Scholars@Duke
John Francis Madden

John Francis Madden

Associate Professor of Pathology
Pathology
DUMC Box 3712, Durham, NC 27710
201 Trent Drive, 3105 Davison Bldg (Yellow), Durham, NC 27710-3712

Selected Publications

Case Report: Nontuberculous mycobacterial infections in children with complete DiGeorge anomaly.

Journal Article Front Immunol · 2023 Children with complete DiGeorge anomaly (cDGA) have congenital athymia, resulting in severe T cell immunodeficiency and susceptibility to a broad range of infections. We report the clinical course, immunologic phenotypes, treatment, and outcomes of three c ... Full text Link to item Cite

A Hybrid Human-Machine Learning Approach for Screening Prostate Biopsies Can Improve Clinical Efficiency Without Compromising Diagnostic Accuracy.

Journal Article Arch Pathol Lab Med · June 1, 2022 CONTEXT.—: Prostate cancer is a common malignancy, and accurate diagnosis typically requires histologic review of multiple prostate core biopsies per patient. As pathology volumes and complexity increase, new tools to improve the efficiency of everyday pra ... Full text Link to item Cite

Phase 2 clinical trial of TORC1 inhibition with everolimus in men with metastatic castration-resistant prostate cancer.

Journal Article Urol Oncol · March 2020 BACKGROUND: Activation of the PI3K-Akt-mTOR signaling pathway is common in advanced castration resistant prostate cancer (CRPC), typically through PTEN loss. Preclinical studies suggest that Akt-driven CaP cells are genetically susceptible to mammalian tar ... Full text Link to item Cite

Retraction Note: Can the conventional sextant prostate biopsy reliably diagnose unilateral prostate cancer in low-risk, localized, prostate cancer? (Prostate Cancer and Prostatic Diseases, (2008), 10.1038/pcan.2008.31)

Journal Article Prostate Cancer and Prostatic Diseases · January 1, 2020 The authors hereby retract the e-publication dated 13 May 2008 and entitled, 'Can the conventional sextant prostate biopsy reliably diagnose unilateral prostate cancer in low-risk, localized, prostate cancer?' The authors are submitting a revised version w ... Full text Cite

Low-Grade Papillary Schneiderian Carcinoma of the Sinonasal Cavity and Temporal Bone.

Journal Article Ann Otol Rhinol Laryngol · December 2018 OBJECTIVES:: The aim of this study was to further characterize a newly described neoplasm, low-grade papillary Schneiderian carcinoma, occurring simultaneously in the sinonasal cavity and mastoid. Additionally, the authors review the only 2 similar cases w ... Full text Link to item Cite

Wilms Tumor After Orthotopic Liver Transplant in a Patient With Alagille Syndrome.

Journal Article Urology · November 2018 We present a case of Wilms Tumor in a patient with Alagille syndrome 10 months after liver transplant. We explore a suggested genetic connection between these 2 diseases. In children with Wilms Tumor, we propose a pathoembryologic explanation for not just ... Full text Link to item Cite

Macrophage Epithelial Reprogramming Underlies Mycobacterial Granuloma Formation and Promotes Infection.

Journal Article Immunity · October 18, 2016 Mycobacterium tuberculosis infection in humans triggers formation of granulomas, which are tightly organized immune cell aggregates that are the central structure of tuberculosis. Infected and uninfected macrophages interdigitate, assuming an altered, flat ... Full text Link to item Cite

Can Radiologic Staging With Multiparametric MRI Enhance the Accuracy of the Partin Tables in Predicting Organ-Confined Prostate Cancer?

Journal Article AJR Am J Roentgenol · July 2016 OBJECTIVE: The purpose of this study is to investigate the accuracy of multiparametric MRI with endorectal coil and Partin tables in predicting organ-confined (OC) prostate cancer in a contemporary cohort undergoing radical prostatectomy (RP) and to assess ... Full text Link to item Cite

Identifying Clinically Significant Prostate Cancers using 3-D In Vivo Acoustic Radiation Force Impulse Imaging with Whole-Mount Histology Validation.

Journal Article Ultrasound Med Biol · June 2016 Overly aggressive prostate cancer (PCa) treatment adversely affects patients and places an unnecessary burden on our health care system. The inability to identify and grade clinically significant PCa lesions is a factor contributing to excessively aggressi ... Full text Link to item Cite

Apparent Diffusion Coefficient Values of the Benign Central Zone of the Prostate: Comparison With Low- and High-Grade Prostate Cancer.

Journal Article AJR Am J Roentgenol · August 2015 OBJECTIVE: The apparent diffusion coefficient (ADC) values for benign central zone (CZ) of the prostate were compared with ADC values of benign peripheral zone (PZ), benign transition zone (TZ), and prostate cancer, using histopathologic findings from radi ... Full text Link to item Cite

Disparate results between proliferation rates of surgically excised prostate tumors and an in vitro bioassay using sera from a positive randomized controlled trial.

