Scholars@Duke
John Wiley Williams Jr.

John Wiley Williams Jr.

Professor Emeritus of Medicine
Medicine, General Internal Medicine
Duke Box 104427, Durham, NC 27705
710 W Main Street, 1st Floor, Durham, NC 27701
Manage Profile
Embed Profile Data

Selected Publications

Anticonvulsants in the Treatment of Behavioral and Psychological Symptoms in Dementia: A Systematic Review.

Journal Article Am J Geriatr Psychiatry · October 2024 OBJECTIVES: Behavioral and psychological symptoms of dementia (BPSD) are common and impart a significant burden to patients, caregivers, and the health system. However, there are few pharmacological options for treating BPSD. We conducted a systematic revi ... Full text Link to item Cite

Videoconferencing of Movement-Based and Psychologically Informed Interventions for Chronic Pain: A Systematic Review and Horizon Scan.

Journal Article Telemed J E Health · September 2023 Introduction: With the coronavirus disease 2019 (COVID-19) pandemic, use of telehealth technology increased dramatically. Nonpharmacological approaches to pain management may be well suited for virtual care. Yet, it is not widely understood if this treatme ... Full text Link to item Cite

Frontline Clinician Appraisement of Research Engagement: "I feel out of touch with research".

Journal Article J Gen Intern Med · September 2023 BACKGROUND: Health services research can benefit from frontline clinician input across all stages of research, yet their key perspectives are often not meaningfully engaged. OBJECTIVE: How can we improve clinician engagement in research? DESIGN: Convenienc ... Full text Open Access Link to item Cite

Efficacy of Epidural Blood Patching or Surgery in Spontaneous Intracranial Hypotension: A Systematic Review and Evidence Map.

Journal Article AJNR Am J Neuroradiol · June 2023 BACKGROUND: Spontaneous intracranial hypotension is an important cause of treatable secondary headaches. Evidence on the efficacy of epidural blood patching and surgery for spontaneous intracranial hypotension has not been synthesized. PURPOSE: Our aim was ... Full text Link to item Cite

Pharmacologic Treatment of Primary Osteoporosis or Low Bone Mass to Prevent Fractures in Adults: A Living Clinical Guideline From the American College of Physicians.

Journal Article Ann Intern Med · February 2023 DESCRIPTION: This guideline updates the 2017 American College of Physicians (ACP) recommendations on pharmacologic treatment of primary osteoporosis or low bone mass to prevent fractures in adults. METHODS: The ACP Clinical Guidelines Committee based these ... Full text Link to item Cite

Barriers and facilitators to the implementation and adoption of improvement coaching: A qualitative evidence synthesis.

Journal Article J Clin Nurs · January 2023 BACKGROUND: Healthcare organisations and teams perform improvement activities to facilitate high-quality healthcare. The use of an improvement coach who provides support and guidance to the healthcare team may facilitate improvement activities; however, no ... Full text Link to item Cite

Telehealth for the Longitudinal Management of Chronic Conditions: Systematic Review.

Journal Article J Med Internet Res · August 26, 2022 BACKGROUND: Extensive literature support telehealth as a supplement or adjunct to in-person care for the management of chronic conditions such as congestive heart failure (CHF) and type 2 diabetes mellitus (T2DM). Evidence is needed to support the use of t ... Full text Link to item Cite

Efficacy of epidural blood patching or surgery in spontaneous intracranial hypotension: an evidence map protocol.

Journal Article Syst Rev · June 7, 2022 BACKGROUND: Spontaneous intracranial hypotension (SIH) is a debilitating disorder caused by non-iatrogenic spinal cerebrospinal fluid leaks. SIH is increasingly recognized as an important treatable cause of secondary headaches. Treatment involves either ep ... Full text Link to item Cite

Primary Care Engagement Among Individuals with Experiences of Homelessness and Serious Mental Illness: an Evidence Map.

Journal Article J Gen Intern Med · May 2022 BACKGROUND: Experiences of homelessness and serious mental illness (SMI) negatively impact health and receipt of healthcare. Interventions that promote the use of primary care services for people with both SMI and homelessness may improve health outcomes, ... Full text Link to item Cite

Effectiveness of Quality Improvement Coaching on Process Outcomes in Health Care Settings: A Systematic Review.

Journal Article J Gen Intern Med · March 2022 BACKGROUND: A culture of improvement is an important feature of high-quality health care systems. However, health care teams often need support to translate quality improvement (QI) activities into practice. One method of support is consultation from a QI ... Full text Link to item Cite

Colonoscopy for Diagnostic Evaluation and Interventions to Prevent Recurrence After Acute Left-Sided Colonic Diverticulitis: A Clinical Guideline From the American College of Physicians.

Journal Article Ann Intern Med · March 2022 DESCRIPTION: The American College of Physicians (ACP) developed this guideline to provide clinical recommendations on the role of colonoscopy for diagnostic evaluation of colorectal cancer (CRC) after a presumed diagnosis of acute left-sided colonic divert ... Full text Link to item Cite

Diagnosis and Management of Acute Left-Sided Colonic Diverticulitis: A Clinical Guideline From the American College of Physicians.

Journal Article Ann Intern Med · March 2022 DESCRIPTION: The American College of Physicians (ACP) developed this guideline to provide clinical recommendations on the diagnosis and management of acute left-sided colonic diverticulitis in adults. This guideline is based on current best available evide ... Full text Link to item Cite

Adjustment Disorders in U.S. Active Duty Military Women: A Scoping Review for the Years 2000 to 2018.

Journal Article Womens Health Issues · August 25, 2021 BACKGROUND: Adjustment disorder (AD) is the most common mental health diagnosis in the U.S. military and is more than twice as likely to be diagnosed in active duty servicewomen as compared with male servicemembers. The literature on ADs, particularly in f ... Full text Link to item Cite

Options for Meaningful Engagement in Clinical Research for Busy Frontline Clinicians.

Journal Article J Gen Intern Med · July 2021 In order for health care innovations to be effective and actionable, they must align with the needs and practice patterns of those delivering care at the bedside. While research has started to incorporate the patient voice, it has yet to fully invest in th ... Full text Link to item Cite

Appropriate Use of High-Flow Nasal Oxygen in Hospitalized Patients for Initial or Postextubation Management of Acute Respiratory Failure: A Clinical Guideline From the American College of Physicians.

Journal Article Ann Intern Med · July 2021 DESCRIPTION: The American College of Physicians (ACP) developed this guideline to provide clinical recommendations on the appropriate use of high-flow nasal oxygen (HFNO) in hospitalized patients for initial or postextubation management of acute respirator ... Full text Link to item Cite

Appropriate Use of Point-of-Care Ultrasonography in Patients With Acute Dyspnea in Emergency Department or Inpatient Settings: A Clinical Guideline From the American College of Physicians.

Journal Article Ann Intern Med · July 2021 DESCRIPTION: The American College of Physicians (ACP) developed this guideline to provide clinical recommendations on the appropriate use of point-of-care ultrasonography (POCUS) in patients with acute dyspnea in emergency department (ED) or inpatient sett ... Full text Link to item Cite

Risk of Transmitting Coronavirus Disease 2019 During Nebulizer Treatment: A Systematic Review.

Journal Article J Aerosol Med Pulm Drug Deliv · June 2021 Rationale: There is an urgent need to understand the risk of viral transmission during nebulizer treatment of patients with coronavirus disease 2019 (COVID-19). Objectives: To assess the risk of transmitting severe acute respiratory syndrome coronavirus 2 ... Full text Open Access Link to item Cite

Anticonvulsants in the Treatment of Behavioral and Psychological Symptoms in Dementia: A Systematic Review.

Journal Article Am J Geriatr Psychiatry · October 2024 OBJECTIVES: Behavioral and psychological symptoms of dementia (BPSD) are common and impart a significant burden to patients, caregivers, and the health system. However, there are few pharmacological options for treating BPSD. We conducted a systematic revi ... Full text Link to item Cite

Videoconferencing of Movement-Based and Psychologically Informed Interventions for Chronic Pain: A Systematic Review and Horizon Scan.

Journal Article Telemed J E Health · September 2023 Introduction: With the coronavirus disease 2019 (COVID-19) pandemic, use of telehealth technology increased dramatically. Nonpharmacological approaches to pain management may be well suited for virtual care. Yet, it is not widely understood if this treatme ... Full text Link to item Cite

Frontline Clinician Appraisement of Research Engagement: "I feel out of touch with research".

Journal Article J Gen Intern Med · September 2023 BACKGROUND: Health services research can benefit from frontline clinician input across all stages of research, yet their key perspectives are often not meaningfully engaged. OBJECTIVE: How can we improve clinician engagement in research? DESIGN: Convenienc ... Full text Open Access Link to item Cite

Efficacy of Epidural Blood Patching or Surgery in Spontaneous Intracranial Hypotension: A Systematic Review and Evidence Map.

Journal Article AJNR Am J Neuroradiol · June 2023 BACKGROUND: Spontaneous intracranial hypotension is an important cause of treatable secondary headaches. Evidence on the efficacy of epidural blood patching and surgery for spontaneous intracranial hypotension has not been synthesized. PURPOSE: Our aim was ... Full text Link to item Cite

Pharmacologic Treatment of Primary Osteoporosis or Low Bone Mass to Prevent Fractures in Adults: A Living Clinical Guideline From the American College of Physicians.

Journal Article Ann Intern Med · February 2023 DESCRIPTION: This guideline updates the 2017 American College of Physicians (ACP) recommendations on pharmacologic treatment of primary osteoporosis or low bone mass to prevent fractures in adults. METHODS: The ACP Clinical Guidelines Committee based these ... Full text Link to item Cite

Barriers and facilitators to the implementation and adoption of improvement coaching: A qualitative evidence synthesis.

Journal Article J Clin Nurs · January 2023 BACKGROUND: Healthcare organisations and teams perform improvement activities to facilitate high-quality healthcare. The use of an improvement coach who provides support and guidance to the healthcare team may facilitate improvement activities; however, no ... Full text Link to item Cite

Telehealth for the Longitudinal Management of Chronic Conditions: Systematic Review.

Journal Article J Med Internet Res · August 26, 2022 BACKGROUND: Extensive literature support telehealth as a supplement or adjunct to in-person care for the management of chronic conditions such as congestive heart failure (CHF) and type 2 diabetes mellitus (T2DM). Evidence is needed to support the use of t ... Full text Link to item Cite

Efficacy of epidural blood patching or surgery in spontaneous intracranial hypotension: an evidence map protocol.

Journal Article Syst Rev · June 7, 2022 BACKGROUND: Spontaneous intracranial hypotension (SIH) is a debilitating disorder caused by non-iatrogenic spinal cerebrospinal fluid leaks. SIH is increasingly recognized as an important treatable cause of secondary headaches. Treatment involves either ep ... Full text Link to item Cite

Primary Care Engagement Among Individuals with Experiences of Homelessness and Serious Mental Illness: an Evidence Map.

Journal Article J Gen Intern Med · May 2022 BACKGROUND: Experiences of homelessness and serious mental illness (SMI) negatively impact health and receipt of healthcare. Interventions that promote the use of primary care services for people with both SMI and homelessness may improve health outcomes, ... Full text Link to item Cite

Effectiveness of Quality Improvement Coaching on Process Outcomes in Health Care Settings: A Systematic Review.

Journal Article J Gen Intern Med · March 2022 BACKGROUND: A culture of improvement is an important feature of high-quality health care systems. However, health care teams often need support to translate quality improvement (QI) activities into practice. One method of support is consultation from a QI ... Full text Link to item Cite

Colonoscopy for Diagnostic Evaluation and Interventions to Prevent Recurrence After Acute Left-Sided Colonic Diverticulitis: A Clinical Guideline From the American College of Physicians.

