Journal ArticleNPJ Breast Cancer · July 29, 2024
Therapeutic resistance presents a significant hurdle in combating inflammatory breast cancer (IBC), adding to the complexity of its management. To investigate these mechanisms, we conducted a comprehensive analysis using transcriptomic and proteomic profil ...
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Journal ArticleTransl Oncol · May 2024
OBJECTIVE: To assess the expression pattern of X-linked inhibitor of apoptosis protein (XIAP), a cellular stress sensor, and delineate the associated changes in the tumor immune microenvironment (TiME) for prognostic value and new therapeutic targets in in ...
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Journal ArticlePrev Med Rep · December 2023
The purpose of this study, based in the United States, was to evaluate knowledge gaps and barriers related to diagnosis and care of inflammatory breast cancer (IBC), a rare but lethal breast cancer subtype, amongst Primary Care Providers (PCP) as they are ...
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Journal ArticleSci Rep · November 20, 2023
Individual environmental contaminants have been associated with breast cancer; however, evaluations of multiple exposures simultaneously are limited. Herein, we evaluated associations between breast cancer summary stages and the Environmental Quality Index ...
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ConferenceAIP Conference Proceedings · November 14, 2023
To compare the material removal rate obtained during dry turning of AISI H13 tool steel using novel TiN coated and uncoated carbide tools. Materials and Methods:The work material chosen for the study is AISI H13 tool steel of dimension 25 mm diameter and 5 ...
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ConferenceAIP Conference Proceedings · November 14, 2023
This research is about the comparison of novel TiN coated and uncoated carbide tools in CNC wet turning of EN31 to maximize material removal rate. Materials and methods: Work material used was EN31 tool steel and cutting tools used was novel TiN coated and ...
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Journal ArticleCancers (Basel) · April 12, 2023
Inflammatory breast cancer (IBC), an understudied and lethal breast cancer, is often misdiagnosed due to its unique presentation of diffuse tumor cell clusters in the skin and dermal lymphatics. Here, we describe a window chamber technique in combination w ...
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ConferenceCancer Research · April 4, 2023
AbstractIndividual environmental contaminants have been associated with breast cancer (BCa); however, simultaneous evaluations of multiple exposures are limited. The USEPA has constructed an environmental qu ...
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ConferenceCancer Research · March 1, 2023
AbstractBackground: Individual environmental contaminants have been associated with breast cancer; however, evaluations of multiple exposures simultaneously are limited. The USPA has constructed an environme ...
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ConferenceCancer Research · March 1, 2023
AbstractBackground: Lymphovascular invasion (LVI) is a major route of metastatic dissemination and recent studies indicate its value as an independent prognostic indicator for advanced breast, colorectal, sq ...
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ConferenceCancer Epidemiology, Biomarkers & Prevention · January 1, 2023
AbstractBackground: Although recognized as the most lethal breast cancer, inflammatory breast cancer (IBC), a NCI designated rare cancer and a cancer health disparity, is severely understudied. Given the uni ...
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Conference2023 International Conference on System, Computation, Automation and Networking, ICSCAN 2023 · January 1, 2023
The process of drying rice paddies holds immense significance in rice production, profoundly influencing thequality of the final yield by ensuring the ideal moisture content. Among the conventional techniques for managing the solar drying process, manual t ...
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Conference2023 International Conference on System, Computation, Automation and Networking, ICSCAN 2023 · January 1, 2023
This Python -based scheme presents an innovative approach to bolstering road safety by harnessing the power of computer vision and machine learning. The primary objective is to provide drivers with crucial real-time information for informed lane change dec ...
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Journal ArticleRes Sq · December 5, 2022
PURPOSE: The purpose of this study was to evaluate knowledge gaps and barriers related to diagnosis and care of inflammatory breast cancer (IBC), a rare but most lethal breast cancer subtype, amongst Primary Care Providers (PCP) as they are often the first ...
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Journal ArticleNPJ Breast Cancer · June 13, 2022
Aggressive breast cancer variants, like triple negative and inflammatory breast cancer, contribute to disparities in survival and clinical outcomes among African American (AA) patients compared to White (W) patients. We previously identified the dominant r ...
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ConferenceCancer Research · February 15, 2022
AbstractBACKGROUND: Inflammatory breast cancer (IBC) is a rare, but aggressive type of locally advanced breast cancer for which a specific immune response seems to be an important driver (Van Laere et al., C ...
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Journal ArticleNPJ Breast Cancer · January 18, 2022
Inflammatory breast cancer (IBC) is an aggressive disease for which the spectrum of preclinical models was rather limited in the past. More recently, novel cell lines and xenografts have been developed. This study evaluates the transcriptome of an extended ...
