Scholars@Duke
James T. Voyvodic

James T. Voyvodic

Associate Professor in Radiology
Radiology
jim.voyvodic@duke.edu
Brain Imaging and Analysis Ctr, Box 3918, Durham, NC 27710
40 Duke Medicine Circle, Davison 414, Box 3918, Durham, NC 27710

Selected Publications

Febrile status epilepticus and epileptogenesis: The FEBSTAT study.

Journal Article Epilepsia Open · August 6, 2025 The multicenter FEBSTAT study (Consequences of Prolonged Febrile Seizures in Childhood: https://grantome.com/grant/NIH/R37-NS043209-12; PI S. Shinnar) examined the outcome of febrile status epilepticus (FSE) in over 200 prospectively enrolled infants, with ... Full text Link to item Cite

Resting-state functional MRI in pediatric epilepsy: a narrative review.

Journal Article Childs Nerv Syst · February 18, 2025 The role of connectivity in the function and development of the human brain has been intensely studied over the last two decades. These findings have begun to be translated to the clinical setting, particularly in the context of epilepsy. Determining conne ... Full text Link to item Cite

Motor network reorganization associated with rTMS-induced writing improvement in writer's cramp dystonia.

Journal Article Brain Stimul · 2025 BACKGROUND: Writer's cramp (WC) dystonia is an involuntary movement disorder with distributed abnormalities in the brain's motor network. Prior studies established the potential for repetitive transcranial magnetic stimulation (rTMS) to either premotor cor ... Full text Link to item Cite

Motor priming induces changes in resting state dynamics in cerebellum of writer’s cramp dystonia: insights for clinical therapies

Journal Article Dystonia · January 1, 2025 Background: Writer’s cramp (WC) is an adult-onset focal dystonia that impairs hand and arm movements during writing tasks. Previous studies have identified abnormal resting state connectivity between the basal ganglia and cerebellum in WC. However, the rol ... Full text Cite

Hippocampal sclerosis and temporal lobe epilepsy following febrile status epilepticus: The FEBSTAT study.

Journal Article Epilepsia · June 2024 OBJECTIVE: This study was undertaken to determine whether hippocampal T2 hyperintensity predicts sequelae of febrile status epilepticus, including hippocampal atrophy, sclerosis, and mesial temporal lobe epilepsy. METHODS: Acute magnetic resonance imaging ... Full text Link to item Cite

Development and Ongoing Regulation of Synaptic Connections and Neuronal Morphology in Autonomic Ganglia

Chapter · January 1, 2024 The development of synaptic connections in autonomic ganglia is closely correlated with the development of ganglion cell dendritic geometry. There is now considerable evidence that this correlation is due to preganglionic inputs adjusting their synapses ac ... Full text Cite

Auditory oddball hypoactivation in schizophrenia.

Journal Article Psychiatry Res Neuroimaging · October 2023 Individuals with schizophrenia (SZ) show aberrant activations, assessed via functional magnetic resonance imaging (fMRI), during auditory oddball tasks. However, associations with cognitive performance and genetic contributions remain unknown. This study c ... Full text Link to item Cite

Effects of alfaxalone, propofol and isoflurane on cerebral blood flow and cerebrovascular reactivity to carbon dioxide in dogs: A pilot study.

Journal Article Vet J · January 2023 Propofol total intravenous anesthesia is a common choice to anesthetize patients with increased intracranial pressure, reducing cerebral blood flow while maintaining cerebrovascular reactivity to CO2. Propofol and alfaxalone are commonly used for total int ... Full text Link to item Cite

Reward Processing in Novelty Seekers: A Transdiagnostic Psychiatric Imaging Biomarker.

Journal Article Biol Psychiatry · October 15, 2021 BACKGROUND: Dysfunctional reward processing is implicated in multiple mental disorders. Novelty seeking (NS) assesses preference for seeking novel experiences, which is linked to sensitivity to reward environmental cues. METHODS: A subset of 14-year-old ad ... Full text Link to item Cite

Association of Heavy Drinking With Deviant Fiber Tract Development in Frontal Brain Systems in Adolescents.

