map is solved by using prior information, a deformation model, and new pr ... Full text Link to item Cite

Digital tomosynthesis of the chest for lung nodule detection: interim sensitivity results from an ongoing NIH-sponsored trial.

Journal Article Med Phys · June 2008 The authors report interim clinical results from an ongoing NIH-sponsored trial to evaluate digital chest tomosynthesis for improving detectability of small lung nodules. Twenty-one patients undergoing computed tomography (CT) to follow up lung nodules wer ... Full text Link to item Cite

Digital tomosynthesis of the chest.

Journal Article J Thorac Imaging · May 2008 Digital tomosynthesis is a technique that generates an arbitrary number of section images of a patient from a single pass of the x-ray tube. It is under investigation for application to a number of clinical detection tasks, and has recently been implemente ... Full text Link to item Cite

Fast reconstruction of digital tomosynthesis using on-board images.

Journal Article Med Phys · May 2008 Digital tomosynthesis (DTS) is a method to reconstruct pseudo three-dimensional (3D) volume images from two-dimensional x-ray projections acquired over limited scan angles. Compared with cone-beam computed tomography, which is frequently used for 3D image ... Full text Link to item Cite

Automatic registration between reference and on-board digital tomosynthesis images for positioning verification.

Journal Article Med Phys · February 2008 The authors developed a hybrid multiresolution rigid-body registration technique to automatically register reference digital tomosynthesis (DTS) images with on-board DTS images to guide patient positioning in radiation therapy. This hybrid registration tec ... Full text Link to item Cite

SU‐GG‐I‐52: Conversion of On‐Board Digital TomoSynthesis (DTS) to HU Values

Conference Medical Physics · January 1, 2008 Purpose: To investigate a method to convert the pixel values of DTS images to HU values with reference HU values from CT images. Method and Materials: This study included CT and DTS images of two phantoms (Catphan and a chest phantom) and three patients (p ... Full text Cite

SU‐GG‐J‐119: Localization Accuracy of Target Verification System Using Digitial Tomosynthesis (DTS)

Conference Medical Physics · January 1, 2008 Purposes: A research platform was developed for target verification using digital tomosynthesis (DTS). To verify its accuracy, a phantom study was conducted and several clinical cases were investigated. Method and Materials: customer‐developed reconstructi ... Full text Cite

SU‐GG‐J‐93: Feasibility Study On Artifact Reduction Using Dual Energy Digital Tomosynthesis

Conference Medical Physics · January 1, 2008 Purpose: We propose a simulation study to examine the feasibility of incorporating dual energy (DE) subtraction with digital tomosynthesis (DTS) to help reduce DTS reconstruction artifacts. Method and Materials: We have previously investigated the incorpor ... Full text Cite

SU‐GG‐I‐53: The Impact of Scan Angles On the Visibility of Anatomy in On‐Board Digital Tomosynthesis (DTS) Images for Head and Neck Cancer Patients: A Single‐Observer Study

Conference Medical Physics · January 1, 2008 Purpose: To assess the impact of scan angles on the visibility of anatomy in on‐board digital tomosynthesis (DTS) images as a means to optimize this technique. Method and Materials: Head and neck cancer patients undergoing intensity‐modulated radiotherapy ... Full text Cite

TU‐EE‐A3‐03: On‐Board Four‐Dimensional Digital Tomosynthesis (4D‐DTS): Optimization of Respiratory Motion Dependent Acquisition and Reconstruction Parameters

Conference Medical Physics · January 1, 2008 Purpose: Amplitude and period of respiratory motion vary among patients. For four‐dimensional digital tomosynthesis (4D‐DTS), the frequency of projection acquisition and the phase window must be optimized based on respiratory motion. The purpose of this st ... Full text Cite

TH‐D‐351‐02: A Novel Digital Tomosynthesis (DTS) Reconstruction Method Using Prior Information and a Deformation Model

Conference Medical Physics · January 1, 2008 Purpose: Digital Tomosynthesis (DTS) is a quasi‐3D imaging technique which reconstructs images from a limited angle of on‐board projections with significantly lower dose and shorter acquisition time than full cone‐beam CT (CBCT). However, DTS images recons ... Full text Cite

SU‐GG‐J‐94: Feasibility Study On the Efficacy of Dual Energy Cine Imaging in Radiation Therapy for Lung Cancer