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Journal ArticleMol Ther · January 5, 2022
Serine/threonine kinase 3 (STK3) is an essential member of the highly conserved Hippo tumor suppressor pathway that regulates Yes-associated protein 1 (YAP1) and TAZ. STK3 and its paralog STK4 initiate a phosphorylation cascade that regulates YAP1/TAZ inhi ...
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Journal ArticleEnviron Res · October 2021
Polycyclic aromatic hydrocarbons (PAHs) are a toxic and ubiquitous class of environmental chemicals, products of fuel combustion from human and natural sources. The objective of this study was to identify vulnerable populations for high PAH exposure and va ...
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Journal ArticleCancers (Basel) · June 4, 2021
XIAP, the most potent inhibitor of cell death pathways, is linked to chemotherapy resistance and tumor aggressiveness. Currently, multiple XIAP-targeting agents are in clinical trials. However, the characterization of XIAP expression in relation to clinico ...
Full textLink to itemCite
Journal ArticleNPJ Breast Cancer · July 29, 2024
Therapeutic resistance presents a significant hurdle in combating inflammatory breast cancer (IBC), adding to the complexity of its management. To investigate these mechanisms, we conducted a comprehensive analysis using transcriptomic and proteomic profil ...
Full textLink to itemCite
Journal ArticleTransl Oncol · May 2024
OBJECTIVE: To assess the expression pattern of X-linked inhibitor of apoptosis protein (XIAP), a cellular stress sensor, and delineate the associated changes in the tumor immune microenvironment (TiME) for prognostic value and new therapeutic targets in in ...
Full textLink to itemCite
Journal ArticlePrev Med Rep · December 2023
The purpose of this study, based in the United States, was to evaluate knowledge gaps and barriers related to diagnosis and care of inflammatory breast cancer (IBC), a rare but lethal breast cancer subtype, amongst Primary Care Providers (PCP) as they are ...
Full textOpen AccessLink to itemCite
Journal ArticleSci Rep · November 20, 2023
Individual environmental contaminants have been associated with breast cancer; however, evaluations of multiple exposures simultaneously are limited. Herein, we evaluated associations between breast cancer summary stages and the Environmental Quality Index ...
Full textLink to itemCite
ConferenceAIP Conference Proceedings · November 14, 2023
To compare the material removal rate obtained during dry turning of AISI H13 tool steel using novel TiN coated and uncoated carbide tools. Materials and Methods:The work material chosen for the study is AISI H13 tool steel of dimension 25 mm diameter and 5 ...
Full textCite
ConferenceAIP Conference Proceedings · November 14, 2023
This research is about the comparison of novel TiN coated and uncoated carbide tools in CNC wet turning of EN31 to maximize material removal rate. Materials and methods: Work material used was EN31 tool steel and cutting tools used was novel TiN coated and ...
Full textCite
Journal ArticleCancers (Basel) · April 12, 2023
Inflammatory breast cancer (IBC), an understudied and lethal breast cancer, is often misdiagnosed due to its unique presentation of diffuse tumor cell clusters in the skin and dermal lymphatics. Here, we describe a window chamber technique in combination w ...
Full textOpen AccessLink to itemCite
ConferenceCancer Research · April 4, 2023
AbstractIndividual environmental contaminants have been associated with breast cancer (BCa); however, simultaneous evaluations of multiple exposures are limited. The USEPA has constructed an environmental qu ...
Full textCite
ConferenceCancer Research · March 1, 2023
AbstractBackground: Individual environmental contaminants have been associated with breast cancer; however, evaluations of multiple exposures simultaneously are limited. The USPA has constructed an environme ...
Full textCite
ConferenceCancer Research · March 1, 2023
AbstractBackground: Lymphovascular invasion (LVI) is a major route of metastatic dissemination and recent studies indicate its value as an independent prognostic indicator for advanced breast, colorectal, sq ...
Full textCite
ConferenceCancer Epidemiology, Biomarkers & Prevention · January 1, 2023
AbstractBackground: Although recognized as the most lethal breast cancer, inflammatory breast cancer (IBC), a NCI designated rare cancer and a cancer health disparity, is severely understudied. Given the uni ...
Full textCite
Conference2023 International Conference on System, Computation, Automation and Networking, ICSCAN 2023 · January 1, 2023
The process of drying rice paddies holds immense significance in rice production, profoundly influencing thequality of the final yield by ensuring the ideal moisture content. Among the conventional techniques for managing the solar drying process, manual t ...
Full textCite
Conference2023 International Conference on System, Computation, Automation and Networking, ICSCAN 2023 · January 1, 2023
This Python -based scheme presents an innovative approach to bolstering road safety by harnessing the power of computer vision and machine learning. The primary objective is to provide drivers with crucial real-time information for informed lane change dec ...
