Scholars@Duke
Larry Ronald Jackson II

Larry Ronald Jackson II

Associate Professor of Medicine
Medicine, Cardiology
larry.jackson@duke.edu
300 W Morgan Street, Office 635, Durham, NC 27701

Selected Publications

Characteristics of Cardiomyopathy in Patients With Chronic Left Bundle Branch Block Undergoing Right Ventricular Pacing.

Journal Article Pacing Clin Electrophysiol · September 2025 BACKGROUND: Left bundle branch block (LBBB) and right ventricular pacing (RVP) are associated with abnormal myocardial mechanics and cardiomyopathy. Consequently, chronic LBBB may increase the risk of heart failure and mortality in patients undergoing RVP. ... Full text Link to item Cite

Atrial fibrillation in the Americas

Journal Article Lancet Regional Health Americas · July 1, 2025 Atrial Fibrillation is the most common sustained cardiac arrhythmia, and is associated with significant impairments in quality of life. Regional variations and challenges in the management of atrial fibrillation are present throughout the Americas. Atrial ... Full text Cite

Evolving Indications, Challenges and Advances in Cardiac Resynchronization Therapy for Heart Failure.

Journal Article J Card Fail · April 16, 2025 Cardiac resynchronization therapy (CRT) via biventricular pacing has markedly improved heart failure outcomes over the past 2 decades. However, some patients show no clinical improvement or evidence of reverse remodeling following device implantation. Chal ... Full text Link to item Cite

Use of a Stylet Driven Lead With a Flexible Neck for Left Bundle Branch Area Pacing: A Single Center Experience.

Journal Article J Cardiovasc Electrophysiol · April 2025 BACKGROUND: The majority of data on left bundle branch area pacing (LBBAP) are on a lumenless lead. Data on the safety and effectiveness of stylet driven leads are comparatively lacking. METHODS: We retrospectively analyzed 265 patients who underwent attem ... Full text Link to item Cite

Impact of race and ethnicity on the rhythm control of newly diagnosed atrial fibrillation: Insights from the Get With the Guidelines Atrial Fibrillation Registry.

Journal Article Heart Rhythm · March 2025 BACKGROUND: An early rhythm control strategy is the preferred management for patients newly diagnosed with atrial fibrillation (AF). A rhythm control strategy, however, has been historically underused for patients from underrepresented racial and ethnic gr ... Full text Link to item Cite

Ethnic Differences in Atrial Fibrillation in the United Kingdom

Journal Article Jacc Advances · December 1, 2024 Background: Within the United States, White individuals experience a higher risk of atrial fibrillation (AF) while exhibiting a lower AF-related stroke risk compared to other ethnic groups. It is possible that these observations stem from phenomena unique ... Full text Cite

Global Health Inequities in Electrophysiology Care: A State-of-the-Art Review

Journal Article Jacc Advances · December 1, 2024 This state-of-the-art review examines disparities in the diagnosis, management, and outcomes of cardiac arrhythmias globally. These arrhythmias include atrial fibrillation, ventricular tachyarrhythmias underlying sudden cardiac death, and bradyarrhythmias ... Full text Cite

Anticoagulation in Patients With Obesity

Journal Article Jacc Case Reports · November 20, 2024 Full text Cite

Addressing racial differences in the management of atrial fibrillation: Focus on black patients.

Journal Article J Natl Med Assoc · October 2024 Atrial fibrillation (AF) is the most common sustained arrhythmia, affecting between 3 and 6 million people in the United States. It is associated with a reduced quality of life and increased risk of stroke, cognitive decline, heart failure and death. Black ... Full text Link to item Cite

Periprocedural Management and Multidisciplinary Care Pathways for Patients With Cardiac Implantable Electronic Devices: A Scientific Statement From the American Heart Association.

Journal Article Circulation · August 20, 2024 The rapid technological advancements in cardiac implantable electronic devices such as pacemakers, implantable cardioverter defibrillators, and loop recorders, coupled with a rise in the number of patients with these devices, necessitate an updated clinica ... Full text Link to item Cite

Depression and Implantable Cardioverter-Defibrillator Implantation in Black Patients at Risk for Sudden Cardiac Death.

