Scholars@Duke
Jennifer Anne Rymer

Jennifer Anne Rymer

John Bush Simpson Assistant Professor of Medicine
Medicine, Cardiology
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Selected Publications

The Use of Cangrelor in Cardiogenic Shock: Insights from the CAMEO Registry

Journal Article Journal of Cardiac Failure · October 1, 2024 Introduction: Little is known about the use of cangrelor in patients with myocardial infarction (MI) presenting with cardiogenic shock (CS). Methods: CAMEO (Cangrelor in Acute MI: Effectiveness and Outcomes) is a multicenter observational registry evaluati ... Full text Cite

Myocardial Revascularization in Heart Failure: A State-of-the-Art Review

Journal Article Journal of Cardiac Failure · October 1, 2024 Patients with heart failure (HF) and underlying coronary artery disease (CAD) have a substantially higher risk of mortality compared with those with HF from other causes. However, identifying individuals with HF for whom revascularization is likely to impr ... Full text Cite

The Management and Treatment of Cardiogenic Shock: Is Sex Still a Factor?

Journal Article Journal of Cardiac Failure · October 1, 2024 Full text Cite

Contribution of Clinical Trial Event Data by Data Source: A Prespecified Analysis of the ADAPTABLE Randomized Clinical Trial.

Journal Article JAMA Cardiol · September 1, 2024 IMPORTANCE: Pragmatic randomized clinical trials (RCTs) often use multiple data sources to examine clinical events, but the relative contribution of data sources to clinical end-point rates is understudied. OBJECTIVE: To assess the contribution of data sou ... Full text Link to item Cite

Interleukin-6 and Cardiovascular Events in Healthy Adults: MESA.

Journal Article JACC Adv · August 2024 BACKGROUND: Elevated interleukin (IL)-6 levels have been linked to adverse outcomes in patients with and without baseline cardiovascular disease (CVD). OBJECTIVES: The purpose of this study was to examine the association between circulating IL-6 levels and ... Full text Link to item Cite

Case Volumes and Outcomes Among Early-Career Interventional Cardiologists in the United States.

Journal Article J Am Coll Cardiol · May 21, 2024 BACKGROUND: Little is known about the procedural characteristics, case volumes, and mortality rates for early- vs non-early-career interventional cardiologists in the United States. OBJECTIVES: This study examined operator-level data for patients who under ... Full text Link to item Cite

Ventricular Arrhythmias After Primary Percutaneous Coronary Intervention for STEMI.

Journal Article JAMA Netw Open · May 1, 2024 IMPORTANCE: Currently, mortality risk for patients with ST-segment elevation myocardial infarction (STEMI) treated with primary percutaneous coronary intervention (PCI) with an uncomplicated postprocedure course is low. Less is known regarding the risk of ... Full text Link to item Cite

Chronological vs Biological Age in Interventional Cardiology: A Comprehensive Approach to Care for Older Adults: JACC Family Series.

Journal Article JACC Cardiovasc Interv · April 22, 2024 Aging is the gradual decline in physical and physiological functioning leading to increased susceptibility to stressors and chronic illnesses, including cardiovascular disease. With an aging global population, in which 1 in 6 individuals will be older than ... Full text Link to item Cite

Risk of Bleeding Among Cangrelor-Treated Patients Administered Upstream P2Y12 Inhibitor Therapy: The CAMEO Registry.

Conference J Soc Cardiovasc Angiogr Interv · February 2024 BACKGROUND: Little is known about the bleeding risk associated with cangrelor use in patients with myocardial infarction (MI) who are exposed to an oral P2Y12 inhibitor before coronary angiography. METHODS: Cangrelor in Acute MI: Effectiveness and Outcomes ... Full text Link to item Cite

Use of Calcium Modification During Percutaneous Coronary Intervention After Introduction of Coronary Intravascular Lithotripsy.

Journal Article J Soc Cardiovasc Angiogr Interv · February 2024 BACKGROUND: Calcified coronary lesions are a challenge for percutaneous coronary interventions (PCIs). Coronary intravascular lithotripsy (IVL) is a novel calcium modification technology approved for commercial use in February 2021, but little is known abo ... Full text Link to item Cite

SCAI Expert Consensus Statement on the Management of Calcified Coronary Lesions

Journal Article Journal of the Society for Cardiovascular Angiography and Interventions · February 1, 2024 The prevalence of calcification in obstructive coronary artery disease is on the rise. Percutaneous coronary intervention of these calcified lesions is associated with increased short-term and long-term risks. To optimize percutaneous coronary intervention ... Full text Cite

Statistical considerations for cardiovascular clinical trials straddling the continuum of pandemic phases

Journal Article Cardiovascular Revascularization Medicine · January 1, 2024 In 2020, the NIH and FDA issued guidance documents that laid the foundation for human subject research during an unprecedented pandemic. To bridge these general considerations to actual applications in cardiovascular interventional device trials, the PAnde ... Full text Cite

Rivaroxaban Plus Aspirin Versus Aspirin Alone After Endovascular Revascularization for Symptomatic PAD: Insights From VOYAGER PAD.