Conference Medical Physics · January 1, 2008 Purpose: Modern IMRT plans have necessitated improved image localization techniques. In the lungs, internal target volumes (ITVs) are often generated from 4DCT images; however, the patient must be properly localized daily for this to work effectively. In t ... Full text Cite

An implantable MOSFET dosimeter for the measurement of radiation dose in tissue during cancer therapy

Journal Article IEEE Sensors Journal · January 1, 2008 This paper describes the functionality, radiation characteristics, and clinical implementation of an implantable MOSFET radiation detector (dosimeter). The dosimeter is powered by radio frequency telemetry eliminating the need for a power source inside the ... Full text Cite

A Preliminary Investigation of Dual Energy (DE) Subtraction Imaging for Improved Soft-Tissue Localization in the Pelvis

Conference International Journal of Radiation Oncology*Biology*Physics · November 2007 Full text Cite

A Preliminary Investigation of Dual Energy Subtraction Imaging for Improved Target Localization in the Thorax

Conference International Journal of Radiation Oncology*Biology*Physics · November 2007 Full text Cite

Clinical Evaluation of Digital Tomosynthesis for Target Localization in Breath-Hold Liver Treatment

Conference International Journal of Radiation Oncology*Biology*Physics · November 2007 Full text Cite

The Effect of Scan Angle on Target Localization Accuracy Using Digital Tomosynthesis

Conference International Journal of Radiation Oncology*Biology*Physics · November 2007 Full text Cite

Implementation of Digital Tomosynthesis for On-Board Target Localization of Radiotherapy

Conference International Journal of Radiation Oncology*Biology*Physics · November 2007 Full text Cite

Initial application of digital tomosynthesis to improve brachytherapy treatment planning

Journal Article Progress in Biomedical Optics and Imaging - Proceedings of SPIE · October 15, 2007 We present preliminary investigations that examine the feasibility of incorporating volumetric images generated using digital tomosynthesis into brachytherapy treatment planning. The Integrated Brachytherapy Unit (IBU) at our facility consists of an L-arm, ... Full text Cite

On-board patient positioning for head-and-neck IMRT: comparing digital tomosynthesis to kilovoltage radiography and cone-beam computed tomography.

Journal Article Int J Radiat Oncol Biol Phys · October 1, 2007 PURPOSE: High-precision intensity-modulated radiotherapy demands high patient positioning accuracy. On-board digital tomosynthesis (DTS) provides three-dimensional (3D) image guidance for daily positioning with a lower imaging dose, faster acquisition, and ... Full text Link to item Cite

Accelerating reconstruction of reference digital tomosynthesis using graphics hardware.

Journal Article Med Phys · October 2007 The successful implementation of digital tomosynthesis (DTS) for on-board image guided radiation therapy (IGRT) requires fast DTS image reconstruction. Both target and reference DTS image sets are required to support an image registration application for I ... Full text Link to item Cite

Evaluation of three types of reference image data for external beam radiotherapy target localization using digital tomosynthesis (DTS).

Journal Article Med Phys · August 2007 Digital tomosynthesis (DTS) is a fast, low-dose three-dimensional (3D) imaging approach which yields slice images with excellent in-plane resolution, though low plane-to-plane resolution. A stack of DTS slices can be reconstructed from a single limited-ang ... Full text Link to item Cite

SU‐FF‐J‐58: Clinical Evaluation Using Digital Tomosynthesis for Positioning Verification of Breath‐Hold Liver Treatment

Conference Medical Physics · January 1, 2007 Purpose: To demonstrate clinical feasibility of generating digital tomosynthesis (DTS) in a single breath‐hold (BH) period compared to multiple BH periods for CBCT acquisition and to examine on‐board BH‐DTS as an efficient alternative to BH‐CBCT for target ... Full text Cite

WE‐E‐AUD‐04: Radiation Characteristics and Hypo‐Fractionation Dose Response for the DVS Implantable MOSFET Dosimeter

Conference Medical Physics · January 1, 2007 Purpose: Evaluation of the radiation characteristics and performance of the DVS® implantable MOSFET dosimeter for typical and hypo‐fractionated protocols. Method and Materials: The commercially available DVS is calibrated for use in the range of 150–250 cG ... Full text Cite

SU‐FF‐J‐54: A Hybrid Multiresolution Method for Automatic Registration Between Reference and On Board Digital Tomosynthesis