Journal Article J Am Heart Assoc · July 16, 2024 BACKGROUND: Black patients meeting indications for implantable cardioverter-defibrillators (ICDs) have lower rates of implantation compared with White patients. There is little understanding of how mental health impacts the decision-making process among Bl ... Full text Link to item Cite

Assisting Black Patients With Decision-Making for Implantable Cardioverter Defibrillator Therapy: Qualitative Findings From the Videos to Reduce Racial Disparities in ICD Therapy via Innovative Designs (VIVID) Trial.

Journal Article Circ Cardiovasc Qual Outcomes · July 2024 BACKGROUND: The VIVID (Videos for Addressing Racial Disparities in Implantable Cardioverter Defibrillator Therapy via Innovative Designs) study was a multicenter, randomized controlled trial aimed at evaluating the effectiveness of a video-based decision s ... Full text Link to item Cite

Past, Present, and Future of Shared Decision-Making.

Journal Article Circ Cardiovasc Qual Outcomes · July 2024 Full text Link to item Cite

MicroRNAs are associated with cardiac biomarkers, cardiac structure and function and incident outcomes in heart failure.

Journal Article ESC Heart Fail · June 2024 AIMS: The association between microRNAs (miRNAs) and established cardiac biomarkers is largely unknown. We aimed to measure the association between plasma miRNAs and N-terminal pro-B-type natriuretic peptide (NT-proBNP), cardiac troponin I, soluble urokina ... Full text Link to item Cite

Discriminatory and valuing communication behaviors in cardiology encounters.

Journal Article Patient Educ Couns · June 2024 OBJECTIVE: Many have found racial differences in clinician-patient communication using validated codebooks that represent effective communication. No codebooks used for examining racial differences, however, have included patient input. In this paper, we d ... Full text Link to item Cite

Racial differences and geographic variations in oral anticoagulation treatment among Medicare patients with non-valvular atrial fibrillation.

Journal Article PLoS One · 2024 INTRODUCTION: Use of oral anticoagulants (OACs) for stroke reduction in atrial fibrillation (AF) varies by race and geography within the United States. We seek to better understand the relationship between OAC underutilization, race, and US geography. METH ... Full text Link to item Cite

Eliminating Health Disparities in Atrial Fibrillation, Heart Failure, and Dyslipidemia: A Path Toward Achieving Pharmacoequity.

Journal Article Curr Atheroscler Rep · December 2023 PURPOSE OF REVIEW: Pharmacoequity refers to the goal of ensuring that all patients have access to high-quality medications, regardless of their race, ethnicity, gender, or other characteristics. The goal of this article is to review current evidence on dis ... Full text Open Access Link to item Cite

Racial and Ethnic Disparities in Implantable Cardioverter-Defibrillator Utilization: A Contemporary Review

Journal Article Current Treatment Options in Cardiovascular Medicine · December 1, 2023 Purpose of review: Sudden cardiac arrest is associated with high morbidity and mortality. Despite having a disproportionate burden of sudden cardiac death (SCD), rates of primary and secondary prevention of SCD with implantable cardioverter-defibrillator ( ... Full text Cite

Abstract 17169: Beyond CHA2DS2-VASc: Independent Predictors of Ischemic Stroke in Patients With Atrial Fibrillation

Conference Circulation · November 7, 2023 Introduction: Factors outside of the CHA 2 DS 2 -VASc score also contribute to stroke risk, and patients presc ... Full text Cite

Association of leadless pacing with ventricular and valvular function.

Journal Article J Cardiovasc Electrophysiol · November 2023 BACKGROUND: Traditional transvenous pacemakers are associated with worsening tricuspid valve function due to lead-related leaflet impingement, as well as ventricular dysfunction related to electromechanical dyssynchrony from chronic right ventricular (RV) ... Full text Link to item Cite

Colchicine for the Prevention of Recurrent Arrhythmia After Catheter Ablation of Atrial Fibrillation: Results of a Single-Center, Retrospective Study.

Journal Article Am J Cardiovasc Drugs · November 2023 BACKGROUND: There is evidence to suggest that colchicine reduces the risk of recurrent atrial fibrillation (AF) after catheter ablation; however, the tolerability and safety of colchicine in routine practice is unknown. METHODS: Patients undergoing cathete ... Full text Link to item Cite

Epidemiology and Outcomes Associated with PR Prolongation.