Conference Circulation · December 12, 2023 BACKGROUND: Rivaroxaban plus aspirin compared with aspirin alone reduced major cardiac and ischemic limb events after lower extremity revascularization (LER) in the VOYAGER PAD (Vascular Outcomes Study of ASA Along With Rivaroxaban in Endovascular or Surgi ... Full text Link to item Cite

Contemporary Methods for Predicting Acute Kidney Injury After Coronary Intervention.

Journal Article JACC Cardiovasc Interv · September 25, 2023 BACKGROUND: Acute kidney injury (AKI) is the most common complication after percutaneous coronary intervention (PCI). Accurately estimating patients' risks not only creates a means of benchmarking performance but can also be used prospectively to inform pr ... Full text Link to item Cite

The Use of Cangrelor in Cardiogenic Shock: Insights from the CAMEO Registry

Journal Article Journal of Cardiac Failure · October 1, 2024 Introduction: Little is known about the use of cangrelor in patients with myocardial infarction (MI) presenting with cardiogenic shock (CS). Methods: CAMEO (Cangrelor in Acute MI: Effectiveness and Outcomes) is a multicenter observational registry evaluati ... Full text Cite

Myocardial Revascularization in Heart Failure: A State-of-the-Art Review

Journal Article Journal of Cardiac Failure · October 1, 2024 Patients with heart failure (HF) and underlying coronary artery disease (CAD) have a substantially higher risk of mortality compared with those with HF from other causes. However, identifying individuals with HF for whom revascularization is likely to impr ... Full text Cite

The Management and Treatment of Cardiogenic Shock: Is Sex Still a Factor?

Journal Article Journal of Cardiac Failure · October 1, 2024 Full text Cite

Contribution of Clinical Trial Event Data by Data Source: A Prespecified Analysis of the ADAPTABLE Randomized Clinical Trial.

Journal Article JAMA Cardiol · September 1, 2024 IMPORTANCE: Pragmatic randomized clinical trials (RCTs) often use multiple data sources to examine clinical events, but the relative contribution of data sources to clinical end-point rates is understudied. OBJECTIVE: To assess the contribution of data sou ... Full text Link to item Cite

Interleukin-6 and Cardiovascular Events in Healthy Adults: MESA.

Journal Article JACC Adv · August 2024 BACKGROUND: Elevated interleukin (IL)-6 levels have been linked to adverse outcomes in patients with and without baseline cardiovascular disease (CVD). OBJECTIVES: The purpose of this study was to examine the association between circulating IL-6 levels and ... Full text Link to item Cite

Case Volumes and Outcomes Among Early-Career Interventional Cardiologists in the United States.

Journal Article J Am Coll Cardiol · May 21, 2024 BACKGROUND: Little is known about the procedural characteristics, case volumes, and mortality rates for early- vs non-early-career interventional cardiologists in the United States. OBJECTIVES: This study examined operator-level data for patients who under ... Full text Link to item Cite

Ventricular Arrhythmias After Primary Percutaneous Coronary Intervention for STEMI.

Journal Article JAMA Netw Open · May 1, 2024 IMPORTANCE: Currently, mortality risk for patients with ST-segment elevation myocardial infarction (STEMI) treated with primary percutaneous coronary intervention (PCI) with an uncomplicated postprocedure course is low. Less is known regarding the risk of ... Full text Link to item Cite

Chronological vs Biological Age in Interventional Cardiology: A Comprehensive Approach to Care for Older Adults: JACC Family Series.

Journal Article JACC Cardiovasc Interv · April 22, 2024 Aging is the gradual decline in physical and physiological functioning leading to increased susceptibility to stressors and chronic illnesses, including cardiovascular disease. With an aging global population, in which 1 in 6 individuals will be older than ... Full text Link to item Cite

Risk of Bleeding Among Cangrelor-Treated Patients Administered Upstream P2Y12 Inhibitor Therapy: The CAMEO Registry.

Conference J Soc Cardiovasc Angiogr Interv · February 2024 BACKGROUND: Little is known about the bleeding risk associated with cangrelor use in patients with myocardial infarction (MI) who are exposed to an oral P2Y12 inhibitor before coronary angiography. METHODS: Cangrelor in Acute MI: Effectiveness and Outcomes ... Full text Link to item Cite

Use of Calcium Modification During Percutaneous Coronary Intervention After Introduction of Coronary Intravascular Lithotripsy.

