Scholars@Duke
Christopher Ryan Kelsey

Christopher Ryan Kelsey

Professor of Radiation Oncology
Radiation Oncology
kelse003@mc.duke.edu
Radiation Oncology, Box 3085, Durham, NC 27710
30 Duke Medicine Circle, Room 05125A, Durham, NC 27710

Selected Publications

ASTCT and USCLC Clinical Practice Recommendations for Allogeneic Stem Cell Transplant in Mycosis Fungoides and Sézary Syndrome.

Journal Article Transplant Cell Ther · November 2024 Mycosis fungoides (MF) and Sézary syndrome (SS) are the most common subtypes of cutaneous T-cell lymphoma (CTCL). While MF generally follows an indolent course, a subset of patients will experience progressive and/or treatment-refractory disease; Sézary sy ... Full text Link to item Cite

Quantifying Regional Radiation-Induced Lung Injury in Patients Using Hyperpolarized 129Xe Gas Exchange Magnetic Resonance Imaging.

Journal Article Int J Radiat Oncol Biol Phys · September 1, 2024 PURPOSE: Radiation-induced lung injury has been shown to alter regional ventilation and perfusion in the lung. However, changes in regional pulmonary gas exchange have not previously been measured. METHODS AND MATERIALS: Ten patients receiving conventional ... Full text Link to item Cite

International Prognostic Score for Nodular Lymphocyte-Predominant Hodgkin Lymphoma.

Journal Article J Clin Oncol · July 1, 2024 PURPOSE: Nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) is a rare cancer, and large international cooperative efforts are needed to evaluate the significance of clinical risk factors and immunoarchitectural patterns (IAPs) for all stages of pediat ... Full text Link to item Cite

Radiotherapy for Advanced Hodgkin Lymphoma with Initial Bulk: A Combined Analysis of Two Randomized Trials.

Journal Article Adv Radiat Oncol · May 2024 PURPOSE: The role of consolidative radiation therapy (RT) in patients with advanced Hodgkin lymphoma with initial bulk is unclear. GITIL/FIL HD0607 and FIL HD0801, 2 randomized controlled trials with similar design and methodologies, did not identify a ben ... Full text Link to item Cite

Lymphomas

Chapter · February 19, 2024 For some hematologic malignancies, particularly Hodgkin lymphoma, larger radiation therapy (RT) fields were the historical norm. Advances in systemic therapy, imaging, and RT techniques have prompted an evolution in RT field design. In the context of more ... Full text Cite

NCCN Guidelines® Insights: B-Cell Lymphomas, Version 6.2023.

Journal Article J Natl Compr Canc Netw · November 2023 Novel targeted therapies (small molecule inhibitors, antibody-drug conjugates, and CD19-directed therapies) have changed the treatment landscape of relapsed/refractory B-cell lymphomas. Bruton's tyrosine kinase (BTK) inhibitors continue to evolve in the ma ... Full text Link to item Cite

Dose-Limiting Pulmonary Toxicity in a Phase 1/2 Study of Radiation and Chemotherapy with Ipilimumab Followed by Nivolumab for Patients With Stage 3 Unresectable Non-Small Cell Lung Cancer.

Journal Article International journal of radiation oncology, biology, physics · July 2023 PurposeWe hypothesized that concurrent ipilimumab with chemoradiationtherapy (chemoRT) followed by maintenance nivolumab would be safe for patients with unresectable stage III non-small cell lung cancer (NSCLC). We aimed to assess the safety (phas ... Full text Cite

Uncertainties in the dosimetric heterogeneity correction and its potential effect on local control in lung SBRT.

Journal Article Biomed Phys Eng Express · March 7, 2023 Objective. Dose calculation in lung stereotactic body radiation therapy (SBRT) is challenging due to the low density of the lungs and small volumes. Here we assess uncertainties associated with tissue heterogeneities using different dose calculation algori ... Full text Link to item Cite

Surgical Evaluation in Patients Undergoing Radiation Therapy for Early-Stage Lung Cancer.

Journal Article Ann Thorac Surg · February 2023 BACKGROUND: Stereotactic body radiation therapy (SBRT) is used to treat stage I non-small cell lung cancer (NSCLC) in nonsurgical candidates, although guidelines specify that inoperability be determined in multidisciplinary fashion. We characterized NSCLC ... Full text Link to item Cite

Divergent Interpretations of Imaging After Stereotactic Body Radiation Therapy for Lung Cancer.

Journal Article Pract Radiat Oncol · 2023 PURPOSE: Conflicting information from health care providers contributes to anxiety among cancer patients. The purpose of this study was to investigate discordant interpretations of follow-up imaging studies after lung stereotactic body radiation therapy (S ... Full text Link to item Cite

View-sharing for 4D magnetic resonance imaging with randomized projection-encoding enables improvements of respiratory motion imaging for treatment planning in abdominothoracic radiotherapy.

Journal Article Phys Imaging Radiat Oncol · January 2023 BACKGROUND AND PURPOSE: The accuracy and precision of radiation therapy are dependent on the characterization of organ-at-risk and target motion. This work aims to demonstrate a 4D magnetic resonance imaging (MRI) method for improving spatial and temporal ... Full text Link to item Cite

Optimizing Management of the Central Nervous System in Patients with Acute Lymphoblastic Leukemia Undergoing Allogeneic Stem Cell Transplantation.

Journal Article Adv Radiat Oncol · 2023 PURPOSE: To evaluate clinical outcomes and patterns of failure, specifically in regards to the central nervous system (CNS), in patients with acute lymphoblastic leukemia (ALL) undergoing allogeneic hematopoietic stem cell transplantation (HSCT) using tota ... Full text Link to item Cite

Long-term outcomes with reduced-dose whole-brain radiotherapy and a stereotactic radiosurgery boost for primary central nervous system lymphoma.

Journal Article Neurooncol Adv · 2023 BACKGROUND: Primary central nervous system lymphoma (PCNSL) is an aggressive diffuse large B-cell lymphoma. Treatment approaches are historically associated with neurotoxicity, particularly with high-dose whole-brain radiotherapy (WBRT). We hypothesized th ... Full text Link to item Cite

Role of Postoperative Radiation Therapy in Non-Small Cell Lung Cancer

Chapter · January 1, 2023 Patients who undergo surgery for non-small cell lung cancer are at relatively high risk of local/regional recurrence, especially those with involved mediastinal lymph nodes. Postoperative radiation therapy (PORT) has been shown to decrease the risk of loca ... Full text Cite

Development of a multi-feature-combined model: proof-of-concept with application to local failure prediction of post-SBRT or surgery early-stage NSCLC patients.

Journal Article Front Oncol · 2023 OBJECTIVE: To develop a Multi-Feature-Combined (MFC) model for proof-of-concept in predicting local failure (LR) in NSCLC patients after surgery or SBRT using pre-treatment CT images. This MFC model combines handcrafted radiomic features, deep radiomic fea ... Full text Link to item Cite

The Evolving Role of Radiation Therapy in DLBCL: From Early-Stage to Refractory Disease.

Journal Article Oncology (Williston Park) · December 20, 2022 Diffuse large B-cell lymphoma (DLBCL) is the most common subtype of non-Hodgkin lymphoma. Historically, radiation therapy (RT) served as the primary treatment modality for patients with localized disease. While still an option for select patients who are n ... Full text Link to item Cite

Tumor Size, Histology, and Survival After Stereotactic Ablative Radiotherapy and Sublobar Resection in Node-negative Non-small Cell Lung Cancer.

Journal Article Ann Surg · December 1, 2022 BACKGROUND: Although SABR is increasingly emerging as an alternative to surgery for node-negative non-small cell lung cancer, there is poor understanding of patients who may most benefit SABR compared to surgery. OBJECTIVE: This study examined the relation ... Full text Link to item Cite

NCCN Guidelines® Insights: Hodgkin Lymphoma, Version 2.2022.

Journal Article Journal of the National Comprehensive Cancer Network : JNCCN · April 2022 Hodgkin lymphoma (HL) is an uncommon malignancy of B-cell origin. Classical HL (cHL) and nodular lymphocyte-predominant HL are the 2 main types of HL. The cure rates for HL have increased so markedly with the advent of modern treatment options that overrid ... Full text Cite

Nomogram Predicting Overall Survival Benefit of Stereotactic Ablative Radiotherapy for Early-Stage Non-Small Cell Lung Cancer.

Journal Article Clin Lung Cancer · March 2022 OBJECTIVES: To develop and validate a nomogram that predicts overall survival (OS) for patients with early-stage non-small cell lung cancer (NSCLC) treated with stereotactic ablative radiotherapy (SABR) vs. observation. MATERIALS AND METHODS: Adults with b ... Full text Link to item Cite

The Effect of Various Dose Normalization Strategies When Implementing Linear Boltzmann Transport Equation Dose Calculation for Lung Stereotactic Body Radiation Therapy Planning.