Journal Article Biotech Histochem · April 2015 In vitro bioassay has been used extensively to test the effects of culturing cancer cells in sera from humans participating in dietary interventions, i.e, studies of modified intake of nutrients for the purpose of reducing cancer risk or progression. It ha ... Full text Link to item Cite

B-mode and acoustic radiation force impulse (ARFI) imaging of prostate zonal anatomy: comparison with 3T T2-weighted MR imaging.

Journal Article Ultrason Imaging · January 2015 Prostate cancer (PCa) is the most common non-cutaneous malignancy among men in the United States and the second leading cause of cancer-related death. Multi-parametric magnetic resonance imaging (mpMRI) has gained recent popularity to characterize PCa. Aco ... Full text Link to item Cite

Combining practical and dialectical commitments for service engagements

Conference Lecture Notes in Computer Science Including Subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics · January 1, 2015 We understand a service engagement as a form of collaboration arising in a sociotechnical system (STS). Although STSs are fruitfully modeled using normative abstractions such as commitments, a conventional (practical) commitment can capture only part of th ... Full text Cite

Comparing 3-T multiparametric MRI and the Partin tables to predict organ-confined prostate cancer after radical prostatectomy.

Journal Article Urol Oncol · November 2014 OBJECTIVES: The purpose of our study was to test our hypothesis that multiparametric magnetic resonance imaging (mpMRI) may have a higher prognostic accuracy than the Partin tables in predicting organ-confined (OC) prostate cancer and extracapsular extensi ... Full text Link to item Cite

3D in vivo ARFI imaging: Prostate cancer sensitivity

Conference IEEE International Ultrasonics Symposium Ius · October 20, 2014 Imaging tools that reliably visualize prostate cancer (PCa) are increasingly needed in the urological community. The objective of this research was to evaluate the ability of Acoustic Radiation Force Impulse (ARFI) imaging to localize PCa in 29 patients wi ... Full text Cite

Evaluation of cold ischemia for preservation of testicular function during partial orchiectomy in the rat model.

Journal Article J Pediatr Urol · August 2014 OBJECTIVE: We hypothesized that cold ischemia during partial orchiectomy would lead to higher serum testosterone levels and preservation of testicular architecture than warm ischemia in a prepubescent rat model. MATERIALS AND METHODS: Eighteen prepubescent ... Full text Link to item Cite

Small renal mass biopsy--how, what and when: report from an international consensus panel.

Journal Article BJU Int · June 2014 To discuss the use of renal mass biopsy (RMB) for small renal masses (SRMs), formulate technical aspects, outline potential pitfalls and provide recommendations for the practicing clinician. The meeting was conducted as an informal consensus process and no ... Full text Link to item Cite

Improving the lens design and performance of a contemporary electromagnetic shock wave lithotripter.

Journal Article Proc Natl Acad Sci U S A · April 1, 2014 The efficiency of shock wave lithotripsy (SWL), a noninvasive first-line therapy for millions of nephrolithiasis patients, has not improved substantially in the past two decades, especially in regard to stone clearance. Here, we report a new acoustic lens ... Full text Open Access Link to item Cite

Bone marrow biopsy: RNA isolation with expression profiling in men with metastatic castration-resistant prostate cancer--factors affecting diagnostic success.

Journal Article Radiology · December 2013 PURPOSE: To determine the rate at which computed tomographically guided pelvic percutaneous bone biopsy in men with metastatic castration-resistant prostate cancer (mCRPC) yields adequate tissue for genomic profiling and to identify issues likely to affect ... Full text Link to item Cite

Flaxseed-derived enterolactone is inversely associated with tumor cell proliferation in men with localized prostate cancer.

Journal Article J Med Food · April 2013 Enterolactone and enterodiol, mammalian lignans derived from dietary sources such as flaxseed, sesame seeds, kale, broccoli, and apricots, may impede tumor proliferation by inhibiting activation of nuclear factor kappa B (NFκB) and vascular endothelial gro ... Full text Link to item Cite

Increasing dwell time of mitomycin C in the upper tract with a reverse thermosensitive polymer.

Journal Article J Endourol · March 2013 UNLABELLED: Abstract Background and Purpose: Topical chemotherapy for urothelial cancer is dependent on adequate contact time of the chemotherapeutic agent with the urothelium. To date, there has not been a reliable method of maintaining this contact for r ... Full text Link to item Cite

Development and clinical validation of a real-time PCR assay for PITX2 DNA methylation to predict prostate-specific antigen recurrence in prostate cancer patients following radical prostatectomy.

Journal Article J Mol Diagn · March 2013 Prostate cancer is the most common cancer among men. The prospective discrimination of aggressive and clinically insignificant tumors still poses a significant and, as yet, unsolved problem. PITX2 DNA methylation is a strong prognostic biomarker in prostat ... Full text Link to item Cite

Comparison of concurrently acquired in vivo 3D ARFI and SWEI images of the prostate

Conference IEEE International Ultrasonics Symposium Ius · December 1, 2012 In the prostate, ARFI and SWEI imaging methods have reported that cancer and other pathologies as being stiffer than the surrounding tissue. A three-dimensional in vivo prostatic imaging system capable of concurrently acquiring ARFI and SWEI data was devel ... Full text Cite

Apical surgical margins status in robot-assisted laparoscopic radical prostatectomy does not depend on disease characteristics.