Conference Medical Physics · January 1, 2007 Purpose: Automatic registration between reference and on‐board digital tomosynthesis (DTS) is a critical step for target localization using DTS. We previously developed an approximate method for automatic registration between reference and on‐board DTS, in ... Full text Cite

SU‐FF‐I‐39: Development of Clinical Application Platform Using Digital Tomosynthesis for Target Localization

Conference Medical Physics · January 1, 2007 Purpose: To develop a workstation for clinical application of digital tomosynthesis (DTS) for real‐time target localization. Specifically, to accelerate the reconstruction both digitally‐reconstructed radiograph (DRR) and DTS using ultra‐fast interpolation ... Full text Cite

WE‐E‐M100F‐01: 3D Interfraction Position Verification for Patients Undergoing Partial Breast Irradiation: Comparing Digital Tomosynthesis to Cone‐Beam CT

Conference Medical Physics · January 1, 2007 Purpose: This clinical study evaluates digital tomosynthesis (DTS) technology for daily imaging guidance for partial breast irradiation (PBI) and compares its positioning accuracy to the 3D CBCT technique. Compared to CBCT, DTS offers lower imaging dose an ... Full text Cite

1025

Conference International Journal of Radiation Oncology*Biology*Physics · November 2006 Full text Cite

2726

Conference International Journal of Radiation Oncology*Biology*Physics · November 2006 Full text Cite

Digital tomosynthesis with an on-board kilovoltage imaging device.

Journal Article Int J Radiat Oncol Biol Phys · May 1, 2006 PURPOSE: To generate on-board digital tomosynthesis (DTS) and reference DTS images for three-dimensional image-guided radiation therapy (IGRT) as an alternative to conventional portal imaging or on-board cone-beam computed tomography (CBCT). METHODS AND MA ... Full text Link to item Cite

Optimization of the matrix inversion tomosynthesis (MITS) impulse response and modulation transfer function characteristics for chest imaging.

Journal Article Med Phys · March 2006 Matrix inversion tomosynthesis (MITS) uses linear systems theory, along with a priori knowledge of the imaging geometry, to deterministically distinguish between true structure and overlying tomographic blur in a set of conventional tomosynthesis planes. I ... Full text Link to item Cite

TH‐C‐330A‐05: Analysis of the Point Spread Function of Isocentric Digital Tomosynthesis (DTS)

Conference Medical Physics · January 1, 2006 Purpose: This project presents an analysis of the point spread function (PSF) of isocentric digital tomosynthesis (DTS). DTS is a limited angle 3‐ dimensional reconstruction from cone beam projections, with high resolution for excellent imaging of both bon ... Full text Cite

SU‐FF‐I‐19: A Study of Megavoltage Beam Tomosynthesis

Conference Medical Physics · January 1, 2006 Purpose: To study the impact of projection numbers on the quality of tomosynthesis images using megavoltage beams. Method and Materials: It has been shown that isocentric kilovoltage tomosynthesis images can be generated with no more than 50 degree scan an ... Full text Cite

TH‐C‐ValB‐04: Evaluation of the Quality of 3D‐3D Mutual Information (MI) Shared Between Reference and On‐Board DTS Images

Conference Medical Physics · January 1, 2006 Purpose: Digital tomosynthesis (DTS) is a fast, low‐dose method for reconstructing 3‐D slices from 2‐D cone‐beam x‐ray projection data acquired with limited source angulation (e.g., 40°). We previously developed a method for reconstructing reference DTS (R ... Full text Cite

SU‐CC‐ValA‐01: Automatic Comparison Between Reference and On Board Digital Tomosynthesis for Target Localization

Conference Medical Physics · January 1, 2006 Purpose: Digital tomosynthesis (DTS) is a method for reconstructing 3D images from cone‐beam projection data acquired with limited angulation (e.g., 40°) of an x‐ray source, and is much faster and lower dose than full cone‐beam CT (CBCT). We previously dev ... Full text Cite

MO‐A‐224C‐01: Daily Localization I: KV/CBCT

Conference Medical Physics · January 1, 2006 Daily target localization is a critical step to secure accurate delivery for 3‐D conformal radiation therapy and intensity‐modulated radiation therapy. One emerging technology using in‐room kilovoltage (kV) imaging has shown to be very promising for target ... Full text Cite

SU‐FF‐J‐118: Respiration Phase‐Based Cone‐Beam Computed Tomography (CBCT) Reconstruction