Journal Article Cardiol Clin · August 2023 PR prolongation is defined primarily as delayed conduction through the AV node, but can also signify delayed electrical impulse propagation through any part of the conduction system. The prevalence of PR prolongation ranges from 1% to 5% in patients younge ... Full text Link to item Cite

Incidence and Prevalence of Atrial Fibrillation in Latinos: What's New Since the Study in Latinos (SOL)?

Journal Article Curr Cardiol Rep · August 2023 PURPOSE OF REVIEW: To assess contemporary epidemiological trends in AF incidence and prevalence in the LatinX population after the Hispanic Community Health Study/Study of Latinos. RECENT FINDINGS: Atrial fibrillation (AF) remains the most abnormal heart r ... Full text Link to item Cite

Effect of a Coaching Intervention to Improve Cardiologist Communication: A Randomized Clinical Trial.

Journal Article JAMA Intern Med · June 1, 2023 IMPORTANCE: Communication between cardiologists and patients can significantly affect patient comprehension, adherence, and satisfaction. To our knowledge, a coaching intervention to improve cardiologist communication has not been tested. OBJECTIVE: To eva ... Full text Open Access Link to item Cite

Racial/ethnic and sex differences in safety outcomes and atrial fibrillation/atrial flutter-related acute healthcare utilization after catheter ablation of atrial fibrillation.

Journal Article Heart Rhythm O2 · May 2023 BACKGROUND: Catheter ablation is recommended for the treatment of symptomatic atrial fibrillation (AF) refractory to medical therapy. OBJECTIVE: The study sought to examine racial/ethnic and sex differences in complications and AF/atrial flutter (AFL)-rela ... Full text Link to item Cite

Facilitating Shared Decision Making Among Black Patients at Risk for Sudden Cardiac Arrest : A Randomized Clinical Trial.

Journal Article Ann Intern Med · May 2023 BACKGROUND: Racial disparities in implantable cardioverter-defibrillator (ICD) implantation are multifactorial and are partly explained by higher refusal rates. OBJECTIVE: To assess the effectiveness of a video decision support tool for Black patients elig ... Full text Link to item Cite

Call to action: Understanding the differences in the use of SGLT-2 inhibitors and GLP-1 receptor agonists.

Journal Article Am J Prev Cardiol · March 2023 Cardiovascular disease remains one of the most prominent global health problems and has been demonstrated to disproportionally affect certain communities. Despite an increasing collective effort to improve health inequalities, a multitude of disparities co ... Full text Open Access Link to item Cite

Race and Ethnic and Sex Differences in Rhythm Control Treatment of Incident Atrial Fibrillation.

Journal Article Clinicoecon Outcomes Res · 2023 BACKGROUND: Atrial fibrillation (AF) is associated with considerable morbidity and mortality. Timely management and treatment is critical in alleviating AF disease burden. Variation in treatment by race and ethnic and sex could lead to inequities in health ... Full text Link to item Cite

Racial differences in setting of implantable cardioverter-defibrillator placement in older adults with heart failure and association with disparate post-implant outcomes

Journal Article Frontiers in Cardiovascular Medicine · January 1, 2023 Background: Implantable cardioverter-defibrillator (ICD) placement in heart failure (HF) patients during or early after (≤90 days) unplanned cardiovascular hospitalizations has been associated with poor outcomes. Racial and ethnic differences in this “peri ... Full text Cite

Examining the relationship between clinician communication and patient participatory behaviors in cardiology encounters.

Journal Article Patient Educ Couns · December 2022 OBJECTIVES: Examine the association of coder ratings of cardiologist behaviors and global scores of cardiologist communication style with patient participation in clinic encounters. METHODS: We coded transcripts of clinic encounters for patient participato ... Full text Link to item Cite

Safety of continuous left atrial phased-array intracardiac echocardiography during left atrial ablation for atrial fibrillation.