Journal Article Ann Intern Med · March 2022 DESCRIPTION: The American College of Physicians (ACP) developed this guideline to provide clinical recommendations on the role of colonoscopy for diagnostic evaluation of colorectal cancer (CRC) after a presumed diagnosis of acute left-sided colonic divert ... Full text Link to item Cite

Diagnosis and Management of Acute Left-Sided Colonic Diverticulitis: A Clinical Guideline From the American College of Physicians.

Journal Article Ann Intern Med · March 2022 DESCRIPTION: The American College of Physicians (ACP) developed this guideline to provide clinical recommendations on the diagnosis and management of acute left-sided colonic diverticulitis in adults. This guideline is based on current best available evide ... Full text Link to item Cite

Adjustment Disorders in U.S. Active Duty Military Women: A Scoping Review for the Years 2000 to 2018.

Journal Article Womens Health Issues · August 25, 2021 BACKGROUND: Adjustment disorder (AD) is the most common mental health diagnosis in the U.S. military and is more than twice as likely to be diagnosed in active duty servicewomen as compared with male servicemembers. The literature on ADs, particularly in f ... Full text Link to item Cite

Options for Meaningful Engagement in Clinical Research for Busy Frontline Clinicians.

Journal Article J Gen Intern Med · July 2021 In order for health care innovations to be effective and actionable, they must align with the needs and practice patterns of those delivering care at the bedside. While research has started to incorporate the patient voice, it has yet to fully invest in th ... Full text Link to item Cite

Appropriate Use of High-Flow Nasal Oxygen in Hospitalized Patients for Initial or Postextubation Management of Acute Respiratory Failure: A Clinical Guideline From the American College of Physicians.

Journal Article Ann Intern Med · July 2021 DESCRIPTION: The American College of Physicians (ACP) developed this guideline to provide clinical recommendations on the appropriate use of high-flow nasal oxygen (HFNO) in hospitalized patients for initial or postextubation management of acute respirator ... Full text Link to item Cite

Appropriate Use of Point-of-Care Ultrasonography in Patients With Acute Dyspnea in Emergency Department or Inpatient Settings: A Clinical Guideline From the American College of Physicians.

Journal Article Ann Intern Med · July 2021 DESCRIPTION: The American College of Physicians (ACP) developed this guideline to provide clinical recommendations on the appropriate use of point-of-care ultrasonography (POCUS) in patients with acute dyspnea in emergency department (ED) or inpatient sett ... Full text Link to item Cite

Risk of Transmitting Coronavirus Disease 2019 During Nebulizer Treatment: A Systematic Review.

Journal Article J Aerosol Med Pulm Drug Deliv · June 2021 Rationale: There is an urgent need to understand the risk of viral transmission during nebulizer treatment of patients with coronavirus disease 2019 (COVID-19). Objectives: To assess the risk of transmitting severe acute respiratory syndrome coronavirus 2 ... Full text Open Access Link to item Cite

Implementing remote triage in large health systems: A qualitative evidence synthesis.

Journal Article Res Nurs Health · February 2021 Remote triage (RT) allows interprofessional teams (e.g., nurses and physicians) to assess patients and make clinical decisions remotely. RT use has developed widespread interest due to the COVID-19 pandemic, and has future potential to address the needs of ... Full text Link to item Cite

Nonpharmacologic and Pharmacologic Management of Acute Pain From Non-Low Back, Musculoskeletal Injuries in Adults: A Clinical Guideline From the American College of Physicians and American Academy of Family Physicians.

Journal Article Ann Intern Med · November 3, 2020 DESCRIPTION: The American College of Physicians (ACP) and American Academy of Family Physicians (AAFP) developed this guideline to provide clinical recommendations on nonpharmacologic and pharmacologic management of acute pain from non-low back, musculoske ... Full text Link to item Cite

Risk for Nephrogenic Systemic Fibrosis After Exposure to Newer Gadolinium Agents: A Systematic Review.

Journal Article Ann Intern Med · July 21, 2020 BACKGROUND: The risk for nephrogenic systemic fibrosis (NSF) after exposure to newer versus older gadolinium-based contrast agents (GBCAs) remains unclear. PURPOSE: To synthesize evidence about NSF risk with newer versus older GBCAs across the spectrum of ... Full text Link to item Cite

Effectiveness of Acute Care Remote Triage Systems: a Systematic Review.

Journal Article J Gen Intern Med · July 2020 BACKGROUND: Technology-based systems can facilitate remote decision-making to triage patients to the appropriate level of care. Despite technologic advances, the effects of implementation of these systems on patient and utilization outcomes are unclear. We ... Full text Open Access Link to item Cite

GRADE guidelines: 21 part 2. Test accuracy: inconsistency, imprecision, publication bias, and other domains for rating the certainty of evidence and presenting it in evidence profiles and summary of findings tables.

Journal Article J Clin Epidemiol · June 2020 OBJECTIVES: This article provides updated GRADE guidance about how authors of systematic reviews and health technology assessments and guideline developers can rate the certainty of evidence (also known as quality of the evidence or confidence in the estim ... Full text Link to item Cite

GRADE guidelines: 21 part 1. Study design, risk of bias, and indirectness in rating the certainty across a body of evidence for test accuracy.

Journal Article J Clin Epidemiol · June 2020 OBJECTIVES: This article provides updated GRADE guidance about how authors of systematic reviews and health technology assessments and guideline developers can assess the results and the certainty of evidence (also known as quality of the evidence or confi ... Full text Link to item Cite

Barriers and facilitators to implementation of epilepsy self-management programs: a systematic review using qualitative evidence synthesis methods.

Journal Article Syst Rev · April 25, 2020 BACKGROUND: Epilepsy affects nearly 50 million people worldwide. Self-management is critical for individuals with epilepsy in order to maintain optimal physical, cognitive, and emotional health. Implementing and adopting a self-management program requires ... Full text Open Access Link to item Cite

Transformational Coaching: Effect on Process of Care Outcomes and Determinants of Uptake

Report · 2020 High-quality health care is a priority for patients and clinicians alike. Quality improvement (QI) is a framework that guides health system actions to improve the delivery of high-quality health care. Quality improvement activities seek to promote high-qua ... Link to item Cite

Qualitative Exploration of Engaging Patients as Advisors in a Program of Evidence Synthesis: Cobuilding the Science to Enhance Impact.

Journal Article Med Care · October 2019 BACKGROUND: There is an increasing expectation for research to involve patient stakeholders. Yet little guidance exists regarding patient-engaged research in evidence synthesis. Embedded in a learning health care system, the Veteran Affairs Evidence Synthe ... Full text Link to item Cite

Self-management of Epilepsy: A Systematic Review.

Journal Article Ann Intern Med · July 16, 2019 BACKGROUND: Although self-management is recommended for persons with epilepsy, its optimal strategies and effects are uncertain. PURPOSE: To evaluate the components and efficacy of self-management interventions in the treatment of epilepsy in community-dwe ... Full text Open Access Link to item Cite

GRADE Guidelines: 19. Assessing the certainty of evidence in the importance of outcomes or values and preferences-Risk of bias and indirectness.

Journal Article J Clin Epidemiol · July 2019 OBJECTIVES: The Grading of Recommendations Assessment, Development, and Evaluation (GRADE) working group defines patient values and preferences as the relative importance patients place on the main health outcomes. We provide GRADE guidance for assessing t ... Full text Link to item Cite

GRADE guidelines: 20. Assessing the certainty of evidence in the importance of outcomes or values and preferences-inconsistency, imprecision, and other domains.

Journal Article J Clin Epidemiol · July 2019 OBJECTIVE: To provide Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) guidance for assessing inconsistency, imprecision, and other domains for the certainty of evidence about the relative importance of outcomes. STUDY DESIGN AND ... Full text Link to item Cite

Emergency Department Interventions for Older Adults: A Systematic Review.

Journal Article J Am Geriatr Soc · July 2019 OBJECTIVES: To evaluate the effect of emergency department (ED) interventions on clinical, utilization, and care experience outcomes for older adults. DESIGN: A conceptual model informed, protocol-based systematic review. SETTING: Emergency Department (ED) ... Full text Link to item Cite

Anticonvulsants for behavioral and psychological symptoms in dementia: protocol for a systematic review.

Journal Article Syst Rev · May 18, 2019 BACKGROUND: Behavioral and psychological symptoms of dementia (BPSD) are present in a majority of patients with dementia contributing to increased morbidity, health care costs, and caregiver burden. While there are no United States Food and Drug Administra ... Full text Link to item Cite

Integrated outpatient palliative care for patients with advanced cancer: A systematic review and meta-analysis.

Journal Article Palliat Med · February 2019 BACKGROUND:: Despite increasing emphasis on integration of palliative care with disease-directed care for advanced cancer, the nature of this integration and its effects on patient and caregiver outcomes are not well-understood. AIM:: We evaluated the effe ... Full text Link to item Cite

Effectiveness of Remote Triage: A Systematic Review

Report · 2019 The US health care system currently faces several challenges including caring for an increasing elderly population, a large numbers of patients with multiple chronic conditions, and an uneven distribution of primary care providers across the country. The f ... Link to item Cite

Telehealth Interventions Designed for Women: an Evidence Map.

Journal Article J Gen Intern Med · December 2018 BACKGROUND: Telehealth employs technology to connect patients to the right healthcare resources at the right time. Women are high utilizers of healthcare with gender-specific health issues that may benefit from the convenience and personalization of telehe ... Full text Open Access Link to item Cite

Behavioral health integration model.

Journal Article J Gen Intern Med · October 2018 Full text Link to item Cite

Interventions That Support or Involve Caregivers or Families of Patients with Traumatic Injury: a Systematic Review.

Journal Article J Gen Intern Med · July 2018 BACKGROUND: Almost 40 million family caregivers care for a loved one with severe physical or cognitive impairments. The purpose of this review is to summarize evidence about the benefits of interventions to support or involve family members/caregivers of p ... Full text Link to item Cite

Does information from ClinicalTrials.gov increase transparency and reduce bias? Results from a five-report case series.

Journal Article Syst Rev · April 16, 2018 BACKGROUND: We investigated whether information in ClinicalTrials.gov would impact the conclusions of five ongoing systematic reviews. METHOD: We considered five reviews that included 495 studies total. Each review team conducted a search of ClinicalTrials ... Full text Link to item Cite

Management of Menopause Symptoms with Acupuncture: An Umbrella Systematic Review and Meta-Analysis.

Journal Article J Altern Complement Med · April 2018 OBJECTIVES: Vasomotor symptoms (VMSs) are the most common symptoms reported during menopause. Although hormone therapy is effective for reducing VMSs, its use is restricted in some women. Many women with VMSs thus seek nonhormonal, nonpharmacologic treatme ... Full text Link to item Cite

TELEHEALTH FOR WOMEN: AN EVIDENCE MAP

Conference JOURNAL OF GENERAL INTERNAL MEDICINE · April 1, 2018 Link to item Cite

Behavioral Health Integration into Primary Care: a Microsimulation of Financial Implications for Practices.

Journal Article Journal of general internal medicine · December 2017 Featured Publication BackgroundNew payments from Medicare encourage behavioral health services to be integrated into primary care practice activities.ObjectiveTo evaluate the financial impact for primary care practices of integrating behavioral health service ... Full text Cite

Metformin Use May Moderate the Effect of DPP-4 Inhibitors on Cardiovascular Outcomes.

