Scholars@Duke
Jamie Lynn Todd

Jamie Lynn Todd

Associate Professor of Medicine
Medicine, Pulmonary, Allergy, and Critical Care Medicine
jamie.todd@duke.edu
Box 103002, MSRB II, Durham, NC 27710
Suite 2073, MSRB II, 106 Research Drive, Durham, NC 27710

Selected Publications

Identification and validation of a threshold for early posttransplant bronchoalveolar fluid hyaluronan that distinguishes lung recipients at risk for chronic lung allograft dysfunction.

Journal Article J Heart Lung Transplant · March 2025 BACKGROUND: Few tools exist for the early identification of patients at risk for chronic lung allograft dysfunction (CLAD). We previously showed hyaluronan (HA), a matrix molecule that regulates lung inflammation and fibrosis, accumulates in bronchoalveola ... Full text Link to item Cite

Long-Term Air Pollution Exposure and Severity of Idiopathic Pulmonary Fibrosis: Data from the Idiopathic Pulmonary Fibrosis Prospective Outcomes (IPF-PRO) Registry.

Journal Article Ann Am Thorac Soc · March 2025 Rationale: Although exposure to air pollution is a known risk factor for adverse pulmonary outcomes, its impact in individuals with idiopathic pulmonary fibrosis (IPF) is less well understood. Objectives: To investigate the effects of long-term exposure to ... Full text Link to item Cite

Extent of lung fibrosis is of greater prognostic importance than HRCT pattern in patients with progressive pulmonary fibrosis: data from the ILD-PRO registry.

Journal Article Respir Res · February 28, 2025 BACKGROUND: The prognostic value of patterns and quantitative measures of lung fibrosis on high-resolution computed tomography (HRCT) in patients identified as having progressive pulmonary fibrosis (PPF) has not been established. We investigated whether HR ... Full text Link to item Cite

Changes in Lung Function and Mortality Risk in Patients With Idiopathic Pulmonary Fibrosis.

Journal Article Chest · February 26, 2025 BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is a progressive fibrosing interstitial lung disease associated with lung function decline and high mortality. RESEARCH QUESTION: What are the associations between thresholds of lung function decline and the ... Full text Link to item Cite

Emergence of inflammatory fibroblasts with aging in Hermansky-Pudlak syndrome associated pulmonary fibrosis.

Journal Article Commun Biol · February 22, 2025 The longitudinal cellular interactions that drive pulmonary fibrosis are not well understood. To investigate the disease underpinnings associated with fibrosis onset and progression, we generated a scRNA-seq atlas of lungs from young and aged mouse models ... Full text Link to item Cite

Prognosis and Risks for Probable Chronic Lung Allograft Dysfunction: A Prospective Multicenter Study.

Journal Article Am J Respir Crit Care Med · February 2025 Rationale: Chronic lung allograft dysfunction (CLAD) hinders lung transplant success. A 2019 consensus refined CLAD diagnosis, introducing probable or definite CLAD based on persistence of lung function decline. Outcomes and risks for probable CLAD remain ... Full text Link to item Cite

Basiliximab induction immunosuppression and lung transplant outcomes: Propensity analysis in a multicenter cohort.

Journal Article J Heart Lung Transplant · December 4, 2024 BACKGROUND: Basiliximab induction immunosuppression is increasingly employed in lung transplant recipients despite limited prospective evidence to support its use in this population. We sought to determine the relationship between basiliximab induction and ... Full text Link to item Cite

Alterations in circulating measures of Th2 immune responses pre-lung transplant associates with reduced primary graft dysfunction.

Journal Article J Heart Lung Transplant · November 2024 Primary graft dysfunction (PGD) is a complication of lung transplantation that continues to cause significant morbidity. The Th2 immune response has been shown to counteract tissue-damaging inflammation. We hypothesized that Th2 cytokines/chemokines in blo ... Full text Link to item Cite

Utility of the 52-Gene Risk Score to Identify Patients with Idiopathic Pulmonary Fibrosis at Greater Risk of Mortality in the Era of Antifibrotic Therapy.

Conference Lung · October 2024 PURPOSE: We investigated whether a 52-gene signature was associated with transplant-free survival and other clinically meaningful outcomes in patients with idiopathic pulmonary fibrosis (IPF) in the IPF-PRO Registry, which enrolled patients who were and we ... Full text Link to item Cite

Clinical Utility of Plasma Microbial Cell-Free DNA Sequencing Among Immunocompromised Patients With Pneumonia.

