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Jennifer Yunyan Zhang

Professor in Dermatology
Dermatology
Duke Box 103052, Durham, NC 27710
Rm 4130, MSRB III Bldg, 3 Genome Ct, Durham, NC 27705

Selected Publications


An aging-susceptible circadian rhythm controls cutaneous antiviral immunity.

Journal Article JCI Insight · October 23, 2023 Aged skin is prone to viral infections, but the mechanisms responsible for this immunosenescent immune risk are unclear. We observed that aged murine and human skin expressed reduced levels of antiviral proteins (AVPs) and circadian regulators, including B ... Full text Link to item Cite

Preparation of injectable hydrophilic dextran/AgNPs nanocomposite product: White light active biomolecules as an antitumor agent.

Journal Article Int J Biol Macromol · August 1, 2023 Incidence of various cancers including melanoma continues to rise worldwide. While treatment options have expanded in the recent years, the benefit of these treatments suffer from short period of duration for many patients. Hence, new treatment options are ... Full text Link to item Cite

Single-cell landscape analysis unravels molecular programming of the human B cell compartment in chronic GVHD.

Journal Article JCI Insight · June 8, 2023 Alloreactivity can drive autoimmune syndromes. After allogeneic hematopoietic stem cell transplantation (allo-HCT), chronic graft-versus-host disease (cGVHD), a B cell-associated autoimmune-like syndrome, commonly occurs. Because donor-derived B cells cont ... Full text Link to item Cite

An Aging-Susceptible Circadian Rhythm Controls Cutaneous Antiviral Immunity.

Conference bioRxiv · April 18, 2023 Aged skin is prone to viral infections, but the mechanisms responsible for this immunosenescent immune risk are unclear. We observed that aged murine and human skin expressed reduced antiviral proteins (AVPs) and circadian regulators including Bmal1 and Cl ... Full text Link to item Cite

Location bias contributes to functionally selective responses of biased CXCR3 agonists.

Journal Article Nat Commun · October 4, 2022 Some G protein-coupled receptor (GPCR) ligands act as "biased agonists" that preferentially activate specific signaling transducers over others. Although GPCRs are primarily found at the plasma membrane, GPCRs can traffic to and signal from many subcellula ... Full text Link to item Cite

Human Skin Explant Preparation and Culture.

Journal Article Bio Protoc · September 20, 2022 The ex vivo experimentation with surgically discarded human skin represents a unique methodology amenable for mechanism and pharmacologic agent studies without the involvement of human subjects. Here, we describe a protocol that includes preparation, cultu ... Full text Open Access Link to item Cite

Skin Injury Activates a Rapid TRPV1-Dependent Antiviral Protein Response.

Journal Article J Invest Dermatol · August 2022 The skin serves as the interface between the body and the environment and plays a fundamental role in innate antimicrobial host immunity. Antiviral proteins (AVPs) are part of the innate host defense system and provide protection against viral pathogens. H ... Full text Link to item Cite

Thymic stromal lymphopoietin controls hair growth.

Journal Article Stem Cell Reports · March 8, 2022 Skin tissue regeneration after injury involves the production and integration of signals by stem cells residing in hair follicles (HFSCs). Much remains unknown about how specific wound-derived factors modulate stem cell contribution to hair growth. We demo ... Full text Link to item Cite

Co-Treatment of Chloroquine and Trametinib Inhibits Melanoma Cell Proliferation and Decreases Immune Cell Infiltration.

Journal Article Front Oncol · 2022 Autophagy is characterized as a cytoprotective process and inhibition of autophagy with medicinally active agents, such as chloroquine (CQ) is proposed as a prospective adjuvant therapy for cancer. Here, we examined the preclinical effects of CQ combined w ... Full text Open Access Link to item Cite

3D Printing of Polytetrafluoroethylene Hollow Needles for Medical Applications

Journal Article JOM · December 1, 2021 The delivery of drugs or vaccines using hollow needles involves a “poke and flow” approach, which involves the movement of the drug or vaccine through the bore of a hollow needle. In this paper, hollow needle arrays were created out of the fluoropolymer po ... Full text Cite

Digital light processing-based 3D printing of polytetrafluoroethylene solid microneedle arrays

Journal Article MRS Communications · December 1, 2021 This study evaluated the structural and skin penetration properties of solid microneedle arrays made by digital light processing-based 3D printing of polytetrafluoroethylene. Confocal laser scanning microscopy and scanning electron microscopy revealed that ... Full text Cite

ENTPD1 (CD39) Expression Inhibits UVR-Induced DNA Damage Repair through Purinergic Signaling and Is Associated with Metastasis in Human Cutaneous Squamous Cell Carcinoma.