Journal Article Pract Radiat Oncol · 2022 PURPOSE: To explore implications of various plan normalizations when implementing a linear Boltzmann transport equation solver dose calculation algorithm (LBTE) for lung stereotactic body radiation therapy (SBRT). METHODS AND MATERIALS: Eighty-seven plans ... Full text Link to item Cite

Hyperpolarized 129Xe Magnetic Resonance Imaging for Functional Avoidance Treatment Planning in Thoracic Radiation Therapy: A Comparison of Ventilation- and Gas Exchange-Guided Treatment Plans.

Journal Article Int J Radiat Oncol Biol Phys · November 15, 2021 PURPOSE: To present a methodology to use pulmonary gas exchange maps to guide functional avoidance treatment planning in radiation therapy (RT) and evaluate its efficacy compared with ventilation-guided treatment planning. METHODS AND MATERIALS: Before rec ... Full text Link to item Cite

NCCN Guidelines® Insights: B-Cell Lymphomas, Version 5.2021.

Journal Article J Natl Compr Canc Netw · November 2021 In the last decade, a better understanding of the molecular pathogenesis of B-cell non-Hodgkin lymphomas has resulted in the development of novel targeted therapies, such as small molecule inhibitors of select kinases in the B-cell receptor pathway, antibo ... Full text Link to item Cite

Prospective Phase I/II Study of Radiation and Chemotherapy With Ipilimumab Followed by Nivolumab for Patients With Stage III Unresectable NSCLC.

Conference International journal of radiation oncology, biology, physics · November 2021 Purpose/objective(s)We hypothesized that the addition of concurrent ipilimumab (IPI) with chemoradiotherapy followed by consolidative nivolumab (NIVO) would be safe and tolerable for patients with unresectable stage III non-small cell lung cancer ... Full text Cite

Interpreting Post-SBRT Lung Imaging: A Comparison of Radiology and Radiation Oncology Impressions.

Conference International journal of radiation oncology, biology, physics · November 2021 Purpose/objective(s)Stereotactic body radiation therapy (SBRT) is an established treatment option for stage I non-small cell lung cancer. SBRT often causes acute inflammatory changes in the lung as well as chronic fibrosis. These radiologic findin ... Full text Cite

GRECO-1: Phase 1/2 Study of Stereotactic Body Radiation Therapy (SBRT) With or Without GC4711 for Early Stage, Centrally Located or Large Non-Small Cell Lung Cancer (NSCLC).

Conference International journal of radiation oncology, biology, physics · November 2021 Purpose/objective(s)The number of patients diagnosed with early-stage NSCLC has been increasing with screening programs and more frequent thoracic imaging. Many patients are not ideal surgical candidates and SBRT offers an effective alternative. S ... Full text Cite

Primary Mediastinal (Thymic) Large B-Cell Lymphoma: Fidelity of Diagnosis Using WHO Criteria.

Journal Article Clin Lymphoma Myeloma Leuk · May 2021 PURPOSE: Diagnosing primary mediastinal (thymic) large B-cell lymphoma (PMBCL) is challenging because it is a clinicopathologic entity that shares characteristics with other lymphomas and lacks pathognomonic features. We sought to investigate the fidelity ... Full text Link to item Cite

Radiogenomic Analysis of Locally Advanced Lung Cancer Based on CT Imaging and Intratreatment Changes in Cell-Free DNA.

Journal Article Radiol Imaging Cancer · April 2021 The radiologic appearance of locally advanced lung cancer may be linked to molecular changes of the disease during treatment, but characteristics of this phenomenon are poorly understood. Radiomics, liquid biopsy of cell-free DNA (cfDNA), and next-generati ... Full text Link to item Cite

Synergy between early-incorporation immunotherapy and extracranial radiotherapy in metastatic non-small cell lung cancer.

Journal Article Transl Lung Cancer Res · January 2021 BACKGROUND: Combining radiotherapy (RT) and immunotherapy (IT) may enhance outcomes for metastatic non-small cell lung cancer (mNSCLC). However, data on the immunomodulatory effects of extracranial RT remains limited. This retrospective database analysis e ... Full text Link to item Cite

Recumbent Total Skin Electron Beam Therapy.

Journal Article Adv Radiat Oncol · 2021 PURPOSE: Our purpose was to describe preliminary dosimetric and clinical results of a recumbent total skin electron beam therapy (TSEBT) technique and compare this to a conventional standing TSEBT technique. METHODS AND MATERIALS: A customized treatment pl ... Full text Link to item Cite

Effective Pain Control With Very Low Dose Palliative Radiation Therapy for Patients With Multiple Myeloma With Uncomplicated Osseous Lesions.

Journal Article Adv Radiat Oncol · 2021 BACKGROUND: Osteolytic lesions are present in 75% of patients with multiple myeloma (MM) and frequently require palliation with radiation therapy (RT). Prior case series of patients with MM with bone pain undergoing palliative RT suggests doses ≥12 Gy (equ ... Full text Link to item Cite

Outcomes in Patients With 4 to 10 Brain Metastases Treated With Dose-Adapted Single-Isocenter Multitarget Stereotactic Radiosurgery: A Prospective Study.

Journal Article Adv Radiat Oncol · 2021 PURPOSE: To examine the effectiveness and safety of single-isocenter multitarget stereotactic radiosurgery using a volume-adapted dosing strategy in patients with 4 to 10 brain metastases. METHODS AND MATERIALS: Adult patients with 4 to 10 brain metastases ... Full text Link to item Cite

Stage I-II nodular lymphocyte-predominant Hodgkin lymphoma: a multi-institutional study of adult patients by ILROG.

Journal Article Blood · June 25, 2020 Nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) is an uncommon histologic variant, and the optimal treatment of stage I-II NLPHL is undefined. We conducted a multicenter retrospective study including patients ≥16 years of age with stage I-II NLPHL ... Full text Link to item Cite

Definitive Radiotherapy for Inoperable Stage IIB Non-small-cell Lung Cancer: Patterns of Care and Comparative Effectiveness.

Journal Article Clin Lung Cancer · May 2020 BACKGROUND: The purpose of this study was to analyze practice patterns and perform comparative effectiveness of definitive radiotherapy techniques for inoperable stage IIB (American Joint Committee on Cancer eighth edition) non-small-cell lung cancer (NSCL ... Full text Link to item Cite

Excessive Exposure.

Journal Article Int J Radiat Oncol Biol Phys · March 1, 2020 Full text Link to item Cite

Primary Mediastinal (Thymic) Large B-cell Lymphoma: The Working Diagnosis vs WHO Classification Criteria

Conference INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS · 2020 Cite

Knowledge Models as Teaching Aid for Training Intensity Modulated Radiation Therapy Planning: A Lung Cancer Case Study.

Journal Article Front Artif Intell · 2020 Purpose: Artificial intelligence (AI) employs knowledge models that often behave as a black-box to the majority of users and are not designed to improve the skill level of users. In this study, we aim to demonstrate the feasibility that AI can serve as an ... Full text Link to item Cite

Phase 2 Study of Dose-Reduced Consolidation Radiation Therapy in Diffuse Large B-Cell Lymphoma.

Journal Article Int J Radiat Oncol Biol Phys · September 1, 2019 PURPOSE: To evaluate the feasibility of reducing the dose of consolidation radiation therapy (RT) in diffuse large B-cell lymphoma. METHODS AND MATERIALS: This phase 2 study enrolled patients with diffuse large B-cell lymphoma, not otherwise specified and ... Full text Link to item Cite

Identification of Radiomic Biomarkers for Patients with Locally Advanced Lung Cancer

Conference International Journal of Radiation Oncology*Biology*Physics · September 2019 Full text Cite

Analysis of Minimum GTV/ITV to 100 Gy BED Isodose Distance as a Risk Factor for Local Failure after SBRT for NSCLC

Conference International Journal of Radiation Oncology*Biology*Physics · September 2019 Full text Cite

Analysis of Dosimetric and Clinical Risk Factors Predicting Chest Wall Toxicity after SBRT for NSCLC

Conference International Journal of Radiation Oncology*Biology*Physics · September 2019 Full text Cite

An Exploratory Radiomics Approach to Quantifying Pulmonary Function in CT Images.

Journal Article Sci Rep · August 8, 2019 Contemporary medical imaging is becoming increasingly more quantitative. The emerging field of radiomics is a leading example. By translating unstructured data (i.e., images) into structured data (i.e., imaging features), radiomics can potentially characte ... Full text Open Access Link to item Cite

NCCN Guidelines Insights: B-Cell Lymphomas, Version 3.2019.

Journal Article J Natl Compr Canc Netw · June 1, 2019 Diffuse large B-cell lymphomas (DLBCLs) and follicular lymphoma (FL) are the most common subtypes of B-cell non-Hodgkin's lymphomas in adults. Histologic transformation of FL to DLBCL (TFL) occurs in approximately 15% of patients and is generally associate ... Full text Link to item Cite

Association of pre-treatment radiomic features with lung cancer recurrence following stereotactic body radiation therapy.