Journal Article JAMA Psychiatry · April 1, 2021 IMPORTANCE: Maturation of white matter fiber systems subserves cognitive, behavioral, emotional, and motor development during adolescence. Hazardous drinking during this active neurodevelopmental period may alter the trajectory of white matter microstructu ... Full text Link to item Cite

Adolescent alcohol use disrupts functional neurodevelopment in sensation seeking girls.

Journal Article Addict Biol · March 2021 Exogenous causes, such as alcohol use, and endogenous factors, such as temperament and sex, can modulate developmental trajectories of adolescent neurofunctional maturation. We examined how these factors affect sexual dimorphism in brain functional network ... Full text Link to item Cite

Time-varying Graphs: A Method to Identify Abnormal Integration and Disconnection in Functional Brain Connectivity with Application to Schizophrenia

Conference Proceedings IEEE 20th International Conference on Bioinformatics and Bioengineering Bibe 2020 · October 1, 2020 Objective: A graph theoretical approach provides a powerful framework for discovering potential biomarkers of psychotic disorders. Comparing the brain graphs of the control and patient groups can help us to discover changes in mental disorders in a more co ... Full text Cite

Meta-Modal Information Flow: A Method for Capturing Multimodal Modular Disconnectivity in Schizophrenia.

Journal Article IEEE Trans Biomed Eng · September 2020 OBJECTIVE: Multimodal measurements of the same phenomena provide complementary information and highlight different perspectives, albeit each with their own limitations. A focus on a single modality may lead to incorrect inferences, which is especially impo ... Full text Link to item Cite

Dentate gyrus volume deficit in schizophrenia.

Journal Article Psychol Med · June 2020 BACKGROUND: Schizophrenia is associated with robust hippocampal volume deficits but subregion volume deficits, their associations with cognition, and contributing genes remain to be determined. METHODS: Hippocampal formation (HF) subregion volumes were obt ... Full text Link to item Cite

Parallel group ICA+ICA: Joint estimation of linked functional network variability and structural covariation with application to schizophrenia.

Journal Article Hum Brain Mapp · September 2019 There is growing evidence that rather than using a single brain imaging modality to study its association with physiological or symptomatic features, the field is paying more attention to fusion of multimodal information. However, most current multimodal f ... Full text Link to item Cite

Autoconnectivity: A new perspective on human brain function.

Journal Article J Neurosci Methods · July 15, 2019 BACKGROUND: Autocorrelation (AC) in fMRI time-series is a well-known phenomenon, typically attributed to colored noise and therefore removed from the data. We hypothesize that AC reflects systematic and meaningful signal fluctuations that may be tied to ne ... Full text Link to item Cite

Distribution of brain iron accrual in adolescence: Evidence from cross-sectional and longitudinal analysis.

Journal Article Hum Brain Mapp · April 1, 2019 To track iron accumulation and location in the brain across adolescence, we repurposed diffusion tensor imaging (DTI) and functional magnetic resonance imaging (fMRI) data acquired in 513 adolescents and validated iron estimates with quantitative susceptib ... Full text Link to item Cite

A framework for linking resting-state chronnectome/genome features in schizophrenia: A pilot study.

Journal Article Neuroimage · January 1, 2019 Multimodal, imaging-genomics techniques offer a platform for understanding genetic influences on brain abnormalities in psychiatric disorders. Such approaches utilize the information available from both imaging and genomics data and identify their associat ... Full text Link to item Cite

Resting-state thalamic dysconnectivity in schizophrenia and relationships with symptoms.

Journal Article Psychol Med · November 2018 BACKGROUND: Schizophrenia (SZ) is a severe neuropsychiatric disorder associated with disrupted connectivity within the thalamic-cortico-cerebellar network. Resting-state functional connectivity studies have reported thalamic hypoconnectivity with the cereb ... Full text Link to item Cite

Polygenic risk score, genome-wide association, and gene set analyses of cognitive domain deficits in schizophrenia.

Journal Article Schizophr Res · November 2018 This study assessed genetic contributions to six cognitive domains, identified by the MATRICS Cognitive Consensus Battery as relevant for schizophrenia, cognition-enhancing, clinical trials. Psychiatric Genomics Consortium Schizophrenia polygenic risk scor ... Full text Link to item Cite

Cortical Brain Abnormalities in 4474 Individuals With Schizophrenia and 5098 Control Subjects via the Enhancing Neuro Imaging Genetics Through Meta Analysis (ENIGMA) Consortium.