Journal Article Heart Rhythm O2 · December 2022 BACKGROUND: Pulmonary vein (PV) isolation using radiofrequency ablation (RFA) to treat atrial fibrillation (AF) requires delivery of contiguous transmural lesions at the PV antra while avoiding injury to the esophagus. Continuous 2-dimensional phased-array ... Full text Link to item Cite

Racial and ethnic differences in implantable cardioverter-defibrillator patient selection, management, and outcomes

Journal Article Heart Rhythm O2 · December 1, 2022 Racial and ethnic differences in treatment—cardiovascular and otherwise—have been documented in many aspects of the American health care system and can be seen in implantable cardioverter-defibrillator (ICD) patient selection, counseling, and management. I ... Full text Cite

Characteristics Associated with Burnout among Cardiologists in an Academic Medical Setting: Baseline Survey Results from a Communication Coaching RCT.

Journal Article Behav Sci (Basel) · September 27, 2022 OBJECTIVES: Clinician burnout poses risks not just to clinicians but also to patients and the health system. Cardiologists might be especially prone to burnout due to performing high-risk procedures, having to discuss serious news, and treating diseases th ... Full text Link to item Cite

Leadless pacemaker implantation after lead extraction for cardiac implanted electronic device infection.

Journal Article J Cardiovasc Electrophysiol · March 2022 BACKGROUND: Cardiac implanted electronic device (CIED) pocket and systemic infection remain common complications with traditional CIEDs and are associated with high morbidity and mortality. Leadless pacemakers may be an attractive pacing alternative for ma ... Full text Link to item Cite

Epidemiology and Outcomes Associated with PR Prolongation.

Journal Article Card Electrophysiol Clin · December 2021 PR prolongation is defined primarily as delayed conduction through the AV node, but can also signify delayed electrical impulse propagation through any part of the conduction system. The prevalence of PR prolongation ranges from 1% to 5% in patients younge ... Full text Link to item Cite

The atrial fibrillation paradox -connecting hypertension to atrial disease and stroke

Journal Article American Journal of Preventive Cardiology · December 1, 2021 Full text Cite

Outcomes for patients with anterior myocardial infarction and prior cardiac arrest in the home automated external defibrillator trial (HAT).

Journal Article Resuscitation · November 2021 BACKGROUND: Patients with sudden cardiac arrest occurring in the acute phase of myocardial infarction (MI-SCA) are believed to be at similar risk of death after revascularization compared with MI patients without SCA (MI-no SCA). Among patients with anteri ... Full text Link to item Cite

Optimizing mechanically sensed atrial tracking in patients with atrioventricular-synchronous leadless pacemakers: A single-center experience.

Journal Article Heart Rhythm O2 · October 2021 BACKGROUND: Atrioventricular (AV)-synchronous single-chamber leadless pacing using a mechanical atrial sensing algorithm produced high AV synchrony in clinical trials, but clinical practice experience with these devices has not yet been described. OBJECTIV ... Full text Open Access Link to item Cite

Dosing of Direct Oral Anticoagulants in Patients with Moderate Chronic Kidney Disease in US Clinical Practice: Results from the Outcomes Registry for Better Informed Treatment of AF (ORBIT-AF II).

Journal Article Am J Cardiovasc Drugs · September 2021 INTRODUCTION: Direct oral anticoagulants (DOACs) have partial renal clearance and generally require dosage adjustments based on renal function. While current US and European guidance recommends dose adjustments in patients with moderate chronic kidney dise ... Full text Link to item Cite

Communication Coaching in Cardiology (CCC): A study protocol and methodological challenges and solutions of a randomized controlled trial in outpatient cardiology clinics.

Journal Article Contemp Clin Trials · June 2021 Given the role of effective communication in improving patient adherence and satisfaction, high quality patient-clinician communication is critical. Building on previous communication interventions in oncology and pediatrics, we developed a tailored commun ... Full text Link to item Cite

African American-Caucasian American differences in aortic valve replacement in patients with severe aortic stenosis.

Journal Article Am Heart J · April 2021 BACKGROUND: Among patients with severe aortic stenosis (AS), there are limited data on aortic valve replacement (AVR), reasons for nonreceipt and mortality by race. METHODS: Utilizing the Duke Echocardiography Laboratory Database, we analyzed data from 110 ... Full text Link to item Cite

Evaluation of Women and Underrepresented Racial and Ethnic Group Representation in a General Cardiology Fellowship After a Systematic Recruitment Initiative.

