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Disease Severity and Quality of Life in Patients With Idiopathic Pulmonary Fibrosis: A Cross-Sectional Analysis of the IPF-PRO Registry.

Publication ,  Journal Article
O'Brien, EC; Hellkamp, AS; Neely, ML; Swaminathan, A; Bender, S; Snyder, LD; Culver, DA; Conoscenti, CS; Todd, JL; Palmer, SM; Leonard, TB ...
Published in: Chest
May 2020

BACKGROUND: Limited data are available on the association between clinically measured disease severity markers and quality of life (QOL) in idiopathic pulmonary fibrosis (IPF). The study examined the associations between objective disease severity metrics and QOL in a contemporary IPF population. METHODS: This study evaluated baseline data from patients enrolled in the multicenter, US-based Idiopathic Pulmonary Fibrosis Prospective Outcomes Registry between June 2014 and July 2018. Disease severity metrics included FVC % predicted, diffusing capacity for carbon monoxide (Dlco) % predicted, supplemental oxygen use with activity, supplemental oxygen use at rest, and two summary scores (the Gender-Age-Lung Physiology index, based on gender, age, and % predicted values for Dlco and FVC; and the Composite Physiologic Index, based on % predicted values for Dlco, FVC, and FEV1). Multivariable adjusted regression models were used to examine cross-sectional associations between each severity measure and St. George's Respiratory Questionnaire (SGRQ) total score. RESULTS: Among 829 patients with complete SGRQ data, the median (interquartile range) SGRQ score at enrollment was 40 (26-53), with higher scores indicating worse QOL. Modest SGRQ impairments were observed with increasing Gender-Age-Lung Physiology score (2.9 [1.8-4.0] per 1-point increase] and with increasing Composite Physiologic Index scores (3.0 [2.4-3.6] per 5-point increase). Substantial SGRQ impairments were observed for oxygen use with activity (15.6 [12.9-18.2]), oxygen use at rest (16.2 [13.0-19.4]), and decreasing Dlco (5.0 [4.0-6.1] per 10% decrease in % predicted). CONCLUSIONS: Objective measures of disease severity, including severity scores, physiologic parameters, and supplemental oxygen use, are associated with worse QOL in patients with IPF. TRIAL REGISTRY: ClinicalTrials.gov; No.: NCT01915511; URL: www.clinicaltrials.gov.

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Published In

Chest

DOI

EISSN

1931-3543

Publication Date

May 2020

Volume

157

Issue

5

Start / End Page

1188 / 1198

Location

United States

Related Subject Headings

  • United States
  • Surveys and Questionnaires
  • Severity of Illness Index
  • Respiratory System
  • Respiratory Function Tests
  • Registries
  • Quality of Life
  • Prospective Studies
  • Middle Aged
  • Male
 

Citation

APA
Chicago
ICMJE
MLA
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O’Brien, E. C., Hellkamp, A. S., Neely, M. L., Swaminathan, A., Bender, S., Snyder, L. D., … IPF-PRO Registry investigators. (2020). Disease Severity and Quality of Life in Patients With Idiopathic Pulmonary Fibrosis: A Cross-Sectional Analysis of the IPF-PRO Registry. Chest, 157(5), 1188–1198. https://doi.org/10.1016/j.chest.2019.11.042
O’Brien, Emily C., Anne S. Hellkamp, Megan L. Neely, Aparna Swaminathan, Shaun Bender, Laurie D. Snyder, Daniel A. Culver, et al. “Disease Severity and Quality of Life in Patients With Idiopathic Pulmonary Fibrosis: A Cross-Sectional Analysis of the IPF-PRO Registry.Chest 157, no. 5 (May 2020): 1188–98. https://doi.org/10.1016/j.chest.2019.11.042.
O’Brien EC, Hellkamp AS, Neely ML, Swaminathan A, Bender S, Snyder LD, et al. Disease Severity and Quality of Life in Patients With Idiopathic Pulmonary Fibrosis: A Cross-Sectional Analysis of the IPF-PRO Registry. Chest. 2020 May;157(5):1188–98.
O’Brien, Emily C., et al. “Disease Severity and Quality of Life in Patients With Idiopathic Pulmonary Fibrosis: A Cross-Sectional Analysis of the IPF-PRO Registry.Chest, vol. 157, no. 5, May 2020, pp. 1188–98. Pubmed, doi:10.1016/j.chest.2019.11.042.
O’Brien EC, Hellkamp AS, Neely ML, Swaminathan A, Bender S, Snyder LD, Culver DA, Conoscenti CS, Todd JL, Palmer SM, Leonard TB, IPF-PRO Registry investigators. Disease Severity and Quality of Life in Patients With Idiopathic Pulmonary Fibrosis: A Cross-Sectional Analysis of the IPF-PRO Registry. Chest. 2020 May;157(5):1188–1198.

Published In

Chest

DOI

EISSN

1931-3543

Publication Date

May 2020

Volume

157

Issue

5

Start / End Page

1188 / 1198

Location

United States

Related Subject Headings

  • United States
  • Surveys and Questionnaires
  • Severity of Illness Index
  • Respiratory System
  • Respiratory Function Tests
  • Registries
  • Quality of Life
  • Prospective Studies
  • Middle Aged
  • Male