Journal Article J Invest Dermatol · October 2021 UVR and immunosuppression are major risk factors for cutaneous squamous cell carcinoma (cSCC). Regulatory T cells promote cSCC carcinogenesis, and in other solid tumors, infiltrating regulatory T cells and CD8+ T cells express ectonucleoside triphosphate d ... Full text Link to item Cite

Potential Utility of Synthetic D-Lactate Polymers in Skin Cancer.

Journal Article JID innovations : skin science from molecules to population health · September 2021 Increased breakdown of glucose through glycolysis in both aerobic and anaerobic conditions is a hallmark feature of mammalian cancer and leads to increased production of L-lactate. The high-level lactate present within the tumor microenvironment is reused ... Full text Cite

Epithelia-Sensory Neuron Cross Talk Underlies Cholestatic Itch Induced by Lysophosphatidylcholine.

Journal Article Gastroenterology · July 2021 BACKGROUND & AIMS: Limited understanding of pruritus mechanisms in cholestatic liver diseases hinders development of antipruritic treatments. Previous studies implicated lysophosphatidic acid (LPA) as a potential mediator of cholestatic pruritus. METHODS: ... Full text Link to item Cite

Novel light-driven functional AgNPs induce cancer death at extra low concentrations.

Journal Article Scientific reports · June 2021 The current study is aimed at preparing light-driven novel functional AgNPs- bio-hydrogel and evaluating anticancer potency against human melanoma cells. With an average size of 16-18 nm, the hydrogel nano-silver particle composite (AgNPs@C_MA_O) was synth ... Full text Cite

Single-Cell RNA Sequencing Reveals Cellular and Transcriptional Changes Associated With M1 Macrophage Polarization in Hidradenitis Suppurativa.

Journal Article Front Med (Lausanne) · 2021 Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease characterized by recurrent abscesses, nodules, and sinus tracts in areas of high hair follicle and sweat gland density. These sinus tracts can present with purulent drainage and scar form ... Full text Open Access Link to item Cite

IL-27 Derived From Macrophages Facilitates IL-15 Production and T Cell Maintenance Following Allergic Hypersensitivity Responses.

Journal Article Front Immunol · 2021 Crosstalk between T cells, dendritic cells, and macrophages in temporal leukocyte clusters within barrier tissues provides a new concept for T cell activation in the skin. Activated T cells from these leukocyte clusters play critical roles in the efferent ... Full text Link to item Cite

The Ubiquitin-Modifying Enzyme A20 Terminates C-Type Lectin Receptor Signals and Is a Suppressor of Host Defense against Systemic Fungal Infection.

Journal Article Infect Immun · August 19, 2020 C-type lectin receptors (CLRs) play key roles in antifungal defense. CLR-induced NF-κB is central to CLR functions in immunity, and thus, molecules that control the amplitude of CLR-induced NF-κB could profoundly influence host defense against fungal patho ... Full text Link to item Cite

An aging-susceptible circadian rhythm controls cutaneous antiviral immunity.

Journal Article JCI Insight · October 23, 2023 Aged skin is prone to viral infections, but the mechanisms responsible for this immunosenescent immune risk are unclear. We observed that aged murine and human skin expressed reduced levels of antiviral proteins (AVPs) and circadian regulators, including B ... Full text Link to item Cite

Preparation of injectable hydrophilic dextran/AgNPs nanocomposite product: White light active biomolecules as an antitumor agent.

Journal Article Int J Biol Macromol · August 1, 2023 Incidence of various cancers including melanoma continues to rise worldwide. While treatment options have expanded in the recent years, the benefit of these treatments suffer from short period of duration for many patients. Hence, new treatment options are ... Full text Link to item Cite

Single-cell landscape analysis unravels molecular programming of the human B cell compartment in chronic GVHD.

Journal Article JCI Insight · June 8, 2023 Alloreactivity can drive autoimmune syndromes. After allogeneic hematopoietic stem cell transplantation (allo-HCT), chronic graft-versus-host disease (cGVHD), a B cell-associated autoimmune-like syndrome, commonly occurs. Because donor-derived B cells cont ... Full text Link to item Cite

An Aging-Susceptible Circadian Rhythm Controls Cutaneous Antiviral Immunity.