Journal Article Open Forum Infect Dis · August 2024 BACKGROUND: Plasma microbial cell-free DNA (mcfDNA) sequencing can establish the etiology of multiple infectious syndromes by identifying microbial DNA in plasma. However, data are needed to define the clinical scenarios where this tool offers the highest ... Full text Link to item Cite

Plasma Microbial Cell-Free DNA Sequencing in Immunocompromised Patients With Pneumonia: A Prospective Observational Study.

Journal Article Clin Infect Dis · March 20, 2024 BACKGROUND: Pneumonia is a common cause of morbidity and mortality, yet a causative pathogen is identified in a minority of cases. Plasma microbial cell-free DNA sequencing may improve diagnostic yield in immunocompromised patients with pneumonia. METHODS: ... Full text Link to item Cite

Circulating metabolic profile in idiopathic pulmonary fibrosis: data from the IPF-PRO Registry.

Journal Article Respir Res · January 25, 2024 BACKGROUND: The circulating metabolome, reflecting underlying cellular processes and disease biology, has not been fully characterized in patients with idiopathic pulmonary fibrosis (IPF). We evaluated whether circulating levels of metabolites correlate wi ... Full text Link to item Cite

The Impact of Donor Smoking on Primary Graft Dysfunction and Mortality after Lung Transplantation.

Journal Article Am J Respir Crit Care Med · January 1, 2024 Rationale: Primary graft dysfunction (PGD) is the leading cause of early morbidity and mortality after lung transplantation. Prior studies implicated proxy-defined donor smoking as a risk factor for PGD and mortality. Objectives: We aimed to more accuratel ... Full text Link to item Cite

Associations of circulating matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases with clinically relevant outcomes in idiopathic pulmonary fibrosis: Data from the IPF-PRO Registry.

Journal Article PLoS One · 2024 INTRODUCTION: We assessed the prognostic utility of circulating levels of matrix metalloproteinases (MMPs) and tissue inhibitors of matrix metalloproteinases (TIMPs) in patients with idiopathic pulmonary fibrosis (IPF) in the IPF-PRO Registry. METHODS: MMP ... Full text Link to item Cite

Prevalence and significance of clonal hematopoiesis of indeterminate potential in lung transplant recipients.

Journal Article BMC Pulm Med · October 30, 2023 BACKGROUND: Clonal hematopoiesis of indeterminate potential (CHIP), the age-related acquisition of somatic mutations that leads to an expanded blood cell clone, has been associated with development of a pro-inflammatory state. An enhanced or dysregulated i ... Full text Link to item Cite

BAL Fluid Eosinophilia Associates With Chronic Lung Allograft Dysfunction Risk: A Multicenter Study.

Journal Article Chest · September 2023 BACKGROUND: Chronic lung allograft dysfunction (CLAD) is the leading cause of death among lung transplant recipients. Eosinophils, effector cells of type 2 immunity, are implicated in the pathobiology of many lung diseases, and prior studies suggest their ... Full text Link to item Cite

Lung function trajectories in patients with idiopathic pulmonary fibrosis.

Journal Article Respir Res · August 24, 2023 BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is a progressive fibrosing interstitial lung disease characterised by decline in lung function. We evaluated trajectories of forced vital capacity (FVC) and diffusing capacity (DLco) in a cohort of patients w ... Full text Link to item Cite

Early posttransplant reductions in club cell secretory protein associate with future risk for chronic allograft dysfunction in lung recipients: results from a multicenter study.

Journal Article J Heart Lung Transplant · June 2023 BACKGROUND: Chronic lung allograft dysfunction (CLAD) increases morbidity and mortality for lung transplant recipients. Club cell secretory protein (CCSP), produced by airway club cells, is reduced in the bronchoalveolar lavage fluid (BALF) of lung recipie ... Full text Link to item Cite

Integrative multi-omics analysis reveals novel idiopathic pulmonary fibrosis endotypes associated with disease progression.

Journal Article Respir Res · May 31, 2023 BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is characterized by the accumulation of extracellular matrix in the pulmonary interstitium and progressive functional decline. We hypothesized that integration of multi-omics data would identify clinically me ... Full text Link to item Cite

JAK-STAT activation contributes to cytotoxic T cell-mediated basal cell death in human chronic lung allograft dysfunction.