Journal Article Diabetes Care · December 2017 OBJECTIVE: To explore prevalent metformin use as a potential moderator of the cardiovascular effects of dipeptidyl peptidase 4 inhibitors (DPP-4i). RESEARCH DESIGN AND METHODS: We performed a meta-analysis of the three major cardiovascular outcomes trials ... Full text Link to item Cite

Diagnostic Accuracy of Screening Tests and Treatment for Post-Acute Coronary Syndrome Depression: A Systematic Review.

Journal Article Ann Intern Med · November 21, 2017 BACKGROUND: Patients who have had an acute coronary syndrome (ACS) event have an increased risk for depression. PURPOSE: To evaluate the diagnostic accuracy of depression screening instruments and to compare safety and effectiveness of depression treatment ... Full text Link to item Cite

Improving vasomotor symptoms; psychological symptoms; and health-related quality of life in peri- or post-menopausal women through yoga: An umbrella systematic review and meta-analysis.

Journal Article Complement Ther Med · October 2017 OBJECTIVES: Vasomotor symptoms (VMS), commonly reported during menopausal transition, negatively affect psychological health and health-related quality of life (HRQoL). While hormone therapy is an effective treatment, its use is limited by concerns about p ... Full text Link to item Cite

Depression Status Is Associated with Functional Decline Over 1-Year Following Acute Stroke.

Journal Article J Stroke Cerebrovasc Dis · July 2017 BACKGROUND: We investigated the independent association of depression status at 3 and 12 months after stroke and functional decline. METHODS: Data were obtained as part of the multicenter Adherence eValuation After Ischemic stroke Longitudinal (AVAIL) regi ... Full text Link to item Cite

Use of mindfulness, meditation and relaxation to treat vasomotor symptoms.

Journal Article Climacteric · April 2017 Postmenopausal women with bothersome vasomotor symptoms (VMS) often seek alternatives to hormone-based treatment due to medication risks or personal preference. We sought to identify the effects of meditation, mindfulness, hypnosis and relaxation on VMS an ... Full text Link to item Cite

Clinical Outcomes of Metformin Use in Populations With Chronic Kidney Disease, Congestive Heart Failure, or Chronic Liver Disease: A Systematic Review.

Journal Article Ann Intern Med · February 7, 2017 Featured Publication BACKGROUND: Recent changes to the U.S. Food and Drug Administration boxed warning for metformin will increase its use in persons with historical contraindications or precautions. Prescribers must understand the clinical outcomes of metformin use in these p ... Full text Link to item Cite

The Impact of Interventions that Integrate Accelerometers on Physical Activity and Weight Loss: A Systematic Review.

Journal Article Ann Behav Med · February 2017 BACKGROUND: Regular physical activity is important for improving and maintaining health, but sedentary behavior is difficult to change. Providing objective, real-time feedback on physical activity with wearable motion-sensing technologies (activity monitor ... Full text Link to item Cite

Cardiometabolic Risk

Chapter · 2017 Cite

Cannabis

Chapter · 2017 Cite

Respiratory Disease

Chapter · 2017 Cite

Psychosocial

Chapter · 2017 Cite

Injury and Death

Chapter · 2017 Cite

Problem Cannabis Use

Chapter · 2017 Cite

Immunity

Chapter · 2017 Cite

Cancer

Chapter · 2017 Cite

Mental Health

Chapter · 2017 Cite

Reporting of Sex Effects by Systematic Reviews on Interventions for Depression, Diabetes, and Chronic Pain.

Journal Article Ann Intern Med · August 2, 2016 Featured Publication Systematic reviews (SRs) have the potential to contribute uniquely to the evaluation of sex and gender differences (termed "sex effects"). This article describes the reporting of sex effects by SRs on interventions for depression, type 2 diabetes mellitus, ... Full text Link to item Cite

An overview and discussion of the Patient-Centered Outcomes Research Institute's decision aid portfolio.

Journal Article J Comp Eff Res · July 2016 Decision aids (DAs) help patients make informed healthcare decisions in a manner consistent with their values and preferences. Despite their promise, DAs developed with public research dollars are not being implemented and adopted in real-world patient car ... Full text Link to item Cite

Internet Versus DVD Decision Aids for Hip and Knee Osteoarthritis.

Journal Article Musculoskeletal Care · June 2016 INTRODUCTION: Decision aids (DAs) can improve multiple decision-making outcomes, but it is not known whether different formats of delivery differ in their effectiveness or acceptability. The present study compared the effectiveness and acceptability of int ... Full text Link to item Cite

Nonpharmacologic, nonherbal management of menopause-associated vasomotor symptoms: an umbrella systematic review (protocol).

Journal Article Syst Rev · April 7, 2016 BACKGROUND: Vasomotor symptoms such as hot flashes and night sweats are a common concern of perimenopausal and postmenopausal women and are associated with a decreased quality of life. These symptoms can be effectively managed with hormone therapy, but saf ... Full text Open Access Link to item Cite

An evidence map of yoga for low back pain.

Journal Article Complement Ther Med · April 2016 OBJECTIVE: Yoga is being increasingly studied as a treatment strategy for a variety of different clinical conditions, including low back pain (LBP). We set out to conduct an evidence map of yoga for the treatment, prevention and recurrence of acute or chro ... Full text Link to item Cite

Evidence Map of Yoga for Depression, Anxiety, and Posttraumatic Stress Disorder.

Journal Article J Phys Act Health · March 2016 BACKGROUND: This study describes evidence of yoga's effectiveness for depressive disorders, general anxiety disorder (GAD), panic disorder (PD), and posttraumatic stress disorder (PTSD) in adults. We also address adverse events associated with yoga. METHOD ... Full text Link to item Cite

Seize the Day to Implement Depression Guidelines.

Journal Article Ann Intern Med · March 1, 2016 Full text Link to item Cite

Effectiveness of Intermittent Pneumatic Compression Devices for Venous Thromboembolism Prophylaxis in High-Risk Surgical Patients: A Systematic Review.

Journal Article J Arthroplasty · February 2016 BACKGROUND: Thromboprophylaxis regimens include pharmacologic and mechanical options such as intermittent pneumatic compression devices (IPCDs). There are a wide variety of IPCDs available, but it is uncertain if they vary in effectiveness or ease of use. ... Full text Link to item Cite

WITHDRAWN: Antibiotics for acute maxillary sinusitis in adults.

Journal Article Cochrane Database Syst Rev · October 16, 2015 Currently, two separate Cochrane reviews, ‘Antibiotics for acute maxillary sinusitis in adults’ and ‘Antibiotics for clinically diagnosed acute rhinosinusitis in adults’ describe the effect of antibiotics for acute rhinosinusitis. Although both Cochrane re ... Full text Link to item Cite

Electronic Interventions for Alcohol Misuse and Alcohol Use Disorders: A Systematic Review.

Journal Article Ann Intern Med · August 4, 2015 Featured Publication BACKGROUND: The use of electronic interventions (e-interventions) may improve treatment of alcohol misuse. PURPOSE: To characterize treatment intensity and systematically review the evidence for efficacy of e-interventions, relative to controls, for reduci ... Full text Link to item Cite

Does This Patient Have Posttraumatic Stress Disorder?: Rational Clinical Examination Systematic Review.

Journal Article JAMA · August 4, 2015 IMPORTANCE: Posttraumatic stress disorder (PTSD) is a relatively common mental health condition frequently seen, though often unrecognized, in primary care settings. Identifying and treating PTSD can greatly improve patient health and well-being. OBJECTIVE ... Full text Link to item Cite

Stability of Diagnoses of Cognitive Impairment, Not Dementia in a Veterans Affairs Primary Care Population.

Journal Article J Am Geriatr Soc · June 2015 OBJECTIVES: To describe the stability of cognitive impairment, not dementia (CIND) in a longitudinal cohort of primary care veterans. To examine the association between baseline brief cognitive screening tests, demographic and clinical characteristics, and ... Full text Link to item Cite

Shared medical appointments for patients with diabetes mellitus: a systematic review.

Journal Article J Gen Intern Med · January 2015 OBJECTIVES: Shared medical appointments (SMAs) are an increasingly used system-redesign strategy for improving access to and quality of chronic illness care. We conducted a systematic review of the existing literature on SMA interventions for patients with ... Full text Link to item Cite

Patient Decision Aids: A Case for Certification at the National Level in the United States.

Journal Article J Clin Ethics · 2015 Patient decision aids enable patients to be better informed about the potential benefits and harms of their healthcare options. Certification of patient decision aids at the national level in the United States is a critical step towards responsible governa ... Link to item Cite

Utilizing Evidence to Address the Health and Health Care Needs of Veterans.

Journal Article N C Med J · 2015 This issue brief focuses on opportunities to address the health needs of our nation's heroes--service members and veterans who have served the United States in the armed forces. Since the North Carolina Medical Journal (NCMJ) last examined this issue in 20 ... Full text Link to item Cite

Effects of nurse-managed protocols in the outpatient management of adults with chronic conditions: a systematic review and meta-analysis.

Journal Article Ann Intern Med · July 15, 2014 Featured Publication BACKGROUND: Changes in federal health policy are providing more access to medical care for persons with chronic disease. Providing quality care may require a team approach, which the American College of Physicians calls the "medical home." One new model ma ... Full text Link to item Cite

Does this patient have generalized anxiety or panic disorder?: The Rational Clinical Examination systematic review.

Journal Article JAMA · July 2, 2014 Featured Publication IMPORTANCE: In primary care settings, generalized anxiety disorder (GAD) and panic disorder are common but underrecognized illnesses. Identifying accurate and feasible screening instruments for GAD and panic disorder has the potential to improve detection ... Full text Link to item Cite

Pharmacologic and behavioral interventions to improve cardiovascular risk factors in adults with serious mental illness: a systematic review and meta-analysis.

Journal Article J Clin Psychiatry · May 2014 OBJECTIVE: Individuals with serious mental illness have high rates of cardiovascular disease (CVD) risk factors and mortality. This systematic review was conducted to evaluate pharmacologic and behavioral interventions to reduce CVD risk in adults with ser ... Full text Link to item Cite

Antibiotics for acute maxillary sinusitis in adults.

Journal Article Cochrane Database Syst Rev · February 11, 2014 BACKGROUND: Sinusitis is one of the most common diagnoses among adults in ambulatory care, accounting for 15% to 21% of all adult outpatient antibiotic prescriptions. However, the role of antibiotics for sinusitis is controversial. OBJECTIVES: To assess th ... Full text Link to item Cite

Comparative effectiveness of new oral anticoagulants and standard thromboprophylaxis in patients having total hip or knee replacement: a systematic review.

Journal Article Ann Intern Med · August 20, 2013 BACKGROUND: Pharmacologic thromboprophylaxis reduces the risk for venous thromboembolism after total hip replacement (THR) or total knee replacement (TKR). New oral anticoagulants (NOACs), including direct thrombin inhibitors and factor Xa inhibitors, are ... Full text Link to item Cite

An evidence synthesis of care models to improve general medical outcomes for individuals with serious mental illness: a systematic review.

Journal Article J Clin Psychiatry · August 2013 OBJECTIVE: To conduct a systematic review of studies of interventions that integrated medical and mental health care to improve general medical outcomes in individuals with serious mental illness. DATA SOURCES: English-language publications in MEDLINE (via ... Full text Link to item Cite

Uptake of Web-based clinical resources from the MacArthur Initiative on Depression and Primary Care.

Journal Article Community Ment Health J · April 2013 This study assessed the usability and desired enhancements for the MacArthur Foundation's Depression and Primary Care (MDPC) Web site to determine if resources for integrated depression care that are disseminated through the Web site are incorporated into ... Full text Link to item Cite

The patient centered medical home. A systematic review.