Conference bioRxiv · April 18, 2023 Aged skin is prone to viral infections, but the mechanisms responsible for this immunosenescent immune risk are unclear. We observed that aged murine and human skin expressed reduced antiviral proteins (AVPs) and circadian regulators including Bmal1 and Cl ... Full text Link to item Cite

Location bias contributes to functionally selective responses of biased CXCR3 agonists.

Journal Article Nat Commun · October 4, 2022 Some G protein-coupled receptor (GPCR) ligands act as "biased agonists" that preferentially activate specific signaling transducers over others. Although GPCRs are primarily found at the plasma membrane, GPCRs can traffic to and signal from many subcellula ... Full text Link to item Cite

Human Skin Explant Preparation and Culture.

Journal Article Bio Protoc · September 20, 2022 The ex vivo experimentation with surgically discarded human skin represents a unique methodology amenable for mechanism and pharmacologic agent studies without the involvement of human subjects. Here, we describe a protocol that includes preparation, cultu ... Full text Open Access Link to item Cite

Skin Injury Activates a Rapid TRPV1-Dependent Antiviral Protein Response.

Journal Article J Invest Dermatol · August 2022 The skin serves as the interface between the body and the environment and plays a fundamental role in innate antimicrobial host immunity. Antiviral proteins (AVPs) are part of the innate host defense system and provide protection against viral pathogens. H ... Full text Link to item Cite

Thymic stromal lymphopoietin controls hair growth.

Journal Article Stem Cell Reports · March 8, 2022 Skin tissue regeneration after injury involves the production and integration of signals by stem cells residing in hair follicles (HFSCs). Much remains unknown about how specific wound-derived factors modulate stem cell contribution to hair growth. We demo ... Full text Link to item Cite

Co-Treatment of Chloroquine and Trametinib Inhibits Melanoma Cell Proliferation and Decreases Immune Cell Infiltration.

Journal Article Front Oncol · 2022 Autophagy is characterized as a cytoprotective process and inhibition of autophagy with medicinally active agents, such as chloroquine (CQ) is proposed as a prospective adjuvant therapy for cancer. Here, we examined the preclinical effects of CQ combined w ... Full text Open Access Link to item Cite

3D Printing of Polytetrafluoroethylene Hollow Needles for Medical Applications

Journal Article JOM · December 1, 2021 The delivery of drugs or vaccines using hollow needles involves a “poke and flow” approach, which involves the movement of the drug or vaccine through the bore of a hollow needle. In this paper, hollow needle arrays were created out of the fluoropolymer po ... Full text Cite

Digital light processing-based 3D printing of polytetrafluoroethylene solid microneedle arrays

Journal Article MRS Communications · December 1, 2021 This study evaluated the structural and skin penetration properties of solid microneedle arrays made by digital light processing-based 3D printing of polytetrafluoroethylene. Confocal laser scanning microscopy and scanning electron microscopy revealed that ... Full text Cite

ENTPD1 (CD39) Expression Inhibits UVR-Induced DNA Damage Repair through Purinergic Signaling and Is Associated with Metastasis in Human Cutaneous Squamous Cell Carcinoma.

Journal Article J Invest Dermatol · October 2021 UVR and immunosuppression are major risk factors for cutaneous squamous cell carcinoma (cSCC). Regulatory T cells promote cSCC carcinogenesis, and in other solid tumors, infiltrating regulatory T cells and CD8+ T cells express ectonucleoside triphosphate d ... Full text Link to item Cite

Potential Utility of Synthetic D-Lactate Polymers in Skin Cancer.

Journal Article JID innovations : skin science from molecules to population health · September 2021 Increased breakdown of glucose through glycolysis in both aerobic and anaerobic conditions is a hallmark feature of mammalian cancer and leads to increased production of L-lactate. The high-level lactate present within the tumor microenvironment is reused ... Full text Cite

Epithelia-Sensory Neuron Cross Talk Underlies Cholestatic Itch Induced by Lysophosphatidylcholine.

Journal Article Gastroenterology · July 2021 BACKGROUND & AIMS: Limited understanding of pruritus mechanisms in cholestatic liver diseases hinders development of antipruritic treatments. Previous studies implicated lysophosphatidic acid (LPA) as a potential mediator of cholestatic pruritus. METHODS: ... Full text Link to item Cite

Novel light-driven functional AgNPs induce cancer death at extra low concentrations.