Journal Article JCI Insight · March 22, 2023 Chronic lung allograft dysfunction (CLAD) is the leading cause of death in lung transplant recipients. CLAD is characterized clinically by a persistent decline in pulmonary function and histologically by the development of airway-centered fibrosis known as ... Full text Link to item Cite

Club Cell Secretory Protein in Lung Disease: Emerging Concepts and Potential Therapeutics.

Journal Article Annu Rev Med · January 27, 2023 Club cell secretory protein (CCSP), also known as secretoglobin 1A1 (gene name SCGB1A1), is one of the most abundant proteins in the lung, primarily produced by club cells of the distal airway epithelium. At baseline, CCSP is found in large concentrations ... Full text Link to item Cite

Lung Allograft Microbiome Association with Gastroesophageal Reflux, Inflammation, and Allograft Dysfunction.

Journal Article Am J Respir Crit Care Med · December 15, 2022 Rationale: It remains unclear how gastroesophageal reflux disease (GERD) affects allograft microbial community composition in lung transplant recipients and its impact on lung allograft inflammation and function. Objectives: Our objective was to compare th ... Full text Link to item Cite

Prognostic implications of and clinical risk factors for acute lung injury and organizing pneumonia after lung transplantation: Data from a multicenter prospective cohort study.

Journal Article Am J Transplant · December 2022 We determined prognostic implications of acute lung injury (ALI) and organizing pneumonia (OP), including timing relative to transplantation, in a multicenter lung recipient cohort. We sought to understand clinical risks that contribute to development of A ... Full text Link to item Cite

Plasma CXCL9 and CXCL10 at allograft injury predict chronic lung allograft dysfunction.

Journal Article Am J Transplant · September 2022 Histopathologic lung allograft injuries are putative harbingers for chronic lung allograft dysfunction (CLAD). However, the mechanisms responsible are not well understood. CXCL9 and CXCL10 are potent chemoattractants of mononuclear cells and potential prop ... Full text Link to item Cite

Rare and Common Variants in KIF15 Contribute to Genetic Risk of Idiopathic Pulmonary Fibrosis.

Journal Article Am J Respir Crit Care Med · July 1, 2022 Rationale: Genetic studies of idiopathic pulmonary fibrosis (IPF) have improved our understanding of this disease, but not all causal loci have been identified. Objectives: To identify genes enriched with rare deleterious variants in IPF and familial pulmo ... Full text Link to item Cite

Bronchiolitis obliterans syndrome after lung or haematopoietic stem cell transplantation: current management and future directions.

Journal Article ERJ Open Res · July 2022 Bronchiolitis obliterans syndrome (BOS) may develop after either lung or haematopoietic stem cell transplantation (HSCT), with similarities in histopathological features and clinical manifestations. However, there are differences in the contributory factor ... Full text Link to item Cite

Association of Circulating Proteins with Death or Lung Transplant in Patients with Idiopathic Pulmonary Fibrosis in the IPF-PRO Registry Cohort.

Journal Article Lung · February 2022 Idiopathic pulmonary fibrosis (IPF) is a progressive and ultimately fatal disease with a variable clinical course. Biomarkers that predict patient outcomes are needed. We leveraged data from 300 patients in the multicenter IPF-PRO Registry to determine ass ... Full text Link to item Cite

Correlation between BAL CXCR3 chemokines and lung allograft histopathologies: A multicenter study.

Journal Article Am J Transplant · October 2021 The histopathologic diagnosis of acute allograft injury is prognostically important in lung transplantation with evidence demonstrating a strong and consistent association between acute rejection (AR), acute lung injury (ALI), and the subsequent developmen ... Full text Link to item Cite

National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: IV. The 2020 Highly morbid forms report.

Journal Article Transplant Cell Ther · October 2021 Chronic graft-versus-host disease (GVHD) can be associated with significant morbidity, in part because of nonreversible fibrosis, which impacts physical functioning (eye, skin, lung manifestations) and mortality (lung, gastrointestinal manifestations). Pro ... Full text Link to item Cite

Immunity to varicella, measles, and mumps in patients evaluated for lung transplantation.