Journal Article Phys Med Biol · January 8, 2019 The purpose of this work was to investigate the potential relationship between radiomic features extracted from pre-treatment x-ray CT images and clinical outcomes following stereotactic body radiation therapy (SBRT) for non-small-cell lung cancer (NSCLC). ... Full text Open Access Link to item Cite

Are Higher Doses of Consolidation Radiation Therapy Necessary in Diffuse Large B-cell Lymphoma Involving Osseous Sites?

Journal Article Adv Radiat Oncol · 2019 PURPOSE: This study aimed to evaluate whether higher doses of consolidation radiation therapy (RT), which have been traditionally recommended for osseous sites in diffuse large B-cell lymphoma (DLBCL), are still necessary. METHODS AND MATERIALS: Patients w ... Full text Link to item Cite

Impact of Esophageal Motion on Dosimetry and Toxicity With Thoracic Radiation Therapy.

Journal Article Technol Cancer Res Treat · 2019 PURPOSE: To investigate the impact of intra- and inter-fractional esophageal motion on dosimetry and observed toxicity in a phase I dose escalation study of accelerated radiotherapy with concurrent chemotherapy for locally advanced lung cancer. METHODS AND ... Full text Open Access Link to item Cite

Dynamic Changes in Circulating Tumor DNA During Chemoradiation for Locally Advanced Lung Cancer.

Journal Article Adv Radiat Oncol · 2019 PURPOSE: Concurrent chemoradiation therapy (CRT) is the principal treatment modality for locally advanced lung cancer. Cell death due to CRT leads to the release of cell-free DNA (cfDNA) and circulating tumor DNA (ctDNA) into the bloodstream, but the kinet ... Full text Link to item Cite

Durable Control of Mycosis Fungoides after Sepsis: "Coley's Toxin?" Case Report and Review of the Literature.

Journal Article Case Rep Hematol · 2019 Mycosis fungoides, along with Sezary syndrome, is the most common subtype of cutaneous T-cell lymphoma. In this report, we present a patient with advanced-stage mycosis fungoides, who after successful treatment of methicillin-resistant Staphylococcus aureu ... Full text Link to item Cite

Hyperpolarized 129 Xe gas transfer MRI: the transition from 1.5T to 3T.

Journal Article Magn Reson Med · December 2018 PURPOSE: Hyperpolarized 129 Xe MRI depicting 3D ventilation, interstitial barrier uptake, and transfer to red blood cells (RBCs) has emerged as a powerful new means of detecting pulmonary disease. However, given the challenging susceptibility environment o ... Full text Link to item Cite

Spatial-temporal variability of radiomic features and its effect on the classification of lung cancer histology.

Journal Article Phys Med Biol · November 8, 2018 The purpose of this research was to study the sensitivity of Computed Tomography (CT) radiomic features to motion blurring and signal-to-noise ratios (SNR), and investigate its downstream effect regarding the classification of non-small cell lung cancer (N ... Full text Open Access Link to item Cite

Stereotactic body radiation therapy versus sublobar resection for stage I NSCLC.

Journal Article Lung Cancer · November 2018 PURPOSE: To compare sublobar resection and stereotactic body radiation therapy (SBRT) in patients with stage I non-small cell lung cancer (NSCLC). METHODS: Patients undergoing sublobar resection or SBRT for stage I NSCLC from 2007 to 2014 at Duke Universit ... Full text Link to item Cite

Commissioning and Clinical Implementation of a Laying Down Technique for Total Skin Irradiation

Conference International Journal of Radiation Oncology*Biology*Physics · November 2018 Full text Cite

Patterns of Failure with SBRT Versus Sublobar Resection for Stage I NSCLC

Conference International Journal of Radiation Oncology*Biology*Physics · November 2018 Full text Cite

Are Higher Doses of Consolidation Radiation Therapy Necessary for Diffuse Large B-Cell Lymphoma Eith Osseous Involvement

Conference International Journal of Radiation Oncology*Biology*Physics · November 2018 Full text Cite

Correlation of Regional Lung Ventilation and Gas Transfer to Red Blood Cells: Implications for Functional-Avoidance Radiation Therapy Planning.

Journal Article Int J Radiat Oncol Biol Phys · August 1, 2018 PURPOSE: To investigate the degree to which lung ventilation and gas exchange are regionally correlated, using the emerging technology of hyperpolarized (HP)-129Xe magnetic resonance imaging (MRI). METHODS AND MATERIALS: Hyperpolarized-129Xe MRI studies we ... Full text Link to item Cite

Radiation Therapy for Solitary Plasmacytoma and Multiple Myeloma: Guidelines From the International Lymphoma Radiation Oncology Group.

Journal Article Int J Radiat Oncol Biol Phys · July 15, 2018 PURPOSE: To develop guidelines for the work-up and radiation therapy (RT) management of patients with plasma cell neoplasms. METHODS AND MATERIALS: A literature review was conducted covering staging, work-up, and RT management of plasma cell neoplasms. Gui ... Full text Link to item Cite

Chemotherapy or Combined Modality Therapy for Early-stage Hodgkin Lymphoma.

Journal Article Anticancer Res · May 2018 BACKGROUND/AIM: Optimizing treatment of early-stage Hodgkin lymphoma (HL) requires balancing cure with potential acute and late toxicities from treatment. We reviewed our institutional experience with chemotherapy alone (ChT) versus combined modality thera ... Full text Link to item Cite

Role of Radiation Therapy in Patients With Relapsed/Refractory Diffuse Large B-Cell Lymphoma: Guidelines from the International Lymphoma Radiation Oncology Group.

Journal Article Int J Radiat Oncol Biol Phys · March 1, 2018 Approximately 30% to 40% of patients with diffuse large B-cell lymphoma (DLBCL) will have either primary refractory disease or relapse after chemotherapy. In transplant-eligible patients, those with disease sensitive to salvage chemotherapy will significan ... Full text Link to item Cite

Text messaging and activity tracker motivation program to increase physical activity in cancer survivors.

Conference Journal of Clinical Oncology · March 1, 2018 92 Background: Cancer survivors have high rates of sedentary behavior leading to obesity and cardiovascular disease. Physical activity improves quality of life (QOL) and reduces morbidity and mortality. However, cancer survivors ... Full text Cite

Surgery versus stereotactic body radiation therapy for stage I non-small cell lung cancer: A comprehensive review.

Journal Article Cancer · February 15, 2018 Non-small cell lung cancer (NSCLC) is the leading cause of cancer-related death in the United States. With the implementation of lung cancer screening, the number and proportion of patients diagnosed with early-stage disease are anticipated to increase. Su ... Full text Link to item Cite

Functional airway obstruction observed with hyperpolarized 129 Xenon-MRI.

Journal Article J Med Imaging Radiat Oncol · February 2018 Hyperpolarized 129 Xenon-MRI (HP 129 Xe MRI) is an emerging imaging modality that allows assessment of both ventilation and gas transfer. Most research to date has focused on non-malignant pulmonary diseases. However, the capability of evaluating the two p ... Full text Link to item Cite

Consolidation Radiation Therapy for Patients With Advanced Hodgkin Lymphoma in Complete Metabolic Response According to PET-CT or Gallium Imaging.

Journal Article Clin Lymphoma Myeloma Leuk · February 2018 INTRODUCTION: The purpose of this study was to evaluate the role of consolidation radiation therapy (RT) in advanced Hodgkin lymphoma (HL) in the setting of a complete metabolic response (CR) to chemotherapy (ChT). PATIENTS AND METHODS: Patients with stage ... Full text Link to item Cite

Phase 2 Study of Dose-Reduced Consolidation Radiation Therapy in Patients With Diffuse Large B-cell Lymphoma

Conference International Journal of Radiation Oncology*Biology*Physics · October 2017 Full text Cite

Impact of Esophageal Motion on Dosimetry and Toxicity for Lung Radiation Therapy

Conference International Journal of Radiation Oncology*Biology*Physics · October 2017 Full text Cite

SBRT Versus Sublobar Resection for Stage I NSCLC

Conference International Journal of Radiation Oncology*Biology*Physics · October 2017 Full text Cite

Dynamic Changes in Cell-Free DNA During Chemoradiation for Non–small Cell Lung Cancer

Conference International Journal of Radiation Oncology*Biology*Physics · October 2017 Full text Cite

Uncertainties of IGRT for lung cancer

Chapter · September 18, 2017 Accurate dose delivery is critical to achieve an optimal risk/benefit profile. Complicating this, are many uncertainties present throughout the process of staging, treatment planning, and implementation. Treatment delivery accuracy is critical for lung can ... Cite

Patterns of Failure After Surgery for Non-Small-cell Lung Cancer Invading the Chest Wall.

Journal Article Clin Lung Cancer · July 2017 INTRODUCTION: The patterns of failure after resection of non-small-cell lung cancer (NSCLC) invading the chest wall are not well documented, and the role of adjuvant radiation therapy (RT) is unclear, prompting the present analysis. MATERIALS AND METHODS: ... Full text Link to item Cite

Surgery Versus Optimal Medical Management for N1 Small Cell Lung Cancer.