Journal Article Ann Intern Med · February 5, 2013 Featured Publication BACKGROUND: The patient-centered medical home (PCMH) describes mechanisms for organizing primary care to provide high quality care across the full range of individuals' health care needs.It is being widely implemented by provider organizations and third pa ... Full text Link to item Cite

ECG-based signal analysis technologies for evaluating patients with acute coronary syndrome: a systematic review.

Journal Article J Electrocardiol · 2013 BACKGROUND/OBJECTIVES: Timely identification of cardiac ischemia is critical in patients with acute coronary syndrome (ACS). The first test is often the standard, resting 12-lead ECG. Given its limitations, signal analysis enhancements have been proposed. ... Full text Link to item Cite

Comparative effectiveness of warfarin and new oral anticoagulants for the management of atrial fibrillation and venous thromboembolism: a systematic review.

Journal Article Ann Intern Med · December 4, 2012 BACKGROUND: New oral anticoagulants (NOACs), including direct thrombin inhibitors (DTIs) and factor Xa (FXa) inhibitors, are emerging alternatives for prophylaxis and treatment of atrial fibrillation (AF) and venous thromboembolism (VTE). PURPOSE: To compa ... Full text Link to item Cite

Effect of clinical decision-support systems: a systematic review.

Journal Article Ann Intern Med · July 3, 2012 BACKGROUND: Despite increasing emphasis on the role of clinical decision-support systems (CDSSs) for improving care and reducing costs, evidence to support widespread use is lacking. PURPOSE: To evaluate the effect of CDSSs on clinical outcomes, health car ... Full text Link to item Cite

Closing the quality gap: revisiting the state of the science (vol. 2: the patient-centered medical home).

Journal Article Evid Rep Technol Assess (Full Rep) · July 2012 OBJECTIVES: As part of the Closing the Quality Gap: Revisiting the State of the Science series of the Agency for Healthcare Research and Quality (AHRQ), this systematic review sought to identify completed and ongoing evaluations of the comprehensive patien ... Link to item Cite

Depression and antidepressant use after stroke and transient ischemic attack.

Journal Article Stroke · June 2012 BACKGROUND AND PURPOSE: Patients with stroke and transient ischemic attack (TIA) often have comparable comorbidities, but it is unclear whether they have similar rates of depression or antidepressant use. METHODS: This study was a secondary analysis of a p ... Full text Link to item Cite

Screening for cognitive impairment: comparing the performance of four instruments in primary care.

Journal Article J Am Geriatr Soc · June 2012 OBJECTIVES: To determine whether brief cognitive screening tests perform as well as a longer screening test in diagnosis of cognitive impairment, no dementia (CIND) or dementia. DESIGN: A cross-sectional comparison of cognitive screening tests to an indepe ... Full text Link to item Cite

Psychometric characteristics of outcome measures in juvenile idiopathic arthritis: a systematic review.

Journal Article Arthritis Care Res (Hoboken) · April 2012 OBJECTIVE: To review the performance characteristics of the instruments most commonly used to measure clinical outcomes in juvenile idiopathic arthritis (JIA), including global assessments, articular indices, functional/disability assessments, and quality ... Full text Link to item Cite

Enabling health care decisionmaking through clinical decision support and knowledge management.

Journal Article Evid Rep Technol Assess (Full Rep) · April 2012 OBJECTIVES: To catalogue study designs used to assess the clinical effectiveness of CDSSs and KMSs, to identify features that impact the success of CDSSs/KMSs, to document the impact of CDSSs/KMSs on outcomes, and to identify knowledge types that can be in ... Link to item Cite

Treatment of mild to moderate sinusitis.

Journal Article Arch Intern Med · March 26, 2012 BACKGROUND: The National Physicians Alliance (NPA)-initiated a project titled "Promoting Good Stewardship in Clinical Practice" to develop a list of the "Top 5" activities in primary care, where changes in practice could lead simultaneously to higher quali ... Full text Link to item Cite

Systematic review of disease-modifying antirheumatic drugs for juvenile idiopathic arthritis.

Journal Article BMC Pediatr · March 15, 2012 BACKGROUND: Treatment of juvenile idiopathic arthritis (JIA) with disease-modifying antirheumatic drugs (DMARDs) may improve outcomes compared to conventional therapy (e.g., non-steroidal anti-inflammatory drugs, intra-articular corticosteroids). The purpo ... Full text Link to item Cite

Smoking cessation interventions for patients with depression: a systematic review and meta-analysis.

Journal Article J Gen Intern Med · March 2012 OBJECTIVES: We conducted a systematic literature review of smoking cessation interventions for patients with histories of depressive disorders or current significant depressive symptoms. We examined the comparative effectiveness of smoking cessation strate ... Full text Link to item Cite

Brief psychotherapy for depression: a systematic review and meta-analysis.

Journal Article Int J Psychiatry Med · 2012 OBJECTIVE: Because evidence-based psychotherapies of 12 to 20 sessions can be perceived as too lengthy and time intensive for the treatment of depression in primary care, a number of studies have examined abbreviated psychotherapy protocols. The purpose of ... Full text Link to item Cite

GRADE guidelines 6. Rating the quality of evidence--imprecision.

Journal Article J Clin Epidemiol · December 2011 GRADE suggests that examination of 95% confidence intervals (CIs) provides the optimal primary approach to decisions regarding imprecision. For practice guidelines, rating down the quality of evidence (i.e., confidence in estimates of effect) is required i ... Full text Link to item Cite

GRADE guidelines: 5. Rating the quality of evidence--publication bias.

Journal Article J Clin Epidemiol · December 2011 In the GRADE approach, randomized trials start as high-quality evidence and observational studies as low-quality evidence, but both can be rated down if a body of evidence is associated with a high risk of publication bias. Even when individual studies inc ... Full text Link to item Cite

Risk factors and preventive interventions for Alzheimer disease: state of the science.

Journal Article Arch Neurol · September 2011 BACKGROUND: Numerous studies have investigated risk factors for Alzheimer disease (AD). However, at a recent National Institutes of Health State-of-the-Science Conference, an independent panel found insufficient evidence to support the association of any m ... Full text Link to item Cite

Examination of the utility of psychotherapy for patients with treatment resistant depression: a systematic review.

Journal Article J Gen Intern Med · June 2011 OBJECTIVE: To examine the utility of psychotherapy in managing treatment resistant depression. DATA SOURCES: PubMed, PsycInfo, Embase, Cochrane Registry of Controlled Clinical Trials, article bibliographies. REVIEW METHODS: Eligible articles had to be in E ... Full text Link to item Cite

Grading quality of evidence and strength of recommendations in clinical practice guidelines part 3 of 3. The GRADE approach to developing recommendations.

Journal Article Allergy · May 2011 This is the third and last article in the series about the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach to grading the quality of evidence and the strength of recommendations in clinical practice guidelines and its app ... Full text Link to item Cite

Acceptability of dementia screening in primary care patients.

Journal Article Int J Geriatr Psychiatry · April 2011 OBJECTIVES: To determine the acceptability of dementia screening in two populations of older adults in different primary care settings. METHODS: Cross-sectional study of consecutive patients presenting for primary care appointments in the Duke University H ... Full text Link to item Cite

GRADE guidelines: 4. Rating the quality of evidence--study limitations (risk of bias).

Journal Article J Clin Epidemiol · April 2011 In the GRADE approach, randomized trials start as high-quality evidence and observational studies as low-quality evidence, but both can be rated down if most of the relevant evidence comes from studies that suffer from a high risk of bias. Well-established ... Full text Link to item Cite

GRADE guidelines: 6. Rating the quality of evidence-imprecision

Journal Article Chinese Journal of Evidence-Based Medicine · January 1, 2011 Cite

Percutaneous heart valve replacement for aortic stenosis: state of the evidence.

Journal Article Ann Intern Med · September 7, 2010 Surgical aortic valve replacement (SAVR) is the only treatment known to improve symptoms and survival in patients with severe, symptomatic aortic stenosis. Perioperative mortality, however, is high among many patients for whom SAVR may be indicated. Percut ... Full text Link to item Cite

Taking healthcare interventions from trial to practice.

Journal Article BMJ · August 13, 2010 Featured Publication Full text Link to item Cite

Systematic review: factors associated with risk for and possible prevention of cognitive decline in later life.

Journal Article Ann Intern Med · August 3, 2010 Featured Publication BACKGROUND: Many biological, behavioral, social, and environmental factors may contribute to the delay or prevention of cognitive decline. PURPOSE: To summarize evidence about putative risk and protective factors for cognitive decline in older adults and t ... Full text Link to item Cite

Capecitabine, bevacizumab, and mitomycin in first-line treatment of metastatic colorectal cancer: results of the Australasian Gastrointestinal Trials Group Randomized Phase III MAX Study.

Journal Article J Clin Oncol · July 1, 2010 PURPOSE: To determine whether adding bevacizumab, with or without mitomycin, to capecitabine monotherapy improves progression-free survival (PFS) in patients with metastatic colorectal cancer (mCRC) in an open-label, three-arm randomized trial. PATIENTS AN ... Full text Link to item Cite

Preventing Alzheimer's disease and cognitive decline.

Journal Article Evid Rep Technol Assess (Full Rep) · April 2010 OBJECTIVES: To assess whether previous research on purported risk or protective factors for Alzheimer's disease (AD) and cognitive decline is of sufficient strength to warrant specific recommendations for behavioral, lifestyle, or pharmaceutical interventi ... Link to item Cite

The contribution of intrinsic and extrinsic apoptotic pathways in Th2-mediated inflammation

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · 2010 Cite

IRF4 expression in dendritic cells regulates Th2 immune responses

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · 2010 Cite

Grading quality of evidence and strength of recommendations for diagnostic tests and strategies

Journal Article Chinese Journal of Evidence-Based Medicine · August 28, 2009 Cite

Marketing off-label uses: Shady practices within a gray market

Journal Article Psychiatric Times · August 1, 2009 Cite

Grading quality of evidence and strength of recommendations in clinical practice guidelines. Part 1 of 3. An overview of the GRADE approach and grading quality of evidence about interventions.

Journal Article Allergy · May 2009 The GRADE (Grades of Recommendation, Assessment, Development, and Evaluation) approach provides guidance to grading the quality of underlying evidence and the strength of recommendations in health care. The GRADE system's conceptual underpinnings allow for ... Full text Link to item Cite

IMPACT OF WEIGHT LOSS ON SEXUAL FUNCTION IN OBESE WOMEN

Conference The Journal of Urology · April 2009 Full text Cite

How reviews covered the unfolding scientific story of gabapentin for bipolar disorder.

Journal Article Gen Hosp Psychiatry · 2009 BACKGROUND: Despite the lack of randomized controlled trials (RCTs), gabapentin use increased rapidly in the 1990s for mental health conditions. Subsequent RCTs did not demonstrate efficacy for bipolar disorder (BD). We examined the characteristics of revi ... Full text Link to item Cite

Developing a national dissemination plan for collaborative care for depression: QUERI Series.

Journal Article Implement Sci · December 31, 2008 Featured Publication BACKGROUND: Little is known about effective strategies for disseminating and implementing complex clinical innovations across large healthcare systems. This paper describes processes undertaken and tools developed by the U.S. Department of Veterans Affairs ... Full text Link to item Cite

RESPECT-Mil: feasibility of a systems-level collaborative care approach to depression and post-traumatic stress disorder in military primary care.