Conference Am J Transplant · August 2021 Vaccine-preventable viral infections are associated with increased risk of morbidity and mortality in post-transplant patients on immunosuppression regimens. Therefore, we studied rates of immunity against vaccine-preventable viruses in lung transplantatio ... Full text Open Access Link to item Cite

Intragraft Hyaluronan Increases in Association With Acute Lung Transplant Rejection.

Journal Article Transplant Direct · April 2021 BACKGROUND: Acute perivascular rejection (AR) is common in lung recipients and increases the risk for chronic lung allograft dysfunction (CLAD). Hyaluronan (HA), an extracellular matrix constituent, accumulates in experimental AR and can act as an innate i ... Full text Link to item Cite

Advances in Human Lung Transplantation.

Journal Article Annu Rev Med · January 27, 2021 Lung transplantation improves survival and quality of life in patients with advanced pulmonary disease. Over the past several decades, the volume of lung transplants has grown substantially, with increasing transplantation of older and acutely ill individu ... Full text Link to item Cite

Research Highlights.

Journal Article Transplantation · January 1, 2021 Full text Link to item Cite

Chronic Lung Allograft Dysfunction

Chapter · January 1, 2021 Lung transplantation is an effective short-term intervention for select patients with end-stage lung disease; however, long-term outcomes remain limited with a median posttransplant survival of only 5–6years. Chronic lung allograft dysfunction (CLAD) is th ... Full text Cite

International Society for Heart and Lung Transplantation consensus statement for the standardization of bronchoalveolar lavage in lung transplantation.

Journal Article J Heart Lung Transplant · November 2020 Bronchoalveolar lavage (BAL) is a key clinical and research tool in lung transplantation (LTx). However, BAL collection and processing are not standardized across LTx centers. This International Society for Heart and Lung Transplantation-supported consensu ... Full text Link to item Cite

Bronchoalveolar bile acid and inflammatory markers to identify high-risk lung transplant recipients with reflux and microaspiration.

Journal Article J Heart Lung Transplant · September 2020 BACKGROUND: Gastroesophageal reflux disease (GERD) is a risk factor for chronic lung allograft dysfunction. Bile acids-putative markers of gastric microaspiration-and inflammatory proteins in the bronchoalveolar lavage (BAL) have been associated with chron ... Full text Link to item Cite

Risk Factors for Acute Rejection in the First Year after Lung Transplant. A Multicenter Study.

Journal Article Am J Respir Crit Care Med · August 15, 2020 Rationale: Acute rejection, manifesting as lymphocytic inflammation in a perivascular (acute perivascular rejection [AR]) or peribronchiolar (lymphocytic bronchiolitis [LB]) distribution, is common in lung transplant recipients and increases the risk for c ... Full text Link to item Cite

Highlights from the clinical trials in organ transplantation (CTOT)-20 and CTOT-22 Consortium studies in lung transplant.

Journal Article Am J Transplant · June 2020 Long-term survival after lung transplant lags behind that of other commonly transplanted organs, reflecting the current incomplete understanding of the mechanisms involved in the development of posttransplant lung injury, rejection, infection, and chronic ... Full text Link to item Cite

Disease Severity and Quality of Life in Patients With Idiopathic Pulmonary Fibrosis: A Cross-Sectional Analysis of the IPF-PRO Registry.

Journal Article Chest · May 2020 BACKGROUND: Limited data are available on the association between clinically measured disease severity markers and quality of life (QOL) in idiopathic pulmonary fibrosis (IPF). The study examined the associations between objective disease severity metrics ... Full text Link to item Cite

NanoString Gene Expression Profiling in Chronic Lung Allograft Dysfunction (CLAD)

Conference The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · April 1, 2020 PURPOSE: CLAD, mainly manifest as bronchiolitis obliterans syndrome (BOS), is the leading cause of late death in lung recipients. BOS develops despite routine immunosuppression and its pathogenesis is poorly understood. The histological correlate of BOS is ... Full text Cite

Pulmonary Microbiome Changes in Lung Transplant Recipients with Gastroesophageal Reflux

Conference The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · April 1, 2020 PURPOSE: The pulmonary microbiome modulates the immune milieu in the lung allograft and is in turn influenced by external factors such as microaspiration of oropharyngeal contents. A potential driver of microaspiration is gastroesophageal reflux disease (G ... Full text Cite