Journal Article Biol Psychiatry · November 1, 2018 BACKGROUND: The profile of cortical neuroanatomical abnormalities in schizophrenia is not fully understood, despite hundreds of published structural brain imaging studies. This study presents the first meta-analysis of cortical thickness and surface area a ... Full text Link to item Cite

Multimodal neuromarkers in schizophrenia via cognition-guided MRI fusion.

Journal Article Nat Commun · August 2, 2018 Cognitive impairment is a feature of many psychiatric diseases, including schizophrenia. Here we aim to identify multimodal biomarkers for quantifying and predicting cognitive performance in individuals with schizophrenia and healthy controls. A supervised ... Full text Link to item Cite

Influences of Age, Sex, and Moderate Alcohol Drinking on the Intrinsic Functional Architecture of Adolescent Brains.

Journal Article Cereb Cortex · March 1, 2018 The transition from adolescent to adult cognition and emotional control requires neurodevelopmental maturation likely involving intrinsic functional networks (IFNs). Normal neurodevelopment may be vulnerable to disruption from environmental insult such as ... Full text Link to item Cite

Multimodal Fusion With Reference: Searching for Joint Neuromarkers of Working Memory Deficits in Schizophrenia.

Journal Article IEEE Trans Med Imaging · January 2018 By exploiting cross-information among multiple imaging data, multimodal fusion has often been used to better understand brain diseases. However, most current fusion approaches are blind, without adopting any prior information. There is increasing interest ... Full text Link to item Cite

Plasma cytokines associated with febrile status epilepticus in children: A potential biomarker for acute hippocampal injury.

Journal Article Epilepsia · June 2017 OBJECTIVE: Our aim was to explore the association between plasma cytokines and febrile status epilepticus (FSE) in children, as well as their potential as biomarkers of acute hippocampal injury. METHODS: Analysis was performed on residual samples of childr ... Full text Link to item Cite

Adolescent Development of Cortical and White Matter Structure in the NCANDA Sample: Role of Sex, Ethnicity, Puberty, and Alcohol Drinking.

Journal Article Cereb Cortex · October 2016 Brain structural development continues throughout adolescence, when experimentation with alcohol is often initiated. To parse contributions from biological and environmental factors on neurodevelopment, this study used baseline National Consortium on Alcoh ... Full text Link to item Cite

Supervised multimodal fusion and its application in searching joint neuromarkers of working memory deficits in schizophrenia.

Conference Annu Int Conf IEEE Eng Med Biol Soc · August 2016 Multimodal fusion is an effective approach to better understand brain disease. To date, most current fusion approaches are unsupervised; there is need for a multivariate method that can adopt prior information to guide multimodal fusion. Here we proposed a ... Full text Link to item Cite

Risk factors for subsequent febrile seizures in the FEBSTAT study.

Journal Article Epilepsia · July 2016 OBJECTIVES: To identify risk and risk factors for developing a subsequent febrile seizure (FS) in children with a first febrile status epilepticus (FSE) compared to a first simple febrile seizure (SFS). To identify home use of rescue medications for subseq ... Full text Link to item Cite

Harmonizing DTI measurements across scanners to examine the development of white matter microstructure in 803 adolescents of the NCANDA study.

Journal Article Neuroimage · April 15, 2016 Neurodevelopment continues through adolescence, with notable maturation of white matter tracts comprising regional fiber systems progressing at different rates. To identify factors that could contribute to regional differences in white matter microstructur ... Full text Link to item Cite

The Function Biomedical Informatics Research Network Data Repository.

Journal Article Neuroimage · January 1, 2016 The Function Biomedical Informatics Research Network (FBIRN) developed methods and tools for conducting multi-scanner functional magnetic resonance imaging (fMRI) studies. Method and tool development were based on two major goals: 1) to assess the major so ... Full text Link to item Cite

Neuropsychological profile in adult schizophrenia measured with the CMINDS.

Journal Article Psychiatry Res · December 30, 2015 Schizophrenia neurocognitive domain profiles are predominantly based on paper-and-pencil batteries. This study presents the first schizophrenia domain profile based on the Computerized Multiphasic Interactive Neurocognitive System (CMINDS(®)). Neurocogniti ... Full text Link to item Cite

Neural Mechanisms of Emotion Regulation in Autism Spectrum Disorder.