Full textCite
Journal ArticleRes Sq · December 5, 2022
PURPOSE: The purpose of this study was to evaluate knowledge gaps and barriers related to diagnosis and care of inflammatory breast cancer (IBC), a rare but most lethal breast cancer subtype, amongst Primary Care Providers (PCP) as they are often the first ...
Full textLink to itemCite
Journal ArticleNPJ Breast Cancer · June 13, 2022
Aggressive breast cancer variants, like triple negative and inflammatory breast cancer, contribute to disparities in survival and clinical outcomes among African American (AA) patients compared to White (W) patients. We previously identified the dominant r ...
Full textOpen AccessLink to itemCite
ConferenceCancer Research · February 15, 2022
AbstractBACKGROUND: Inflammatory breast cancer (IBC) is a rare, but aggressive type of locally advanced breast cancer for which a specific immune response seems to be an important driver (Van Laere et al., C ...
Full textCite
Journal ArticleNPJ Breast Cancer · January 18, 2022
Inflammatory breast cancer (IBC) is an aggressive disease for which the spectrum of preclinical models was rather limited in the past. More recently, novel cell lines and xenografts have been developed. This study evaluates the transcriptome of an extended ...
Full textOpen AccessLink to itemCite
Journal ArticleMol Ther · January 5, 2022
Serine/threonine kinase 3 (STK3) is an essential member of the highly conserved Hippo tumor suppressor pathway that regulates Yes-associated protein 1 (YAP1) and TAZ. STK3 and its paralog STK4 initiate a phosphorylation cascade that regulates YAP1/TAZ inhi ...
Full textLink to itemCite
Journal ArticleEnviron Res · October 2021
Polycyclic aromatic hydrocarbons (PAHs) are a toxic and ubiquitous class of environmental chemicals, products of fuel combustion from human and natural sources. The objective of this study was to identify vulnerable populations for high PAH exposure and va ...
Full textLink to itemCite
Journal ArticleCancers (Basel) · June 4, 2021
XIAP, the most potent inhibitor of cell death pathways, is linked to chemotherapy resistance and tumor aggressiveness. Currently, multiple XIAP-targeting agents are in clinical trials. However, the characterization of XIAP expression in relation to clinico ...
Full textLink to itemCite
Journal ArticleXenotransplantation · May 2021
BACKGROUND: Thrombosis is a known consequence of intraportal islet transplantation, particularly for xenogeneic islets. To define the origins of thrombosis after islet xenotransplantation and relate it to early inflammation, we examined porcine islets tran ...
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Journal ArticleMol Cancer Ther · February 2021
Triple-negative breast cancer (TNBC) is the most aggressive subgroup of breast cancer, and patients with TNBC have few therapeutic options. Apoptosis resistance is a hallmark of human cancer, and apoptosis regulators have been targeted for drug development ...
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Journal ArticleEvol Med Public Health · 2021
BACKGROUND AND OBJECTIVES: An individual's risk of breast cancer is profoundly affected by evolutionary mismatch. Mismatches in Western society known to increase the risk of breast cancer include a sedentary lifestyle and reproductive factors. Biota altera ...
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Journal ArticleCarcinogenesis · December 31, 2020
Emerging evidence suggests the role of environmental chemicals, in particular endocrine-disrupting chemicals (EDCs), in progression of breast cancer and treatment resistance, which can impact survival outcomes. However, most research tends to focus on tumo ...
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Journal ArticleJ Clin Transl Sci · November 5, 2020
North Carolina Central University (NCCU) and Duke Cancer Institute implemented an NCI-funded Translational Cancer Disparities Research Partnership to enhance translational cancer research, increase the pool of underrepresented racial and ethnic group (UREG ...
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Journal ArticleCancer Epidemiol Biomarkers Prev · October 2020
Background: Breast cancer is a complex and multifactorial disease, and environmental factors have been suggested to increase its risk. However, prior research has largely focused on studying exposures to one factor/contaminant at a time, which does not ref ...
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ConferenceCancer Research · August 15, 2020
AbstractBackground: Apoptosis resistance is a hallmark of cancer, and apoptosis regulators have been targeted for cancer treatment. A class of such regulators is inhibitor of apoptosis proteins (IAPs), which ...
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ConferenceCancer Epidemiology, Biomarkers & Prevention · June 1, 2020
AbstractIntroduction: The higher incidence of biologically aggressive and treatment-resistant breast cancer (BCa) subtypes, which includes triple negative (TN), basal, and inflammatory breast cancer (IBC), c ...
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ConferenceCancer Epidemiology, Biomarkers & Prevention · June 1, 2020
AbstractThree interrelated contributors to cancer disparities include the lack of diversity among investigators contributing to cancer research, the deficiency of minority participation in clinical trials an ...