Journal Article Mil Med · October 2008 BACKGROUND: U.S. military ground forces report high rates of war-related traumatic stressors, posttraumatic stress disorder (PTSD), and depression following deployment in support of recent armed conflicts in Iraq and Afghanistan. Affected service members d ... Full text Link to item Cite

Antibiotics for acute maxillary sinusitis.

Journal Article Cochrane database of systematic reviews (Online) · June 17, 2008 BACKGROUND: Expert opinions vary on the appropriate role of antibiotics for sinusitis, one of the most commonly diagnosed conditions among adults in ambulatory care. OBJECTIVES: We examined whether antibiotics are effective in treating acute sinusitis, and ... Cite

Grading quality of evidence and strength of recommendations for diagnostic tests and strategies.

Journal Article BMJ · May 17, 2008 Featured Publication The GRADE system can be used to grade the quality of evidence and strength of recommendations for diagnostic tests or strategies. This article explains how patient-important outcomes are taken into account in this process ... Full text Link to item Cite

Collaborative mental health and primary care for bipolar disorder.

Journal Article J Psychiatr Pract · May 2008 This article discusses the use of integrated care models, in particular, collaborative care, in the treatment of bipolar disorder. Dr. Williams first discusses how care delivered via a collaboration between primary care and psychiatric providers has the po ... Full text Link to item Cite

Antibiotics for acute maxillary sinusitis.

Journal Article Cochrane Database Syst Rev · April 16, 2008 BACKGROUND: Expert opinions vary on the appropriate role of antibiotics for sinusitis, one of the most commonly diagnosed conditions among adults in ambulatory care. OBJECTIVES: We examined whether antibiotics are effective in treating acute sinusitis, and ... Full text Link to item Cite

Gabapentin in the treatment of mental illness: the echo chamber of the case series.

Journal Article J Psychiatr Pract · March 2008 BACKGROUND: Bipolar disorder is a common and debilitating psychiatric illness. Several antiepileptic drugs (AEDs) have been approved for the treatment of bipolar disorder. Gabapentin gained a large market share of AED use in the late 1990s in spite of a la ... Full text Link to item Cite

Effectiveness of antiepileptic drugs for the treatment of bipolar disorder: findings from a systematic review.

Journal Article J Psychiatr Pract · March 2008 Bipolar disorder is characterized by chronic and recurrent symptoms including mania, hypomania, and depressive and mixed episodes, with approximately 5.7 million Americans over age 18, or 2.6% of the U.S. population, suffering from the illness. The prevale ... Full text Link to item Cite

Impact of pain on the outcomes of depression treatment: results from the RESPECT trial.

Journal Article Pain · January 2008 OBJECTIVE: Pain is prevalent in patients with depression. The purpose of this study was to determine the impact of pain on depression treatment outcomes. METHODS: Data was analyzed from a randomized controlled trial comparing a collaborative care intervent ... Full text Link to item Cite

Identifying depressed older adults in primary care: a secondary analysis of a multisite randomized controlled trial.

Journal Article Prim Care Companion J Clin Psychiatry · 2008 OBJECTIVE: To determine whether a subset of depressive symptoms could be identified to facilitate diagnosis of depression in older adults in primary care. METHOD: Secondary analysis was conducted on 898 participants aged 60 years or older with major depres ... Full text Link to item Cite

The challenges of multimorbidity from the patient perspective.

Journal Article J Gen Intern Med · December 2007 BACKGROUND: Although multiple co-occurring chronic illnesses within the same individual are increasingly common, few studies have examined the challenges of multimorbidity from the patient perspective. OBJECTIVE: The aim of this study is to examine the sel ... Full text Link to item Cite

Screening for dementia in primary care

Journal Article Journal of Clinical Outcomes Management · September 1, 2007 Cite

Does this patient have dementia?

Journal Article JAMA · June 6, 2007 CONTEXT: While as many as 5 million individuals in the United States have dementia, many others have memory complaints. Brief tests to screen for cognitive impairment could help guide dementia diagnosis. OBJECTIVE: To review the literature concerning the p ... Full text Link to item Cite

Best practices: comparing medication treatments in mental health: drug class reviews and policy challenges.

Journal Article Psychiatr Serv · June 2007 Advances in the number and type of medications for psychiatric illness have substantially aided physicians. However, as the number of available medications within a class increases, so does the complexity in decision making for provider and patient. System ... Full text Link to item Cite

Performance indicators for bipolar disorder: Development and feasibility testing

Conference JOURNAL OF GENERAL INTERNAL MEDICINE · April 1, 2007 Link to item Cite

Sustainable impact of a primary care depression intervention.

Journal Article J Am Board Fam Med · 2007 BACKGROUND: Re-Engineering Systems for Primary Care Treatment of Depression (RESPECT-D) sought to improve patient outcomes by disseminating the 3-component model of depression management. The purpose of this study was to determine whether an integrated mod ... Full text Link to item Cite

Systematic review of multifaceted interventions to improve depression care.

Journal Article Gen Hosp Psychiatry · 2007 OBJECTIVE: Depression is a prevalent high-impact illness with poor outcomes in primary care settings. We performed a systematic review to determine to what extent multifaceted interventions improve depression outcomes in primary care and to define key elem ... Full text Link to item Cite

A fidelity measure for integrated management of depression in primary care.

Journal Article Med Care · November 2006 BACKGROUND: Integrated models of primary care depression management improve outcomes. Subsequent dissemination efforts and their evaluation need a fidelity measure. OBJECTIVES: We sought to develop and validate a fidelity measure using data gathered during ... Full text Link to item Cite

Reducing suicidal ideation in depressed older primary care patients.

Journal Article J Am Geriatr Soc · October 2006 OBJECTIVES: To determine the effect of a primary care-based collaborative care program for depression on suicidal ideation in older adults. DESIGN: Randomized, controlled trial. SETTING: Eighteen diverse primary care clinics. PARTICIPANTS: One thousand eig ... Full text Link to item Cite

Dissemination of evidence-based mental health interventions: importance to the trauma field.

Journal Article J Trauma Stress · October 2006 Randomized controlled trials have established the efficacy of psychotherapy and medication treatments for posttraumatic stress disorder (PTSD). Despite these advancements, many individuals do not receive guideline-concordant PTSD care. In an effort to adva ... Full text Link to item Cite

Crack cocaine causing fatal vasoconstriction of the aorta

Journal Article The Journal of Emergency Medicine · August 2006 Full text Cite

Long term outcomes from the IMPACT randomised trial for depressed elderly patients in primary care.

Journal Article BMJ · February 4, 2006 OBJECTIVE: To determine the long term effectiveness of collaborative care management for depression in late life. DESIGN: Two arm, randomised, clinical trial; intervention one year and follow-up two years. SETTING: 18 primary care clinics in eight US healt ... Full text Link to item Cite

Cost-effectiveness and net benefit of enhanced treatment of depression for older adults with diabetes and depression.

Journal Article Diabetes Care · February 2006 Featured Publication OBJECTIVE: To determine the incremental cost-effectiveness and net benefit of a depression collaborative care program compared with usual care for patients with diabetes and depression. RESEARCH DESIGN AND METHODS: This article describes a preplanned subgr ... Full text Link to item Cite

The efficacy of olanzapine for decreasing cue-elicited craving in individuals with schizophrenia and cocaine dependence: a preliminary report.

Journal Article J Clin Psychopharmacol · February 2006 OBJECTIVE: Although a growing body of research suggests that atypical neuroleptic medications are efficacious in the treatment of cocaine addiction among individuals with schizophrenia, more rigorously controlled trials are needed. To extend this research, ... Full text Link to item Cite

Cost-effectiveness of improving primary care treatment of late-life depression.

Journal Article Arch Gen Psychiatry · December 2005 CONTEXT: Depression is a leading cause of functional impairment in elderly individuals and is associated with high medical costs, but there are large gaps in quality of treatment in primary care. OBJECTIVE: To determine the incremental cost-effectiveness o ... Full text Link to item Cite

Improving depression care for older, minority patients in primary care.

Journal Article Med Care · April 2005 OBJECTIVE: Few older minorities receive adequate treatment of depression in primary care. This study examines whether a collaborative care model for depression in primary care is as effective in older minorities as it is in nonminority elderly patients in ... Full text Link to item Cite

Systems for grading the quality of evidence and the strength of recommendations II: pilot study of a new system.

Journal Article BMC Health Serv Res · March 23, 2005 Featured Publication BACKGROUND: Systems that are used by different organisations to grade the quality of evidence and the strength of recommendations vary. They have different strengths and weaknesses. The GRADE Working Group has developed an approach that addresses key short ... Full text Link to item Cite

Leflunomide for polyomavirus type BK nephropathy.

Journal Article N Engl J Med · March 17, 2005 Full text Link to item Cite

Adherence to mental health treatment in a primary care clinic.

Journal Article J Am Board Fam Pract · 2005 BACKGROUND: Patient nonadherence is common for the standard mental health treatments in primary care: antidepressants and referrals to specialty mental health treatment. This is one of few studies to prospectively identify predictors of nonadherence. METHO ... Full text Link to item Cite

Suicidal ideation and risk levels among primary care patients with uncomplicated depression.

Journal Article Ann Fam Med · 2005 PURPOSE: We investigated the prevalence, severity, and course of passive and active suicidal ideation occurring in primary care patients with an uncomplicated depressive disorder. METHODS: We studied suicidal ideation experienced by patients recruited in 6 ... Full text Link to item Cite

Impact of comorbid panic and posttraumatic stress disorder on outcomes of collaborative care for late-life depression in primary care.

Journal Article Am J Geriatr Psychiatry · January 2005 OBJECTIVE: Comorbid anxiety disorders may result in worse depression treatment outcomes. The authors evaluated the effect of comorbid panic disorder and posttraumatic stress disorder (PTSD) on response to a collaborative-care intervention for late-life dep ... Full text Link to item Cite

Improving depression outcomes in older adults with comorbid medical illness.

Journal Article Gen Hosp Psychiatry · 2005 BACKGROUND: Depression is common in older adults and often coexists with multiple chronic diseases, which may complicate its diagnosis and treatment. OBJECTIVE: To determine whether or not the presence of multiple comorbid medical illnesses affects patient ... Full text Link to item Cite

Systems for grading the quality of evidence and the strength of recommendations I: critical appraisal of existing approaches The GRADE Working Group

Journal Article BMC health services research · December 22, 2004 BACKGROUND: A number of approaches have been used to grade levels of evidence and the strength of recommendations. The use of many different approaches detracts from one of the main reasons for having explicit approaches: to concisely characterise and comm ... Cite

Systems for grading the quality of evidence and the strength of recommendations I: critical appraisal of existing approaches The GRADE Working Group.

Journal Article BMC Health Serv Res · December 22, 2004 BACKGROUND: A number of approaches have been used to grade levels of evidence and the strength of recommendations. The use of many different approaches detracts from one of the main reasons for having explicit approaches: to concisely characterise and comm ... Full text Link to item Cite

Rapid responses from bmj.com

Journal Article BMJ · December 11, 2004 Full text Cite

Common comorbidity scales were similar in their ability to predict health care costs and mortality.

Journal Article J Clin Epidemiol · October 2004 OBJECTIVE: To compare the ability of commonly used measures of medical comorbidity (ambulatory care groups [ACGs], Charlson comorbidity index, chronic disease score, number of prescribed medications, and number of chronic diseases) to predict mortality and ... Full text Link to item Cite

Re-engineering systems for the treatment of depression in primary care: cluster randomised controlled trial.

Journal Article BMJ · September 11, 2004 OBJECTIVE: To test the effectiveness of an evidence based model for management of depression in primary care with support from quality improvement resources. DESIGN: Cluster randomised controlled trial. SETTING: Five healthcare organisations in the United ... Full text Link to item Cite

A double-blind placebo-controlled pilot study of risperidone for decreasing cue-elicited craving in recently withdrawn cocaine dependent patients.