Journal Article J Endourol · April 2012 BACKGROUND AND PURPOSE: Positive surgical margins (PSM) during robot-assisted laparoscopic radical prostatectomy (RALP) are generally considered an adverse event. We attempted to identify the factors associated with PSM and their location. PATIENTS AND MET ... Full text Link to item Cite

111-In-capromab pendetide imaging using hybrid-γ camera-computer tomography technology is not reliable in detecting seminal vesicle invasion in patients with prostate cancer.

Journal Article Urol Oncol · 2012 OBJECTIVES: In this study, we evaluate the diagnostic utility of a hybrid γ-camera-computer tomography (SPECT-CT) indium-111 (111-In)-capromab pendetide scan in detecting seminal vesicle invasion (SVI) in select patients evaluated for primary surgical trea ... Full text Link to item Cite

Acoustic radiation force impulse imaging of human prostates: initial in vivo demonstration.

Journal Article Ultrasound Med Biol · January 2012 Reliably detecting prostate cancer (PCa) has been a challenge for current imaging modalities. Acoustic radiation force impulse (ARFI) imaging is an elasticity imaging method that uses remotely generated, focused acoustic beams to probe tissue stiffness. A ... Full text Link to item Cite

Prostatic alpha-linolenic acid (ALA) is positively associated with aggressive prostate cancer: a relationship which may depend on genetic variation in ALA metabolism.

Journal Article PLoS One · 2012 Previous observational studies have reported associations between prostate cancer and alpha-linolenic acid (ALA). However, few investigations have been able to study this relationship prospectively and in well-controlled settings. Moreover, no studies have ... Full text Open Access Link to item Cite

Methodology to register prostate B-mode and ARFI images to MR and histology

Conference IEEE International Ultrasonics Symposium Ius · December 1, 2011 Acoustic Radiation Force Impulse (ARFI) imaging is being developed for guiding needle biopsy and focal therapy of Prostate cancer (PCa). In vivo ARFI images portray internal structures in the prostate with higher contrast than matched B-mode images. Given ... Full text Cite

Therapy for non-clear cell histologies in renal cancer.

Journal Article Curr Clin Pharmacol · August 2011 The advent of targeted systemic therapies has significantly improved treatment options for patients with metastatic renal cell carcinoma (RCC). Multiple agents that inhibit angiogenesis cell growth and proliferation via the VEGF and mTOR (TORC1) pathways h ... Full text Link to item Cite

Clinical predictors of renal mass pathological features.

Journal Article BJU Int · March 2011 OBJECTIVE: • To evaluate the influence of radiographic tumour size and other preoperative variables on the pathological characteristics of the lesion to determine the distribution of pathological features and assess preoperative risk factors for potentiall ... Full text Link to item Cite

Can the conventional sextant prostate biopsy accurately predict unilateral prostate cancer in low-risk, localized, prostate cancer?

Journal Article Urol Oncol · 2011 We evaluate the reliability of routine sextant prostate biopsy to detect unilateral lesions. A total of 365 men with complete records including all clinical and pathologic variables who underwent a preoperative sextant biopsy and subsequent radical prostat ... Full text Link to item Cite

Characterizing stiffness of human prostates using acoustic radiation force.

Journal Article Ultrason Imaging · October 2010 Acoustic Radiation Force Impulse (ARFI) imaging has been previously reported to portray normal anatomic structures and pathologies in ex vivo human prostates with good contrast and resolution. These findings were based on comparison with histological slide ... Full text Link to item Cite

Predicting occult multifocality of renal cell carcinoma.

Journal Article Eur Urol · July 2010 BACKGROUND: Multifocal renal cell carcinoma (RCC) has been reported in up to 25% of all radical nephrectomy specimens. Modern imaging tends to underestimate the rate of multifocality. Recognition of multifocality before treatment may guide physicians and p ... Full text Link to item Cite

Multicenter clinical validation of PITX2 methylation as a prostate specific antigen recurrence predictor in patients with post-radical prostatectomy prostate cancer.

Journal Article J Urol · July 2010 PURPOSE: Radical prostatectomy is potentially curative in patients with clinically localized prostate cancer. However, biochemical recurrence affects 15% to 30% of men who undergo radical prostatectomy. We previously reported the prognostic potential of PI ... Full text Link to item Cite

Acoustic radiation force impulse imaging of human prostates ex vivo.

Journal Article Ultrasound Med Biol · April 2010 It has been challenging for clinicians using current imaging modalities to visualize internal structures and detect lesions inside human prostates. Lack of contrast among prostatic tissues and high false positive or negative detection rates of prostate les ... Full text Link to item Cite

Tumor volume, tumor percentage involvement, or prostate volume: which is predictive of prostate-specific antigen recurrence?