Journal Article J Autism Dev Disord · November 2015 Autism spectrum disorder (ASD) is characterized by high rates of comorbid internalizing and externalizing disorders. One mechanistic account of these comorbidities is that ASD is characterized by impaired emotion regulation (ER) that results in deficits mo ... Full text Link to item Cite

Relating Intrinsic Low-Frequency BOLD Cortical Oscillations to Cognition in Schizophrenia.

Journal Article Neuropsychopharmacology · November 2015 The amplitude of low-frequency fluctuations (ALFF) in the blood oxygenation level-dependent (BOLD) signal during resting-state fMRI reflects the magnitude of local low-frequency BOLD oscillations, rather than interregional connectivity. ALFF is of interest ... Full text Link to item Cite

Quantitative imaging biomarkers: a review of statistical methods for technical performance assessment.

Journal Article Stat Methods Med Res · February 2015 Technological developments and greater rigor in the quantitative measurement of biological features in medical images have given rise to an increased interest in using quantitative imaging biomarkers to measure changes in these features. Critical to the pe ... Full text Link to item Cite

Visual hallucinations are associated with hyperconnectivity between the amygdala and visual cortex in people with a diagnosis of schizophrenia.

Journal Article Schizophr Bull · January 2015 INTRODUCTION: While auditory verbal hallucinations (AH) are a cardinal symptom of schizophrenia, people with a diagnosis of schizophrenia (SZ) may also experience visual hallucinations (VH). In a retrospective analysis of a large sample of SZ and healthy c ... Full text Link to item Cite

Cerebrovascular reactivity mapping in patients with low grade gliomas undergoing presurgical sensorimotor mapping with BOLD fMRI.

Journal Article J Magn Reson Imaging · August 2014 PURPOSE: (i) to validate blood oxygenation level dependent (BOLD) breathhold cerebrovascular reactivity (BH CVR) mapping as an effective technique for potential detection of neurovascular uncoupling (NVU) in a cohort of patients with perirolandic low grade ... Full text Link to item Cite

A multi-scanner study of subcortical brain volume abnormalities in schizophrenia.

Journal Article Psychiatry Res · April 30, 2014 Schizophrenia patients show significant subcortical brain abnormalities. We examined these abnormalities using automated image analysis software and provide effect size estimates for prospective multi-scanner schizophrenia studies. Subcortical and intracra ... Full text Link to item Cite

Converting positive and negative symptom scores between PANSS and SAPS/SANS.

Journal Article Schizophr Res · January 2014 The Scale for the Assessment of Positive Symptoms (SAPS), the Scale for the Assessment of Negative Symptoms (SANS), and the Positive and Negative Syndrome Scale for Schizophrenia (PANSS) are the most widely used schizophrenia symptom rating scales, but des ... Full text Link to item Cite

Written distractor words influence brain activity during overt picture naming.

Journal Article Front Hum Neurosci · 2014 Language production requires multiple stages of processing (e.g., semantic retrieval, lexical selection), each of which may involve distinct brain regions. Distractor words can be combined with picture naming to examine factors that influence language prod ... Full text Link to item Cite

An application of item response theory to fMRI data: prospects and pitfalls.

Journal Article Psychiatry Res · June 30, 2013 When using functional brain imaging to study neuropsychiatric patients an important challenge is determining whether the imaging task assesses individual differences with equal precision in healthy control and impaired patient groups. Classical test theory ... Full text Link to item Cite

Multilingualism and fMRI: Longitudinal Study of Second Language Acquisition.

Journal Article Brain Sci · May 28, 2013 BOLD fMRI is often used for the study of human language. However, there are still very few attempts to conduct longitudinal fMRI studies in the study of language acquisition by measuring auditory comprehension and reading. The following paper is the first ... Full text Link to item Cite

A multi-site resting state fMRI study on the amplitude of low frequency fluctuations in schizophrenia.

Journal Article Front Neurosci · 2013 BACKGROUND: This multi-site study compares resting state fMRI amplitude of low frequency fluctuations (ALFF) and fractional ALFF (fALFF) between patients with schizophrenia (SZ) and healthy controls (HC). METHODS: Eyes-closed resting fMRI scans (5:38 min; ... Full text Link to item Cite

Functional neuroimaging of treatment effects in psychiatry: methodological challenges and recommendations.