Journal Article J Subst Abuse Treat · July 2004 Cocaine use causes an initial increase in dopamine and serotonin neurotransmission that is largely responsible for the pleasurable and reinforcing effects of the drug. Dysregulation of these neurotransmitters during withdrawal plays an important role in cr ... Full text Link to item Cite

Grading quality of evidence and strength of recommendations.

Journal Article BMJ · June 19, 2004 Users of clinical practice guidelines and other recommendations need to know how much confidence they can place in the recommendations. Systematic and explicit methods of making judgments can reduce errors and improve communication. We have developed a sys ... Full text Link to item Cite

The effectiveness of depression care management on diabetes-related outcomes in older patients.

Journal Article Ann Intern Med · June 15, 2004 Featured Publication BACKGROUND: Depression frequently occurs in combination with diabetes mellitus, adversely affecting the course of illness. OBJECTIVE: To determine whether enhancing care for depression improves affective and diabetic outcomes in older adults with diabetes ... Full text Link to item Cite

The door handle sign

Journal Article BMJ · May 15, 2004 Full text Cite

Assessment and management of depression in older adults

Journal Article Primary Psychiatry · May 1, 2004 Approximately 5% to 10% of older patients who visit a primary care provider suffer from clinically significant depression. Making the diagnosis in the older population can be challenging, as the cardinal symptom of depression, depressed mood, is less promi ... Cite

Re-engineering systems for the primary care treatment of depression.

Conference JOURNAL OF GENERAL INTERNAL MEDICINE · April 1, 2004 Link to item Cite

Collaborative care for late-life depression

Conference PSYCHOSOMATICS · March 1, 2004 Link to item Cite

Low yield of thyroid-stimulating hormone testing in elderly patients with depression.

Journal Article Gen Hosp Psychiatry · 2004 Although hypothyroidism is purportedly an important cause of depression, prior studies have involved small samples of young people and produced conflicting results. We examined the yield of thyroid-stimulating hormone (TSH) testing in a large group of elde ... Full text Link to item Cite

The 13- and 20-item Hopkins Symptom Checklist Depression Scale: psychometric properties in primary care patients with minor depression or dysthymia.

Journal Article Int J Psychiatry Med · 2004 OBJECTIVE: Depression scales that are responsive to changes in clinical symptoms are important for clinical monitoring and outcomes assessment in longitudinal studies. We evaluated the psychometric properties and responsiveness to clinical change of the 13 ... Full text Link to item Cite

Depression and comorbid illness in elderly primary care patients: impact on multiple domains of health status and well-being.

Journal Article Ann Fam Med · 2004 PURPOSE: Our objective was to examine the relative association of depression severity and chronicity, other comorbid psychiatric conditions, and coexisting medical illnesses with multiple domains of health status among primary care patients with clinical d ... Full text Link to item Cite

Going to scale: re-engineering systems for primary care treatment of depression.

Journal Article Ann Fam Med · 2004 Featured Publication BACKGROUND: Recent trials have shown improved depression outcomes with chronic care models. We report the methods of a project that assesses the sustainability and transportability of a chronic care model for depression and change strategy. METHODS: In a r ... Full text Link to item Cite

Hispanic ethnicity, language, and depression: physician-patient communication and patient use of alternative treatments.

Journal Article Int J Psychiatry Med · 2004 OBJECTIVE: To examine the relationship between Hispanic ethnicity and language spoken with physician communication about depression and patient use of alternative treatments for depression. METHOD: This is a secondary data analysis from a trial of depressi ... Full text Link to item Cite

Preventing suicide in primary care patients: the primary care physician's role.

Journal Article Gen Hosp Psychiatry · 2004 Suicide is a critical public health problem that primary care physicians potentially can help address given that distressed patients frequently visit them in the weeks and months preceding the successful suicide. This article considers factors placing the ... Full text Link to item Cite

Effect of improving depression care on pain and functional outcomes among older adults with arthritis: a randomized controlled trial.

Journal Article JAMA · November 12, 2003 CONTEXT: Depression and arthritis are disabling and common health problems in late life. Depression is also a risk factor for poor health outcomes among arthritis patients. OBJECTIVE: To determine whether enhancing care for depression improves pain and fun ... Full text Link to item Cite

Dissemination to community-based practices

Conference Journal of Psychosomatic Research · August 2003 Full text Cite

Depression care attitudes and practices of newer obstetrician-gynecologists: a national survey.

Journal Article Am J Obstet Gynecol · July 2003 OBJECTIVE: The study was undertaken to assess attitudes and behavior of newer obstetricians/gynecologists in depression care. STUDY DESIGN: One thousand randomly selected physicians in their final year of training or recent practice received a survey about ... Full text Link to item Cite

Depression treatment in a sample of 1,801 depressed older adults in primary care.

Journal Article J Am Geriatr Soc · April 2003 OBJECTIVES: To examine rates and predictors of lifetime and recent depression treatment in a sample of 1,801 depressed older primary care patients DESIGN: Cross sectional survey data collected from 1999 to 2001 as part of a treatment effectiveness trial. S ... Full text Link to item Cite

Antidepressant therapy in primary care: Does patient preference affect response?

Conference JOURNAL OF GENERAL INTERNAL MEDICINE · April 1, 2003 Link to item Cite

Helping journalists get it right: a physicians's guide to improving health care reporting.

Journal Article J Gen Intern Med · February 2003 Featured Publication News reports are the way that most people, including many physicians and scientists, first learn about new developments in medicine. Because these reports can raise awareness, influence behavior, and confer credibility, physicians should share responsibili ... Full text Link to item Cite

Antibiotics for acute maxillary sinusitis.

Journal Article Cochrane database of systematic reviews (Online) · 2003 BACKGROUND: For adults seeking care in ambulatory medical practices, sinusitis is the most common diagnosis treated with antibiotics. OBJECTIVES: We examined whether antibiotics are indicated for acute sinusitis, and if so, which antibiotic classes are mos ... Cite

Patient beliefs predict response to paroxetine among primary care patients with dysthymia and minor depression.

Journal Article J Am Board Fam Pract · 2003 BACKGROUND: Dysthymia and minor depression are common problems in primary care, but it is not known how patient health beliefs shape response to antidepressant treatment of these less severe forms of depression. METHODS: Three hundred thirty-three primary ... Full text Link to item Cite

Management of allergic rhinitis in the working-age population.

Journal Article Evid Rep Technol Assess (Summ) · January 2003 Link to item Cite

Antibiotics for acute maxillary sinusitis.

Journal Article Cochrane Database Syst Rev · 2003 Featured Publication BACKGROUND: For adults seeking care in ambulatory medical practices, sinusitis is the most common diagnosis treated with antibiotics. OBJECTIVES: We examined whether antibiotics are indicated for acute sinusitis, and if so, which antibiotic classes are mos ... Full text Link to item Cite

Impacting late life depression: integrating a depression intervention into primary care.

Journal Article Psychiatr Q · 2003 groups and semi-structured individual interviews with all Depression Clinical Specialists (DCSs) working with Project IMPACT (Improving Mood: Promoting Access to Collaborative Treatment), a study testing a collaborative care intervention for late life depr ... Full text Link to item Cite

Antibiotic Treatment for Acute Maxillary Sinusitis

Journal Article Annals of Emergency Medicine · January 1, 2003 Full text Cite

Cognitive disparity in schizophrenics with and without cocaine dependency.

Journal Article J Subst Abuse Treat · January 2003 Although cognition has been investigated in individuals with schizophrenia and in non-schizophrenic cocaine abusers, few studies have focused on cocaine-abusing schizophrenics. Previous studies have shown contradictory results despite the fact that individ ... Full text Link to item Cite

Collaborative care management of late-life depression in the primary care setting: a randomized controlled trial.

Journal Article JAMA · December 11, 2002 CONTEXT: Few depressed older adults receive effective treatment in primary care settings. OBJECTIVE: To determine the effectiveness of the Improving Mood-Promoting Access to Collaborative Treatment (IMPACT) collaborative care management program for late-li ... Full text Link to item Cite

An analysis of cue reactivity among persons with and without schizophrenia who are addicted to cocaine.

Journal Article Psychiatr Serv · December 2002 OBJECTIVE: Persons with schizophrenia who are addicted to cocaine experience more psychiatric and substance abuse relapses and worse long-term outcomes than persons with only one of these conditions. This study examined whether individuals with cocaine dep ... Full text Link to item Cite

How a rare diagnosis caused me to sprain my ankle

Journal Article BMJ · November 2, 2002 Full text Cite

The relation between methods and recommendations in clinical practice guidelines for hypertension and hyperlipidemia.

Journal Article J Fam Pract · November 2002 OBJECTIVE: To assess the association between methods used to develop clinical practice guidelines and the recommendations that are made. STUDY DESIGN: Systematic review of clinical practice guidelines for hypertension or hyperlipidemia. OUTCOMES MEASURED: ... Link to item Cite

Risperidone decreases craving and relapses in individuals with schizophrenia and cocaine dependence.

Journal Article Can J Psychiatry · September 2002 OBJECTIVE: To examine the efficacy of atypical neuroleptics for decreasing craving and drug relapses during protracted withdrawal in individuals dually diagnosed with schizophrenia and cocaine dependence. METHOD: We conducted a 6-week, open-label pilot stu ... Full text Link to item Cite

Improving care for late life depression.

Conference JOURNAL OF THE AMERICAN GERIATRICS SOCIETY · April 1, 2002 Link to item Cite

Low yield of TSH testing in elderly patients with depression.

Conference JOURNAL OF GENERAL INTERNAL MEDICINE · April 1, 2002 Link to item Cite

Rational treatment choices for non-major depressions in primary care: an evidence-based review.

Journal Article J Gen Intern Med · April 2002 OBJECTIVE: This review synthesizes available evidence for managing clinically significant dysphoric symptoms encountered in primary care, when formal criteria for major depression or dysthymia are not met. Discussion is focused on premenstrual dysphoric di ... Full text Link to item Cite

Identifying patients with major depression in primary care.

Journal Article JOURNAL OF GENERAL INTERNAL MEDICINE · April 1, 2002 Link to item Cite

Is this patient clinically depressed?

Journal Article JAMA · March 6, 2002 Featured Publication CONTEXT: Depressive disorders are highly prevalent in the general population, but recognition and accurate diagnosis are made difficult by the lack of a simple confirmatory test. OBJECTIVE: To review the accuracy and precision of depression questionnaires ... Full text Link to item Cite

A three-component model for reengineering systems for the treatment of depression in primary care.

Journal Article Psychosomatics · 2002 Depression in primary care is a chronic disease. As with most chronic diseases, long-term adherence to treatment plans is problematic. Evidence-based systems of care address this problem, but persistence and dissemination of systems after testing is a new ... Full text Link to item Cite

Correlates of remission in primary care patients treated for minor depression.

Journal Article Gen Hosp Psychiatry · 2002 As minor depression is perhaps the most common form of mood disorder seen in primary care, we sought to explore the effects of both pharmacologic and psychosocial interventions for primary care patients with this condition. Three hundred and eighteen prima ... Full text Link to item Cite

Identifying depression in primary care: a literature synthesis of case-finding instruments.

Journal Article Gen Hosp Psychiatry · 2002 We evaluated the usefulness of case-finding instruments for identifying patients with major depression or dysthymia in primary care settings using English language literature from Medline, a specialized trials registry and bibliographies of selected papers ... Full text Link to item Cite

Predictors of nonresponse to treatment in primary care patients with dysthymia.