Journal Article JAMA Netw Open · January 4, 2021 IMPORTANCE: The proportion of women and underrepresented racial and ethnic groups (UREGs) matriculating into general cardiology fellowships remains low. OBJECTIVE: To assess a systematic recruitment initiative aimed at ensuring adequate matriculation of wo ... Full text Link to item Cite

Percutaneous left atrial appendage occlusion: A review of current devices, clinical evidence, patient selection, and post procedural antithrombotic management.

Journal Article Prog Cardiovasc Dis · 2021 Stroke is a major driver of increased morbidity and mortality in patients with non-valvular atrial fibrillation (NVAF). While systemic oral anticoagulation (OAC) continues to be the mainstay for stroke reduction therapy in patients with NVAF, several barri ... Full text Link to item Cite

Catheter ablation of atrial fibrillation in patients with diabetes mellitus.

Journal Article Heart Rhythm O2 · August 2020 BACKGROUND: Diabetes mellitus (DM) is an independent risk factor for atrial fibrillation (AF). Few studies have compared clinical outcomes after catheter ablation between patients with and those without DM. OBJECTIVE: The purpose of this study was to compa ... Full text Open Access Link to item Cite

Discontinuation rates of warfarin versus direct acting oral anticoagulants in US clinical practice: Results from Outcomes Registry for Better Informed Treatment of Atrial Fibrillation II (ORBIT-AF II).

Journal Article Am Heart J · August 2020 UNLABELLED: While oral anticoagulation is a cornerstone of stroke prevention therapy in atrial fibrillation (AF), few studies have evaluated comparative discontinuation rates in clinical practice. The objective of this study is to evaluate discontinuation ... Full text Link to item Cite

Safety and efficacy outcomes of left atrial posterior wall isolation compared to pulmonary vein isolation and pulmonary vein isolation with linear ablation for the treatment of persistent atrial fibrillation.

Journal Article Am Heart J · February 2020 BACKGROUND: Pulmonary wall isolation (PWI) is increasingly used as an adjunctive lesion set to compliment pulmonary vein isolation (PVI), especially in patients with persistent atrial fibrillation (AF). The objective was to compare outcomes of catheter abl ... Full text Link to item Cite

Videos to reduce racial disparities in ICD therapy Via Innovative Designs (VIVID) trial: Rational, design and methodology.

Journal Article Am Heart J · February 2020 BACKGROUND: Despite a higher prevalence of sudden cardiac death (SCD), black individuals are less likely than whites to have an implantable cardioverter defibrillator (ICD) implanted. Racial differences in ICD utilization is in part explained by higher ref ... Full text Link to item Cite

Effectiveness of catheter ablation of atrial fibrillation according to heart failure etiology.

Journal Article J Arrhythm · February 2020 BACKGROUND: Catheter ablation is an important rhythm control therapy in patients with atrial fibrillation (AF) with concomitant heart failure (HF). The objective of this study was to assess the comparative efficacy of AF ablation patients with ischemic vs ... Full text Open Access Link to item Cite

Racial and Ethnic Differences in Treatment and Outcomes of Severe Aortic Stenosis: A Review.

Journal Article JACC Cardiovasc Interv · January 27, 2020 Aortic stenosis (AS) is among the most common valvular heart diseases encountered in the United States. In this review the authors examine differences between racial and ethnic groups in the epidemiology and management of severe AS, explore potential expla ... Full text Open Access Link to item Cite

Predicting atrial fibrillation recurrence after ablation in patients with heart failure: Validity of the APPLE and CAAP-AF risk scoring systems.

Journal Article Pacing Clin Electrophysiol · November 2019 BACKGROUND: Compared with medical therapy, catheter ablation of atrial fibrillation (AF) in patients with heart failure (HF) improves cardiovascular outcomes. Risk scores (CAAP-AF and APPLE) have been developed to predict the likelihood of AF recurrence af ... Full text Open Access Link to item Cite

Racial differences in long-term outcomes among black and white patients with drug-eluting stents.

Journal Article Am Heart J · August 2019 BACKGROUND: Some studies suggest that black patients may have worse outcomes after drug-eluting stent (DES) placement. There are limited data characterizing long-term outcomes by race. The objective was to compare long-term outcomes between black and white ... Full text Link to item Cite

Prevalence of atrial fibrillation and association with clinical, sociocultural, and ancestral correlates among Hispanic/Latinos: The Hispanic Community Health Study/Study of Latinos.