Journal Article Urology · February 2010 OBJECTIVES: To compare the effects of tumor volume (TV), tumor percentage involvement (TPI), and prostate volume (PV) on prostate-specific antigen (PSA) recurrence (PSAR) after radical prostatectomy (RP). METHODS: A cohort of 3528 patients receiving RP bet ... Full text Link to item Cite

Utilization of (111)In-Capromab pendetide SPECT-CT for detecting seminal vesicle invasion with recurrent prostate cancer after primary in situ therapy.

Journal Article Int J Urol · December 2009 The aim of this study was to evaluate the diagnostic value of a hybrid (111)In-capromab pendetide fused computed tomography (CT) scan in detecting seminal vesicle invasion (SVI) in the setting of recurrent prostate cancer following primary in situ therapy. ... Full text Link to item Cite

Changes in Gleason score grading and their effect in predicting outcome after radical prostatectomy.

Journal Article Urology · November 2009 OBJECTIVES: To compare Gleason scores (GS) originally assigned in the mid 1990s with the current pathologic evaluation of the same prostatectomy slides, and to assess the GS migration effect on outcome in patients undergoing surgical treatment of prostate ... Full text Link to item Cite

Use of 111in-capromab pendetide immunoscintigraphy to image localized prostate cancer foci within the prostate gland.

Journal Article J Urol · September 2009 PURPOSE: We compared the results of a preoperative (111)In-capromab pendetide scan co-registered with computerized tomography with pathological findings in the surgically excised prostate to determine whether the scan can efficiently detect cancer in the p ... Full text Link to item Cite

Patient selection for hemiablative focal therapy of prostate cancer: variables predictive of tumor unilaterality based upon radical prostatectomy.

Journal Article Cancer · May 15, 2009 BACKGROUND: The application of focal therapy for low-risk prostate cancer (PCa) depended on appropriate patient selection. No definitive criteria existed to characterize patients who may potentially benefit from an organ-sparing approach. We evaluated pret ... Full text Link to item Cite

Utility of a 3-dimensional transrectal ultrasound-guided prostate biopsy system for prostate cancer detection.

Journal Article Technol Cancer Res Treat · April 2009 The 3-D transrectal ultrasound (TRUS)-guided prostate biopsy system is a novel device that allows precise needle placement in a template fashion. We evaluate its utility for prostate cancer (PCa) detection. A retrospective analysis was performed evaluating ... Full text Link to item Cite

Focal therapy for prostate cancer: pathologic basis.

Journal Article Curr Opin Urol · March 2009 PURPOSE OF REVIEW: To summarize pathologic features of low-volume, low-risk prostate cancer relevant to the development of patient selection criteria and treatment strategies for focal therapy of prostate cancer, as an alternative to whole-gland radical tr ... Full text Link to item Cite

Activation of transgene expression in skeletal muscle by focused ultrasound.

Journal Article Biochem Biophys Res Commun · February 6, 2009 To correlate thermal dose from focused ultrasound (FUS) with gene expression and tissue injury, a temperature plateau strategy was employed. Plasmids encoding luciferase gene under the control of hsp70B promoter were transfected into the right gastrocnemiu ... Full text Link to item Cite

Correlation between SWEI and ARFI image findings in ex vivo human prostates

Conference Proceedings IEEE Ultrasonics Symposium · January 1, 2009 Acoustic Radiation Force Impulse (ARFI) imaging has previously been used to visualize normal anatomic structures and pathologies in both ex vivo and in vivo human prostates. Based on the relative displacement amplitudes in ARFI images and comparison with h ... Full text Cite

Flaxseed supplementation (not dietary fat restriction) reduces prostate cancer proliferation rates in men presurgery.

Journal Article Cancer Epidemiol Biomarkers Prev · December 2008 BACKGROUND: Prostate cancer affects one of six men during their lifetime. Dietary factors are postulated to influence the development and progression of prostate cancer. Low-fat diets and flaxseed supplementation may offer potentially protective strategies ... Full text Link to item Cite

Significant discrepancies between diagnostic and pathologic Gleason sums in prostate cancer: the predictive role of age and prostate-specific antigen.

Journal Article Urology · October 2008 OBJECTIVES: To assess the discrepancies between diagnostic and pathologic Gleason sums and the predictive role of age and prostate-specific antigen (PSA) level on Gleason sum discrepancies. METHODS: A total of 2963 patients receiving radical prostatectomy ... Full text Link to item Cite

Pathologic stage T2a and T2b prostate cancer in the recent prostate-specific antigen era: implications for unilateral ablative therapy.

Journal Article Prostate · September 15, 2008 BACKGROUND: Early detection of small volume prostate cancer (PCa) has led to the concept of focal therapy to treat in an organ-sparing manner. We evaluated trends in pathologic staging among patients with localized PCa undergoing radical prostatectomy (RP) ... Full text Link to item Cite

The effect of cryoablation on the histologic interpretation of intraoperative biopsy of small clear cell renal carcinoma and renal oncocytoma.

Journal Article J Endourol · August 2008 BACKGROUND AND PURPOSE: We evaluated the effects of the first freeze-thaw cycle of cryoablation on Fuhrman grade, histology, and tumor architecture of small clear cell renal carcinomas and renal oncocytomas using an 18-gauge needle biopsy. PATIENTS AND MET ... Full text Link to item Cite

Percent tumor involvement and risk of biochemical progression after radical prostatectomy.