Journal Article Int J Neurosci · September 2012 Functional magnetic resonance imaging (fMRI) has helped to elucidate the neurobiological bases of psychiatric and neurodevelopmental disorders by localizing etiologically-relevant aberrations in brain function. Functional MRI also has shown great promise t ... Full text Link to item Cite

Reproducibility of single-subject fMRI language mapping with AMPLE normalization.

Journal Article J Magn Reson Imaging · September 2012 PURPOSE: To evaluate the reproducibility of presurgical functional MRI (fMRI) language mapping based on test-retest scans, comparing traditional activation t-maps to relative activation maps normalized by activation mapping as percentage of local excitatio ... Full text Link to item Cite

Function biomedical informatics research network recommendations for prospective multicenter functional MRI studies.

Journal Article J Magn Reson Imaging · July 2012 This report provides practical recommendations for the design and execution of multicenter functional MRI (MC-fMRI) studies based on the collective experience of the Function Biomedical Informatics Research Network (FBIRN). The study was inspired by many r ... Full text Link to item Cite

The influence of emotional distraction on verbal working memory: an fMRI investigation comparing individuals with schizophrenia and healthy adults.

Journal Article J Psychiatr Res · September 2011 The ability to maintain information over short periods of time (i.e., working memory) is critically important in a variety of cognitive functions including language, planning, and decision-making. Recent functional Magnetic Resonance Imaging (fMRI) researc ... Full text Link to item Cite

A novel method for quantifying scanner instability in fMRI.

Journal Article Magn Reson Med · April 2011 A method was developed to quantify the effect of scanner instability on functional MRI data by comparing the instability noise to endogenous noise present when scanning a human. The instability noise was computed from agar phantom data collected with two f ... Full text Link to item Cite

Multisite reliability of cognitive BOLD data.

Journal Article Neuroimage · February 1, 2011 Investigators perform multi-site functional magnetic resonance imaging studies to increase statistical power, to enhance generalizability, and to improve the likelihood of sampling relevant subgroups. Yet undesired site variation in imaging methods could o ... Full text Link to item Cite

Automated real-time behavioral and physiological data acquisition and display integrated with stimulus presentation for FMRI.

Journal Article Front Neuroinform · 2011 Functional magnetic resonance imaging (fMRI) is based on correlating blood oxygen-level dependent (BOLD) signal fluctuations in the brain with other time-varying signals. Although the most common reference for correlation is the timing of a behavioral task ... Full text Link to item Cite

fMRI activation mapping as a percentage of local excitation: consistent presurgical motor maps without threshold adjustment.

Journal Article J Magn Reson Imaging · April 2009 PURPOSE: To evaluate the performance of a relative activation amplitude algorithm, versus standard t-value thresholding, for reliably establishing the location, amplitude, and spatial extent of functional magnetic resonance imaging (fMRI) brain activation ... Full text Link to item Cite

Voxel-based morphometric multisite collaborative study on schizophrenia.

Journal Article Schizophr Bull · January 2009 Regional gray matter (GM) abnormalities are well known to exist in patients with chronic schizophrenia. Voxel-based morphometry (VBM) has been previously used on structural magnetic resonance images (MRI) data to characterize these abnormalities. Two multi ... Full text Link to item Cite

fMRI activity correlated with auditory hallucinations during performance of a working memory task: data from the FBIRN consortium study.

Journal Article Schizophr Bull · January 2009 INTRODUCTION: Auditory hallucinations are a hallmark symptom of schizophrenia. The neural basis of auditory hallucinations was examined using data from a working memory task. Data were acquired within a multisite consortium and this unique dataset provided ... Full text Link to item Cite

Activation mapping as a percentage of local excitation: fMRI stability within scans, between scans and across field strengths.

Journal Article Magn Reson Imaging · November 2006 Functional magnetic resonance imaging (fMRI) does not typically yield highly reproducible maps of brain activation. Maps can vary significantly even with constant scanning parameters and consistent task performance conditions (Liu et al., Magn. Reson. Med. ... Full text Link to item Cite

Preoperative functional MR imaging localization of language and motor areas: effect on therapeutic decision making in patients with potentially resectable brain tumors.