Journal Article Scientific reports · June 2021 The current study is aimed at preparing light-driven novel functional AgNPs- bio-hydrogel and evaluating anticancer potency against human melanoma cells. With an average size of 16-18 nm, the hydrogel nano-silver particle composite (AgNPs@C_MA_O) was synth ... Full text Cite

Single-Cell RNA Sequencing Reveals Cellular and Transcriptional Changes Associated With M1 Macrophage Polarization in Hidradenitis Suppurativa.

Journal Article Front Med (Lausanne) · 2021 Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease characterized by recurrent abscesses, nodules, and sinus tracts in areas of high hair follicle and sweat gland density. These sinus tracts can present with purulent drainage and scar form ... Full text Open Access Link to item Cite

IL-27 Derived From Macrophages Facilitates IL-15 Production and T Cell Maintenance Following Allergic Hypersensitivity Responses.

Journal Article Front Immunol · 2021 Crosstalk between T cells, dendritic cells, and macrophages in temporal leukocyte clusters within barrier tissues provides a new concept for T cell activation in the skin. Activated T cells from these leukocyte clusters play critical roles in the efferent ... Full text Link to item Cite

The Ubiquitin-Modifying Enzyme A20 Terminates C-Type Lectin Receptor Signals and Is a Suppressor of Host Defense against Systemic Fungal Infection.

Journal Article Infect Immun · August 19, 2020 C-type lectin receptors (CLRs) play key roles in antifungal defense. CLR-induced NF-κB is central to CLR functions in immunity, and thus, molecules that control the amplitude of CLR-induced NF-κB could profoundly influence host defense against fungal patho ... Full text Link to item Cite

The JNK Signaling Pathway in Inflammatory Skin Disorders and Cancer.

Journal Article Cells · April 2, 2020 The c-Jun N-terminal kinases (JNKs), with its members JNK1, JNK2, and JNK3, is a subfamily of (MAPK) mitogen-activated protein kinases. JNK signaling regulates a wide range of cellular processes, including cell proliferation, differentiation, survival, apo ... Full text Open Access Link to item Cite

https://www.intechopen.com/books/cancer-metastasis/genetic-mutations-and-ubiquitination-in-melanoma-growth-and-metastasis

Chapter · November 8, 2019 Upon neoplastic transformation, melanoma is intrinsically prone to metastasis, which marks the most dangerous aspect of the disease and dubs it one of the most challenging cancers to treat. BRAF/MEK oncokinase inhibitors and immunotherapies have shown cons ... Open Access Link to item Cite

Induction of hair follicle neogenesis with cultured mouse dermal papilla cells in de novo regenerated skin tissues.

Journal Article J Tissue Eng Regen Med · September 2019 De novo skin regeneration with human keratinocytes amplified in culture is a life-saving procedure for patients with extensive skin loss and chronic wounds. It also provides a valuable platform for gene function and therapeutic assessments. Nevertheless, t ... Full text Link to item Cite

UBE2N Promotes Melanoma Growth via MEK/FRA1/SOX10 Signaling.

Journal Article Cancer Res · November 15, 2018 UBE2N is a K63-specific ubiquitin conjugase linked to various immune disorders and cancer. Here, we demonstrate that UBE2N and its partners UBE2V1 and UBE2V2 are highly expressed in malignant melanoma. Silencing of UBE2N and its partners significantly decr ... Full text Link to item Cite

1231 UBE2N promotes melanoma growth by maintaining MEK and FRA1 signaling

Journal Article Journal of Investigative Dermatology · May 2018 Full text Cite

MALT1 promotes melanoma progression through JNK/c-Jun signaling.

Journal Article Oncogenesis · July 31, 2017 Mucosa-associated lymphoma antigen 1 (MALT1) is a lymphoma oncogene that regulates signal transduction as a paracaspase and an adaptor protein. Yet, the role of MALT1 in other solid cancers such as melanoma is not well-understood. Here, we demonstrate that ... Full text Open Access Link to item Cite

Animal Models of Skin Disorders

Chapter · June 28, 2017 Skin constitutes the largest biological barrier that protects from dehydration and mechanical injury, environmental toxins and microbes, and participates in immune responses. The epidermis of the skin is comprised of multilayered and stratified epithelial ... Full text Cite

Animal models of skin disorders

Chapter · June 20, 2017 Animal Models for the Study of Human Disease, Second Edition, provides needed information on model sharing, animal alternatives, animal ethics and access to databanks of models, bringing together common descriptions of models for busy ... ... Open Access Cite

TRPV4 Moves toward Center-Fold in Rosacea Pathogenesis.