Journal Article J Urol · August 2008 PURPOSE: Percent tumor involvement has been associated with biochemical progression in organ confined disease, although its role in predicting outcome in men with more advanced disease pathology is unclear. We hypothesized percent tumor involvement may be ... Full text Link to item Cite

WITHDRAWN: Can the conventional sextant prostate biopsy reliably diagnose unilateral prostate cancer in low-risk, localized, prostate cancer?

Other Prostate Cancer Prostatic Dis · May 13, 2008 The authors hereby retract the e-publication dated 13 May 2008 and entitled, 'Can the conventional sextant prostate biopsy reliably diagnose unilateral prostate cancer in low-risk, localized, prostate cancer?' The authors are submitting a revised version w ... Full text Link to item Cite

Preoperative radiotherapy and bevacizumab for angiosarcoma of the head and neck: two case studies.

Journal Article Head Neck · February 2008 BACKGROUND: Angiosarcoma of the face is a vascular tumor with poor local control and short median survival despite standard treatment. Bevacizumab is a humanized monoclonal antibody to vascular endothelial growth factor (VEGF), which can inhibit tumor grow ... Full text Link to item Cite

Overcoming challenges in designing and implementing a phase II randomized controlled trial using a presurgical model to test a dietary intervention in prostate cancer.

Journal Article Clin Trials · 2008 BACKGROUND: The time between the diagnosis of cancer and a planned definitive surgical procedure offers a strong and direct approach for assessing the impact of interventions (including lifestyle interventions) on the biology of the target tissue and the t ... Full text Link to item Cite

Three-dimensional acoustic radiation force impulse (ARFI) imaging of human prostates in vivo

Conference Proceedings IEEE Ultrasonics Symposium · January 1, 2008 We are investigating utilizing ARFI imaging to guide prostate needle biopsy. Our previous ex vivo study demonstrated that ARFI imaging using a VF10-5 linear array was able to visualize the internal anatomy and suspicious lesions in the prostate, which may ... Full text Cite

A single-institution comparison between radical perineal and radical retropubic prostatectomy on perioperative and pathological outcomes for obese men: an analysis of the Duke Prostate Center database.

Journal Article Urology · December 2007 OBJECTIVES: To examine the association between body mass index (BMI) and operative time, estimated blood loss (EBL), and adverse pathologic features in patients undergoing either radical perineal prostatectomy (RPP) or radical retropubic prostatectomy (RRP ... Full text Link to item Cite

Prostate cancer laterality does not predict prostate-specific antigen recurrence after radical prostatectomy.

Journal Article Urology · December 2007 OBJECTIVES: To evaluate biologic behaviors of unilateral cancers compared with bilateral cancers on prostate-specific antigen (PSA) recurrence after radical prostatectomy. METHODS: Analysis included demographic, clinical, and pathologic parameters of 1184 ... Full text Link to item Cite

Visualizing the anatomic structures of human prostates using Acoustic Radiation Force Impulse (ARFI) imaging

Conference Proceedings IEEE Ultrasonics Symposium · December 1, 2007 McNeal's zonal anatomy for prostate has been the standard anatomical model for human prostate for about 30 years. It divides a human prostate into one non-glandular zone (the anterior flbromuscular stroma), and three glandular zones (central zone (CZ), tra ... Full text Cite

Prostate cancer laterality as a rationale of focal ablative therapy for the treatment of clinically localized prostate cancer.

Journal Article Cancer · August 15, 2007 BACKGROUND: Early detection of small-volume prostate cancer (PCa) has led to the concept of focal therapy to treat PCa as an organ-sparing, minimally invasive procedure. The authors sought to determine the frequency of unilateral cancers in the contemporar ... Full text Link to item Cite

Analysis of laterality and percentage of tumor involvement in 1386 prostatectomized specimens for selection of unilateral focal cryotherapy.

Journal Article Technol Cancer Res Treat · April 2007 In total, 1386 paraffin embedded radical prostatectomy specimens from patients with clinically localized prostate cancer (PCa) excised between 2002-06 were analyzed. Pathologic assessment paid particular attention to laterality and percentage of tumor invo ... Full text Link to item Cite

Apical soft tissue biopsies predict biochemical failure in radical perineal prostatectomy patients with apical cancer involvement.

Journal Article Prostate Cancer Prostatic Dis · 2007 The aim of the study was to prospectively assess the role of apical soft tissue biopsies in radical perineal prostatectomy (RPP) patients with documented apical prostate cancer (PCA) involvement. Between June 1998 and May 1999, 77 consecutive men with loca ... Full text Link to item Cite

Malignant cystic nephroma.

Journal Article Can J Urol · December 2006 AIM: To describe a malignant cystic nephroma in an asymptomatic man. METHODS: Case report and review of the literature. RESULTS: A 60 year old white male presented with an incidentally discovered right perirenal mass. An MRI demonstrated a large perinephri ... Link to item Cite

A role for the G12 family of heterotrimeric G proteins in prostate cancer invasion.