Journal Article J Soc Cardiovasc Angiogr Interv · February 2024 BACKGROUND: Calcified coronary lesions are a challenge for percutaneous coronary interventions (PCIs). Coronary intravascular lithotripsy (IVL) is a novel calcium modification technology approved for commercial use in February 2021, but little is known abo ... Full text Link to item Cite

SCAI Expert Consensus Statement on the Management of Calcified Coronary Lesions

Journal Article Journal of the Society for Cardiovascular Angiography and Interventions · February 1, 2024 The prevalence of calcification in obstructive coronary artery disease is on the rise. Percutaneous coronary intervention of these calcified lesions is associated with increased short-term and long-term risks. To optimize percutaneous coronary intervention ... Full text Cite

Statistical considerations for cardiovascular clinical trials straddling the continuum of pandemic phases

Journal Article Cardiovascular Revascularization Medicine · January 1, 2024 In 2020, the NIH and FDA issued guidance documents that laid the foundation for human subject research during an unprecedented pandemic. To bridge these general considerations to actual applications in cardiovascular interventional device trials, the PAnde ... Full text Cite

Rivaroxaban Plus Aspirin Versus Aspirin Alone After Endovascular Revascularization for Symptomatic PAD: Insights From VOYAGER PAD.

Conference Circulation · December 12, 2023 BACKGROUND: Rivaroxaban plus aspirin compared with aspirin alone reduced major cardiac and ischemic limb events after lower extremity revascularization (LER) in the VOYAGER PAD (Vascular Outcomes Study of ASA Along With Rivaroxaban in Endovascular or Surgi ... Full text Link to item Cite

Contemporary Methods for Predicting Acute Kidney Injury After Coronary Intervention.

Journal Article JACC Cardiovasc Interv · September 25, 2023 BACKGROUND: Acute kidney injury (AKI) is the most common complication after percutaneous coronary intervention (PCI). Accurately estimating patients' risks not only creates a means of benchmarking performance but can also be used prospectively to inform pr ... Full text Link to item Cite

Implications of a Race Term in GFR Estimates Used to Predict AKI After Coronary Intervention.

Journal Article JACC Cardiovasc Interv · September 25, 2023 BACKGROUND: The prediction of mortality, bleeding, and acute kidney injury (AKI) after percutaneous coronary intervention (PCI) traditionally relied on race-based estimates of the glomerular filtration rate (GFR). Recently, race agnostic equations were dev ... Full text Link to item Cite

Initial Management Strategy and Long-Term Outcomes in 186 Cases of Spontaneous Coronary Artery Dissection.

Journal Article Semin Thorac Cardiovasc Surg · August 25, 2023 Spontaneous coronary artery dissection (SCAD) is a rare but important nonatherosclerotic cause of acute coronary syndrome. Indications for revascularization and long-term outcomes of SCAD remain areas of active investigation. We report our experience with ... Full text Link to item Cite

A Geriatric Approach to Percutaneous Coronary Interventions in Older Adults, Part II: A JACC: Advances Expert Panel.

Journal Article JACC Adv · July 2023 We review a comprehensive risk assessment approach for percutaneous coronary interventions in older adults and highlight the relevance of geriatric syndromes within that broader perspective to optimize patient-centered outcomes in interventional cardiology ... Full text Link to item Cite

Challenge in Predicting Persistence to P2Y12 Inhibitors: A Perspective From the ARTEMIS Trial.

Journal Article J Am Heart Assoc · June 20, 2023 Background Premature discontinuation of P2Y12 inhibitor therapy has been associated with adverse cardiac events, which might be preventable by improving medication persistence. Current risk models have limited ability to predict patients at risk of P2Y12 i ... Full text Link to item Cite

Variation in resource utilization and mortality among patients with varying MR type and severity.

Journal Article Am Heart J · June 2023 BACKGROUND: Limited data exists regarding the relationships between resource use and outcomes in patients with mitral regurgitation (MR). We examined resource utilization and outcomes across MR type and severity. METHODS: Using the Duke Echocardiography La ... Full text Link to item Cite

Analysis of Oral Anticoagulant Dosing and Adherence to Therapy Among Patients With Nonvalvular Atrial Fibrillation.

Journal Article JAMA Netw Open · June 1, 2023 IMPORTANCE: Although reduced doses of direct oral anticoagulants (DOACs) are approved for patients with nonvalvular atrial fibrillation (NVAF) at high risk of bleeding, little is known about dosing accuracy, particularly in patients with renal dysfunction. ... Full text Link to item Cite

Assessment and Management of Older Adults Undergoing PCI, Part 1: A JACC: Advances Expert Panel.

Journal Article JACC Adv · June 2023 As the population ages, older adults represent an increasing proportion of patients referred to the cardiac catheterization laboratory. Older adults are the highest-risk group for morbidity and mortality, particularly after complex, high-risk percutaneous ... Full text Link to item Cite

Influence of Obesity on Coronary Artery Disease and Clinical Outcomes in the ADVANCE Registry.

Journal Article Circ Cardiovasc Imaging · May 2023 BACKGROUND: The relationship between body size and cardiovascular events is complex. This study utilized the ADVANCE (Assessing Diagnostic Value of Noninvasive FFRCT in Coronary Care) Registry to investigate the association between body mass index (BMI), c ... Full text Link to item Cite

SCAI Expert Consensus Statement on Percutaneous Coronary Intervention Without On-Site Surgical Backup

Journal Article Journal of the Society for Cardiovascular Angiography and Interventions · March 1, 2023 Full text Cite

SCAI Expert Consensus Statement on Management of In-Stent Restenosis and Stent Thrombosis.