Journal Article Gen Hosp Psychiatry · 2002 Dysthymia is one of the most prevalent problems in primary care, especially in the elderly. In this study, we evaluated the demographic and clinical predictors of nonresponse to treatment in primary care patients with dysthymia. The study sample consisted ... Full text Link to item Cite

The rewarming rate and increased peak temperature alter neurocognitive outcome after cardiac surgery.

Other Anesth Analg · January 2002 UNLABELLED: Neurocognitive dysfunction is a common complication after cardiac surgery. We evaluated in this prospective study the effect of rewarming rate on neurocognitive outcome after hypothermic cardiopulmonary bypass (CPB). After IRB approval and info ... Full text Link to item Cite

Efficacy of intranasal corticosteroids for acute sinusitis - Reply

Journal Article JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION · 2002 Cite

Comparison of cefuroxime with or without intranasal fluticasone for the treatment of rhinosinusitis. The CAFFS Trial: a randomized controlled trial.

Journal Article JAMA · December 26, 2001 CONTEXT: It is not known whether intranasal corticosteroids are beneficial to treat acute rhinosinusitis in patients with a history of chronic or recurrent sinus symptoms. OBJECTIVE: To assess whether the addition of an intranasal corticosteroid to antibio ... Full text Link to item Cite

Treatment of depression.

Journal Article J Fam Pract · December 2001 Link to item Cite

Strategies for diagnosing and treating suspected acute bacterial sinusitis: a cost-effectiveness analysis.

Journal Article J Gen Intern Med · October 2001 OBJECTIVE: Symptoms suggestive of acute bacterial sinusitis are common. Available diagnostic and treatment options generate substantial costs with uncertain benefits. We assessed the cost-effectiveness of alternative management strategies to identify the o ... Full text Link to item Cite

Identifying physicians likely to benefit from depression education: a challenge for health care organizations.

Journal Article Med Care · August 2001 BACKGROUND: Few methods exist to identify physicians who might benefit from depression education. OBJECTIVES: To develop a measure of physicians' confidence or self-efficacy in caring for depressed patients and assess it's reliability and validity. RESEARC ... Full text Link to item Cite

Improving primary care for depression in late life: the design of a multicenter randomized trial.

Journal Article Med Care · August 2001 BACKGROUND: Late life depression can be successfully treated with antidepressant medications or psychotherapy, but few depressed older adults receive effective treatment. RESEARCH DESIGN: A randomized controlled trial of a disease management program for la ... Full text Link to item Cite

Treatment of dysthymia and minor depression in primary care: a randomized trial in patients aged 18 to 59 years.

Journal Article J Fam Pract · May 2001 OBJECTIVE: The researchers evaluated the effectiveness of paroxetine and Problem-Solving Treatment for Primary Care (PST-PC) for patients with minor depression or dysthymia. STUDY DESIGN: This was an 11-week randomized placebo-controlled trial conducted in ... Link to item Cite

Journals of the Century in Social Work

Journal Article The Serials Librarian · March 19, 2001 Full text Cite

Status of minor depression or dysthymia in primary care following a randomized controlled treatment.

Journal Article Gen Hosp Psychiatry · 2001 This report describes the rates of recovery and remission from minor depression or dysthymia in primary care patients three months after completing a randomized controlled treatment trial. The subjects were primary care patients who received > or =4 treatm ... Full text Link to item Cite

Treatment of depression [2] multiple letters

Journal Article Journal of Family Practice · January 1, 2001 Cite

Efficacy of newer medications for treating depression in primary care patients

Journal Article British Journal of Clinical Governance · January 1, 2001 Cite

Treatment of mild depression in elderly patients.

Journal Article JAMA · December 20, 2000 Link to item Cite

Treatment of mild depression in elderly patients.

Journal Article JAMA · December 20, 2000 Link to item Cite

Antibiotics for acute maxillary sinusitis

Journal Article Praxis · September 28, 2000 Cite

Treatment of dysthymia and minor depression in primary care: A randomized controlled trial in older adults.

Journal Article JAMA · September 27, 2000 Featured Publication CONTEXT: Insufficient evidence exists for recommendation of specific effective treatments for older primary care patients with minor depression or dysthymia. OBJECTIVE: To compare the effectiveness of pharmacotherapy and psychotherapy in primary care setti ... Full text Link to item Cite

Users' guides to the medical literature: XXIV. How to use an article on the clinical manifestations of disease. Evidence-Based Medicine Working Group.

Journal Article JAMA · August 16, 2000 Clinicians rely on knowledge about the clinical manifestations of disease to make clinical diagnoses. Before using research on the frequency of clinical features found in patients with a disease, clinicians should appraise the evidence for its validity, re ... Full text Link to item Cite

A systematic review of newer pharmacotherapies for depression in adults: evidence report summary.

Journal Article Ann Intern Med · May 2, 2000 BACKGROUND: Depressive disorders are persistent, recurring illnesses that cause great suffering for patients and their families. PURPOSE: To evaluate the benefits and adverse effects of newer pharmacotherapies and herbal treatments for depressive disorders ... Full text Link to item Cite

Antibiotics for acute maxillary sinusitis.

Journal Article Cochrane database of systematic reviews (Online) · 2000 OBJECTIVES: For adults seeking care in ambulatory practices, sinusitis is the most common diagnosis treated with antibiotics. We examined whether antibiotics are indicated for acute sinusitis, and if so, which antibiotic classes are most effective. SEARCH ... Cite

Referrals to psychiatrists. Assessing the communication interface between psychiatry and primary care.

Journal Article Psychosomatics · 2000 The Study of Outpatient Referral Patterns was conducted in 1998 to examine the nature of the communication relationship between psychiatrists and primary care physicians regarding outpatient referrals. Nationally representative psychiatrists were surveyed ... Full text Link to item Cite

The relationship of aging and dysthymia in primary care.

Journal Article Am J Geriatr Psychiatry · 2000 The authors compared symptomatic and functional characteristics between older (age > or =60; n=91) and younger (age 18-59; n=125) primary care patients with dysthymia. Three of six significantly different depression symptoms were of moderate-to-large effec ... Link to item Cite

Efficacy of newer medications for treating depression in primary care patients.

Journal Article Am J Med · January 2000 PURPOSE: Several medications have recently been introduced for the treatment of depression. We reviewed the literature to summarize their efficacy in the treatment of depression in adult patients in primary care settings. METHODS: We searched the literatur ... Full text Link to item Cite

Health promotion research with mexican american elders: Matching approaches to settings at the mediator- and micro-levels of recruitment

Journal Article Journal of Mental Health and Aging · January 1, 2000 Minority elders are inadequately represented in health promotion research. A contributing factor may be that recruitment approaches have not been well adapted to the life experiences of these populations. This article examines recruitment approaches used i ... Cite

Treatment of depression--newer pharmacotherapies.

Journal Article Evid Rep Technol Assess (Summ) · March 1999 Link to item Cite

Characterizing the referral interface between psychiatry and primary care

Conference INTERNATIONAL JOURNAL OF PSYCHIATRY IN MEDICINE · January 1, 1999 Link to item Cite

The treatment effectiveness project. A comparison of the effectiveness of paroxetine, problem-solving therapy, and placebo in the treatment of minor depression and dysthymia in primary care patients: background and research plan.

Journal Article Gen Hosp Psychiatry · 1999 This report describes the background, rationale, and research plan for a comparative treatment trial of the effectiveness of paroxetine, problem-solving therapy (PST-PC), and placebo in the treatment of minor depression and dysthymia in primary care patien ... Full text Link to item Cite

Primary care physicians' approach to depressive disorders. Effects of physician specialty and practice structure.

Journal Article Arch Fam Med · 1999 BACKGROUND: Because primary care physicians (PCPs) are the initial health care contact for most patients with depression, they are in a unique position to provide early detection and integrated care for persons with depression and coexisting medical illnes ... Full text Link to item Cite

Case-finding for depression in primary care: a randomized trial.

Journal Article Am J Med · January 1999 PURPOSE: Depression is a highly prevalent, morbid, and costly illness that is often unrecognized and inadequately treated. Because depression questionnaires have the potential to improve recognition, we evaluated the accuracy and effects on primary care of ... Full text Link to item Cite

The best evidence from ACP Journal Club for general internal medicine, 1999.

Journal Article ACP journal club · January 1, 1999 Cite

Evidence report on: Treatment of depression - Newer pharmacotherapies

Journal Article Psychopharmacology Bulletin · December 1, 1998 Objectives: Depressive disorders are persistent, recurring illnesses that impose enormous personal suffering on individuals and their families. Major depression alone is estimated as the fourth most important cause of worldwide loss in disability-adjusted ... Cite

Targeting depression interviewing.

Journal Article J Gen Intern Med · August 1998 Full text Link to item Cite

Identifying physicians most likely to benefit from depression education

Conference INTERNATIONAL JOURNAL OF PSYCHIATRY IN MEDICINE · January 1, 1998 Link to item Cite

Newer pharmacotherapies for depression in primary care: A literature synthesis

Conference INTERNATIONAL JOURNAL OF PSYCHIATRY IN MEDICINE · January 1, 1998 Link to item Cite

Assessing the referral interface and communication between psychiatry and primary care

Conference INTERNATIONAL JOURNAL OF PSYCHIATRY IN MEDICINE · January 1, 1998 Link to item Cite

The course of depression in primary care.

Conference JOURNAL OF INVESTIGATIVE MEDICINE · January 1, 1998 Link to item Cite

Meeting the needs of primary care physicians: a guide to content for programs on depression.

Journal Article Int J Psychiatry Med · 1998 OBJECTIVE: The purpose of this article is to identify literature-based content for the design of educational programs on depression for practicing primary care physicians. METHODS: A MEDLINE search was conducted of English-language medical literature publi ... Full text Link to item Cite

Treatment of depression--newer pharmacotherapies.

Journal Article Psychopharmacol Bull · 1998 OBJECTIVES: Depressive disorders are persistent, recurring illnesses that impose enormous personal suffering on individuals and their families. Major depression alone is estimated as the fourth most important cause of worldwide loss in disability-adjusted ... Link to item Cite

Serials Cataloging, 1991-1996

Journal Article The Serials Librarian · November 3, 1997 Full text Cite

A practical guide for the diagnosis and treatment of acute sinusitis.

Journal Article CMAJ · March 15, 1997 OBJECTIVE: To develop guidelines for the diagnosis and management of acute sinusitis. OPTIONS: Diagnostic clinical criteria and imaging techniques, the role of antimicrobial therapy and duration of treatment, and the role of adjunct therapy, including deco ... Link to item Cite

Knowledge and attitudes about depression among non-generalists and generalists.

Journal Article J Fam Pract · February 1997 BACKGROUND: The purpose of this study was to learn more about barriers to managing depression by comparing knowledge and attitudes about depression among physicians, internists, obstetrician-gynecologists, and a reference group of psychiatrists. Among the ... Link to item Cite

Reduced blue cone electroretinogram in cocaine-withdrawn patients.

Journal Article Arch Gen Psychiatry · February 1997 BACKGROUND: The main reinforcing effect of cocaine is alteration of dopaminergic neurotransmission in the brain reward systems. Since dopamine is found in high concentrations in the retina, we investigated whether cocaine dependence may be associated with ... Full text Link to item Cite

The relationship of age to dysthymia in primary care

Conference INTERNATIONAL JOURNAL OF PSYCHIATRY IN MEDICINE · January 1, 1997 Link to item Cite

A practical guide for the diagnosis and treatment of acute sinusitis

Journal Article CANADIAN MEDICAL ASSOCIATION JOURNAL · January 1, 1997 Link to item Cite

General internists influence students to choose primary care careers: the power of role modeling.