A Multi-Center Study of BAL CXCR3 Chemokines during Allograft Injury after Lung Transplantation

Conference The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · April 1, 2020 PURPOSE: The occurrence of acute allograft injuries remains one of the most important factors responsible for the development of early chronic lung allograft dysfunction. We and others have previously demonstrated a consistent association between acute lun ... Full text Cite

Agreement between Fried Frailty Phenotype and Cumulative Deficits Frailty Indices: A Prospective Multi-Center Study

Conference The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · April 1, 2020 PURPOSE: Frailty is gaining increased recognition in the evaluation of lung transplant (LTx) candidates. The Fried Frailty Phenotype (FFP) index has been the most commonly used instrument and is associated with pre- and post-transplant morbidity and mortal ... Full text Cite

Prospective Assessment of Chronic Lung Allograft Dysfunction (CLAD); the Clinical Trials in Organ Transplantation (CTOT) Study Experience

Conference The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · April 1, 2020 PURPOSE: Diagnosis of CLAD after lung transplantation (LT) requires sustained decline in lung function and exclusion of other etiologies for the decline. The limitations of relying primarily on pulmonary function test (PFT) decline to define CLAD onset for ... Full text Cite

Circulating matrix metalloproteinases and tissue metalloproteinase inhibitors in patients with idiopathic pulmonary fibrosis in the multicenter IPF-PRO Registry cohort.

Journal Article BMC Pulm Med · March 14, 2020 BACKGROUND: Matrix metalloproteinases (MMPs) and tissue inhibitors of MMPs (TIMPs) play important roles in the turnover of extracellular matrix and in the pathogenesis of idiopathic pulmonary fibrosis (IPF). This study aimed to determine the utility of cir ... Full text Link to item Cite

Amphiregulin contributes to airway remodeling in chronic allograft dysfunction after lung transplantation.

Journal Article Am J Transplant · March 2020 Chronic lung allograft dysfunction (CLAD), a condition of excess matrix deposition and airways fibrosis, limits survival after lung transplantation. Amphiregulin (Areg) is an epidermal growth factor receptor (EGFR) ligand suggested to regulate airway injur ... Full text Link to item Cite

Association of Circulating Proteins with Death or Lung Transplant in the IPF-PRO Registry Cohort

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · 2020 Cite

Peripheral blood proteomic profiling of idiopathic pulmonary fibrosis biomarkers in the multicentre IPF-PRO Registry.

Journal Article Respir Res · October 22, 2019 BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease for which diagnosis and management remain challenging. Defining the circulating proteome in IPF may identify targets for biomarker development. We sought to quantify the circulat ... Full text Link to item Cite

The circulating metabolome in idiopathic pulmonary fibrosis (IPF)

Conference EUROPEAN RESPIRATORY JOURNAL · September 28, 2019 Full text Link to item Cite

Lung Transplant Outcomes in Patients With Pulmonary Fibrosis With Telomere-Related Gene Variants.

Journal Article Chest · September 2019 BACKGROUND: Pulmonary fibrosis (PF) is the most common disease indication for lung transplantation. Our recent work implicated an excess of rare genetic variants in the telomere-related genes TERT, RTEL1, and PARN in PF disease risk. The impact of such var ... Full text Link to item Cite

EGFR-Dependent IL8 Production by Airway Epithelial Cells After Exposure to the Food Flavoring Chemical 2,3-Butanedione.

Journal Article Toxicol Sci · June 1, 2019 2,3-Butanedione (DA), a component of artificial butter flavoring, is associated with the development of occupational bronchiolitis obliterans (BO), a disease of progressive airway fibrosis resulting in lung function decline. Neutrophilic airway inflammatio ... Full text Link to item Cite

Acute Rejection (AR) and Lymphocytic Bronchiolitis (LB) in a Multicenter Lung Transplant Cohort

Conference The Journal of Heart and Lung Transplantation · April 2019 Full text Cite

ISHLT Consensus on Standardization of Bronchoalveolar Lavage in Lung Transplantation

Conference The Journal of Heart and Lung Transplantation · April 2019 Full text Cite

Lung Bile Acid as Biomarker of Microaspiration and Its Relationship to Lung Inflammation

Conference The Journal of Heart and Lung Transplantation · April 2019 Full text Cite

Prognostic significance of early pulmonary function changes after onset of chronic lung allograft dysfunction.