Journal Article J Invest Dermatol · April 2017 Mascarenhas et al. report that TRPV4 expression is upregulated in mast cells in response to the proteolytic cathelicidin fragment LL37 in a murine rosacea model and that TRPV4 loss of function attenuates mast cell degranulation. These findings render TRPV4 ... Full text Link to item Cite

KIND1 Loss Sensitizes Keratinocytes to UV-Induced Inflammatory Response and DNA Damage.

Journal Article J Invest Dermatol · February 2017 Loss of function of KIND1, a cytoskeletal protein involved in β1-integrin function, causes Kindler syndrome, a genetic disease characterized by skin fragility, photosensitivity, and increased risk of squamous cell carcinoma. Dysregulation of β1-integrin un ... Full text Link to item Cite

Printing amphotericin B on microneedles using matrix-assisted pulsed laser evaporation.

Journal Article Int J Bioprint · 2017 Transdermal delivery of amphotericin B, a pharmacological agent with activity against fungi and parasitic protozoa, is a challenge since amphotericin B exhibits poor solubility in aqueous solutions at physiologic pH values. In this study, we have used a la ... Full text Open Access Link to item Cite

Epidermal CYLD inactivation sensitizes mice to the development of sebaceous and basaloid skin tumors.

Journal Article JCI Insight · July 21, 2016 The deubiquitinase-encoding gene Cyld displays a dominant genetic linkage to a wide spectrum of skin-appendage tumors, which could be collectively designated as CYLD mutant-syndrome (CYLDm-syndrome). Despite recent advances, little is understood about the ... Full text Link to item Cite

FRA1 promotes squamous cell carcinoma growth and metastasis through distinct AKT and c-Jun dependent mechanisms.

Journal Article Oncotarget · June 7, 2016 FRA1 (Fos-like antigen 1) is highly expressed in many epithelial cancers including squamous cell carcinoma of the skin (cSCC) and head and neck (HNSCC). However, the functional importance and the mechanisms mediating FRA1 function in these cancers are not ... Full text Open Access Link to item Cite

Transient Receptor Potential Vanilloid 4 Ion Channel Functions as a Pruriceptor in Epidermal Keratinocytes to Evoke Histaminergic Itch.

Journal Article J Biol Chem · May 6, 2016 TRPV4 ion channels function in epidermal keratinocytes and in innervating sensory neurons; however, the contribution of the channel in either cell to neurosensory function remains to be elucidated. We recently reported TRPV4 as a critical component of the ... Full text Open Access Link to item Cite

Use of Drawing Lithography-Fabricated Polyglycolic Acid Microneedles for Transdermal Delivery of Itraconazole to a Human Basal Cell Carcinoma Model Regenerated on Mice.

Journal Article JOM (1989) · April 2016 Itraconazole is a triazole agent that is routinely used for treatment of nail infections and other fungal infections. Recent studies indicate that itraconazole can also inhibit the growth of basal cell carcinoma (BCC) through suppression of the Sonic Hedge ... Full text Link to item Cite

Comparing in vivo pump-probe and multiphoton fluorescence microscopy of melanoma and pigmented lesions.

Journal Article J Biomed Opt · May 2015 We demonstrate a multimodal approach that combines a pump-probe with confocal reflectance and multiphoton autofluorescence microscopy. Pump-probe microscopy has been proven to be of great value in analyzing thin tissue sections of pigmented lesions, as it ... Full text Link to item Cite

RNA-Seq and ChIP-Seq reveal SQSTM1/p62 as a key mediator of JunB suppression of NF-κB-dependent inflammation.

Journal Article J Invest Dermatol · April 2015 Mice with epidermal deletion of JunB transcription factor displayed a psoriasis-like inflammation. The relevance of these findings to humans and the mechanisms mediating JunB function are not fully understood. Here we demonstrate that impaired JunB functio ... Full text Open Access Link to item Cite

In vivo pump-probe microscopy of melanoma: Characterizing shifts in excited state photodynamics with respect to invasiveness

Conference Progress in Biomedical Optics and Imaging - Proceedings of SPIE · January 1, 2015 Pump-probe microscopy is a multiphoton technique that generates molecular contrast from absorptive pigments, such as melanin. It holds the potential to be used as a non-invasive screening tool to discern whether a given early-stage melanoma has acquired th ... Full text Cite

Keratinocyte growth regulation TRP-ed up over downregulated TRPV4?