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ConferenceCancer Epidemiology, Biomarkers & Prevention · June 1, 2020
AbstractIntroduction: Inflammatory breast cancer (IBC) is a rare but the most lethal breast cancer often misdiagnosed as mastitis or dermatitis since majority of cases lack a clinically apparent tumor mass a ...
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ConferenceCancer Epidemiology, Biomarkers & Prevention · June 1, 2020
AbstractIntroduction: Inflammatory breast cancer (IBC) is an understudied and aggressive breast cancer subtype, accounting for 7-10% of all breast cancer-related deaths in the United States. IBC is more comm ...
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ConferenceCancer Epidemiology, Biomarkers & Prevention · June 1, 2020
AbstractPolycyclic aromatic hydrocarbons (PAHs) are a toxic and ubiquitous class of environmental chemicals sourced from industrial practices, tobacco smoke, grilled and smoked meats, car exhaust, and other ...
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ConferenceCancer Epidemiology, Biomarkers & Prevention · June 1, 2020
AbstractIntroduction: Cancer is the leading cause of death in North Carolina. While the incidence rate of breast cancer (BC) is higher in White women, African American and Latino women are more likely to die ...
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ConferenceCancer Epidemiology, Biomarkers & Prevention · June 1, 2020
AbstractIntroduction: A projected 8870 women will be diagnosed with breast cancer in North Carolina (NC) in 2019, with 1390 estimated deaths. However, breast cancer is a heterogenous disease, and investigati ...
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ConferenceCancer Epidemiology, Biomarkers & Prevention · June 1, 2020
AbstractThe purpose of this study is to investigate the biologic significance of novel GLI1 splice variants in breast cancer. African American (AA) women suffer a disproportionately high burden of basal-like ...
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Journal ArticleBreast Cancer Res Treat · April 2020
PURPOSE: Inflammatory breast cancer (IBC) is an aggressive form of breast cancer with elevated metastatic potential, characterized by tumor emboli in dermal and parenchymal lymph vessels. This study has investigated the hypothesis that TGFฮฒ signaling is im ...
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ConferenceCancer Research · February 15, 2020
AbstractBackground: Lymphovascular invasion (LVI), a critical feature of advanced cancers, is a major route of metastatic dissemination. Of the clinically-distinct types of breast cancer, the most lethal var ...
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Journal ArticleBreast Cancer Res Treat · February 2020
PURPOSE: Inflammatory breast cancer (IBC) is an aggressive variant for which axillary lymph node (LN) dissection following neoadjuvant chemotherapy (NACT) remains standard of care. But with increasingly effective systemic therapy, it is unclear whether mor ...
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Journal ArticleXenotransplantation · November 2019
BACKGROUND: Membrane cofactor protein CD46 attenuates the complement cascade by facilitating cleavage of C3b and C4b. In solid organ xenotransplantation, organs expressing CD46 have been shown to resist hyperacute rejection. However, the incremental value ...
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ConferenceDesalination and Water Treatment · July 1, 2019
Elimination of 2,4 D from water bodies is very much essential and possible using adsorption. Using commercial adsorbents, removal of 2,4 D can be efficient but requires high operating cost and hence this study focuses on feasibility of producing Activated ...
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Journal ArticleProc Natl Acad Sci U S A · January 2, 2019
The epithelial-mesenchymal transition (EMT) and cancer stem cell (CSC) formation are two paramount processes driving tumor progression, therapy resistance, and cancer metastasis. Recent experiments show that cells with varying EMT and CSC phenotypes are sp ...
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Journal ArticleJ Cancer · 2019
Inflammatory breast cancer (IBC) is an understudied and aggressive form of breast cancer with a poor prognosis, accounting for 2-6% of new breast cancer diagnoses but 10% of all breast cancer-related deaths in the United States. Currently there are no ther ...
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ConferenceCancer Research · July 1, 2018
AbstractRibonucleotide reductase (RR) catalyzes the conversion of ribonucleotides to deoxyribonucleotides during the rate-limiting step of DNA synthesis. Given its significant role in cell cycle regulation, ...
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Journal ArticleAm J Transplant · April 2018
Porcine islet xenografts have the potential to provide an inexhaustible source of islets for ฮฒ cell replacement. Proof-of-concept has been established in nonhuman primates. However, significant barriers to xenoislet transplantation remain, including the po ...
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Journal ArticleCancer Res · April 1, 2018
Hyperactivation of the NFฮบB pathway is a distinct feature of inflammatory breast cancer (IBC), a highly proliferative and lethal disease. Gene expression studies in IBC patient tissue have linked EGFR (EGFR/HER2)-mediated MAPK signaling to NFฮบB hyperactivi ...