Journal Article J Heart Lung Transplant · February 2019 BACKGROUND: Chronic lung allograft dysfunction (CLAD), including the phenotypes of bronchiolitis obliterans syndrome (BOS) and restrictive CLAD (R-CLAD), represents the leading cause of late death after lung transplantation. Little is known, however, regar ... Full text Link to item Cite

Peripheral Blood Proteomic Profiling to Distinguish Disease Biomarkers in the Multicenter IPF-PRO Registry Cohort

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · January 1, 2019 Link to item Cite

Peripheral Blood Gene Expression Profiling in the Multicenter IPF-PRO Registry Cohort

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · January 1, 2019 Link to item Cite

Association of Circulating Proteins with Disease Specific Measures in the Multicenter IPF-PRO Registry Cohort

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · January 1, 2019 Link to item Cite

Randomized, Double-Blind, Placebo-Controlled, Phase 2 Trial of BMS-986020, a Lysophosphatidic Acid Receptor Antagonist for the Treatment of Idiopathic Pulmonary Fibrosis.

Journal Article Chest · November 2018 BACKGROUND: Idiopathic pulmonary fibrosis (IPF) causes irreversible loss of lung function. The lysophosphatidic acid receptor 1 (LPA1) pathway is implicated in IPF etiology. Safety and efficacy of BMS-986020, a high-affinity LPA1 antagonist, was assessed v ... Full text Link to item Cite

Genomic characterization of recurrent mold infections in thoracic transplant recipients.

Journal Article Transpl Infect Dis · October 2018 Invasive mold disease in thoracic organ transplant recipients is a well-recognized complication, but the long-term persistence of molds within the human body and evasion of host defenses has not been well-described. We present 2 cases of invasive mold dise ... Full text Link to item Cite

Hyaluronan in Acute Rejection After Lung Transplantation

Conference The Journal of Heart and Lung Transplantation · April 2018 Full text Cite

Bronchoalveolar Lavage Fluid Proteome in Chronic Lung Allograft Dysfunction

Conference The Journal of Heart and Lung Transplantation · April 2018 Full text Cite

Factors associated with reporting results for pulmonary clinical trials in ClinicalTrials.gov.

Journal Article Clin Trials · February 2018 Background/aims The Food and Drug Administration Amendments Act mandates that applicable clinical trials report basic summary results to the ClinicalTrials.gov database within 1 year of trial completion or termination. We aimed to determine the proportion ... Full text Link to item Cite

An Exome Sequencing Study to Assess the Role of Rare Genetic Variation in Pulmonary Fibrosis.

Journal Article Am J Respir Crit Care Med · July 1, 2017 RATIONALE: Idiopathic pulmonary fibrosis (IPF) is an increasingly recognized, often fatal lung disease of unknown etiology. OBJECTIVES: The aim of this study was to use whole-exome sequencing to improve understanding of the genetic architecture of pulmonar ... Full text Link to item Cite

Danger signals in regulating the immune response to solid organ transplantation.

Journal Article J Clin Invest · June 30, 2017 Endogenous danger signals, or damage-associated molecular patterns (DAMPs), are generated in response to cell stress and activate innate immunity to provide a pivotal mechanism by which an organism can respond to damaged self. Accumulating experimental and ... Full text Link to item Cite

Automating the Diagnosis of Potential CLAD and Its Subtypes in Lung Transplant Recipients

Conference JOURNAL OF HEART AND LUNG TRANSPLANTATION · April 1, 2017 Link to item Cite

Proteomics Of Bronchoalveolar Lavage (bal) Fluid In Bronchiolitis Obliterans Syndrome (bos)

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · January 1, 2017 Link to item Cite

Loxl-2 Contributes To The Development Of Obliterative Bronchiolitis (ob) In Humans

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · January 1, 2017 Link to item Cite

Validation and Refinement of Chronic Lung Allograft Dysfunction Phenotypes in Bilateral and Single Lung Recipients.