Journal Article J Soc Cardiovasc Angiogr Interv · 2023 Stent failure remains the major drawback to the use of coronary stents as a revascularization strategy. Recent advances in imaging have substantially improved our understanding of the mechanisms underlying these occurrences, which have in common numerous c ... Full text Link to item Cite

Apixaban for Patients With Atrial Fibrillation on Hemodialysis: A Multicenter Randomized Controlled Trial.

Journal Article Circulation · December 6, 2022 BACKGROUND: There are no randomized data evaluating the safety or efficacy of apixaban for stroke prevention in patients with end-stage kidney disease on hemodialysis and with atrial fibrillation (AF). METHODS: The RENAL-AF trial (Renal Hemodialysis Patien ... Full text Link to item Cite

One-Year Follow-Up of Vascular Intervention Trials Disrupted by the COVID-19 Pandemic: A Use-Case landscape.

Journal Article Cardiovasc Revasc Med · December 2022 INTRODUCTION: The COVID-19 pandemic had an unprecedented impact on cardiovascular clinical research. The decision-making and state of study operations in cardiovascular trials 1-year after interruption has not been previously described. METHODS: In the spr ... Full text Link to item Cite

Does the Effectiveness of a Medicine Copay Voucher Vary by Baseline Medication Out-Of-Pocket Expenses? Insights From ARTEMIS.

Journal Article J Am Heart Assoc · October 18, 2022 Background Persistence to P2Y12 inhibitors after myocardial infarction (MI) remains low. Out-of-pocket cost is cited as a factor affecting medication compliance. We examined whether a copayment intervention affected 1-year persistence to P2Y12 inhibitors a ... Full text Link to item Cite

Lipid-Lowering Therapy in Women of Childbearing Age: a Review and Stepwise Clinical Approach.

Journal Article Curr Cardiol Rep · October 2022 PURPOSE OF REVIEW: Women are less often recognized to have cardiovascular disease (CVD) risk and are underrepresented in randomized trials of lipid-lowering therapy. Here, we summarize non-pharmacologic and pharmacologic strategies for lipid-lowering in wo ... Full text Link to item Cite

Impact of risk factor control on peripheral artery disease outcomes and health disparities.

Journal Article Vasc Med · August 2022 BACKGROUND: Peripheral artery disease (PAD) is associated with modifiable atherosclerotic risk factors like hypertension, diabetes, hyperlipidemia, and smoking. However, the effect of risk factor control on outcomes and disparities in achieving control is ... Full text Link to item Cite

Disrupting the Management of Calcified Femoropopliteal Peripheral Artery Disease: Mid-term Outcomes From Disrupt PAD III

Journal Article Journal of the Society for Cardiovascular Angiography and Interventions · July 1, 2022 Full text Cite

SCAI Publications Committee Manual of Standard Operating Procedures: 2022 Update

Journal Article Journal of the Society for Cardiovascular Angiography and Interventions · July 1, 2022 Evidence-based recommendations for clinical practice are intended to help health care providers and patients make decisions, minimize inappropriate practice variation, promote effective resource use, improve clinical outcomes, and direct future research. S ... Full text Cite

Cangrelor Use Patterns and Transition to Oral P2Y12 Inhibitors Among Patients With Myocardial Infarction: Initial Results From the CAMEO Registry.

Journal Article J Am Heart Assoc · June 7, 2022 Background In clinical trials, cangrelor has been shown to reduce percutaneous coronary intervention-related ischemic complications without increasing major bleeding. This study was performed to examine cangrelor use and transition to oral P2Y12 inhibitors ... Full text Link to item Cite

Racial Disparities in Invasive Management for Patients With Acute Myocardial Infarction With Chronic Kidney Disease.

Journal Article Circ Cardiovasc Interv · January 2022 BACKGROUND: Due to increased risks of contrast nephropathy, chronic kidney disease (CKD) can deter consideration of invasive management for patients with myocardial infarction (MI). Black patients have a higher prevalence of CKD. Whether racial disparities ... Full text Link to item Cite

Patient-Reported Outcome Measures in Symptomatic, Non-Limb-Threatening Peripheral Artery Disease: A State-of-the-Art Review.

Journal Article Circ Cardiovasc Interv · January 2022 Patient-reported outcome measures (PROMs) are health outcomes directly reported by the patient that can be used to measure the effect of disease and treatments on patient perceived well-being. This review summarizes current evidence regarding the validatio ... Full text Link to item Cite

Bridging Antiplatelet Therapy After Percutaneous Coronary Intervention: JACC Review Topic of the Week.

Journal Article J Am Coll Cardiol · October 12, 2021 Patients undergoing early surgery after coronary stent implantation are at increased risk for mortality from ischemic and hemorrhagic complications. The optimal antiplatelet strategy in patients who cannot discontinue dual antiplatelet therapy (DAPT) befor ... Full text Link to item Cite

A new classification of cardio-oncology syndromes.