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Journal ArticleJ Clin Transl Sci · February 2018
INTRODUCTION: The Duke Multidisciplinary Education and Research in Translational Sciences Program provides educational resources for faculty and trainees in translational research. METHODS: To aid in program development, we assessed perceptions of translat ...
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Journal ArticleJ Environ Public Health · 2018
Polycyclic aromatic hydrocarbon (PAH) exposure is widespread, and many PAHs are considered carcinogenic. The PAH-contaminated AWI Superfund site in Virginia provides a model for studying a complex PAH mixture and its extrapolation to cancer risk and PAH ex ...
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Journal ArticleCancer Lett · December 28, 2017
Activation of the Hedgehog (Hh) pathway effector GLI1 is linked to tumorigenesis and invasiveness in a number of cancers, with targeting of GLI1 by small molecule antagonists shown to be effective. We profiled a collection of GLI antagonists possessing dis ...
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Journal ArticleOncotarget · April 18, 2017
Inflammatory breast cancer (IBC) is one of the most lethal breast cancer variants; with existing therapy, 5-yr survival rate is only 35%. Current barriers to successful treatment of IBC include frequent infiltration and the presence of tumor cell clusters, ...
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Journal ArticlePlast Reconstr Surg · April 2017
BACKGROUND: Gold nanostars are unique nanoplatforms that can be imaged in real time and transform light energy into heat to ablate cells. Adipose-derived stem cells migrate toward tumor niches in response to chemokines. The ability of adipose-derived stem ...
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Journal ArticleCarcinogenesis · March 1, 2017
Emerging evidence from epidemiological studies suggests a link between environmental chemical exposure and progression of aggressive breast cancer subtypes. Of all clinically distinct types of breast cancers, the most lethal phenotypic variant is inflammat ...
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ConferenceCancer Research · February 15, 2017
AbstractIntroduction: Due to the aggressive nature of inflammatory breast cancer (IBC) and insensitive imaging techniques, patients diagnosed with IBC have a poor prognosis. IBC's unique ability to form embo ...
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ConferenceCancer Epidemiology, Biomarkers & Prevention · February 1, 2017
AbstractBackground: Inflammatory breast cancer (IBC) is a distinct, aggressive and the most lethal form of breast cancer. Furthermore, data from population-based registries, when stratified by race and compa ...
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Journal ArticleInt J Nanomedicine · 2017
Inflammatory breast cancer (IBC) is rare, but it is the most aggressive subtype of breast cancer. IBC has a unique presentation of diffuse tumor cell clusters called tumor emboli in the dermis of the chest wall that block lymph vessels causing a painful, e ...
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Journal ArticleJ Cancer · 2017
In 2006, a remarkable collaboration between University of Texas MD Anderson Cancer Center clinicians and Texas and New Mexico State legislators led to the formation of a dedicated IBC Research Program and Clinic at MD Anderson. This initiative provided fun ...
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ConferenceCancer Research · July 15, 2016
AbstractInflammatory breast cancer (IBC) is the most lethal, distinct form of breast cancer, however, the basis for its aggressiveness and rapid acquisition of drug resistance is not fully understood. Using ...
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Journal ArticlePharmacol Ther · July 2016
Cancer cells propagated in three-dimensional (3D) culture systems exhibit physiologically relevant cell-cell and cell-matrix interactions, gene expression and signaling pathway profiles, heterogeneity and structural complexity that reflect in vivo tumors. ...
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Journal ArticleCell Death Dis · January 28, 2016
Inflammatory breast cancer (IBC) is the deadliest, distinct subtype of breast cancer. High expression of epidermal growth factor receptors [EGFR or human epidermal growth factor receptor 2 (HER2)] in IBC tumors has prompted trials of anti-EGFR/HER2 monoclo ...
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Journal ArticleMethods Mol Biol · 2016
Dendritic cell (DC)-based vaccines are commonly used for cancer immunotherapy. To prepare vaccines, DCs are pulsed or transfected with either: (a) defined peptides of tumor-associated antigens, (b) total protein isolated from the tumor cell, (c) autologous ...
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Journal ArticleJ Natl Cancer Inst · May 2015
Exercise has been shown to improve postischemia perfusion of normal tissues; we investigated whether these effects extend to solid tumors. Estrogen receptor-negative (ER-, 4T1) and ER+ (E0771) tumor cells were implanted orthotopically into syngeneic mice ( ...
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ConferenceCancer Research · May 1, 2015
AbstractBackground: Inflammatory breast cancer (IBC) has the highest lethality amongst all subtypes of breast cancer and develops rapid therapeutic resistance. High NFฮบB activation has been identified as a d ...