Conference Medical Physics · January 1, 2006 Purpose: To develop a method to reconstruct CBCT data based on projection data acquired at a specific respiration phase. Methods and Materials: The original projection data were acquired using an on‐board imager (OBI) (Varian Medical Systems) over scanning ... Full text Cite

Assessment of Setup Accuracy for Prostate Radiotherapy using On-board Imaging and Cone Beam Computed Tomography

Conference International Journal of Radiation Oncology*Biology*Physics · October 2005 Full text Cite

Online Digital Tomosynthesis (DTS): A Novel Technique for Improving Target Localization in Radiation Therapy

Conference International Journal of Radiation Oncology*Biology*Physics · October 2005 Full text Cite

Initial application of digital tomosynthesis with on-board imaging in radiation oncology

Journal Article Progress in Biomedical Optics and Imaging - Proceedings of SPIE · August 25, 2005 We present preliminary investigations that examine the feasibility of incorporating digital tomosynthesis into radiation oncology practice with the use of kilovoltage on-board imagers (OBI). Modern radiation oncology linear accelerators now include hardwar ... Full text Cite

MO‐D‐I‐6B‐04: Matrix Inversion Tomosynthesis (MITS) Imaging of the Chest

Journal Article Medical Physics · January 1, 2005 Tomosynthesis is a method for reconstructing 3‐dimensional (3‐D) image data from a series of x‐ray projection radiographs, acquired with limited motion of the x‐ray source (typically no more than 40 degrees). Digital tomosynthesis (DTS) is implemented with ... Full text Cite

SU‐FF‐J‐57: Digital Tomosynthesis for Verification of Radiation Therapy Positioning: Preliminary Results From a Kilovoltage On‐Board Imaging System

Conference Medical Physics · January 1, 2005 Purpose: This study introduces a new radiation therapy target localization technique using online digital tomosynthesis (DTS), a method for reconstructing 3‐D slices from 2‐D projection data acquired with limited source motion. By separating the visualizat ... Full text Cite

Digital x-ray tomosynthesis: current state of the art and clinical potential.

Journal Article Phys Med Biol · October 7, 2003 Digital x-ray tomosynthesis is a technique for producing slice images using conventional x-ray systems. It is a refinement of conventional geometric tomography, which has been known since the 1930s. In conventional geometric tomography, the x-ray tube and ... Full text Link to item Cite

Practical strategies for the clinical implementation of matrix inversion tomosynthesis (MITS)

Journal Article Proceedings of SPIE - The International Society for Optical Engineering · September 15, 2003 Digital tomosynthesis is a method that enables the retroactive reconstruction of arbitrary tomographic planes in an object from a finite series of digital projection radiographs, acquired with limited angle tube movement. Conventional tomosynthesis suffers ... Full text Cite

Tomosynthesis imaging of the chest

Conference MEDICAL PHYSICS · 2003 Cite

Optimization of matrix inverse tomosynthesis

Journal Article Proceedings of SPIE - The International Society for Optical Engineering · January 1, 2001 Digital tomosynthesis is a method for reconstructing arbitrary planes in an object from a series of projection radiographs, acquired with limited angle tube movement. Conventional 'shift and add' tomosynthesis suffers from the presence of blurring artifact ... Full text Cite

Applications of matrix inverse tomosynthesis

Journal Article Proceedings of SPIE - The International Society for Optical Engineering · January 1, 2000 The improved image quality and characteristics of new flat-panel x-ray detectors have renewed interest in advanced algorithms such as tomosynthesis. Digital tomosynthesis is a method of acquiring and reconstructing a three-dimensional data set with limited ... Cite

Frequency-domain technique for optical property measurements in moderately scattering media.

Journal Article Opt Lett · January 1, 2000 We demonstrate a reflection geometry frequency-domain technique that is suitable for measurement of the optical properties of a medium with moderate scatter and absorption (mu(s) and mu(a) ~ 1 m(-1)). Variations in absorption and scatter produce opposing t ... Full text Link to item Cite

Application of frequency domain techniques to samples with moderate scatter

Journal Article Proceedings of SPIE - The International Society for Optical Engineering · January 1, 1999 We show that the optical properties of a sample with moderate scatter can be obtained by performing frequency domain measurements in a reflection geometry. In experiments and Monte Carlo simulations we show that absorption and scatter produce opposing tren ... Cite