Journal Article Ann Thorac Surg · June 2017 BACKGROUND: Adjuvant chemotherapy has been demonstrated to improve the outcomes of patients with N1 non-small cell lung cancer. It is unknown whether patients previously thought to have unresectable small cell lung cancer (SCLC) may have tumors amenable to ... Full text Link to item Cite

Effects of Motion on Radiomics Analysis of Thoracic Cancers.

Journal Article Int J Radiat Oncol Biol Phys · May 1, 2017 Full text Link to item Cite

NCCN Guidelines Insights: Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma, Version 1.2017.

Journal Article J Natl Compr Canc Netw · March 2017 Chronic lymphocytic leukemia (CLL) and small lymphocytic lymphoma (SLL) are different manifestations of the same disease and managed in much the same way. The advent of novel CD20 monoclonal antibodies led to the development of effective chemoimmunotherapy ... Full text Link to item Cite

Plasma Metabolites and Risk of Radiation-induced Esophagitis: A Secondary Analysis from a Prospective Study.

Journal Article Anticancer Res · February 2017 AIM: Metabolic profiling was performed on plasma samples obtained prior to and during radiation therapy (RT) for locally advanced lung cancer to identify metabolites predictive of RT-induced esophagitis. PATIENTS AND METHODS: Patients received cisplatin/et ... Full text Link to item Cite

Patterns of Distant Metastases After Surgical Management of Non-Small-cell Lung Cancer.

Journal Article Clin Lung Cancer · January 2017 BACKGROUND: Patients with limited metastases, oligometastases (OMs), might have improved outcomes compared with patients with widespread distant metastases (DMs). The incidence and behavior of OMs from non-small-cell lung cancer (NSCLC) need further charac ... Full text Link to item Cite

Leukemia and lymphoma

Journal Article Medical Radiology · January 1, 2017 Leukemias and lymphomas comprise a diverse collection of malignancies with unique clinical behavior. Radiation therapy plays an integral role in the definitive, adjuvant, and palliative management of these hematologic malignancies. As opposed to most epith ... Full text Cite

Dosimetric advantages of intensity modulated radiation therapy in locally advanced lung cancer.

Journal Article Adv Radiat Oncol · 2017 PURPOSE: Radiation therapy plays an essential role in the treatment of locally advanced lung cancer, but it inevitably leads to incidental and unnecessary dose to critical organs, including the lung, heart, and esophagus. Numerous radiation dose-volumetric ... Full text Link to item Cite

Stereotactic body radiation therapy for early-stage non-small cell lung cancer: Executive Summary of an ASTRO Evidence-Based Guideline.

Journal Article Pract Radiat Oncol · 2017 PURPOSE: This guideline presents evidence-based recommendations for stereotactic body radiation therapy (SBRT) in challenging clinical scenarios in early-stage non-small cell lung cancer (NSCLC). METHODS AND MATERIALS: The American Society for Radiation On ... Full text Link to item Cite

NCCN Guidelines Insights: Non-Hodgkin's Lymphomas, Version 3.2016.

Journal Article J Natl Compr Canc Netw · September 2016 Peripheral T-cell lymphomas (PTCLs) represent a relatively uncommon heterogeneous group of non-Hodgkin's lymphomas (NHLs) with an aggressive clinical course and poor prognosis. Anthracycline-based multiagent chemotherapy with or without radiation therapy f ... Full text Link to item Cite

Toxicity of definitive and post-operative radiation following ipilimumab in non-small cell lung cancer.

Journal Article Lung Cancer · August 2016 To determine the feasibility and toxicity of radiation therapy, delivered either as definitive treatment or following surgery, following neo-adjuvant immune checkpoint inhibition for locally advanced NSCLC sixteen patients who received neo-adjuvant chemoth ... Full text Link to item Cite

Diffuse Large B-Cell Lymphoma Version 1.2016.

Journal Article J Natl Compr Canc Netw · February 2016 Diffuse large B-cell lymphomas (DLBCL) are now considered a heterogeneous group of distinct molecular subtypes (germinal center B-cell DLBCL, activated B-cell DLBCL, and primary mediastinal large B-cell lymphoma (PMBL) with varied natural history and respo ... Full text Link to item Cite

Adaptive planning using positron emission tomography for locally advanced lung cancer: A feasibility study.

Journal Article Pract Radiat Oncol · 2016 PURPOSE: To evaluate the feasibility of adaptive planning using positron emission tomography-computed tomography (PET-CT) in locally advanced non-small cell lung cancer. METHODS AND MATERIALS: Patients with locally advanced non-small cell lung cancer recei ... Full text Link to item Cite

Myeloablative conditioning with total body irradiation for AML: Balancing survival and pulmonary toxicity.

Conference Adv Radiat Oncol · 2016 PURPOSE: The purpose of this study was to compare leukemia-free survival (LFS) and other clinical outcomes in patients with acute myelogenous leukemia who underwent a myeloablative allogeneic stem cell transplant with and without total body irradiation (TB ... Full text Open Access Link to item Cite

Phase 1 Dose Escalation Study of Accelerated Radiation Therapy With Concurrent Chemotherapy for Locally Advanced Lung Cancer.

Journal Article Int J Radiat Oncol Biol Phys · December 1, 2015 PURPOSE: To determine the maximum tolerated dose of radiation therapy (RT) given in an accelerated fashion with concurrent chemotherapy using intensity modulated RT. METHODS AND MATERIALS: Patients with locally advanced lung cancer (non-small cell and smal ... Full text Link to item Cite

Phase 1 Dose-Escalation Study of Accelerated Fractionation and Concurrent Chemotherapy for Locally Advanced Lung Cancer

Conference International Journal of Radiation Oncology*Biology*Physics · November 2015 Full text Cite

A Prospective Study of Adaptive Planning Utilizing Interim PET-CT for Locally Advanced Lung Cancer

Conference International Journal of Radiation Oncology*Biology*Physics · November 2015 Full text Cite

Radiation Therapy for Cutaneous T-Cell Lymphomas.

Journal Article Dermatol Clin · October 2015 Radiation therapy is an extraordinarily effective skin-directed therapy for cutaneous T-cell lymphomas. Lymphocytes are extremely sensitive to radiation and a complete response is generally achieved even with low doses. Radiation therapy has several import ... Full text Link to item Cite

Long-Term Outcomes of Lobectomy for Non-Small Cell Lung Cancer After Definitive Radiation Treatment.

Journal Article Ann Thorac Surg · June 2015 BACKGROUND: Salvage surgical resection for non-small cell lung cancer (NSCLC) patients initially treated with definitive chemotherapy and radiotherapy can be performed safely, but the long-term benefits are not well characterized. METHODS: Perioperative co ... Full text Link to item Cite

Low-dose consolidation radiation therapy for early stage unfavorable Hodgkin lymphoma.

Journal Article Int J Radiat Oncol Biol Phys · May 1, 2015 PURPOSE: The German Hodgkin Study Group (GHSG) trial HD11 established 4 cycles of doxorubicin, bleomycin, vinblastine, and dacarbazine (ABVD) and 30 Gy of radiation therapy (RT) as a standard for early stage (I, II), unfavorable Hodgkin lymphoma (HL). Addi ... Full text Link to item Cite

Nodal stage of surgically resected non-small cell lung cancer and its effect on recurrence patterns and overall survival.

Journal Article Int J Radiat Oncol Biol Phys · March 15, 2015 PURPOSE: Current National Comprehensive Cancer Network guidelines recommend postoperative radiation therapy (PORT) for patients with resected non-small cell lung cancer (NSCLC) with N2 involvement. We investigated the relationship between nodal stage and l ... Full text Link to item Cite

Standardized beam bouquets for lung IMRT planning.

Journal Article Phys Med Biol · March 7, 2015 The selection of the incident angles of the treatment beams is a critical component of intensity modulated radiation therapy (IMRT) planning for lung cancer due to significant variations in tumor location, tumor size and patient anatomy. We investigate the ... Full text Link to item Cite

Chronic lymphocytic leukemia/small lymphocytic lymphoma, version 1.2015.

Journal Article J Natl Compr Canc Netw · March 2015 Chronic lymphocytic leukemia (CLL) and small lymphocytic lymphoma (SLL) are different manifestations of the same disease, which are managed in the same way. The advent of novel monoclonal antibodies (ofatumumab and obinutuzumab) led to the development of e ... Full text Link to item Cite

Smoking history predicts for increased risk of second primary lung cancer: a comprehensive analysis.

Journal Article Cancer · February 15, 2015 BACKGROUND: Tobacco use is the most important risk factor for the development of lung cancer. The objective of the current study was to determine the effect of smoking on the development of second primary lung cancers (SPLCs) and other clinical outcomes af ... Full text Link to item Cite

Accuracy of positron emission tomography in identifying hilar (N1) lymph node involvement in non-small cell lung cancer: Implications for stereotactic body radiation therapy.