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Journal ArticleFree Radic Biol Med · March 2014
Resistance to therapy-mediated apoptosis in inflammatory breast cancer, an aggressive and distinct subtype of breast cancer, was recently attributed to increased superoxide dismutase (SOD) expression, glutathione (GSH) content, and decreased accumulation o ...
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Chapter · January 1, 2014
Breast cancer is the most common cancer in women worldwide and it accounts for the second highest morbidity and mortality. Disease etiology and progression is multifactorial and several risk factors associated with breast cancer exert their effects by modu ...
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ConferenceCancer Research · April 15, 2013
AbstractInflammatory breast cancer (IBC) is characterized by rapid progression from onset of disease, therefore an early and aggressive multimodal therapy is essential to improve outcome. IBC tumors are freq ...
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Journal ArticlePLoS One · 2013
The forkhead transcription factor FOXP3 is necessary for induction of regulatory T lymphocytes (Tregs) and their immunosuppressive function. We have previously demonstrated that targeting Tregs by vaccination of mice with murine FOXP3 mRNA-transfected dend ...
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Journal ArticleCancer Immunol Immunother · November 2012
We recently demonstrated that Venezuelan equine encephalitis virus-based replicon particle (VRPs) encoding tumor antigens could break tolerance in the immunomodulatory environment of advanced cancer. We hypothesized that local injection of VRP-expressing i ...
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Journal ArticleBMC Cancer · September 10, 2012
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BACKGROUND: Crosstalk between malignant hepatocytes and the surrounding peritumoral stroma is a key modulator of hepatocarcinogenesis and therapeutic resistance. To examine the chemotherapy resistance of these two cellular compartments in vitro, we evaluat ...
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Journal ArticleMol Cancer Ther · July 2012
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We recently identified superoxide dismutase (SOD) overexpression and decreased induction of reactive oxygen species (ROS)-mediated apoptosis in models of inflammatory breast cancer (IBC) cells with acquired therapeutic resistance. This population of cells ...
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Journal ArticleHum Gene Ther · June 2012
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Successful amelioration of cardiac dysfunction and heart failure through gene therapy approaches will require a transgene effective at attenuating myocardial injury, and subsequent remodeling, using an efficient and safe delivery vehicle. Our laboratory ha ...
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Journal ArticleBreast Cancer Res Treat · February 2012
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Overexpression of epidermal growth factor receptors (ErbB) is frequently seen in inflammatory breast cancer (IBC). Treatment with ErbB1/2-targeting agents (lapatinib) mediates tumor apoptosis by downregulating ErbB1/2 phosphorylation and downstream surviva ...
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Journal ArticleCancer Gene Ther · January 2012
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CD4+CD25+regulatory T cells (T(reg)) impair anti-tumor and anti-viral immunity. As there are higher T(reg) levels in cancer patients compared with healthy individuals, there is considerable interest in eliminating them or altering their function as part of ...
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Journal ArticleFree Radic Res · November 2011
Due to the ability to easily accept and donate electrons Mn(III)N-alkylpyridylporphyrins (MnPs) can dismute O(2)(ยท-), reduce peroxynitrite, but also generate reactive species and behave as pro-oxidants if conditions favour such action. Herein two ortho iso ...
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Journal ArticleBr J Cancer · May 10, 2011
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BACKGROUND: Inflammatory breast cancer (IBC) is an aggressive subtype of breast cancer with distinct molecular profiles. Gene expression profiling previously identified sonic hedgehog (SHH) as part of a gene signature that is differentially regulated in IB ...
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Journal ArticleImmunol Res · April 2011
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Aberrant signaling pathways are a hallmark of cancer. A variety of strategies for inhibiting signaling pathways have been developed, but monoclonal antibodies against receptor tyrosine kinases have been among the most successful. A challenge for these ther ...
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Journal ArticleMol Cancer Ther · February 2011
In this study, the role of hyper-radiation sensitivity (HRS) in potentiating the effects of cisplatin by low-dose fractionated radiation (LDFRT) was evaluated in four human non-small cell lung cancer cell lines. Presence of HRS and cisplatin enhancement ra ...
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Journal ArticleCancer Research · December 15, 2010
AbstractTRAIL, a proapoptotic receptor agonist, is a promising tool for anticancer therapy due to its selective triggering of death receptor-mediated apoptosis in cancer cells while sparing the majority of n ...
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Journal ArticleJ Clin Invest · September 2010
Therapeutic anticancer vaccines are designed to boost patients' immune responses to tumors. One approach is to use a viral vector to deliver antigen to in situ DCs, which then activate tumor-specific T cell and antibody responses. However, vector-specific ...
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Journal ArticleInt J Cancer · June 15, 2010
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The monoclonal antibody trastuzumab and the EGFR/HER2 tyrosine kinase inhibitor lapatinib improve the clinical outcome of patients with HER2-overexpressing breast cancer. However, the majority of metastatic cancers will eventually progress, suggesting the ...