Journal Article J Biol Chem · September 8, 2006 Many studies have suggested a role for the members of the G12 family of heterotrimeric G proteins (Galpha12 and Galpha13) in oncogenesis and tumor cell growth. However, few studies have examined G12 signaling in actual human cancers. In this study, we exam ... Full text Link to item Cite

Progressive increase of lithotripter output produces better in-vivo stone comminution.

Journal Article J Endourol · September 2006 BACKGROUND AND PURPOSE: Shockwave lithotripsy (SWL) has become a first-line intervention for treatment of nephrolithiasis. However, few studies have examined the effects of modifications in the method of shockwave energy administration on comminution effic ... Full text Link to item Cite

CD10 expression in trichoepithelioma and basal cell carcinoma.

Journal Article J Cutan Pathol · February 2006 BACKGROUND: Trichoepithelioma (TE) is a benign neoplasm that shares both clinical and histologic features with basal cell carcinoma (BCC). However, it is important to distinguish these neoplasms. Limited immunohistochemical stains are available to separate ... Full text Link to item Cite

Loss of heterozygosity of M6P/IGF2R gene is an early event in the development of prostate cancer.

Journal Article Prostate Cancer Prostatic Dis · 2006 BACKGROUND: The genetic events leading to initiation and/or progression of prostate cancer are not well characterized. The gene coding for the mannose 6-phosphate/insulin-like growth factor 2 receptor (M6P/IGF2R) has recently been identified as a tumor sup ... Full text Link to item Cite

Renal cryoablation and radio frequency ablation: an evaluation of worst case scenarios in a porcine model.

Journal Article J Urol · June 2005 PURPOSE: Although ablative technologies, including radio frequency (RF) ablation (RFA) and cryoablation (CA), are being used to treat renal masses, complications associated with injury to vital renal structures are not well understood. We investigated thes ... Full text Link to item Cite

Anterior rectal wall gastrointestinal stromal tumor presenting clinically as prostatic mass.

Journal Article Urol Oncol · 2005 Gastrointestinal stromal tumors (GIST) of the anterior rectal wall can present as a prostatic mass, with concomitant obstructive symptoms. Transrectal biopsies of GIST may be misdiagnosed as primary prostatic sarcomas. We report 3 cases of GIST that were i ... Full text Link to item Cite

Lysophosphatidic acid promotes survival of androgen-insensitive prostate cancer PC3 cells via activation of NF-kappaB.

Journal Article Prostate · October 1, 2004 BACKGROUND: Dysregulated cell survival contributes to the poor efficacy of many chemotherapeutic regimens for patients with advanced prostate cancer. In this study we examined ability of the lipid growth factor lysophosphatidic acid (LPA), a G protein-coup ... Full text Link to item Cite

Diagnostic impact of core-needle biopsy on fine-needle aspiration of non-Hodgkin lymphoma.

Journal Article Diagn Cytopathol · July 2004 We retrospectively reviewed 74 fine-needle aspiration (FNA) cases of presumptive non-Hodgkin lymphoma (NHL). All the cases had cytology and core-needle biopsy and 53 cases had concurrent flow cytometric analysis. FNA (cytology and flow cytometry) and core- ... Full text Link to item Cite

Pathology of parainfluenza virus infection in patients with congenital immunodeficiency syndromes.

Journal Article Hum Pathol · May 2004 Infection with parainfluenza virus typically produces a mild, self-limited upper respiratory infection. However, parainfluenza infections have become increasingly recognized as a source of severe morbidity and mortality in immunocompromised patients. In th ... Full text Link to item Cite

Immunological and clinical responses in metastatic renal cancer patients vaccinated with tumor RNA-transfected dendritic cells.

Journal Article Cancer Res · May 1, 2003 Autologous dendritic cells transfected with total renal tumor RNA have been shown to be potent stimulators of CTLs and antitumor immunity in vitro. A Phase I trial was conducted to evaluate this strategy for feasibility, safety, and efficacy to induce tumo ... Link to item Cite

Liposarcoma presenting as an intraluminal ureteral mass.

Journal Article Urology · May 2003 An 86-year-old woman with a previous excision of a large retroperitoneal low-grade liposarcoma presented with a 4-month history of persistent left flank discomfort. Workup revealed left hydronephrosis secondary to obstruction, which was caused by a recurre ... Full text Link to item Cite

Bradykinin receptor subtype 1 expression and function in prostate cancer.

Journal Article Cancer Res · May 1, 2003 Kinins exert multiple pathophysiological functions, including vascular permeability and mitogenesis, by activating their cognate receptors, bradykinin subtype 1 receptor (B1R) and bradykinin subtype 2 receptor (B2R), which belong to the superfamily of G pr ... Link to item Cite

Laser Doppler flowmetric determination of ureteral blood flow after ureteral access sheath placement.

Journal Article J Endourol · October 2002 BACKGROUND AND PURPOSE: The ureteral access sheath has positively impacted ureteroscopy by decreasing operative times and increasing success rates. However, as previous studies have suggested that large-caliber endoscopes may cause ureteral ischemia, conce ... Full text Link to item Cite

Atypical squamous epithelium in cytologic specimens from the pancreas: cytological differential diagnosis and clinical implications.