Journal Article J Invest Dermatol · September 2014 This commentary on an exciting new study (Fusi et al., 2014) puts the finding of TRPV4 downregulation in several nonmelanoma skin cancers into context. The original paper point toward possible use of TRPV4 as dermatopathologic marker, also toward the possi ... Full text Link to item Cite

Effects of Y27632 on keratinocyte procurement and wound healing.

Journal Article Clin Exp Dermatol · October 2013 A number of Rho-kinase inhibitors have been developed for various clinical applications. We examined the effects of the Rho-kinase inhibitor Y27632 on keratinocyte proliferation and migration, and found that it promoted primary human keratinocyte prolifera ... Full text Link to item Cite

CYLD inhibits melanoma growth and progression through suppression of the JNK/AP-1 and β1-integrin signaling pathways.

Journal Article J Invest Dermatol · January 2013 The molecular mechanisms mediating cylindromatosis (CYLD) tumor suppressor function appear to be manifold. Here, we demonstrate that, in contrast to the increased levels of phosphorylated c-Jun NH(2)-terminal kinase (pJNK), CYLD was decreased in a majority ... Full text Open Access Link to item Cite

CYLD inhibits melanoma growth and progression through suppression of the jnk/ap-1 and β1-integrin signaling pathways

Journal Article Journal of Investigative Dermatology · 2013 The molecular mechanisms mediating cylindromatosis (CYLD) tumor suppressor function appear to be manifold. Here, we demonstrate that, in contrast to the increased levels of phosphorylated c-Jun NH 2 -terminal kinase (pJNK), CYLD was decreased in a majority ... Full text Cite

Role of Jun proteins in epidermal growth regulation

Conference JOURNAL OF INVESTIGATIVE DERMATOLOGY · May 1, 2012 Link to item Cite

In vivo pump-probe microscopy of melanoma and pigmented lesions

Journal Article Progress in Biomedical Optics and Imaging - Proceedings of SPIE · April 16, 2012 A growing number of dermatologists and pathologists are concerned that the rapidly rising incidence of melanoma reflects not a true 'epidemic' but an increasing tendency to overdiagnose pigmented lesions. Addressing this problem requires both a better unde ... Full text Cite

Abstract 381: Non-invasive histology for early detection of cutaneous melanoma and pigmented lesions in vivo

Journal Article Cancer Research · April 15, 2012 AbstractRationale The diagnosis of melanoma is based on clinical identification followed by histopathologic confirmation. Surgical excision remains the mainstay for a suspicious lesion that will be evaluated ... Full text Cite

In vivo pump-probe microscopy of eumelanin, pheomelanin in melanoma

Journal Article Biomedical Optics, BIOMED 2012 · January 1, 2012 We employ pump-probe microscopy to highlight eumelanin versus pheomelanin content of pigmented skin lesions in vivo, and combine the technique with confocal reflectance and fluorescence microscopies to gain a more familiar illustration of the skin. © 2012. ... Full text Cite

The role of the c-Jun N-terminal Kinase signaling pathway in skin cancer.

Journal Article Am J Cancer Res · 2012 The c-Jun N-terminal Kinases (JNK), along with Erk and p38, constitute the principle members of the mitogen-activated protein kinase (MAPK) family. JNK functions primarily through AP1 family transcription factors to regulate a plethora of cellular processe ... Link to item Cite

Pump-probe melanoma imaging: Applications to high-resolution and in-vivo microscopy

Journal Article Optics InfoBase Conference Papers · December 1, 2011 Pump-probe imaging of melanin with near-infrared pulses has been extended to two new domains: high-resolution imaging of the melanin content of melanosomes in an individual melanocyte and epi-detected in vivo microscopy of a developing melanoma. © OSA/ CLE ... Cite

Pump-probe melanoma imaging: Applications to high-resolution and in-vivo microscopy

Journal Article Optics InfoBase Conference Papers · December 1, 2011 Pump-probe imaging of melanin with near-infrared pulses has been extended to two new domains: high-resolution imaging of the melanin content of melanosomes in an individual melanocyte and epi-detected in vivo microscopy of a developing melanoma. © OSA/ CLE ... Cite

Pump-probe microscopy captures cellular detail of melanoma in-vivo.