Journal Article Pract Radiat Oncol · 2015 PURPOSE: To assess the efficacy of preoperative positron emission tomography (PET) to stage the ipsilateral hilum in resected non-small cell lung cancer (NSCLC). METHODS AND MATERIALS: All patients who underwent surgery for NSCLC between 1995 and 2008 were ... Full text Link to item Cite

Defining the optimal planning target volume in image-guided stereotactic radiosurgery of brain metastases: results of a randomized trial.

Journal Article Int J Radiat Oncol Biol Phys · January 1, 2015 PURPOSE: To identify an optimal margin about the gross target volume (GTV) for stereotactic radiosurgery (SRS) of brain metastases, minimizing toxicity and local recurrence. METHODS AND MATERIALS: Adult patients with 1 to 3 brain metastases less than 4 cm ... Full text Link to item Cite

In Reply to Giron et al.

Journal Article Pract Radiat Oncol · 2015 Full text Link to item Cite

Lymphomas

Chapter · January 1, 2015 For some hematologic malignancies, particularly Hodgkin lymphoma, larger radiation therapy (RT) fields were the historical norm. Advances in systemic therapy, imaging, and RT technique have prompted an evolution in RT field design. In the context of more a ... Full text Cite

Improving outcomes in advanced DLBCL: systemic approaches and radiotherapy.

Journal Article Oncology (Williston Park) · December 2014 Diffuse large B-cell lymphoma (DLBCL) is the most common subtype of non-Hodgkin lymphoma. Approximately half of patients will present with advanced (stage III/IV) disease. The cornerstone of treatment is a combination of chemotherapy and immunotherapy, mos ... Link to item Cite

When is a biopsy-proven diagnosis necessary before stereotactic ablative radiotherapy for lung cancer?: A decision analysis.

Journal Article Chest · October 2014 BACKGROUND: The practice of treating a solitary pulmonary nodule (SPN) suspicious for stage I non-small cell lung cancer (NSCLC) with stereotactic ablative radiotherapy (SABR) in the absence of pathology is growing. In the absence of randomized evidence, t ... Full text Link to item Cite

Cardiopulmonary exercise testing prior to myeloablative allo-SCT: a feasibility study.

Journal Article Bone Marrow Transplant · October 2014 The feasibility of symptom-limited cardiopulmonary exercise testing (CPET) prior to allo-SCT was assessed in addition to the prognostic value of CPET-derived measures. CPET was performed prospectively on 21 patients with hematologic malignancies, with asse ... Full text Link to item Cite

Non-Hodgkin's lymphomas, version 4.2014.

Journal Article J Natl Compr Canc Netw · September 2014 Non-Hodgkin's lymphomas (NHL) are a heterogeneous group of lymphoproliferative disorders originating in B lymphocytes, T lymphocytes, or natural killer cells. Mantle cell lymphoma (MCL) accounts for approximately 6% of all newly diagnosed NHL cases. Radiat ... Full text Link to item Cite

Predictive Models for Assuring Quality and Consistency of Lung IMRT Plans Across Institutions in Cooperative Group Trials

Conference International Journal of Radiation Oncology*Biology*Physics · September 2014 Full text Cite

Tobacco Use and Secondary Lung Malignancies After Surgery for Non-Small Cell Lung Cancer

Conference International Journal of Radiation Oncology*Biology*Physics · September 2014 Full text Cite

Low-Dose Consolidation Radiation Therapy for Early-Stage Unfavorable Hodgkin Lymphoma

Conference International Journal of Radiation Oncology*Biology*Physics · September 2014 Full text Cite

Automatic Determination of Beam Angles in Lung IMRT Planning

Conference International Journal of Radiation Oncology*Biology*Physics · September 2014 Full text Cite

Thoracoscopic approach to lobectomy for lung cancer does not compromise oncologic efficacy.

Journal Article Ann Thorac Surg · July 2014 BACKGROUND: We compared survival between video-assisted thoracoscopic surgery (VATS) and thoracotomy approaches to lobectomy for non-small cell lung cancer. METHODS: Overall survival of patients who had lobectomy for any stage non-small cell lung cancer wi ... Full text Link to item Cite

Radiation Oncology Consultation for Hematologic Malignancies

Chapter · June 20, 2014 This chapter presents a series of case studies which describe the use of radiation oncology for hematologic malignancies. It explains the necessity for consolidation radiation therapy (RT) if a CR by positron emission tomography (PET) is achieved after R-C ... Full text Cite

Non-Hodgkin's lymphomas, version 2.2014.

Journal Article J Natl Compr Canc Netw · June 2014 Non-Hodgkin's lymphomas (NHLs) are a heterogeneous group of lymphoproliferative disorders originating in B lymphocytes, T lymphocytes, or natural killer cells. Follicular lymphoma (FL) is the most common subtype of indolent NHL, accounting for approximatel ... Full text Link to item Cite

Stereotactic body radiotherapy: a critical review for nonradiation oncologists.

Journal Article Cancer · April 1, 2014 Stereotactic body radiotherapy (SBRT) involves the treatment of extracranial primary tumors or metastases with a few, high doses of ionizing radiation. In SBRT, tumor kill is maximized and dose to surrounding tissue is minimized, by precise and accurate de ... Full text Link to item Cite

Dosimetric effects of rotational offsets in stereotactic body radiation therapy (SBRT) for lung cancer.

Journal Article Med Dosim · 2014 To quantitatively evaluate dosimetric effects of rotational offsets in stereotactic body radiation therapy (SBRT) for lung cancer. Overall, 11 lung SBRT patients (8 female and 3 male; mean age: 75.0 years) with medially located tumors were included. Treatm ... Full text Link to item Cite

Low-dose whole brain radiotherapy combined with radiosurgery for primary CNS lymphoma achieving partial response to induction methotrexate-based chemotherapy.

Journal Article J Radiosurg SBRT · 2014 PURPOSE: For patients with primary CNS lymphoma who achieve complete response (CR) after induction methotrexate-based chemotherapy with rituximab, low-dose whole brain radiation therapy (LD-WBRT) appears effective and is well tolerated. For patients who re ... Link to item Cite

Uncertainties of 4-dimensional computed tomography-based tumor motion measurement for lung stereotactic body radiation therapy.

Journal Article Pract Radiat Oncol · 2014 PURPOSE: To evaluate how well tumor motion measured prior to treatment based on 4-dimensional computer tomography (4DCT) reflects actual tumor motion during beam-on throughout the course of treatment. METHODS AND MATERIALS: Twenty-three patients who had lu ... Full text Link to item Cite

Local recurrence after surgery for non-small cell lung cancer: a recursive partitioning analysis of multi-institutional data.

Journal Article J Thorac Cardiovasc Surg · October 2013 OBJECTIVE: To define subgroups at high risk of local recurrence (LR) after surgery for non-small cell lung cancer using a recursive partitioning analysis (RPA). METHODS: This Institutional Review Board-approved study included patients who underwent upfront ... Full text Link to item Cite

Are discordant positron emission tomography and pathological assessments of the mediastinum in non-small cell lung cancer significant?

Journal Article J Thorac Cardiovasc Surg · October 2013 OBJECTIVE: Many patients with non-small cell lung cancer have positive mediastinal lymph nodes on preoperative positron emission tomography (PET) but do not have mediastinal involvement after surgery. The prognostic significance of this discordance was ass ... Full text Link to item Cite

Adaptive stereotactic body radiation therapy planning for lung cancer.

Journal Article Int J Radiat Oncol Biol Phys · September 1, 2013 PURPOSE: To investigate the dosimetric effects of adaptive planning on lung stereotactic body radiation therapy (SBRT). METHODS AND MATERIALS: Forty of 66 consecutive lung SBRT patients were selected for a retrospective adaptive planning study. CBCT images ... Full text Link to item Cite

In reply to Kumar et al.

Journal Article Int J Radiat Oncol Biol Phys · September 1, 2013 Full text Link to item Cite

Metastasis dynamics for non-small-cell lung cancer: effect of patient and tumor-related factors.

Journal Article Clin Lung Cancer · July 2013 BACKGROUND: We studied event dynamics (probability of an event occurring over a specific time interval) in patients undergoing surgery for early-stage non-small-cell lung cancer (NSCLC) according to patient and tumor characteristics. METHODS: By using a da ... Full text Link to item Cite

Stereotactic body radiation therapy for treatment of primary and metastatic pulmonary malignancies.

Journal Article Surg Oncol Clin N Am · July 2013 Stereotactic body radiation therapy (SBRT) has become the preferred treatment approach for patients with stage I non-small cell lung cancer who are medically inoperable or refuse surgery. SBRT consists of 3 to 5 radiation treatments delivered over a 10- to ... Full text Link to item Cite

Oncologic Imaging/Oncologic Anatomy

Chapter · June 5, 2013 Inside the Sixth Edition of this now-classic reference, you will discover encyclopedic coverage of topics ranging from basic science to sophisticated computer-based radiation therapy treatment planning and supportive care. ... Cite

MO-F-WAB-11: Investigation of CBCT-Based Patient Positioning Accuracy in Lung SBRT: Correlation with Breathing Irregularity.