Journal Article Diagn Cytopathol · July 2001 Atypical squamous epithelium is an uncommon finding in cytologic specimens obtained from pancreatic lesions. A variety of pathologic conditions can result in the presence of these cells, including primary or metastatic carcinomas, chronic pancreatitis, and ... Full text Link to item Cite

Zinc alpha-2-glycoprotein is expressed by malignant prostatic epithelium and may serve as a potential serum marker for prostate cancer.

Journal Article Clin Cancer Res · April 2001 Zinc alpha-2-glycoprotein (ZAG) is a M(r) 41,000 glycoprotein secreted by a variety of normal epithelia. ZAG was recently shown to stimulate lipolysis in adipocytes, leading to the development of cachexia in animals with ZAG-producing tumors. To understand ... Link to item Cite

Mechanisms of ischemic injury are different in the steatotic and normal rat liver.

Journal Article Hepatology · December 2000 Hepatic steatosis is associated with significant morbidity and mortality after liver resection and transplantation. Although apoptosis is a key mechanism of reperfusion injury in the normal liver, the pathway leading to cell death in steatotic hepatocytes ... Full text Link to item Cite

Parasitic lesion of the insula suggesting cerebral sparganosis: case report.

Journal Article Neuroradiology · March 2000 Cerebral sparganosis, a parasitic disease, rarely produces a chronic active inflammatory response in the brain. Clinically and radiographically the process may mimic a neoplasm. We report a 30-year-old man who underwent surgical exploration for a mass in t ... Full text Link to item Cite

Species and genotypic diversities and similarities of pathogenic yeasts colonizing women.

Journal Article J Clin Microbiol · December 1999 We examined the patterns of strain relatedness among pathogenic yeasts from within and among groups of women to determine whether there were significant associations between genotype and host condition or body site. A total of 80 yeast strains were isolate ... Full text Link to item Cite

Diagnosis of anaplastic large-cell lymphoma, including multifocal osseous KI-1 lymphoma, by fine-needle aspiration biopsy.

Journal Article Diagn Cytopathol · September 1999 We present the fine-needle aspiration (FNA) findings of 4 cases of anaplastic (Ki-1) large-cell lymphoma (ALCL). A primary diagnosis of ALCL was made on FNA material in 2 cases, of which one was a multifocal osseous Ki-1 lymphoma. In the other 2 patients w ... Full text Link to item Cite

Calpain inhibition prevents sinusoidal endothelial cell apoptosis in the cold ischemic rat liver.

Journal Article Transplantation · July 15, 1999 BACKGROUND: Cold preservation of the liver followed by reperfusion results in sinusoidal endothelial cell (SEC) apoptosis. Calpain-like activity is dramatically increased during reperfusion and inhibition of calpains results in lower graft injury and longe ... Full text Link to item Cite

Endothelial cell and hepatocyte deaths occur by apoptosis after ischemia-reperfusion injury in the rat liver.

Journal Article Transplantation · April 27, 1999 BACKGROUND: Ischemic injury of the liver is generally considered to result in necrosis, but it has recently been recognized that mediators of apoptosis are activated during ischemia/reperfusion. This study was designed to characterize the extent and the ty ... Full text Link to item Cite

Cryptosporidium, enterocytozoon, and cyclospora infections in pediatric and adult patients with diarrhea in Tanzania.

Journal Article Clin Infect Dis · February 1999 Cryptosporidiosis, microsporidiosis, and cyclosporiasis were studied in four groups of Tanzanian inpatients: adults with AIDS-associated diarrhea, children with chronic diarrhea (of whom 23 of 59 were positive [+] for human immunodeficiency virus [HIV]), c ... Full text Link to item Cite

Calpain mediates ischemic injury of the liver through modulation of apoptosis and necrosis.

Journal Article Gastroenterology · January 1999 BACKGROUND & AIMS: Calpain proteases have been implicated in cell death by necrosis and more recently by apoptosis. Experiments were designed to determine the role of calpain proteases in ischemic rat liver injury by measurement of cytosolic calpain activi ... Full text Link to item Cite

Features of benign granular cell tumor on fine needle aspiration.

Journal Article Acta Cytol · 1999 OBJECTIVE: To describe the cytomorphologic features of benign granular cell tumor (GCT) on fine needle aspiration (FNA) biopsy and discuss the differential diagnosis. STUDY DESIGN: We reviewed three fine needle aspirates of surgically confirmed benign GCT. ... Full text Link to item Cite

Apoptosis of sinusoidal endothelial cells is a critical mechanism of preservation injury in rat liver transplantation.