Journal Article Ann Am Thorac Soc · May 2016 RATIONALE: The clinical course of chronic lung allograft dysfunction (CLAD) is heterogeneous. Forced vital capacity (FVC) loss at onset, which may suggest a restrictive phenotype, was associated with worse survival for bilateral lung transplant recipients ... Full text Link to item Cite

FVC and FEV1 Decline in Chronic Lung Allograft Dysfunction (CLAD) Phenotypes

Conference The Journal of Heart and Lung Transplantation · April 2016 Full text Cite

Disease Severity And Quality Of Life In Newly Diagnosed Idiopathic Pulmonary Fibrosis Patients

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · January 1, 2016 Link to item Cite

Early and Long-term Outcomes of Older Adults after Acute Care Encounters for Chronic Obstructive Pulmonary Disease Exacerbation.

Journal Article Ann Am Thorac Soc · December 2015 RATIONALE: Older patients are at high risk of death and rehospitalization after hospitalizations for acute exacerbations of chronic obstructive pulmonary disease (AE-COPD). Emergency department visits comprise a substantial portion of acute care encounters ... Full text Link to item Cite

Impact of CLAD Phenotype on Survival After Lung Retransplantation: A Multicenter Study.

Journal Article Am J Transplant · August 2015 Chronic lung allograft dysfunction (CLAD) remains a major problem after lung transplantation with no definitive treatment except redo lung transplantation (re-LTx) in selected candidates. However, CLAD is not a homogeneous entity and different phenotypes e ... Full text Link to item Cite

Neutrophil extracellular traps are pathogenic in primary graft dysfunction after lung transplantation.

Journal Article Am J Respir Crit Care Med · February 15, 2015 RATIONALE: Primary graft dysfunction (PGD) causes early mortality after lung transplantation and may contribute to late graft failure. No effective treatments exist. The pathogenesis of PGD is unclear, although both neutrophils and activated platelets have ... Full text Link to item Cite

Quantitative proteomics of bronchoalveolar lavage fluid in idiopathic pulmonary fibrosis.

Journal Article J Proteome Res · February 6, 2015 The proteomic analysis of bronchoalveolar lavage fluid (BALF) can give insight into pulmonary disease pathology and response to therapy. Here, we describe the first gel-free quantitative analysis of BALF in idiopathic pulmonary fibrosis (IPF), a chronic an ... Full text Link to item Cite

Increased Amphiregulin Expression Is Associated With Chronic Allograft Dysfunction After Lung Transplantation

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · January 1, 2015 Link to item Cite

Atypical Primary Effusion Lymphoma In A Lung Transplant Recipient

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · January 1, 2015 Link to item Cite

Brincidofovir In Progressive Multifocal Leukoencephalopathy After Lung Transplant

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · January 1, 2015 Link to item Cite

Alemtuzumab induction in lung transplantation: time to move on?

Journal Article Am J Transplant · August 2014 This editorial puts into perspective the findings of the first randomized, controlled trial examining alemtuzumab induction for lung transplantation, and highlights the challenges encountered with alemtuzumab induction in other solid organs. See article by ... Full text Link to item Cite

Update in lung transplantation 2013.

Journal Article Am J Respir Crit Care Med · July 1, 2014 Research in pulmonary transplantation is actively evolving in quality and scope to meet the challenges of a growing population of lung allograft recipients. In 2013, research groups leveraged large publicly available datasets in addition to multicenter res ... Full text Link to item Cite

Whole Exome Sequencing: A Novel Strategy to Understand Chronic Lung Allograft Dysfunction (CLAD)

Conference The Journal of Heart and Lung Transplantation · April 2014 Full text Cite

Elevated Hyaluronan Is Associated with Bronchiolitis Obliterans Syndrome

Conference The Journal of Heart and Lung Transplantation · April 2014 Full text Cite

Hyaluronan contributes to bronchiolitis obliterans syndrome and stimulates lung allograft rejection through activation of innate immunity.

Journal Article Am J Respir Crit Care Med · March 1, 2014 RATIONALE: Although innate immunity is increasingly recognized to contribute to lung allograft rejection, the significance of endogenous innate ligands, such as hyaluronan (HA) fragments, in clinical or experimental lung transplantation is uncertain. OBJEC ... Full text Link to item Cite

Impact of forced vital capacity loss on survival after the onset of chronic lung allograft dysfunction.

Journal Article Am J Respir Crit Care Med · January 15, 2014 RATIONALE: Emerging evidence suggests a restrictive phenotype of chronic lung allograft dysfunction (CLAD) exists; however, the optimal approach to its diagnosis and clinical significance is uncertain. OBJECTIVES: To evaluate the hypothesis that spirometri ... Full text Link to item Cite

Using ClinicalTrials.gov to understand the state of clinical research in pulmonary, critical care, and sleep medicine.