Journal Article Heart Rhythm · May 2019 BACKGROUND: Hispanics/Latinos represent the largest ethnic minority group in the United States. Atrial fibrillation (AF) is the most common cardiac arrhythmia in the United States. OBJECTIVE: The purpose of this study was to provide data on the prevalence ... Full text Link to item Cite

Research Participation of a Professional Organization in Clinical Trials: The Association of Black cardiologists Clinical Trial Investigator Identification Project.

Journal Article J Natl Med Assoc · April 2019 INTRODUCTION: Black individuals continue to be underrepresented in clinical trials despite efforts by the National Institutes of Health and the Federal Drug Administration to increase their enrollment. Health care providers play a critical role in the recr ... Full text Link to item Cite

Race Effects in CVD Prediction Models.

Journal Article J Gen Intern Med · April 2019 Full text Link to item Cite

Atrial fibrillation and mortality risk: seeing the big picture.

Journal Article Eur Heart J Qual Care Clin Outcomes · January 1, 2019 Full text Link to item Cite

Assessing heterogeneity of treatment effect analyses in health-related cluster randomized trials: A systematic review.

Journal Article PLoS One · 2019 BACKGROUND: Cluster-randomized trials (CRTs) are being increasingly used to test a range of interventions, including medical interventions commonly used in clinical practice. Policies created by the NIH and the Food and Drug Administration (FDA) require th ... Full text Link to item Cite

Association of Race/Ethnicity With Oral Anticoagulant Use in Patients With Atrial Fibrillation: Findings From the Outcomes Registry for Better Informed Treatment of Atrial Fibrillation II.

Journal Article JAMA Cardiol · December 1, 2018 IMPORTANCE: Black and Hispanic patients are less likely than white patients to use oral anticoagulants for atrial fibrillation. Little is known about racial/ethnic differences in use of direct-acting oral anticoagulants (DOACs) for atrial fibrillation. OBJ ... Full text Link to item Cite

Early therapeutic persistence on dabigatran versus warfarin therapy in patients with atrial fibrillation: results from the Outcomes Registry for Better Informed Treatment of Atrial Fibrillation (ORBIT-AF) registry.

Journal Article J Thromb Thrombolysis · November 2018 Anticoagulation is highly effective for the prevention of stroke in patients with atrial fibrillation (AF) but it is dependent on patients continuing therapy. While studies have demonstrated suboptimal therapeutic persistence on warfarin, few have studied ... Full text Link to item Cite

Effectiveness of high rate and delayed detection ICD programming by race: A MADIT-RIT substudy.

Journal Article J Cardiovasc Electrophysiol · October 2018 INTRODUCTION: Data on inappropriate and appropriate ICD therapy, and efficacy of ICD programing strategies by race are limited. METHODS: In MADIT-RIT, we evaluated the risk of ICD therapy by race, and the efficacy of high rate cut-off ventricular tachycard ... Full text Link to item Cite

Racial and ethnic differences in the prevalence, management, and outcomes in patients with atrial fibrillation: A systematic review.

Journal Article Heart Rhythm · September 2018 Atrial fibrillation (AF) is the most common cardiac arrhythmia in the United States and is associated with increased morbidity, mortality, and health care expenditures. In this review, our aim was to assess the racial and ethnic differences in the epidemio ... Full text Link to item Cite

Stroke Risk and Treatment in Patients with Atrial Fibrillation and Low CHA2DS2-VASc Scores: Findings From the ORBIT-AF I and II Registries.

Journal Article J Am Heart Assoc · August 21, 2018 Background Current American College of Cardiology/American Heart Association guidelines suggest that for patients with atrial fibrillation who are at low risk for stroke (CHA2DS2VASc=1) (or women with CHA2DS2VASc=2) a variety of treatment strategies may be ... Full text Open Access Link to item Cite

Pacemaker programming in patients with first-degree AV-block: Programming pattern and possible consequences.

Journal Article Health Sci Rep · June 2018 BACKGROUND: The optimal way of pacing in patients with an indication for pacing and concomitant first-degree atrioventricular (AV)-block is not known, and consequently, firm guidelines on this topic are lacking. This study explored the current pacemaker pr ... Full text Link to item Cite

Catheter ablation of atrial fibrillation in patients with heart failure and preserved ejection fraction.