Journal Article Am J Med · December 1996 PURPOSE: To determine whether medical students supervised by general internist attendings during the third-year medicine clerkship are more likely to choose primary care careers than students supervised by subspecialist attendings. METHODS: One hundred for ... Full text Link to item Cite

Introduction

Journal Article The Serials Librarian · July 1996 Full text Cite

BECK DEPRESSION INVENTORY (VOL 122, PG 913, 1995)

Journal Article ANNALS OF INTERNAL MEDICINE · December 15, 1995 Link to item Cite

Three vs 10 Days of Trimethoprim/Sulfamethoxazole for Acute Maxillary Sinusitis-Reply

Journal Article JAMA: The Journal of the American Medical Association · November 1, 1995 Full text Cite

Case-finding instruments for depression in primary care settings.

Journal Article Ann Intern Med · June 15, 1995 OBJECTIVE: To evaluate the usefulness of case-finding instruments for identifying patients with major depression in primary care settings. DATA SOURCES: A MEDLINE search of the English-language medical literature; bibliographies of selected papers; and exp ... Full text Link to item Cite

Users' Guides to the Medical Literature

Journal Article JAMA · May 24, 1995 Full text Cite

Randomized controlled trial of 3 vs 10 days of trimethoprim/sulfamethoxazole for acute maxillary sinusitis.

Journal Article JAMA · April 5, 1995 OBJECTIVE: To compare 14-day outcomes and relapse and recurrence rates among patients with acute maxillary sinusitis randomized to 3-day (3D) vs 10-day (10D) treatment with trimethoprim/sulfamethoxazole (TMP/SMX). SETTING: University-affiliated Veterans Af ... Link to item Cite

Measuring shoulder function with the Shoulder Pain and Disability Index.

Journal Article J Rheumatol · April 1995 OBJECTIVE: To extend the validity of the Shoulder Pain and Disability Index (SPADI) by (1) making it suitable for telephone administration; (2) determining its convergent validity with other health status measures; and (3) assessing the responsiveness of t ... Link to item Cite

Usual care and outcomes in patients with sinus complaints and normal results of sinus roentgenography.

Journal Article Arch Fam Med · March 1995 OBJECTIVE: To describe the usual care and outcomes of patients with sinus symptoms and normal sinus roentgenograms. DESIGN: Prospective cohort with 60-day follow-up. SETTING: Medical outpatient clinics at a university-affiliated Veterans Affairs medical ce ... Full text Link to item Cite

Depressive disorders in primary care: prevalence, functional disability, and identification.

Journal Article J Gen Intern Med · January 1995 OBJECTIVES: To assess the relative prevalence of subsyndromal depression (SubD) and major depression (MDD) in primary care patients and describe their associated functional impairments, and to define the operating characteristics of a short depression scre ... Full text Link to item Cite

Users' Guides to the Medical Literature

Journal Article JAMA · November 2, 1994 Full text Cite

Performance of case-finding tools for depression in the nursing home: influence of clinical and functional characteristics and selection of optimal threshold scores.

Journal Article J Am Geriatr Soc · October 1994 OBJECTIVE: To compare case-finding tools for depression in the nursing home setting and to evaluate effects of subject function, cognition, and disease number on test performance. DESIGN: Cross-sectional survey. SETTING: One academic and four community hom ... Full text Link to item Cite

Users' Guides to the Medical Literature

Journal Article JAMA · July 20, 1994 Full text Cite

Users' Guides to the Medical Literature

Journal Article JAMA · May 25, 1994 Full text Cite

Epstein-Barr virus DNA is abundant and monoclonal in the Reed-Sternberg cells of Hodgkin's disease: association with mixed cellularity subtype and Hispanic American ethnicity.

Journal Article Blood · March 15, 1994 One hundred twenty-five cases of Hodgkin's disease from the United States (79), Mexico City (31), and Costa Rica (15) were analyzed for the presence of Epstein-Barr virus (EBV) by in situ hybridization to EBER1 transcripts. EBV was more frequently detected ... Link to item Cite

In Reply

Journal Article JAMA: The Journal of the American Medical Association · February 16, 1994 Full text Cite

DOES THIS PATIENT HAVE SINUSITIS - REPLY

Journal Article JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION · February 16, 1994 Link to item Cite

Users' Guides to the Medical Literature

Journal Article JAMA · January 5, 1994 Full text Cite

Current diagnosis and management of sinusitis.

Journal Article J Gen Intern Med · January 1994 Full text Link to item Cite

Users' Guides to the Medical Literature

Journal Article JAMA · December 1, 1993 Full text Cite

Diagnosing sinusitis.

Journal Article Ann Intern Med · July 1, 1993 Full text Link to item Cite

Diagnosing Sinusitis

Journal Article Annals of Internal Medicine · July 1, 1993 Full text Cite

SOCIAL NEEDS AND SUBTHRESHOLD DEPRESSION

Conference CLINICAL RESEARCH · April 1, 1993 Link to item Cite

Serials Cataloging, 1985- 1990

Journal Article The Serials Librarian · November 9, 1992 Full text Cite

Introduction

Journal Article The Serials Librarian · November 9, 1992 Full text Cite

Clinical evaluation for sinusitis. Making the diagnosis by history and physical examination.

Journal Article Ann Intern Med · November 1, 1992 OBJECTIVE: To identify the most useful clinical examination findings for the diagnosis of acute and subacute sinusitis. DESIGN: Prospective comparison of clinical findings with radiographs. SETTING: General medicine clinics at a university-affiliated Veter ... Full text Link to item Cite

In Reply

Journal Article JAMA: The Journal of the American Medical Association · October 28, 1992 Full text Cite

Argon laser treatment of trichiasis.

Journal Article Am J Ophthalmol · September 15, 1992 Full text Link to item Cite

Diagnosing sinusitis by X-ray: is a single Waters view adequate?

Journal Article J Gen Intern Med · 1992 OBJECTIVE: To determine whether a single Waters view (occipito-mental) radiograph could be substituted for a four-view sinus series to diagnose sinusitis, and to determine the inter- and intraobserver variabilities for sinus radiography. DESIGN: Radiograph ... Full text Link to item Cite

The rational clinical examination [1]

Journal Article Journal of the American Medical Association · 1992 Full text Cite

Renal colic. Utility of the plain abdominal roentgenogram.

Journal Article Arch Intern Med · August 1991 We conducted a retrospective cohort study of 85 consecutive symptomatic patients to evaluate the sensitivity, specificity, and predictive value of plain abdominal roentgenography (PAR) compared with clinical evaluation alone in diagnosis and treatment of r ... Full text Link to item Cite

MEDICAL WASTE-DISPOSAL IN THE HOME CARE SETTING

Journal Article JOURNAL OF THE AMERICAN GERIATRICS SOCIETY · August 1, 1991 Link to item Cite

Serials Cataloging in 1989

Journal Article The Serials Librarian · June 1991 Full text Cite

LACK OF SEASONAL VARIABILITY FOR ACUTE AND SUBACUTE SINUSITIS

Journal Article CLINICAL RESEARCH · April 1, 1991 Link to item Cite

Serials Cataloging Trends and Developments

Journal Article The Serials Librarian · August 2, 1990 Full text Cite

Diagnosis of major depression in cancer patients according to four sets of criteria.

Journal Article Am J Psychiatry · August 1990 Diagnoses of major depression in 152 cancer patients differed as much as 13% depending on the diagnostic system used. The Beck Depression Inventory and the Hamilton Rating Scale for Depression were useful tools for screening patients with depressive sympto ... Full text Link to item Cite

Distress associated with cancer as measured by the illness distress scale.

Journal Article Psychosomatics · 1990 Over 400 cancer patients were given the Illness Distress Scale (IDS), a brief measure of the physical and emotional distress related to serious illness. Physical manifestations of the disease proved to be the source of greatest discomfort among these patie ... Full text Link to item Cite

Serials Cataloging in 1987

Journal Article The Serials Librarian · November 1988 Full text Cite

Serials Cataloging in 1986

Journal Article The Serials Librarian · November 1987 Full text Cite

Serials Cataloging with AACR2

Journal Article The Serials Librarian · August 24, 1987 Full text Cite

STRUCTURE-ACTIVITY-RELATIONSHIPS OF INSECTICIDES UTILIZING AN NMR METHOD FOR ESTIMATING SIGMA-STAR

Conference ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY · 1987 Cite

Methyldopa therapy and outcome in cadaveric renal transplantation.

Journal Article South Med J · September 1985 Methyldopa therapy for hypertension after renal transplantation could affect graft outcome adversely, since methyldopa inhibits suppressor cells. To study effects of methyldopa on transplant outcome, we analyzed prospective data on 1,648 hypertensive, firs ... Full text Link to item Cite

MYOFIBRILLAR ULTRASTRUCTURE AND MORPHOMETRY IN POULTRY

Conference JOURNAL OF ELECTRON MICROSCOPY TECHNIQUE · 1985 Cite

Bacterial removal of mercury from sewage.

Journal Article Biotechnol Bioeng · November 1984 Mercury-resistant bacteria, which are able to reduce mercuric ion (Hg(2+)) to metallic mercury (Hg(0)), were examined for their ability to remove mercury from waste-water aerobically. Growth studies in artificial medium indicated that mercury increases the ... Full text Link to item Cite

Pre-1950 Serials in OCLC

Journal Article The Serials Librarian · May 7, 1984 Full text Cite

TRANSPLANTATION OF THE LIVER AND CURRENT PROBLEMS OF TREATMENT

Conference SOUTHERN MEDICAL JOURNAL · 1983 Cite

Serum dehydroepiandrosterone (DHA) and sulphate (DHAS) after acute growth hormone therapy.

Journal Article Acta Paediatr Scand · May 1980 To test the hypothesis that growth hormone (hGH) may increase adrenal androgen production dehydroepiandrosterone (DHA) and its sulphate (DHAS) concentrations were measured by radioimmunoassay in the serum from 7 children with growth hormone deficiency, 2 o ... Full text Link to item Cite

A study of pituitary function in patients with idiopathic hemochromatosis.

Journal Article J Clin Endocrinol Metab · October 1976 Pituitary function was assessed in twelve male patients with idiopathic hemochromatosis. Though clinical features suggestive of hypogonadism were noted in nine cases, impaired pituitary function was demonstrated in only two instances. Our findings suggest ... Full text Link to item Cite

Luteinizing release hormone tests in impotent diabetic males.

Journal Article Diabetes · October 1976 Assessment of pituitary-gonadal function was made in impotent diabetic males using luteinizing hormone-release hormone tests. Serum testosterone, sex-hormone-binding globulin capacity, and basal and incremental gonadotrophin concentrations in the impotent ... Full text Link to item Cite

A radioimmunoassay for the estimation of serum dehydroepiandrosterone sulphate in normal and pathological sera.

Journal Article Clin Chim Acta · November 15, 1975 A radioimmunoassay is described for the measurement of dehydroepiandrosterone sulphate in serum. The method requires 0.1 ml of serum that needs no purification other than a single ether extraction. It is both rapid and economical, procedural losses are sma ... Full text Link to item Cite

Sex hormone levels and gonadotrophin release in the polycystic ovary syndrome.

Journal Article Clin Endocrinol (Oxf) · May 1975 The response to synthetic luteinizing hormone-releasing hormone was studied in eighteen patients with the polycystic ovary syndrome. The release of follicle-stimulating hormone was similar to that found in normal women. The mean response of luteinizing hor ... Full text Link to item Cite