Journal Article Optics InfoBase Conference Papers · December 1, 2011 Pump-probe imaging of melanin with near-infrared pulses coupled with multphoton autofluorescence captures both chemical contrast and cellular detail in a live, developing melanoma. © 2011 OSA. ... Cite

CYLD inhibits tumorigenesis and metastasis by blocking JNK/AP1 signaling at multiple levels.

Journal Article Cancer Prev Res (Phila) · June 2011 CYLD has been recognized as a tumor suppressor due to its dominant genetic linkage to multiple types of epidermal tumors and a range of other cancers. The molecular mechanisms governing CYLD control of skin cancer are still unclear. Here, we showed that K1 ... Full text Link to item Cite

In vivo and ex vivo epi-mode pump-probe imaging of melanin and microvasculature.

Journal Article Biomed Opt Express · June 1, 2011 We performed epi-mode pump-probe imaging of melanin in excised human pigmented lesions and both hemoglobin and melanin in live xenograft mouse melanoma models to depths greater than 100 µm. Eumelanin and pheomelanin images, which have been previously demon ... Full text Open Access Link to item Cite

c-Jun promotes whereas JunB inhibits epidermal neoplasia.

Journal Article J Invest Dermatol · May 2011 Featured Publication Deregulation of the activator protein 1 (AP1) family gene regulators has been implicated in a wide range of diseases, including cancer. In this study we report that c-Jun was activated in human squamous cell carcinoma (SCC) and coexpression of c-Jun with o ... Full text Link to item Cite

Pump-probe melanoma imaging: Applications to high-resolution and in-vivo microscopy

Conference Optics InfoBase Conference Papers · January 1, 2011 Pump-probe imaging of melanin with near-infrared pulses has been extended to two new domains: high-resolution imaging of the melanin content of melanosomes in an individual melanocyte and epi-detected in vivo microscopy of a developing melanoma. © OSA/ CLE ... Full text Cite

Pump-probe microscopy captures cellular detail of melanoma in-vivo.

Conference Optics InfoBase Conference Papers · January 1, 2011 Pump-probe imaging of melanin with near-infrared pulses coupled with multphoton autofluorescence captures both chemical contrast and cellular detail in a live, developing melanoma. © 2011 OSA. ... Full text Cite

BCL2 interaction with actin in vitro may inhibit cell motility by enhancing actin polymerization.

Journal Article Cell Adh Migr · 2011 In addition to its well-defined role as an antagonist in apoptosis, we propose that BCL2 may act as an intracellular suppressor of cell motility and adhesion under certain conditions. Our evidence shows that, when over-expressed in both cancer and non-canc ... Full text Link to item Cite

The c-Jun NH2-terminal kinase 2 plays a dominant role in human epidermal neoplasia.

Journal Article Cancer Res · April 15, 2010 Featured Publication The c-Jun NH(2)-terminal kinase (JNK) signaling cascade has been implicated in a wide range of diseases, including cancer. It is unclear how different JNK proteins contribute to human cancer. Here, we report that JNK2 is activated in more than 70% of human ... Full text Link to item Cite

Epidermal expression of a mutant CYLD promotes skin carcinogenesis and metastasis

Conference JOURNAL OF INVESTIGATIVE DERMATOLOGY · April 1, 2010 Link to item Cite

BCL2 inhibits cell adhesion, spreading, and motility by enhancing actin polymerization.

Journal Article Cell Res · April 2010 BCL2 is best known as a multifunctional anti-apoptotic protein. However, little is known about its role in cell-adhesive and motility events. Here, we show that BCL2 may play a role in the regulation of cell adhesion, spreading, and motility. When BCL2 was ... Full text Open Access Link to item Cite

JunB and c-Jun display opposite effects on epidermal growth and neoplasia.

Conference JOURNAL OF INVESTIGATIVE DERMATOLOGY · April 1, 2009 Link to item Cite

The c-Jun N-terminal kinase 2 promotes human epidermal neoplasia

Conference JOURNAL OF INVESTIGATIVE DERMATOLOGY · April 1, 2009 Link to item Cite

Reversal of epidermal aging by NF-kappa B blockade

Conference JOURNAL OF INVESTIGATIVE DERMATOLOGY · April 1, 2008 Link to item Cite

C-Jun N-terminal kinases display differential roles in human epidermal neoplasia

Conference JOURNAL OF INVESTIGATIVE DERMATOLOGY · April 1, 2008 Link to item Cite

Motif module map reveals enforcement of aging by continual NF-kappaB activity.