Journal Article Heart Rhythm · May 2018 BACKGROUND: Few studies have examined outcomes of catheter ablation for atrial fibrillation (AF) in patients with heart failure (HF) with preserved ejection fraction (HFpEF). OBJECTIVE: The purpose of this study was to compare outcomes of AF ablation in pa ... Full text Link to item Cite

The REstart or STop Antithrombotics Randomised Trial (RESTART) after stroke due to intracerebral haemorrhage: study protocol for a randomised controlled trial.

Journal Article Trials · March 5, 2018 BACKGROUND: For adults surviving stroke due to spontaneous (non-traumatic) intracerebral haemorrhage (ICH) who had taken an antithrombotic (i.e. anticoagulant or antiplatelet) drug for the prevention of vaso-occlusive disease before the ICH, it is unclear ... Full text Link to item Cite

Representation of black patients in randomized clinical trials of heart failure with reduced ejection fraction.

Journal Article Am Heart J · March 2018 BACKGROUND: Black individuals have a disproportionately higher burden of heart failure with reduced ejection fraction (HFrEF) relative to other racial and ethnic populations. We conducted a systematic review to determine the representation, enrollment tren ... Full text Link to item Cite

Prevalence, Characteristics, and Outcomes of Valvular Heart Disease in Patients With Atrial Fibrillation: Insights From the ORBIT-AF (Outcomes Registry for Better Informed Treatment for Atrial Fibrillation).

Journal Article J Am Heart Assoc · December 22, 2017 BACKGROUND: The presence of valvular heart disease (VHD) may affect the risk of stroke and mortality in patients with atrial fibrillation (AF). Community-based estimates of prevalence and outcomes of specific forms of VHD in patients with AF are lacking. M ... Full text Link to item Cite

Effects of Once-Weekly Exenatide on Cardiovascular Outcomes in Type 2 Diabetes.

Journal Article N Engl J Med · September 28, 2017 BACKGROUND: The cardiovascular effects of adding once-weekly treatment with exenatide to usual care in patients with type 2 diabetes are unknown. METHODS: We randomly assigned patients with type 2 diabetes, with or without previous cardiovascular disease, ... Full text Open Access Link to item Cite

Sinus Node Dysfunction and Atrial Fibrillation: A Reversible Phenomenon?

Journal Article Pacing Clin Electrophysiol · April 2017 BACKGROUND: Symptomatic sinus node dysfunction (SND) consists of a variety of manifestations, including tachycardia-bradycardia syndrome. Atrial fibrillation (AF) is commonly associated with SND, which complicates the management of both conditions. This pa ... Full text Link to item Cite

Impact of Proton Pump Inhibitor Use on the Comparative Effectiveness and Safety of Prasugrel Versus Clopidogrel: Insights From the Treatment With Adenosine Diphosphate Receptor Inhibitors: Longitudinal Assessment of Treatment Patterns and Events After Acute Coronary Syndrome (TRANSLATE-ACS) Study.

Journal Article J Am Heart Assoc · October 21, 2016 BACKGROUND: Proton pump inhibitors (PPIs) reduce gastrointestinal bleeding events but may alter clopidogrel metabolism. We sought to understand the comparative effectiveness and safety of prasugrel versus clopidogrel in the context of proton pump inhibitor ... Full text Link to item Cite

Dual Antiplatelet Therapy and Outcomes in Patients With Atrial Fibrillation and Acute Coronary Syndromes Managed Medically Without Revascularization: Insights From the TRILOGY ACS Trial.

Journal Article Clin Cardiol · September 2016 Associations between atrial fibrillation (AF), outcomes, and response to antiplatelet therapies in patients with acute coronary syndrome (ACS) managed medically without revascularization remain uncertain. We examined these associations for medically manage ... Full text Link to item Cite

Review of venous thromboembolism and race: the generalizability of treatment guidelines for high-risk populations.