Journal Article Ann Am Thorac Soc · October 2013 RATIONALE: ClinicalTrials.gov is the largest trial registry in the world. Strengthened registration requirements, including federal mandates in 2007, have increased study representation. A systematic evaluation of all registered studies has been limited by ... Full text Link to item Cite

Bronchoalveolar lavage as a tool to predict, diagnose and understand bronchiolitis obliterans syndrome.

Journal Article Am J Transplant · March 2013 Bronchiolitis obliterans syndrome (BOS), a condition of irreversible small airway fibrosis, is the principal factor limiting long-term survival after lung transplantation. Bronchoscopy and bronchoalveolar lavage (BAL), techniques central to lung transplant ... Full text Link to item Cite

Lung Transplantation For Pulmonary Complications After Bone Marrow Transplantation

Journal Article AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · January 1, 2013 Link to item Cite

Restrictive Spirometry At Bronchiolitis Obliterans Syndrome Onset Predicts Worse Survival

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · January 1, 2013 Link to item Cite

Innate immune responses and bronchiolitis obliterans syndrome

Chapter · January 1, 2013 The innate immune system, central to host defense, is now recognized to play a critical role in regulating adaptive immune responses, including allograft rejection. Innate immunity is of particular importance in lung transplantation, given the specialized ... Full text Cite

Spirometrically significant acute rejection increases the risk for BOS and death after lung transplantation.

Journal Article Am J Transplant · March 2012 Acute rejection (AR) is a common complication following lung transplantation and is an established risk factor for bronchiolitis obliterans syndrome (BOS). AR clinical presentation varies considerably and is sometimes associated with an acute decrease in f ... Full text Link to item Cite

The state of genome-wide association studies in pulmonary disease: a new perspective.

Journal Article Am J Respir Crit Care Med · October 15, 2011 With rapid advances in our knowledge of the human genome and increasing availability of high-throughput investigative technology, genome-wide association (GWA) studies have recently gained marked popularity. As an unbiased approach to identifying genomic r ... Full text Link to item Cite

Bronchiolitis obliterans syndrome: the final frontier for lung transplantation.

Journal Article Chest · August 2011 Bronchiolitis obliterans syndrome (BOS) is a form of chronic lung allograft dysfunction that affects a majority of lung transplant recipients and is the principal factor limiting long-term transplant survival. BOS is characterized by progressive airflow ob ... Full text Link to item Cite

Lung transplantation in advanced COPD: is it worth it?

Journal Article Semin Respir Crit Care Med · June 2010 Chronic obstructive pulmonary disease (COPD) is a condition of progressive airflow obstruction occurring primarily as a result of tobacco use that accounts for substantial worldwide morbidity and mortality. Medical therapy, with the exception of oxygen and ... Full text Link to item Cite

Thrombolytic therapy for acute pulmonary embolism: a critical appraisal.

Journal Article Chest · May 2009 Pulmonary embolism (PE) is a prevalent condition that may account for > 300,000 deaths annually in the United States alone. Although thrombolytics have been studied as a treatment for acute PE since the 1960s, to date there have been only 11 randomized con ... Full text Link to item Cite

Has the HIV epidemic in rural Mwanza, Tanzania reached a plateau?

Journal Article Tanzan J Health Res · July 2008 Data from studies in Mwanza Region in Tanzania suggest stabilising HIV prevalence. The objective was to determine the factors that may have contributed to the relatively stable pattern of the HIV prevalence observed in the comparison communities of the Mwa ... Full text Link to item Cite

Portal hypertension and granulomatous liver disease in a lung transplant recipient due to disseminated atypical mycobacterial infection.

Journal Article Am J Transplant · May 2007 The incidence of atypical mycobacterial infection among solid organ transplant recipients is increasing. While lung transplant recipients in particular are at greater risk of atypical mycobacterial infection than other solid organ transplant recipients, it ... Full text Link to item Cite

Expectations of patients and physicians regarding patient-accessible medical records

Journal Article Journal of Medical Internet Research · January 1, 2005 Background: Middle class populations have supported shared medical records, including Internet-accessible medical records. The attitudes of lower income populations, and of physicians, are less clear.Objectives: The objective of this study was to compare t ... Full text Cite