Journal Article Genes Dev · December 15, 2007 Aging is characterized by specific alterations in gene expression, but their underlying mechanisms and functional consequences are not well understood. Here we develop a systematic approach to identify combinatorial cis-regulatory motifs that drive age-dep ... Full text Link to item Cite

Tumor necrosis factor receptor 1/c-Jun-NH2-kinase signaling promotes human neoplasia.

Journal Article Cancer Res · April 15, 2007 Featured Publication The tumor necrosis factor alpha receptor (TNFR1) activates downstream effectors that include the mitogen-activated protein kinase kinase 7 (MKK7)/c-Jun-NH(2)-kinase (JNK)/activator protein 1 (AP1) cascade. Here, we report that JNK is activated in a majorit ... Full text Link to item Cite

CDK4 regulation by TNFR1 and JNK is required for NF-kappaB-mediated epidermal growth control.

Journal Article J Cell Biol · February 14, 2005 Featured Publication Nuclear factor kappaB (NF-kappaB) mediates homeostatic growth inhibition in the epidermis, and a loss of NF-kappaB function promotes proliferation and oncogenesis. To identify mechanisms responsible for these effects, we impaired NF-kappaB action in the ep ... Full text Link to item Cite

NF-kappaB RelA opposes epidermal proliferation driven by TNFR1 and JNK.

Journal Article Genes Dev · January 1, 2004 Featured Publication NF-kappaB inhibition promotes epidermal tumorigenesis; however, whether this reflects an underlying role in homeostasis or a special case confined to neoplasia is unknown. Embryonic lethality of mice lacking NF-kappaB RelA has hindered efforts to address t ... Full text Link to item Cite

Innate inhibition of adaptive immunity: Mycobacterium tuberculosis-induced IL-6 inhibits macrophage responses to IFN-gamma.

Journal Article J Immunol · November 1, 2003 Featured Publication In humans and in mice, control of the intracellular pathogen, Mycobacterium tuberculosis (Mtb), requires IFN-gamma. Although the adaptive immune response results in production of substantial amounts of IFN-gamma in response to Mtb, the immune response is u ... Full text Link to item Cite

Divergent gene regulation and growth effects by NF-kappa B in epithelial and mesenchymal cells of human skin.

Journal Article Oncogene · April 3, 2003 Featured Publication NF-kappa B regulates normal and pathological processes, including neoplasia, in a tissue-context-dependent manner. In skin, NF-kappa B is implicated in epidermal homeostasis as well as in the pathogenesis of squamous cell carcinoma; however, its function i ... Full text Link to item Cite

NF-kappaB blockade and oncogenic Ras trigger invasive human epidermal neoplasia.

Journal Article Nature · February 6, 2003 Featured Publication The nuclear factor NF-kappaB and oncogenic Ras can alter proliferation in epidermis, the most common site of human cancer. These proteins are implicated in epidermal squamous cell carcinoma in mice, however, the potential effects of altering their function ... Full text Link to item Cite

A linking function for the cellulose-binding protein SP85 in the spore coat of Dictyostelium discoideum.

Journal Article J Cell Sci · December 1999 Featured Publication SP85 is a multidomain protein of the Dictyostelium spore coat whose C-terminal region binds cellulose in vitro. To map domains critical for localizing SP85 and for binding to other proteins in vivo, its N- and C-terminal regions, and a hybrid fusion of the ... Full text Link to item Cite

Two proteins of the Dictyostelium spore coat bind to cellulose in vitro.

Journal Article Biochemistry · July 28, 1998 Featured Publication The spore coat of Dictyostelium contains nine different proteins and cellulose. Interactions between protein and cellulose were investigated using an in vitro binding assay. Proteins extracted from coats with urea and 2-mercaptoethanol could, after removal ... Full text Link to item Cite

SP75 is encoded by the DP87 gene and belongs to a family of modular Dictyostelium discoideum outer layer spore coat proteins.

Journal Article Microbiology (Reading) · August 1996 Featured Publication Highly purified spore coats of Dictyostelium discoideum each contained about 5 x 10(6) protein molecules as determined by amino acid composition analysis. By two-dimensional gel electrophoresis the coats were found to contain nine major-abundance and numer ... Full text Link to item Cite