Journal Article Radiology · September 2006 PURPOSE: To prospectively evaluate the effect of preoperative functional magnetic resonance (MR) imaging localization of language and motor areas on therapeutic decision making in patients with potentially resectable brain tumors. MATERIALS AND METHODS: Th ... Full text Link to item Cite

Dynamic perception of facial affect and identity in the human brain.

Journal Article Cereb Cortex · October 2003 Functional magnetic resonance imaging (fMRI) was used to compare brain activation to static facial displays versus dynamic changes in facial identity or emotional expression. Static images depicted prototypical fearful, angry and neutral expressions. Ident ... Full text Link to item Cite

Functional MR imaging using a visually guided saccade paradigm for comparing activation patterns in patients with probable Alzheimer's disease and in cognitively able elderly volunteers.

Journal Article AJNR Am J Neuroradiol · March 2000 BACKGROUND AND PURPOSE: Alzheimer's disease is associated with progressive visuospatial dysfunction. This study used functional MR (fMR) imaging with an eye movement paradigm to investigate differences in visuospatial cognition between patients with probab ... Link to item Cite

Developmental and lesion effects in brain activation during sentence comprehension and mental rotation.

Journal Article Dev Neuropsychol · 2000 The development of neurocognitive networks was examined in 2 cognitive paradigms: auditory sentence comprehension and mental rotation of alphanumeric stimuli. Patterns of brain activation were measured with whole brain echoplanar functional magnetic resona ... Full text Link to item Cite

Real-time fMRI paradigm control, physiology, and behavior combined with near real-time statistical analysis.

Journal Article Neuroimage · August 1999 This study presents an integrated approach to on-line fMRI data processing that combines real-time paradigm control and real-time MR image statistical analysis with nearly real-time integration of fMRI behavioral and physiological data. The real-time parad ... Full text Link to item Cite

Functional organization of activation patterns in children: whole brain fMRI imaging during three different cognitive tasks.

Journal Article Prog Neuropsychopharmacol Biol Psychiatry · May 1999 1. Patterns of brain activation were measured with whole brain echo-planar functional magnetic resonance imaging (fMRI) at 3.0 Tesla in healthy children (N = 6) and in one child with a left-hemisphere encephalomalacic lesion as sequellae from early stroke. ... Full text Link to item Cite

Cortical networks subserving pursuit and saccadic eye movements in humans: an FMRI study.

Journal Article Hum Brain Mapp · 1999 High-field (3 Tesla) functional magnetic resonance imaging (MRI) was used to investigate the cortical circuitry subserving pursuit tracking in humans and compare it to that for saccadic eye movements. Pursuit performance, relative to visual fixation, elici ... Full text Link to item Cite

A functional MRI study of face recognition in patients with prosopagnosia..

Conference JOURNAL OF COGNITIVE NEUROSCIENCE · January 1, 1999 Link to item Cite

High resolution real-time functional MRI

Journal Article Neuroimage · January 1, 1998 Full text Cite

High spatial resolution fMRI of human visual cortex at 3.0 tesla

Journal Article Neuroimage · December 1, 1997 Cite

Differentiation and morphogenesis in pellet cultures of developing rat retinal cells.

Journal Article J Comp Neurol · January 20, 1997 We previously developed a reaggregate cell culture system (pellet cultures) in which retinal neuroepithelial cells proliferate and give rise to rod photoreceptor cells (rods) in vitro (Watanabe and Raff, 1990, Neuron 4:461-467). In the present study, we an ... Full text Link to item Cite

High-resolution echo-planar fMRI of human visual cortex at 3.0 tesla.

Journal Article NMR Biomed · 1997 Known specialized properties of the human visual cortex have been used to investigate the role of spatial resolution on fMRI using blood oxygenation level dependent (BOLD) echo-planar MRI at 3.0 tesla. The magnitude of BOLD signal changes has been examined ... Full text Link to item Cite

Differentiation and morphogenesis in pellet cultures of developing rat retinal cells

Journal Article Investigative Ophthalmology and Visual Science · February 15, 1996 Purpose: We previously developed a reaggregate cell culture system (pellet cultures) in which retinal neuroepithelial cells proliferate and give rise to rod photoreceptor cells (rods) in vitro (Watanabe and Raff, Neuron, 4, 461-467, 1990). In the present s ... Cite

Differentiation and morphogenesis in pellet cultures of developing rat retinal cells

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · February 15, 1996 Link to item Cite

Quantification of normal cell death in the rat retina: implications for clone composition in cell lineage analysis.