Conference Med Phys · June 2013 PURPOSE: To evaluate breathing irregularity induced error in CBCT-based patient positioning in lung SBRT and correlate the error with a measure of breathing variability. METHODS: The 4D extended cardiac-torso (XCAT) digital phantom was used to generate 10- ... Full text Link to item Cite

Does pneumonectomy have a role in the treatment of stage IIIA non-small cell lung cancer?

Journal Article Ann Thorac Surg · May 2013 BACKGROUND: The role of surgical resection for stage IIIA non-small cell lung cancer (NSCLC) is unclear. We sought to examine outcomes after pneumonectomy for patients with stage IIIA disease. METHODS: All patients with stage IIIA NSCLC who had pneumonecto ... Full text Link to item Cite

Analysis of single nucleotide polymorphisms and radiation sensitivity of the lung assessed with an objective radiologic endpoin.

Journal Article Clin Lung Cancer · May 2013 BACKGROUND: The primary objective of this study was to evaluate the association between radiation sensitivity of the lungs and candidate single nucleotide polymorphisms (SNP) in genes implicated in radiation-induced toxicity. METHODS: Patients with lung ca ... Full text Link to item Cite

Diabetes mellitus: A significant co-morbidity in the setting of lung cancer?

Journal Article Thorac Cancer · May 2013 BACKGROUND: To evaluate the effect of diabetes mellitus (DM) on clinical outcomes in patients managed surgically for non-small cell lung cancer (NSCLC). METHODS: Patients who underwent surgery for pathological I-IIIA NSCLC at Duke University from 1995-2005 ... Full text Link to item Cite

Non-Hodgkin's lymphomas, version 1.2013.

Journal Article J Natl Compr Canc Netw · March 1, 2013 These NCCN Guidelines Insights summarize several key updates to the NCCN Guidelines for Non-Hodgkin's Lymphomas (NHL) and provide a discussion of the clinical evidence that support the updates. The updates discussed in this article feature recommendations ... Full text Link to item Cite

Quantification and minimization of uncertainties of internal target volume for stereotactic body radiation therapy of lung cancer.

Journal Article Int J Radiat Oncol Biol Phys · February 1, 2013 PURPOSE: To quantify uncertainties in delineating an internal target volume (ITV) and to understand how these uncertainties may be individually minimized for stereotactic body radiation therapy (SBRT) of early stage non-small cell lung cancer (NSCLC). METH ... Full text Link to item Cite

Investigation of sliced body volume (SBV) as respiratory surrogate.

Journal Article J Appl Clin Med Phys · January 7, 2013 The purpose of this study was to evaluate the sliced body volume (SBV) as a respiratory surrogate by comparing with the real-time position management (RPM) in phantom and patient cases. Using the SBV surrogate, breathing signals were extracted from unsorte ... Full text Open Access Link to item Cite

SU‐E‐T‐474: Adaptive Stereotactic Body Radiation Therapy (SBRT) Planning for Lung Cancer: Can We Predict Who Will Benefit?

Conference Medical Physics · January 1, 2013 Purpose: We have previously shown that adaptive lung SBRT planning can mitigate dose to adjacent organs at risk (OARs). The aim of this study is to investigate factors that affect dosimetric effectiveness of adaptive lung SBRT, so that we may predict which ... Full text Cite

Investigation of sliced body volume (SBV) as respiratory surrogate

Journal Article Journal of Applied Clinical Medical Physics · January 1, 2013 The purpose of this study was to evaluate the sliced body volume (SBV) as a respiratory surrogate by comparing with the real-time position management (RPM) in phantom and patient cases. Using the SBV surrogate, breathing signals were extracted from unsorte ... Full text Cite

Combined-modality therapy for early-stage Hodgkin lymphoma: maintaining high cure rates while minimizing risks.

Journal Article Oncology (Williston Park) · December 2012 Multiple randomized studies have demonstrated that chemotherapy, most commonly ABVD (doxorubicin [Adriamycin], bleomycin, vinblastine, dacarbazine), followed by consolidation radiation therapy is the most effective treatment program for early-stage Hodgkin ... Link to item Cite

Non-Hodgkin's Lymphomas, version 3.2012.

Journal Article J Natl Compr Canc Netw · December 1, 2012 These NCCN Guidelines Insights summarize several key updates to the 2012 NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Non-Hodgkin's Lymphomas (NHL) and describe the clinical evidence supporting the updates. The featured updates inclu ... Full text Link to item Cite

Reproducibility of tumor motion probability distribution function in stereotactic body radiation therapy of lung cancer.

Journal Article Int J Radiat Oncol Biol Phys · November 1, 2012 PURPOSE: To evaluate the reproducibility of tumor motion probability distribution function (PDF) in stereotactic body radiation therapy (SBRT) of lung cancer using cine megavoltage (MV) images. METHODS AND MATERIALS: Cine MV images of 20 patients acquired ... Full text Link to item Cite

Impact of consolidation radiation therapy in stage III-IV diffuse large B-cell lymphoma with negative post-chemotherapy radiologic imaging.

Journal Article Int J Radiat Oncol Biol Phys · November 1, 2012 PURPOSE: While consolidation radiation therapy (i.e., RT administered after chemotherapy) is routine treatment for patients with early-stage diffuse large B-cell lymphoma (DLBCL), the role of consolidation RT in stage III-IV DLBCL is controversial. METHODS ... Full text Link to item Cite

Lymphovascular invasion in non-small-cell lung cancer: implications for staging and adjuvant therapy.

Journal Article J Thorac Oncol · July 2012 BACKGROUND: Lymphovascular space invasion (LVI) is an established negative prognostic factor and an indication for postoperative radiation therapy in many malignancies. The purpose of this study was to evaluate LVI in patients with early-stage non-small-ce ... Full text Link to item Cite

Radiotherapy dose-response analysis for diffuse large B-cell lymphoma with a complete response to chemotherapy.

Journal Article Radiat Oncol · June 21, 2012 OBJECTIVE: To examine the efficacy of different radiation doses after achievement of a complete response to chemotherapy in diffuse large B-cell lymphoma (DLBCL). METHODS: Patients with stage I-IV DLBCL treated from 1995-2009 at Duke Cancer Institute who a ... Full text Link to item Cite

TU-E-BRB-04: Adaptive Stereotactic-Body Radiation Therapy (SBRT) Planning for Lung Cancer.

Journal Article Med Phys · June 2012 PURPOSE: Tumor shrinkage during lung SBRT has been reported. Adaptive SBRT planning can potentially escalate dose to the target and mitigate dose to surrounding tissues. In this study, we investigated dosimetric effects of adaptive lung SBRT planning using ... Full text Link to item Cite

Local failure in resected N1 lung cancer: implications for adjuvant therapy.

Journal Article Int J Radiat Oncol Biol Phys · June 1, 2012 PURPOSE: To evaluate actuarial rates of local failure in patients with pathologic N1 non-small-cell lung cancer and to identify clinical and pathologic factors associated with an increased risk of local failure after resection. METHODS AND MATERIALS: All p ... Full text Link to item Cite

Dosimetric comparison of treatment plans based on free breathing, maximum, and average intensity projection CTs for lung cancer SBRT.

Journal Article Med Phys · May 2012 PURPOSE: To determine whether there is a CT dataset may be more favorable for planning and dose calculation by comparing dosimetric characteristics between treatment plans calculated using free breathing (FB), maximum and average intensity projection (MIP ... Full text Link to item Cite

Effect of increasing experience on dosimetric and clinical outcomes in the management of malignant pleural mesothelioma with intensity-modulated radiation therapy.

Journal Article Int J Radiat Oncol Biol Phys · May 1, 2012 PURPOSE: To assess the impact of increasing experience with intensity-modulated radiation therapy (IMRT) after extrapleural pneumonectomy (EPP) for malignant pleural mesothelioma (MPM). METHODS AND MATERIALS: The records of all patients who received IMRT f ... Full text Link to item Cite

Outcomes after surgical management of synchronous bilateral primary lung cancers.

Journal Article Ann Thorac Surg · April 2012 BACKGROUND: Distinguishing between synchronous primary lung cancers and metastatic disease in patients with bilateral lung masses is often difficult. The objective of this study is to examine outcomes associated with a strategy of performing staged bilater ... Full text Link to item Cite

Recurrence dynamics for non-small-cell lung cancer: effect of surgery on the development of metastases.

Journal Article J Thorac Oncol · April 2012 INTRODUCTION: We study event rates over time (event dynamics) in patients undergoing surgery for early-stage non-small-cell lung cancer (NSCLC). METHODS: Using a database of patients undergoing initial surgery for NSCLC, the event dynamics, based on the ha ... Full text Link to item Cite

A polymorphism within the promoter of the TGFβ1 gene is associated with radiation sensitivity using an objective radiologic endpoint.