Journal Article Cardiooncology · June 21, 2021 Increasing evidence suggests a multifaceted relationship exists between cancer and cardiovascular disease (CVD). Here, we introduce a 5-tier classification system to categorize cardio-oncology syndromes (COS) that represent the aspects of the relationship ... Full text Link to item Cite

Differences in Preferences Between Clinicians and Patients for the Use and Dosing of Direct Oral Anticoagulants for Atrial Fibrillation.

Journal Article J Am Heart Assoc · June 2021 Background Direct oral anticoagulants (DOACs) are effective in reducing the stroke risk for patients with nonvalvular atrial fibrillation if prescribed at the labeled dose, yet underdosing is frequent. Little is known about clinician knowledge and patient ... Full text Link to item Cite

Characteristics and Outcomes of Patients With History of CABG Undergoing Cardiac Catheterization Via the Radial Versus Femoral Approach.

Journal Article JACC Cardiovasc Interv · April 26, 2021 OBJECTIVES: The aims of this study were to examine rates of radial artery access in post-coronary artery bypass grafting (CABG) patients undergoing diagnostic catherization and/or percutaneous coronary intervention (PCI), whether operators with higher proc ... Full text Link to item Cite

Characteristics and Outcomes of Patients With Diabetes Mellitus Undergoing Peripheral Vascular Intervention for Infrainguinal Symptomatic Peripheral Artery Disease.

Journal Article Vasc Endovascular Surg · February 2021 PURPOSE: Patients with diabetes mellitus (DM) are known to be at higher risk for peripheral artery disease (PAD), amputations, and major adverse cardiovascular events, though it is unclear whether they are at any higher risk for repeat intervention. LIBERT ... Full text Link to item Cite

The Current Evidence for Lipid Management in Patients with Lower Extremity Peripheral Artery Disease: What Is the Therapeutic Target?

Journal Article Curr Cardiol Rep · January 22, 2021 PURPOSE OF REVIEW: There is a lack of consistency among the ACC/AHA and ESC Guidelines on the treatment of patients with lower extremity PAD to a targeted LDL-c level. A review of the current guidelines, as well as the evidence that exists for use of vario ... Full text Link to item Cite

Difference in Medication Adherence Between Patients Prescribed a 30-Day Versus 90-Day Supply After Acute Myocardial Infarction.

Journal Article J Am Heart Assoc · January 5, 2021 Background Evidence-based medication adherence rates after a myocardial infarction are low. We hypothesized that 90-day prescriptions are underused and may lead to higher evidence-based medication adherence compared with 30-day fills. Methods and Results W ... Full text Link to item Cite

Evaluation of Women and Underrepresented Racial and Ethnic Group Representation in a General Cardiology Fellowship After a Systematic Recruitment Initiative.

Journal Article JAMA Netw Open · January 4, 2021 IMPORTANCE: The proportion of women and underrepresented racial and ethnic groups (UREGs) matriculating into general cardiology fellowships remains low. OBJECTIVE: To assess a systematic recruitment initiative aimed at ensuring adequate matriculation of wo ... Full text Link to item Cite

Implantable Cardioverter Defibrillator Utilization and Mortality Among Patients ≥65 Years of Age With a Low Ejection Fraction After Coronary Revascularization.

Journal Article Am J Cardiol · January 1, 2021 The purpose of this analysis was to assess implantable cardioverter-defibrillator (ICD) utilization and its association with mortality among patients ≥65 years of age after coronary revascularization. Patients in the National Cardiovascular Database Regist ... Full text Link to item Cite

Economic Evaluation of Catheter Ablation of Atrial Fibrillation in Patients with Heart Failure With Reduced Ejection Fraction.

Journal Article Circ Cardiovasc Qual Outcomes · December 2020 BACKGROUND: Randomized clinical trials have demonstrated that catheter ablation for atrial fibrillation in patients with heart failure with reduced ejection fraction may improve survival and other cardiovascular outcomes. METHODS: We constructed a decision ... Full text Link to item Cite

The impact of chronic kidney disease on outcomes following peripheral vascular intervention.

Journal Article Clin Cardiol · November 2020 BACKGROUND: Patients with chronic kidney disease (CKD) have worsened clinical outcomes following percutaneous coronary intervention; however, limited evidence exists in patients undergoing peripheral vascular intervention (PVI). PURPOSE: We aimed to assess ... Full text Link to item Cite

Association of Health Status Scores With Cardiovascular and Limb Outcomes in Patients With Symptomatic Peripheral Artery Disease: Insights From the EUCLID (Examining Use of Ticagrelor in Symptomatic Peripheral Artery Disease) Trial.

Journal Article J Am Heart Assoc · October 20, 2020 Background There are limited data on health status instruments in patients with peripheral artery disease and cardiovascular and limb events. We evaluated the relationship between health status changes and cardiovascular and limb events. Methods and Result ... Full text Link to item Cite

Association of Disease Progression With Cardiovascular and Limb Outcomes in Patients With Peripheral Artery Disease: Insights From the EUCLID Trial.