Journal Article Eur J Neurosci · December 1, 1995 Naturally occurring cell death complicates the analysis of cell lineage studies by making the surviving members of a clone appear more closely related than they actually are. Here we ask how much normal cell death occurs during rat retinal development, and ... Full text Link to item Cite

Control of lens epithelial cell survival.

Journal Article J Cell Biol · May 1993 We have studied the survival requirements of developing lens epithelial cells to test the hypothesis that most cells are programmed to kill themselves unless they are continuously signaled by other cells not to do so. The lens cells survived for weeks in b ... Full text Link to item Cite

Cell death in the oligodendrocyte lineage.

Journal Article J Neurobiol · November 1992 We have recently found that about 50% of newly formed oligodendrocytes normally die in the developing rat optic nerve. When purified oligodendrocytes or their precursors are cultured in the absence of serum or added signalling molecules, they die rapidly w ... Full text Link to item Cite

Cell death and control of cell survival in the oligodendrocyte lineage.

Journal Article Cell · July 10, 1992 Dead cells are observed in many developing animal tissues, but the causes of these normal cell deaths are mostly unknown. We show that about 50% of oligodendrocytes normally die in the developing rat optic nerve, apparently as a result of a competition for ... Full text Link to item Cite

Myelinated axon origin [6]

Journal Article Nature · January 1, 1990 Full text Cite

Target size regulates calibre and myelination of sympathetic axons.

Journal Article Nature · November 23, 1989 Axons in vertebrate peripheral nerves are ensheathed by Schwann cells. For some axons, this sheath consists of a single layer of glial cell cytoplasm and plasma membranes; for other axons, Schwann cells form multilayered myelin. Whether or not a Schwann ce ... Full text Link to item Cite

Peripheral target regulation of dendritic geometry in the rat superior cervical ganglion.

Journal Article J Neurosci · June 1989 Dendritic arborizations of neurons in the adult rat superior cervical ganglion were measured in control ganglia and in ganglia innervating peripheral targets that were relatively larger or smaller than normal. The relative size of the target--the submandib ... Full text Link to item Cite

Trophic regulation of nerve cell morphology and innervation in the autonomic nervous system.

Journal Article Nature · November 10, 1988 A remarkable feature of nerve cells is the complex and variable pattern of their axonal and dendritic branches. Quantitative studies of a simple part of the nervous system in mammals provide evidence that neuronal geometry and innervation are regulated by ... Full text Link to item Cite

Nerve terminal remodeling visualized in living mice by repeated examination of the same neuron.

Journal Article Science · November 20, 1987 The distribution of presynaptic endings on the surfaces of autonomic ganglion cells was mapped in living mice after intravenous administration of a styryl pyridinium dye. The staining and imaging techniques did not appear to damage the ganglion cells, or t ... Full text Link to item Cite

Development and regulation of dendrites in the rat superior cervical ganglion.

Journal Article J Neurosci · March 1987 Intracellular injection of HRP was used to study the postnatal development of dendrites in the rat superior cervical ganglion (SCG). This study had 2 goals: to describe the growth of dendrites during normal development and to determine the influence of pre ... Full text Link to item Cite

Imaging mammalian nerve cells and their connections over time in living animals

Journal Article Trends in Neurosciences · January 1, 1987 A variety of technical advances have provided a means of following individual nerve cells and their connections over intervals of weeks or months in living animals. Such observations allow an assessment of the stability of pre- and postsynaptic elements in ... Full text Cite

Dynamic changes in the dendritic geometry of individual neurons visualized over periods of up to three months in the superior cervical ganglion of living mice.

Journal Article J Neurosci · April 1986 We describe a means of visualizing the same neuron in the superior cervical ganglion of young adult mice over intervals of up to 3 months. The dendrites of these neurons change during this interval; some branches retract, others elongate, and still others ... Full text Link to item Cite