Journal Article J Thromb Thrombolysis · August 2016 The American College of Chest Physicians (ACCP) has established guidelines for the treatment of VTE, but the generalizability to all populations is unclear. In this review we analyzed the rate of reporting and enrollment of blacks and women in clinical tri ... Full text Link to item Cite

Predictors and Risk of Ventricular Tachyarrhythmias or Death in Black and White Cardiac Patients: A MADIT-CRT Trial Substudy.

Journal Article JACC Clin Electrophysiol · August 2016 OBJECTIVES: The study sought to analyze the risk of ventricular tachyarrhythmia (VTA) or death in black and white subjects implanted with implantable cardioverter-defibrillators (ICDs) or defibrillator and combined cardiac resynchronization therapy (CRT-D) ... Full text Link to item Cite

Racial/ethnic differences in atrial fibrillation symptoms, treatment patterns, and outcomes: Insights from Outcomes Registry for Better Informed Treatment for Atrial Fibrillation Registry.

Journal Article Am Heart J · April 2016 BACKGROUND: Significant racial/ethnic differences exist in the incidence of atrial fibrillation (AF). However, less is known about racial/ethnic differences in quality of life (QoL), treatment, and outcomes associated with AF. METHODS: Using data from the ... Full text Link to item Cite

Sinus Node Dysfunction Is Associated With Higher Symptom Burden and Increased Comorbid Illness: Results From the ORBIT-AF Registry.

Journal Article Clin Cardiol · February 2016 BACKGROUND: Patients with sinus node dysfunction (SND) have increased risk of atrial tachyarrhythmias, including atrial fibrillation (AF). To date, treatment patterns and outcomes of patients with SND and AF have not been well described. HYPOTHESIS: Patien ... Full text Open Access Link to item Cite

Outcomes of Patients With Acute Myocardial Infarction Undergoing Percutaneous Coronary Intervention Receiving an Oral Anticoagulant and Dual Antiplatelet Therapy: A Comparison of Clopidogrel Versus Prasugrel From the TRANSLATE-ACS Study.

Journal Article JACC Cardiovasc Interv · December 21, 2015 OBJECTIVES: The purpose of this study was to determine whether bleeding risk varies depending on which P2Y12 receptor inhibitor agent is used. BACKGROUND: Prior studies have shown significant bleeding risk among patients treated with triple therapy (i.e., ... Full text Link to item Cite

Effect of Sitagliptin on Cardiovascular Outcomes in Type 2 Diabetes.

Journal Article N Engl J Med · July 16, 2015 BACKGROUND: Data are lacking on the long-term effect on cardiovascular events of adding sitagliptin, a dipeptidyl peptidase 4 inhibitor, to usual care in patients with type 2 diabetes and cardiovascular disease. METHODS: In this randomized, double-blind st ... Full text Link to item Cite

Localization of pacing and defibrillator leads using standard x-ray views is frequently inaccurate and is not reproducible.

Journal Article J Interv Card Electrophysiol · June 2015 PURPOSE: While the accuracy of roentography for evaluation of lead tip position compared with three-dimensional imaging techniques has been well described, there remains considerable variability in the interpretation of the reproducibility of standard x-ra ... Full text Link to item Cite

Review of race/ethnicity in non vitamin K antagonist oral anticoagulants clinical trials.

Journal Article J Thromb Thrombolysis · February 2015 Non vitamin K antagonist oral anticoagulants (NOACs) have advantages relative to traditional vitamin K antagonist oral anticoagulants and represents an important advance in the management of patients with atrial fibrillation and venous thromboembolism. Yet ... Full text Link to item Cite

Novel oral anticoagulants: pharmacology, coagulation measures, and considerations for reversal.

Journal Article J Thromb Thrombolysis · April 2014 Novel oral anticoagulants (NOAC) provide an effective and, in some cases, superior alternative to traditional, oral vitamin K antagonists such as warfarin. These drugs differ in their pharmacokinetic and pharmacodynamics profiles, which is important for se ... Full text Link to item Cite

Expanding the benefits of implantable cardioverter-defibrillator therapy: "is less more"?

Journal Article Prog Cardiovasc Dis · 2012 Implantable cardioverter-defibrillator (ICD) therapy improves survival in patients with significant left ventricular systolic dysfunction. Although this lifesaving therapy has many benefits, inappropriate ICD shocks may increase morbidity and mortality. Wi ... Full text Link to item Cite