Journal Article Int J Radiat Oncol Biol Phys · February 1, 2012 PURPOSE: To evaluate whether single nucleotide polymorphisms (SNPs) in the transforming growth factor-β1 (TGFβ1) gene are associated with radiation sensitivity using an objective radiologic endpoint. METHODS AND MATERIALS: Preradiation therapy and serial p ... Full text Link to item Cite

TH‐A‐BRA‐11: Treatment‐Induced Dosimetric/Volume Changes During the Course of Radiotherapy for Lung Cancer

Conference Medical Physics · January 1, 2012 Purpose: To investigate the necessity for adaptive radiation therapy (RT) in lung cancer IMRT treatments by quantifying tumor changes during radiotherapy and the associated impact on target, lung and esophagus. Methods: As part of an IRB‐approved lung dose ... Full text Cite

Combined-modality therapy for early-stage Hodgkin lymphoma: Maintaining high cure rates while minimizing risks

Journal Article ONCOLOGY (United States) · January 1, 2012 Multiple randomized studies have demonstrated that chemotherapy, most commonly ABVD (doxorubicin [Adriamycin], bleomycin(Drug information on bleomycin), vinblastine(Drug information on vinblastine), dacarbazine(Drug information on dacarbazine)), followed b ... Cite

Severe pulmonary toxicity after myeloablative conditioning using total body irradiation: an assessment of risk factors.

Journal Article Int J Radiat Oncol Biol Phys · November 1, 2011 PURPOSE: To assess factors associated with severe pulmonary toxicity after myeloablative conditioning using total body irradiation (TBI) followed by allogeneic stem cell transplantation. METHODS AND MATERIALS: A total of 101 adult patients who underwent TB ... Full text Link to item Cite

Persistent N2 disease after neoadjuvant chemotherapy for non-small-cell lung cancer.

Journal Article J Thorac Cardiovasc Surg · November 2011 OBJECTIVES: Patients achieving a mediastinal pathologic complete response with neoadjuvant chemotherapy have improved outcomes compared with patients with persistent N2 disease. How to best manage this latter group of patients is unknown, prompting a revie ... Full text Link to item Cite

Lymphovascular Invasion in Non-small Cell Lung Cancer: Implications for Staging and Adjuvant Therapy

Journal Article International Journal of Radiation Oncology*Biology*Physics · October 2011 Full text Cite

Pathologic N1 Non-small Cell Lung Cancer: Identifying Subsets of Patients at High Risk of Local Failure

Journal Article International Journal of Radiation Oncology*Biology*Physics · October 2011 Full text Cite

PERSISTENT N2 DISEASE AFTER NEOADJUVANT CHEMOTHERAPY-NOW WHAT?

Conference JOURNAL OF THORACIC ONCOLOGY · June 1, 2011 Link to item Cite

Non-Hodgkin's lymphomas.

Journal Article J Natl Compr Canc Netw · May 2011 Full text Link to item Cite

How well does the new lung cancer staging system predict for local/regional recurrence after surgery?: A comparison of the TNM 6 and 7 systems.

Journal Article J Thorac Oncol · April 2011 INTRODUCTION: To evaluate how well the tumor, node, metastasis (TNM) 6 and TNM 7 staging systems predict rates of local/regional recurrence (LRR) after surgery alone for non-small cell lung cancer. METHODS: All patients who underwent surgery for non-small ... Full text Link to item Cite

Renal shielding and dosimetry for patients with severe systemic sclerosis receiving immunoablation with total body irradiation in the scleroderma: cyclophosphamide or transplantation trial.

Journal Article Int J Radiat Oncol Biol Phys · March 15, 2011 PURPOSE: To describe renal shielding techniques and dosimetry in delivering total body irradiation (TBI) to patients with severe systemic sclerosis (SSc) enrolled in a hematopoietic stem cell transplant protocol. METHODS AND MATERIALS: The Scleroderma: Cyc ... Full text Link to item Cite

The impact of radiation therapy in patients with diffuse large B-cell lymphoma with positive post-chemotherapy FDG-PET or gallium-67 scans.

Journal Article Ann Oncol · February 2011 Featured Publication BACKGROUND: 2-[fluorine-18]fluoro-2-deoxy-D-glucose-positron emission tomography (PET) and gallium-67 citrate (gallium) response after chemotherapy are powerful prognostic factors in diffuse large B-cell lymphoma (DLBCL). However, clinical outcomes when co ... Full text Link to item Cite

MO‐D‐BRB‐03: Investigation of the Reproducibility of Probability Distribution function (PDF) of Tumor Motion in Lung Stereotactic Body Radiation Therapy (SBRT)

Conference Medical Physics · January 1, 2011 Purpose: To investigate the reproducibility of probability distribution function (PDF) of lung tumor motion using cine‐MV images from lung SBRT treatments. Findings of the study will provide valuable information for probability‐based treatment planning. Me ... Full text Cite

Radiation therapy in the management of diffuse large B-cell lymphoma: still relevant?

Journal Article Oncology (Williston Park) · November 30, 2010 Diffuse large B-cell lymphoma (DLBCL) is the most common subtype of non-Hodgkin lymphoma in the United States. Historically, radiation therapy (RT) was the primary treatment for patients with localized disease. Several randomized trials have demonstrated t ... Link to item Cite

Radiation therapy in the management of diffuse large B-cell lymphoma: still relevant?

Journal Article Oncology (Williston Park, N.Y.) · November 30, 2010 Diffuse large B-cell lymphoma (DLBCL) is the most common subtype of non-Hodgkin lymphoma in the United States. Historically, radiation therapy (RT) was the primary treatment for patients with localized disease. Several randomized trials have demonstrated t ... Cite

Factors associated with the development of brain metastases: analysis of 975 patients with early stage nonsmall cell lung cancer.

Journal Article Cancer · November 1, 2010 BACKGROUND: The risk of developing brain metastases after definitive treatment of locally advanced nonsmall cell lung cancer (NSCLC) is approximately 30%-50%. The risk for patients with early stage disease is less defined. The authors sought to investigate ... Full text Link to item Cite

Impact of Consolidative Radiation Therapy in Stage III-IV Diffuse Large B-cell Lymphoma

Conference International Journal of Radiation Oncology*Biology*Physics · November 2010 Full text Cite

Timing of local and distant failure in resected lung cancer: implications for reported rates of local failure.

Journal Article J Thorac Oncol · February 2010 INTRODUCTION: Most adjuvant lung cancer trials only report first sites of failure. The relative timing of local (i.e., local/regional) versus distant recurrence after surgery could potentially affect reported rates of local failure. We assessed this phenom ... Full text Link to item Cite

Assessing neurotoxicity from the low-dose radiation component of radiosurgery using magnetic resonance spectroscopy.

Journal Article Neuro Oncol · February 2010 Featured Publication The aim of the study was to determine if biochemical changes indicative of injury, assessed using magnetic resonance spectroscopic imaging (SI), are observed after stereotactic radiosurgery (SRS). The study included patients who underwent SI immediately be ... Full text Link to item Cite

Regional lung density changes after radiation therapy for tumors in and around thorax.

Journal Article Int J Radiat Oncol Biol Phys · January 1, 2010 PURPOSE: To study the temporal nature of regional lung density changes and to assess whether the dose-dependent nature of these changes is associated with patient- and treatment-associated factors. METHODS AND MATERIALS: Between 1991 and 2004, 118 patients ... Full text Link to item Cite

Preoperative chemotherapy versus preoperative chemoradiotherapy for stage III (N2) non-small-cell lung cancer.

Journal Article Int J Radiat Oncol Biol Phys · December 1, 2009 Featured Publication PURPOSE: To compare preoperative chemotherapy (ChT) and preoperative chemoradiotherapy (ChT-RT) in operable Stage III non-small-cell lung cancer. METHODS AND MATERIALS: This retrospective study analyzed all patients with pathologically confirmed Stage III ... Full text Link to item Cite

Local recurrence after surgery for early stage lung cancer: an 11-year experience with 975 patients.

Journal Article Cancer · November 15, 2009 Featured Publication BACKGROUND: The objective of the current study was to evaluate the actuarial risk of local failure (LF) after surgery for stage I to II nonsmall cell lung cancer (NSCLC) and assess surgical and pathologic factors affecting this risk. METHODS: The records, ... Full text Link to item Cite

Positive PET Prior to Consolidative Radiation Therapy Increases Risk of In-field Failure in Diffuse Large B-cell Lymphoma

Conference International Journal of Radiation Oncology*Biology*Physics · November 2009 Full text Cite

Association between RT-induced changes in lung tissue density and global lung function.

Journal Article Int J Radiat Oncol Biol Phys · July 1, 2009 PURPOSE: To assess the association between radiotherapy (RT)-induced changes in computed tomography (CT)-defined lung tissue density and pulmonary function tests (PFTs). METHODS AND MATERIALS: Patients undergoing incidental partial lung RT were prospective ... Full text Link to item Cite

The Association between RT-induced Changes in Lung Tissue Density and Global Lung Function

Conference International Journal of Radiation Oncology*Biology*Physics · September 2008 Full text Cite

Intensity-modulated radiotherapy for resected mesothelioma: the Duke experience.