Journal Article Circ Cardiovasc Interv · October 2020 BACKGROUND: Patients with peripheral artery disease have a high risk of future cardiovascular disease events and mortality. Little is known about the changes in symptom classification over time in patients with peripheral artery disease and the association ... Full text Link to item Cite

Transcatheter aortic valve replacement for patients with severe bicuspid aortic stenosis.

Journal Article Am Heart J · June 2020 BACKGROUND: Patients with bicuspid aortic valve stenosis (BAV) were excluded from all the trileaflet aortic valve stenosis (TAV) pivotal trials, and therefore, their outcomes are not clearly defined. The aim of the study was to evaluate the outcomes of tra ... Full text Link to item Cite

Use of Low-Density Lipoprotein-Lowering Therapies Before and After PCSK9 Inhibitor Initiation.

Journal Article J Am Heart Assoc · May 5, 2020 Background Proprotein convertase subtilisin/kexin type 9 inhibitors (PCSK9i) are used to reduce low-density lipoprotein (LDL) cholesterol. PCSK9i use after initiation, as well as persistence with or alterations to other LDL-lowering therapy after PCSK9i in ... Full text Link to item Cite

Sex Differences in Quality of Life and Clinical Outcomes in Patients With Advanced Heart Failure: Insights From the PAL-HF Trial.

Journal Article Circ Heart Fail · April 2020 BACKGROUND: Palliative care improves quality of life in patients with heart failure. Whether men and women with heart failure derive similar benefit from palliative care interventions remains unknown. METHODS: In a secondary analysis of the PAL-HF trial (P ... Full text Link to item Cite

Operator Experience and Outcomes of Transcatheter Mitral Valve Repair in the United States.

Journal Article J Am Coll Cardiol · December 17, 2019 BACKGROUND: Transcatheter mitral valve repair (TMVr) for the treatment of mitral regurgitation (MR) is a complex procedure that requires development of a unique skillset. OBJECTIVES: The purpose of this study was to examine the relationship between operato ... Full text Link to item Cite

Pre- Versus Post-Procedure Health Care Resource Utilization in Patients Undergoing Commercial Transcatheter Mitral Valve Repair.

Journal Article JACC Cardiovasc Interv · December 9, 2019 OBJECTIVES: The aim of this study was to assess the real-world impact of transcatheter mitral valve repair (TMVR) on hospitalizations and Medicare costs pre- versus post-TMVR. BACKGROUND: TMVR is effective in degenerative mitral regurgitation (MR) and appr ... Full text Link to item Cite

Opportunities for enhancing the care of older patients with ST-elevation myocardial infarction presenting for primary percutaneous coronary intervention: Rationale and design of the SAFE-STEMI for Seniors trial.

Journal Article Am Heart J · December 2019 Advanced age is directly related to worse outcomes following ST-elevation myocardial infarction (STEMI) and higher complication rates from antithrombotic therapies and primary percutaneous coronary intervention (PCI). Often excluded from clinical trials, s ... Full text Link to item Cite

Same-day discharge among patients undergoing elective PCI: Insights from the VA CART Program.

Journal Article Am Heart J · December 2019 BACKGROUND: Available data suggest that same-day discharge (SDD) after elective percutaneous coronary intervention (PCI) is safe in select patients. Yet, little is known about contemporary adoption rates, safety, and costs in a universal health care system ... Full text Link to item Cite

Ad hoc percutaneous coronary intervention in patients with stable coronary artery disease: A report from the National Cardiovascular Data Registry CathPCI Registry.

Journal Article Am Heart J · October 2019 UNLABELLED: Percutaneous coronary intervention (PCI) may be performed in the same procedure as diagnostic coronary angiography (ad hoc PCI). This study aimed to evaluate current rates of ad hoc PCI use and associated risks of adverse outcomes in patients w ... Full text Link to item Cite

Readmissions After Acute Myocardial Infarction: How Often Do Patients Return to the Discharging Hospital?

Journal Article J Am Heart Assoc · October 2019 Background When patients require readmission after a recent myocardial infarction (MI), returning to the discharging (index) hospital may be associated with better outcomes as a result of greater continuity in care. However, little evidence exists to answe ... Full text Link to item Cite

Factors Associated With and Outcomes of Aborted Procedures During Elective Transcatheter Aortic Valve Replacement.

Journal Article JACC Cardiovasc Interv · September 23, 2019 OBJECTIVES: This study sought to evaluate the outcomes and factors associated with aborted procedures among patients undergoing elective transcatheter aortic valve replacement (TAVR). BACKGROUND: Elective TAVR procedures can be aborted because of device li ... Full text Link to item Cite

Relation of Postdischarge Care Fragmentation and Outcomes in Transcatheter Aortic Valve Implantation from the STS/ACC TVT Registry.