Journal Article Hepatology · June 1998 In livers excised for transplantation, sinusoidal endothelium appears especially vulnerable to injury during organ preservation in the cold and subsequent reperfusion. The degree of endothelial cell injury correlates with functional impairment of the graft ... Full text Link to item Cite

Platelets induce endothelial cell apoptosis upon reperfusion following cold ischemia in rat liver

Journal Article European Journal of Gastroenterology and Hepatology · January 1, 1998 Full text Cite

Microscopic screening of respiratory specimens submitted for culture: A re-evaluation

Journal Article Clinical Infectious Diseases · December 1, 1997 Clinical laboratories examine respiratory specimens microscopically to screen out poor quality collections and optimize the clinical utility of cultures. This study evaluated the accuracy and clinical impact of screening at a large, tertiary-care medical c ... Cite

Interleukin-6 protects liver against warm ischemia/reperfusion injury and promotes hepatocyte proliferation in the rodent.

Journal Article Hepatology · December 1997 Interleukin-6 (IL-6) is an acute reactant cytokine with anti-inflammatory properties, which has been found to prevent injury in a model of acute hepatitis in mice through downregulation of tumor necrosis factor alpha (TNF-alpha); to correlate inversely wit ... Full text Link to item Cite

Infections in patients with cystic fibrosis following lung transplantation.

Journal Article Chest · October 1997 BACKGROUND: There is controversy over whether colonization with drug-resistant organisms is a contraindication to lung transplantation. METHODS: We undertook a retrospective review of the results of lung transplantation for patients with cystic fibrosis (C ... Full text Link to item Cite

Prognostic factors for fibromatoses: a correlation of proliferation index, estrogen receptor, p53, retinoblastoma, and src gene products and clinical features with outcome.

Journal Article J Surg Oncol · June 1997 BACKGROUND: The aggressiveness of fibromatoses is difficult to predict by morphologic analysis. Additional prognostic markers would be helpful for clinical management. MATERIALS AND METHODS: Proliferation index (MIB-1), p53, src, retinoblastoma gene protei ... Full text Link to item Cite

Duration of incubation of fungal cultures.

Journal Article J Clin Microbiol · June 1996 To determine the optimum duration of incubation for recovery of fungi, the results of 2,173 consecutive clinical cultures were reviewed. Overall, 94% of fungal isolates were detected by day 7 and 98% were detected by day 14. Yeasts were usually (98%) detec ... Full text Link to item Cite

Fungal infections in lung and heart-lung transplant recipients. Report of 9 cases and review of the literature.

Journal Article Medicine (Baltimore) · May 1996 We reviewed the pattern and incidence of fungal infections in patients undergoing lung and heart-lung transplantation at Duke University Medical Center from September 1992 until August 1995, and present here 9 illustrative cases. Of the 73 lung and heart-l ... Full text Link to item Cite

Cerebral phaeohyphomycosis complicated with brain abscess: a case report.

Journal Article Zhonghua Yi Xue Za Zhi (Taipei) · June 1995 Cerebral phaeohyphomycosis is used to describe the rare clinical syndrome of cerebral infection caused by dematiaceous (i.e. pigmented olivaceous-brown) fungi. It usually presents as brain abscess. In view of the rarity of this fungal infection and its cli ... Link to item Cite

Dynamic contrast-enhanced MR imaging assessment of vascularized free fibular grafts.

Journal Article J Magn Reson Imaging · 1994 Magnetic resonance (MR) imaging may be a noninvasive method for assessing perfusion of vascularized bone grafts placed for treatment of avascular necrosis. One proximal femur of seven beagles was devascularized, with insertion of a vascularized fibular gra ... Full text Link to item Cite

Meningioangiomatosis: CT and MR findings.

Journal Article J Comput Assist Tomogr · 1992 Meningioangiomatosis (MA) is a rare hamartomatous lesion of the cerebral cortex; to date only 18 cases with imaging findings have been reported in the English literature. The origin of MA is probably malformative, with possible association with neurofibrom ... Link to item Cite

Resonance Raman studies of Escherichia coli sulfite reductase hemoprotein. 1. Siroheme vibrational modes.

Journal Article Biochemistry · June 27, 1989 Resonance Raman (RR) spectra are reported for the hemoprotein subunit (SiR-HP) of Escherichia coli NADPH-sulfite reductase (EC 1.8.1.2) in various ligation and redox states. Comparison of the RR spectra of extracted siroheme and the mu-oxo FeIII dimer of o ... Full text Link to item Cite

Resonance Raman studies of Escherichia coli sulfite reductase hemoprotein. 2. Fe4S4 cluster vibrational modes.

Journal Article Biochemistry · June 27, 1989 Resonance Raman (RR) spectra from the hemoprotein subunit of Escherichia coli sulfite reductase (SiR-HP) are examined in the low-frequency (200-500 cm-1) region where Fe-S stretching modes are expected. In spectra obtained with excitation in the siroheme S ... Full text Link to item Cite

Resonance Raman studies of Escherichia coli sulfite reductase hemoprotein. 3. Bound ligand vibrational modes.

Journal Article Biochemistry · June 27, 1989 The vibrations of the bound diatomic heme ligands CO, CN-, and NO are investigated by resonance Raman spectroscopy in various redox states of Escherichia coli sulfite reductase hemoprotein, and assignments are generated by use of isotopically labeled ligan ... Full text Link to item Cite