Journal Article Int J Radiat Oncol Biol Phys · July 15, 2008 PURPOSE: To assess the safety and efficacy of intensity-modulated radiotherapy (IMRT) after extrapleural pneumonectomy for malignant pleural mesothelioma. METHODS AND MATERIALS: Thirteen patients underwent IMRT after extrapleural pneumonectomy between July ... Full text Link to item Cite

The actuarial incidence of brain metastases in 975 patients undergoing surgery for early-stage lung cancer.

Journal Article J Clin Oncol · May 20, 2008 8094 Background: The risk of developing brain metastases after definitive treatment for locally-advanced non-small cell lung cancer (NSCLC) is approximately 30%-50%. The risk for patients with early-stage disease is less defined. We sought to investigate t ... Link to item Cite

The association between RT-induced changes in lung density and global lung function.

Journal Article J Clin Oncol · May 20, 2008 13543 Background: Radiation (RT)-induced lung injury is a common side effect following thoracic RT. The study of RT-induced lung injury is complicated by the multiple endpoints considered (e.g., radiologic vs. symptomatic vs. functional). The association b ... Link to item Cite

Local/regional recurrence following surgery for early-stage lung cancer: A 10-year experience with 975 patients.

Journal Article J Clin Oncol · May 20, 2008 7542 Background: Surgery, with or without chemotherapy, is the preferred treatment for early-stage NSCLC. The risk of local/regional recurrence (LRR) after resection is not well defined, but generally considered to be small in comparison to the risk of dis ... Link to item Cite

A phase I study of UFT/leucovorin, carboplatin, and paclitaxel in combination with external beam radiation therapy for advanced esophageal carcinoma.

Journal Article Int J Radiat Oncol Biol Phys · March 15, 2008 PURPOSE: Concurrent chemotherapy and radiation therapy (RT) are used to treat patients with esophageal cancer. The optimal combination of chemotherapeutic agents with RT is not well established. We evaluated the safety and preliminary efficacy of a combina ... Full text Link to item Cite

Postoperative radiation therapy for lung cancer: where do we stand?

Journal Article Oncology (Williston Park) · March 2008 Lung cancer is the leading cause of cancer mortality in the United States. Local recurrence after surgery for operable disease has long been recognized as a hindrance to long-term survival. Postoperative radiation therapy was logically explored as a means ... Link to item Cite

Radiation-induced lung injury. Assessment, management, and prevention.

Journal Article Oncology (Williston Park) · January 2008 Radiation therapy (RT) is an important treatment modality for multiple thoracic malignancies. Incidental irradiation of the lungs, which are particularly susceptible to injury, is unavoidable and often dose-limiting. The most radiosensitive subunit of the ... Link to item Cite

Duodenal adenocarcinoma: patterns of failure after resection and the role of chemoradiotherapy.

Journal Article Int J Radiat Oncol Biol Phys · December 1, 2007 PURPOSE: To report patterns of disease recurrence after resection of adenocarcinoma of the duodenum and compare outcomes between patients undergoing surgery only vs. surgery with concurrent chemotherapy and radiation therapy (CT-RT). METHODS AND MATERIALS: ... Full text Link to item Cite

Paclitaxel-based chemoradiotherapy in the treatment of patients with operable esophageal cancer.

Journal Article Int J Radiat Oncol Biol Phys · November 1, 2007 PURPOSE: To compare a neoadjuvant regimen of cisplatin/5-fluorouracil (5-FU) and concurrent radiation therapy (RT) with paclitaxel-based regimens and RT in the management of operable esophageal (EC)/gastroesophageal junction (GEJ) cancer. METHODS AND MATER ... Full text Link to item Cite

Stage and Treatment Migration in Patients With Stage III Non-Small Cell Lung Cancer

Conference International Journal of Radiation Oncology*Biology*Physics · November 2007 Full text Cite

Assessing Neurotoxicity From Radiosurgery: Results From a Prospective Study Using Magnetic Resonance Spectroscopy

Conference International Journal of Radiation Oncology*Biology*Physics · November 2007 Full text Cite

Estimating the magnitude and field-size dependence of radiotherapy-induced mortality and tumor control after postoperative radiotherapy for non-small-cell lung cancer: calculations from clinical trials.

Journal Article Int J Radiat Oncol Biol Phys · July 15, 2007 PURPOSE: To create, on the basis of available data, a mathematical model to describe the tumor stage- and field size-dependent risks/benefits of postoperative radiotherapy (PORT) for non-small-cell lung cancer (NSCLC), and to assess whether this simple mod ... Full text Link to item Cite

A Phase I study of capecitabine, carboplatin, and paclitaxel with external beam radiation therapy for esophageal carcinoma.

Journal Article Int J Radiat Oncol Biol Phys · March 15, 2007 PURPOSE: Concurrent chemotherapy and radiation therapy (RT) are used to treat patients with esophageal cancer. The optimal combination of chemotherapeutic agents with RT is undefined. We evaluated a combination of capecitabine, carboplatin, and paclitaxel ... Full text Link to item Cite

2147

Conference International Journal of Radiation Oncology*Biology*Physics · November 2006 Full text Cite

2136

Conference International Journal of Radiation Oncology*Biology*Physics · November 2006 Full text Cite

Stage III lung cancer: two or three modalities? The continued role of thoracic radiotherapy.

Journal Article Oncology (Williston Park) · September 2006 Lung cancer is the leading cause of cancer mortality in the United States. A significant number of patients present with disease involving mediastinal lymph nodes. As survival after surgery alone for stage III disease is poor, radiation therapy and chemoth ... Link to item Cite

Patterns of failure after resection of non-small-cell lung cancer: implications for postoperative radiation therapy volumes.

Journal Article Int J Radiat Oncol Biol Phys · July 15, 2006 Featured Publication PURPOSE: To analyze local-regional patterns of failure after surgical resection of non-small-cell lung cancer (NSCLC). METHODS AND MATERIALS: This retrospective analysis included 61 patients who underwent resection of NSCLC at Duke University Medical Cente ... Full text Link to item Cite

A phase I study of capecitabine (CAP), carboplatin (CARB), paclitaxel (TAX) and external beam radiation therapy (EBRT) for patients with esophageal carcinoma (EC).

Journal Article J Clin Oncol · June 20, 2006 14044 Background: Chemoradiotherapy is used to treat esophageal cancer with curative intent or local symptom control. A phase I study of 5-FU + CARB + TAX + EBRT showed 100% RR and 50% pCR rate. CAP allows for fluoropyrimidine treatment without the inconve ... Link to item Cite

Somnolence syndrome after focal radiation therapy to the pineal region: case report and review of the literature.

Journal Article J Neurooncol · June 2006 Somnolence syndrome classically occurs in children after cranial irradiation for acute lymphocytic leukemia. Symptoms include somnolence, fever, nausea and vomiting, and headache. The authors report a 29 year-old female who developed symptoms compatible wi ... Full text Link to item Cite

Radiation-induced narrowing of the tracheobronchial tree: an in-depth analysis.

Journal Article Lung Cancer · April 2006 Featured Publication PURPOSE: Symptomatic narrowing of the tracheobronchial tree is not a common clinical problem after conventional-dose external beam radiation therapy but has been described when higher doses are utilized. This in-depth study quantifies changes in the calibe ... Full text Link to item Cite

Local recurrence following initial resection of NSCLC: salvage is possible with radiation therapy.

Journal Article Cancer J · 2006 PURPOSE: After surgical resection of non-small cell lung cancer, local/regional recurrence is observed in 20% to 50% of patients, often without evidence of distant metastases. This retrospective study evaluates the utility of salvage radiation therapy in t ... Full text Link to item Cite

Retrospective clinicopathologic correlation of gross tumor size of hepatocellular carcinoma: implications for stereotactic body radiotherapy.

Journal Article Am J Clin Oncol · December 2005 PURPOSE: To determine the degree of correlation between radiographic size and true gross pathologic size for subjects with primary hepatocellular carcinoma (HCC). METHODS AND MATERIALS: This analysis included 18 patients with 27 tumors who underwent either ... Full text Link to item Cite

Radiation-induced narrowing of the tracheobronchial tree: An in-depth 3D analysis

Conference International Journal of Radiation OncologyBiologyPhysics · September 2004 Full text Cite

Different models, different trees: the geographic origin of PTLV-I.

Journal Article Mol Phylogenet Evol · November 1999 Using nucleotide sequences from three genomic regions of the human and simian T-cell lymphotropic virus type I (HTLV-I/STLV-I)-consisting of 69 sequences from a 140-bp segment of the pol region, 98 sequences from a 503-bp segment of the LTR, and 154 sequen ... Full text Link to item Cite

Parallel evolution of drug resistance in HIV: failure of nonsynonymous/synonymous substitution rate ratio to detect selection.

Journal Article Mol Biol Evol · March 1999 Parallel or convergent evolution at the molecular level has been difficult to demonstrate especially when rigorous statistical criteria are applied. We present sequence data from the protease gene from eight patients infected with the human immunodeficienc ... Full text Link to item Cite