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Journal ArticleMol Cancer Ther · May 2010
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Inflammatory breast cancer (IBC) is a highly aggressive subtype of breast cancer that is often characterized by ErbB2 overexpression. ErbB2 targeting is clinically relevant using trastuzumab (anti-ErbB2 antibody) and lapatinib (small-molecule ErbB1/2 inhib ...
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Journal ArticleClin Cancer Res · March 1, 2010
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PURPOSE: Overexpression of the breast cancer oncogene HER2 correlates with poor survival. Current HER2-directed therapies confer limited clinical benefits and most patients experience progressive disease. Because refractory tumors remain strongly HER2+, va ...
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Journal ArticleBr J Cancer · January 5, 2010
BACKGROUND: Novel technologies to redirect T-cell killing against cancer cells are emerging. We hypothesised that metastatic human colorectal cancer (CRC) previously treated with conventional chemotherapy would be sensitive to T-cell killing mediated by ca ...
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Journal ArticleCurr Pharm Biotechnol · September 2009
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Phosphorodiamidate morpholino oligomers (PMO), which have a neutral chemistry, are extensively being used as tools for selective inhibition of gene expression in cell culture models and are currently in human clinical trials. Unlike phosphorothioates (PS O ...
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Journal ArticleBr J Cancer · July 21, 2009
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BACKGROUND: The X-linked inhibitor of apoptosis protein (XIAP), an endogenous apoptosis suppressor, can determine the level of caspase accumulation and the resultant response to apoptosis-inducing agents such as cisplatin in epithelial ovarian cancer (EOC) ...
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Journal ArticleCancer Prev Res (Phila) · June 2009
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PURPOSE: Numerous dietary factors elevate serum levels of insulin and insulin-like growth factor I (IGF-I), both potent prostate cancer mitogens. We tested whether varying dietary carbohydrate and fat, without energy restriction relative to comparison diet ...
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Journal ArticleMethods Mol Biol · 2009
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Phosphorodiamidate morpholino oligomers (PMO), which have a neutral chemistry, are extensively being used as tools for selective inhibition of gene expression in cell culture models and are currently in human clinical trials. PMO oligomers possess a unique ...
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Journal ArticleLung Cancer · June 2008
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BACKGROUND: c-MYC amplification and overexpression has been correlated with progression and chemotherapy resistance in lung cancer. AVI-4126, a neutral antisense phosphorodiamidate morpholino oligomer (PMO) has been identified to specifically inhibit c-MYC ...
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Journal ArticleMol Cancer Ther · January 2008
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Inflammatory breast cancer (IBC) patients show poor survival and a significant incidence of epidermal growth factor receptor-2 (ErbB2) overexpression. A distinct mechanism involving increased expression of X-linked inhibitor of apoptosis protein (XIAP) and ...
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Journal ArticleJ Transl Med · September 6, 2007
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BACKGROUND: The HER2-inhibiting antibody trastuzumab, in combination with chemotherapy, significantly improves survival of women with resected, HER2-overexpressing breast cancers, but is associated with toxicities including a risk of cardiomyopathy. Additi ...
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Journal ArticleCancer Gene Ther · September 2006
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The availability of the human genome sequence has revolutionized the strategy of employing nucleic acids with sequences complementary to specific target genes to improve drug discovery and target validation. Development of sequence-specific DNA or RNA anal ...
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Journal ArticleClin Cancer Res · May 15, 2005
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Phosphorodiamidate morpholino oligomers (PMO) inhibit targeted gene expression by preventing ribosomal assembly, thereby preventing mRNA translation. AVI-4126, a PMO targeted against c-MYC, has been extensively characterized in multiple cancer and other di ...
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Journal ArticleCurr Pharm Biotechnol · October 2004
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Antisense technology constitutes development of sequence-specific DNA or RNA analogs that can block the activity of selected single-stranded genetic sequences and offer the potential of high specificity lacking in many current drug treatments. The sequenci ...
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Journal ArticleJ Urol · September 2004
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PURPOSE: Androgen receptor (AR) has a pivotal role in the growth and proliferation of prostate cancer (PCa). Even in advanced stages of PCa AR continues to be expressed and appears to be functional. Since the mechanisms of AR activation in androgen indepen ...
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Journal ArticleMol Cancer Ther · June 2004
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Androgen-insensitive prostate cancer cells are highly resistant to several chemotherapeutic drugs and are characterized by the appearance of apoptosis-resistant cells. In this study, we identified the critical role of X-linked inhibitor of apoptosis protei ...