Journal Article Am J Cardiol · September 15, 2019 Fragmented care following elective surgery has been associated with poor outcomes. The association between fragmented care and outcomes in patients undergoing transcatheter aortic valve implantation (TAVI) is unknown. We examined patients who underwent TAV ... Full text Link to item Cite

Institutional Experience With Transcatheter Mitral Valve Repair and Clinical Outcomes: Insights From the TVT Registry.

Journal Article JACC Cardiovasc Interv · July 22, 2019 OBJECTIVES: The aim of this study was to examine the relation between institutional experience and procedural results of transcatheter mitral valve repair. BACKGROUND: Transcatheter mitral valve repair for the treatment of mitral regurgitation (MR) is a co ... Full text Link to item Cite

Trends and Outcomes of Alternative-Access Transcatheter Aortic Valve Replacement.

Journal Article J Invasive Cardiol · July 2019 BACKGROUND: Alternative access (AA) is still required for a significant proportion of patients undergoing transcatheter aortic valve replacement (TAVR). We sought to compare the clinical outcomes of patients undergoing AA vs transfemoral (TF) access. METHO ... Link to item Cite

Safety of Dual-Antiplatelet Therapy After Myocardial Infarction Among Patients With Chronic Kidney Disease.

Journal Article J Am Heart Assoc · May 21, 2019 Background Although recommended in the guidelines, the safety of chronic P2Y12 inhibitor therapy in patients with chronic kidney disease ( CKD ) after an acute myocardial infarction ( MI ) is not well studied. Methods and Results The TRANSLATE -ACS (Treatm ... Full text Link to item Cite

Comparison of Rates of Bleeding and Vascular Complications Before, During, and After Trial Enrollment in the SAFE-PCI Trial for Women.

Journal Article Circ Cardiovasc Interv · May 2019 BACKGROUND: SAFE-PCI for Women (Study of Access Site for Enhancement of PCI for Women), a randomized controlled trial comparing radial and femoral access in women undergoing cardiac catheterization or percutaneous coronary intervention (PCI), was terminate ... Full text Link to item Cite

Recommendations for Institutions Transitioning to High-Sensitivity Troponin Testing: JACC Scientific Expert Panel.

Journal Article J Am Coll Cardiol · March 12, 2019 High-sensitivity cardiac troponin (hs-cTn) I or T methods have been in use in certain regions for years but are now increasingly globally adopted, including in the United States. Accordingly, inevitable challenges are created for institutions transitioning ... Full text Link to item Cite

Predictors and Changes in Cardiac Hemodynamics and Geometry With Transcatheter Aortic Valve Implantation.

Journal Article Am J Cardiol · March 1, 2019 The introduction of transcatheter aortic valve implantation (TAVI) has revolutionized the treatment of patients with severe aortic stenosis (AS). However, despite the great clinical success of TAVI, less is known about the cardiac hemodynamics and structur ... Full text Link to item Cite

Prosthesis-Patient Mismatch in Patients Undergoing Transcatheter Aortic Valve Replacement: From the STS/ACC TVT Registry.

Journal Article J Am Coll Cardiol · December 4, 2018 BACKGROUND: Prosthesis-patient mismatch (PPM) after surgical aortic valve replacement (AVR) for aortic stenosis is generally associated with worse outcomes. Transcatheter AVR (TAVR) can achieve a larger valve orifice and the effects of PPM after TAVR are l ... Full text Link to item Cite

Femoropopliteal In-Stent Restenosis.

Journal Article Circ Cardiovasc Interv · December 2018 Full text Link to item Cite

Preventing Acute Radial Artery Occlusion: A Battle on Multiple Fronts.

Journal Article JACC Cardiovasc Interv · November 26, 2018 Full text Link to item Cite

Advanced Practice Provider Versus Physician-Only Outpatient Follow-Up After Acute Myocardial Infarction.

Journal Article J Am Heart Assoc · September 4, 2018 Background Physician shortages and reimbursement changes have led to greater use of advanced practice providers ( APP s). Prevalence of and outcomes associated with APP care following myocardial infarction are unknown. Methods and Results We examined outpa ... Full text Link to item Cite

Discharge timing and outcomes after uncomplicated non-ST-segment elevation acute myocardial infarction.

Journal Article Am Heart J · July 2018 BACKGROUND: Length of stay after non-ST-segment elevation myocardial infarction (NSTEMI) continues to decrease, but information to guide duration of hospitalization is limited. METHODS: We used landmark analyses, in which the landmark defined potential day ... Full text Link to item Cite

Hospital evaluation of health literacy and associated outcomes in patients after acute myocardial infarction.

Journal Article Am Heart J · April 2018 BACKGROUND: Low health literacy is common in the United States and may affect outcomes after myocardial infarction (MI). How often hospitals screen for low health literacy is unknown. METHODS: We surveyed 122 hospitals in the TRANSLATE-ACS study and divide ... Full text Link to item Cite

Anemia and coronary artery disease: pathophysiology, prognosis, and treatment.

Journal Article Coron Artery Dis · March 2018 The mechanisms, pathophysiology, and treatment of anemia in coronary artery disease (CAD) are complex. The hemodynamic changes found in the acute anemic state may contribute to progressive arterial wall and left ventricular hypertrophy if the anemic state ... Full text Link to item Cite

Failure to Launch: Targeting Inflammation in Acute Coronary Syndromes.

Journal Article JACC Basic Transl Sci · August 2017 The importance of inflammation and inflammatory pathways in atherosclerotic disease and acute coronary syndromes (ACS) is well established. The success of statin therapy rests not only on potently reducing levels of low-density lipoprotein cholesterol, but ... Full text Link to item Cite

Trends in Bare-Metal Stent Use in the United States in Patients Aged ≥65 Years (from the CathPCI Registry).

Journal Article Am J Cardiol · October 1, 2016 In 2006, the United States (US) Food and Drug Administration published advisory highlighting concerns for late drug-eluting stent thrombosis; its impact on US bare-metal stent (BMS) utilization is unknown. We examined rates of BMS use among Medicare patien ... Full text Link to item Cite

JAMA Patient Page. Acute Coronary Syndrome.

Journal Article JAMA · November 10, 2015 Full text Link to item Cite

Does This Patient With Chest Pain Have Acute Coronary Syndrome?: The Rational Clinical Examination Systematic Review.

Journal Article JAMA · November 10, 2015 IMPORTANCE: About 10% of patients with acute chest pain are ultimately diagnosed with acute coronary syndrome (ACS). Early, accurate estimation of the probability of ACS in these patients using the clinical examination could prevent many hospital admission ... Full text Link to item Cite

Accuracy and validation of an automated electronic algorithm to identify patients with atrial fibrillation at risk for stroke.

Journal Article Am Heart J · January 2015 BACKGROUND: There is no universally accepted algorithm for identifying atrial fibrillation (AF) patients and stroke risk using electronic data for use in performance measures. METHODS: Patients with AF seen in clinic were identified based on International ... Full text Link to item Cite

Persistence of evidence-based medication use after discharge from academic versus nonacademic hospitals among patients with non-ST-segment elevation myocardial infarction.

Journal Article Am J Cardiol · November 15, 2014 There is increasing emphasis on optimizing evidence-based medication (EBM) persistence as a means to improve longitudinal patient outcomes after acute myocardial infarction (MI); yet it is unknown whether differences in medication persistence exist between ... Full text Link to item Cite

High economic burden of caring for patients with suspected extraesophageal reflux.

Journal Article Am J Gastroenterol · June 2013 OBJECTIVES: Extraesophageal symptoms are common manifestations of gastroesophageal reflux disease (GERD). Lack of a definitive diagnostic or treatment standards complicate management, which often leads to multiple specialty consultations, procedures, pharm ... Full text Link to item Cite

Remote Stab Wound Resulting in AV Fistula and High-Output Heart Failure.

Journal Article Case Rep Cardiol · 2013 A 54-year-old African American male with no medical history presented to an urgent care clinic with signs and symptoms of new-onset congestive heart failure. There was an initial concern for congestive heart failure secondary to an ischemic etiology as an ... Full text Link to item Cite

Caution about overinterpretation of symptom indexes in reflux monitoring for refractory gastroesophageal reflux disease.

Journal Article Clin Gastroenterol Hepatol · October 2011 BACKGROUND & AIMS: Symptom index (SI) and symptom association probability (SAP) are indexes used to analyze data collected from ambulatory pH and/or impedance monitoring and quantify the association between symptoms and reflux events. However, their charac ... Full text Link to item Cite

Improvements in medical school wellness and career counseling: A comparison of one-on-one advising to an Advisory College Program.

Journal Article Med Teach · 2010 BACKGROUND: Medical students have unmet needs in the areas of career and wellness advising. AIMS: The goal of this study is to describe the development of an Advisory College Program (ACP) and assess its effectiveness compared to a traditional one-on-one f ... Full text Link to item Cite

Adjuvant chemoradiation therapy for pancreatic adenocarcinoma: who really benefits?

Conference J Am Coll Surg · May 2009 BACKGROUND: The role of adjuvant chemoradiation therapy (CRT) in pancreatic cancer remains controversial. The primary aim of this study was to determine if CRT improved survival in patients with resected pancreatic cancer in a large, multiinstitutional coh ... Full text Link to item Cite

Left-sided pancreatectomy: a multicenter comparison of laparoscopic and open approaches.

Conference Ann Surg · September 2008 OBJECTIVES: To compare perioperative outcomes of laparoscopic left-sided pancreatectomy (LLP) with traditional open left-sided pancreatectomy (OLP) in a multicenter experience. SUMMARY AND BACKGROUND DATA: LLP is being performed more commonly with limited ... Full text Link to item Cite

Circadian rhythms in the mating behavior of the cockroach, Leucophaea maderae.

Journal Article J Biol Rhythms · February 2007 Mating behavior of small populations of virgin males and females of the cockroach Leucophaea maderae were continuously monitored via time-lapse video recording in controlled laboratory conditions. The time of onset of copulation was found to be rhythmic in ... Full text Link to item Cite