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Journal ArticleDrug News Perspect · March 2004
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Progression to androgen independence combined with chemotherapy resistance remains one of the primary obstacles to the improvement of quality of life and survival for patients with advanced prostate cancer. One unique feature of the androgen-independent ce ...
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Journal ArticleCancer Gene Ther · November 2003
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Androgen deprivation therapy causes a paradoxical elevation of matrix metalloproteinases (MMPs) including MMP-9 resulting in aggressive tumor phenotype in many patients with prostate cancer. In this study, we have evaluated a novel antisense phosphorodiami ...
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Journal ArticleClin Cancer Res · July 2003
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PURPOSE: The overexpression of c-myc associated with uncontrolled cell proliferation is a frequent genetic event in androgen-refractory prostatic neoplasia. The purpose of this study was to evaluate the bioavailability and efficacy of a novel antisense pho ...
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ConferenceIDrugs · February 1, 2003
At this excellent meeting, preclinical, phase I and some phase II data were presented concerning significant advances with various viral and non-viral-based vectors. In addition, a few talks discussed genomic-based therapies such as those involving antisen ...
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Journal ArticleAnticancer Drugs · January 2003
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Chemotherapy resistance is a significant obstacle in lung cancer therapy, and has been found to frequently correlate with amplification and overexpression of the c-myc oncogene. Earlier studies have shown that c-Myc inhibition alone is not always effective ...
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Journal ArticleProstate · November 1, 2002
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BACKGROUND: Amplification of the proto-oncogene c-myc has been identified as one of the most common genetic alterations in prostate cancer, thus making it an attractive therapeutic target. However, certain prostate cancer cells are unresponsive to c-Myc in ...
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Journal ArticleProstate · May 1, 2002
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BACKGROUND: Insulin-like growth factor binding protein (IGFBP-3) levels are significantly reduced in malignant prostate epithelial cells. In this study, we evaluated the role of endogenous IGFBP-3 on prostate cancer cell growth and tumorigenesis. METHODS: ...
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Journal ArticleCurr Opin Mol Ther · April 2002
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Prostate cancer, like most other solid tumors, represents a heterogeneous entity consisting of a mixture of androgen-dependent and androgen-independent cells. Although proliferation of prostate tumor cells is often initially androgen-dependent, the inevita ...
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Journal ArticleGrowth Horm IGF Res · August 2001
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Insulin-like growth factor binding protein-3 (IGFBP-3) binds IGF-I and IGF-II with high affinity, at least an order of magnitude higher than the affiniy of the IGFs for the IGFIR. It has been hypothesized that IGFBP-3 inhibits IGF binding to the IGFIR via ...
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Journal ArticleEndocrinology · November 2000
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Insulin-like growth factor (IGF)-binding protein (IGFBP)-related proteins (IGFBP-rPs) are newly described cysteine-rich proteins that share significant aminoterminal structural similarity with the conventional IGFBPs and are involved in a diversity of biol ...
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Journal ArticleEndocrinology · November 2000
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Insulin-like growth factor (IGF)-binding protein-3 (IGFBP-3), the predominant IGF carrier protein in circulation, is posttranslationally modified in vivo by IGFBP-3 protease(s) into a number of fragments. Based on the ascertained and predicted recognition ...
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Journal ArticlePediatrics · October 1999
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The insulin-like growth factor (IGF) binding proteins (IGFBPs) were initially identified as carrier proteins for IGF-I and IGF-II in a variety of biologic fluids. Their presumed function was to protect IGF peptides from degradation and clearance, increase ...
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Journal ArticleCancer Res · September 1, 1999
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The M6P/IGF2R gene, encoding the insulin-like growth factor II (IGF-II)/mannose 6-phosphate receptor (IGF2R), is frequently inactivated during carcinogenesis. M6P/IGF2R is postulated to be a tumor suppressor gene due to its ability to bind and degrade the ...
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Journal ArticleJ Biol Chem · August 20, 1999
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The insulin-like growth factor II/mannose 6-phosphate receptor (IGF2R) carries out multiple regulatory and transport functions, and disruption of IGF2R function has been implicated as a mechanism to increase cell proliferation. Several missense IGF2R mutat ...
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Journal ArticleMol Endocrinol · November 1998
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Insulin-like growth factor II (IGF-II) and phosphomannosylated glycoproteins bind to distinct sites on the same receptor, the IGF-II/mannose 6-phosphate receptor (IGF2R). Analysis of truncated receptors (minireceptors) has been used to map the IGF-II bindi ...
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Journal ArticleMol Endocrinol · June 1996
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Complete understanding of the functional significance of insulin-like growth factor II (IGF-II) binding by the IGF-II/mannose-6-phosphate (Man-6-P) receptor requires mapping and ultimately mutational analysis of the receptor's IGF-II binding domain. Recent ...
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